MX2021007143A - Sintesis de gamma-carbolinas fusionadas con heterociclo sustituido. - Google Patents

Sintesis de gamma-carbolinas fusionadas con heterociclo sustituido.

Info

Publication number
MX2021007143A
MX2021007143A MX2021007143A MX2021007143A MX2021007143A MX 2021007143 A MX2021007143 A MX 2021007143A MX 2021007143 A MX2021007143 A MX 2021007143A MX 2021007143 A MX2021007143 A MX 2021007143A MX 2021007143 A MX2021007143 A MX 2021007143A
Authority
MX
Mexico
Prior art keywords
heterocycle fused
substituted heterocycle
fused gamma
carbolines
synthesis
Prior art date
Application number
MX2021007143A
Other languages
English (en)
Inventor
Peng Li
Original Assignee
Intra Cellular Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intra Cellular Therapies Inc filed Critical Intra Cellular Therapies Inc
Publication of MX2021007143A publication Critical patent/MX2021007143A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems

Abstract

La presente invención proporciona métodos mejorados para la preparación de gamma-carbolinas fusionadas con heterociclo sustituido, intermediarios útiles para producirlas y métodos para producir los intermediarios y las gamma-carbolinas fusionadas con heterociclo.
MX2021007143A 2018-12-17 2019-12-17 Sintesis de gamma-carbolinas fusionadas con heterociclo sustituido. MX2021007143A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862780728P 2018-12-17 2018-12-17
PCT/US2019/066909 WO2020131911A1 (en) 2018-12-17 2019-12-17 Substituted heterocycle fused gamma-carbolines synthesis

Publications (1)

Publication Number Publication Date
MX2021007143A true MX2021007143A (es) 2021-08-18

Family

ID=71100836

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021007143A MX2021007143A (es) 2018-12-17 2019-12-17 Sintesis de gamma-carbolinas fusionadas con heterociclo sustituido.

Country Status (8)

Country Link
US (1) US20220064166A1 (es)
EP (1) EP3898581A4 (es)
JP (1) JP2022514263A (es)
KR (1) KR20210104834A (es)
CN (1) CN113195450B (es)
IL (1) IL283963A (es)
MX (1) MX2021007143A (es)
WO (1) WO2020131911A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110831941A (zh) 2018-06-11 2020-02-21 细胞内治疗公司 取代的杂环稠合的γ-咔啉类化合物合成

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL145998A0 (en) * 1999-06-15 2002-07-25 Du Pont Pharm Co Substituted heterocycle fused gamma-carbolines
US6713471B1 (en) * 1999-06-15 2004-03-30 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
JP5567349B2 (ja) * 2007-03-12 2014-08-06 イントラ−セルラー・セラピーズ・インコーポレイテッド 置換ヘテロ環縮合ガンマ−カルボリンの合成
US8309772B2 (en) * 2008-07-31 2012-11-13 Celanese International Corporation Tunable catalyst gas phase hydrogenation of carboxylic acids
US9708322B2 (en) * 2013-03-15 2017-07-18 Intra-Cellular Therapies, Inc. Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity
CN113786407A (zh) * 2016-01-26 2021-12-14 细胞内治疗公司 有机化合物
US10961245B2 (en) * 2016-12-29 2021-03-30 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders
BR112020001654A2 (pt) * 2017-07-26 2020-07-21 Intra-Cellular Therapies, Inc. compostos orgânicos
IL272249B2 (en) * 2017-07-26 2023-11-01 Intra Cellular Therapies Inc organic compounds
WO2019183341A1 (en) * 2018-03-23 2019-09-26 Intra-Cellular Therapies, Inc. Organic compounds
WO2019237037A1 (en) * 2018-06-08 2019-12-12 Intra-Cellular Therapies, Inc. Novel methods

Also Published As

Publication number Publication date
WO2020131911A1 (en) 2020-06-25
IL283963A (en) 2021-07-29
JP2022514263A (ja) 2022-02-10
EP3898581A4 (en) 2022-08-17
CN113195450A (zh) 2021-07-30
CN113195450B (zh) 2024-04-26
KR20210104834A (ko) 2021-08-25
US20220064166A1 (en) 2022-03-03
EP3898581A1 (en) 2021-10-27

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