JP2017510580A5 - - Google Patents
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- JP2017510580A5 JP2017510580A5 JP2016558569A JP2016558569A JP2017510580A5 JP 2017510580 A5 JP2017510580 A5 JP 2017510580A5 JP 2016558569 A JP2016558569 A JP 2016558569A JP 2016558569 A JP2016558569 A JP 2016558569A JP 2017510580 A5 JP2017510580 A5 JP 2017510580A5
- Authority
- JP
- Japan
- Prior art keywords
- genus
- oxo
- amino
- morganella
- citrobacter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 201000009906 Meningitis Diseases 0.000 claims description 6
- 241000588771 Morganella <proteobacterium> Species 0.000 claims description 6
- 241000589291 Acinetobacter Species 0.000 claims description 5
- 241001453380 Burkholderia Species 0.000 claims description 5
- 241000588923 Citrobacter Species 0.000 claims description 5
- 241000588914 Enterobacter Species 0.000 claims description 5
- 241000588722 Escherichia Species 0.000 claims description 5
- 241000588748 Klebsiella Species 0.000 claims description 5
- 241000588653 Neisseria Species 0.000 claims description 5
- 241000588769 Proteus <enterobacteria> Species 0.000 claims description 5
- 241000589516 Pseudomonas Species 0.000 claims description 5
- 241000607142 Salmonella Species 0.000 claims description 5
- 241000607720 Serratia Species 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 241000606125 Bacteroides Species 0.000 claims description 3
- 241000589876 Campylobacter Species 0.000 claims description 3
- 241000122971 Stenotrophomonas Species 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 241000894007 species Species 0.000 claims description 3
- 208000035143 Bacterial infection Diseases 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- YMGUBTXCNDTFJI-UHFFFAOYSA-N cyclopropanecarboxylic acid Chemical compound OC(=O)C1CC1 YMGUBTXCNDTFJI-UHFFFAOYSA-N 0.000 claims 2
- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- -1 2-aminothiazol-4-yl Chemical group 0.000 claims 1
- 241000255925 Diptera Species 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000027096 gram-negative bacterial infections Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461969735P | 2014-03-24 | 2014-03-24 | |
| US61/969,735 | 2014-03-24 | ||
| US201462088304P | 2014-12-05 | 2014-12-05 | |
| US62/088,304 | 2014-12-05 | ||
| PCT/US2015/022011 WO2015148379A1 (en) | 2014-03-24 | 2015-03-23 | Monobactam organic compounds for the treatment of bacterial infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017510580A JP2017510580A (ja) | 2017-04-13 |
| JP2017510580A5 true JP2017510580A5 (enExample) | 2017-06-01 |
| JP6153674B2 JP6153674B2 (ja) | 2017-06-28 |
Family
ID=52808201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016558569A Active JP6153674B2 (ja) | 2014-03-24 | 2015-03-23 | 細菌感染を治療するためのモノバクタム有機化合物 |
Country Status (37)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT202000480T1 (it) * | 2015-09-23 | 2020-11-10 | Novartis Ag | Sali e forme solide di un antibiotico monobactamico |
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| MA44083A (fr) | 2015-12-15 | 2021-06-02 | Merck Sharp & Dohme | Composés de biarylmonobactame pour le traitement d'infections bactériennes |
| BR112018067930B1 (pt) | 2016-03-07 | 2024-02-15 | Merck Sharp & Dohme Llc | Composto, sal de ácido trifluoroacético, composição farmacêutica, e, uso de um composto |
| US11174260B2 (en) | 2017-03-20 | 2021-11-16 | The Broad Institute, Inc. | Compounds and methods for the treatment of parasitic diseases |
| JP7235718B2 (ja) * | 2017-08-02 | 2023-03-08 | ノバルティス アーゲー | モノバクタム系抗生物質およびその中間体を製造するための化学的方法 |
| WO2019058346A1 (en) * | 2017-09-22 | 2019-03-28 | Novartis Ag | MONOBACTAM ADMINISTRATION IN ASSOCIATION WITH ANTIBIOTIC AGENT FOR THE TREATMENT OF COMPLICATED INTRA-ABDOMINAL INFECTION |
| AU2018345321B2 (en) * | 2017-10-02 | 2021-05-20 | Arixa Pharmaceuticals, Inc. | Aztreonam derivatives and uses thereof |
| AU2018345523B2 (en) | 2017-10-02 | 2021-10-21 | Merck Sharp & Dohme Llc | Chromane monobactam compounds for the treatment of bacterial infections |
| WO2019092180A1 (en) * | 2017-11-10 | 2019-05-16 | Novartis Ag | Administration of monobactam for the treatment of urinary tract infection |
| WO2019144969A1 (zh) | 2018-01-29 | 2019-08-01 | 南京明德新药研发股份有限公司 | 用于治疗细菌感染的单环β-内酰胺化合物 |
| KR102017784B1 (ko) * | 2018-04-11 | 2019-09-03 | 전북대학교산학협력단 | 민감성 및 선택성을 개선한 캠필로박터 검출용 배지 조성물 및 이를 이용한 캠필로박터 검출방법 |
| KR102017785B1 (ko) * | 2018-05-17 | 2019-09-03 | 전북대학교산학협력단 | 민감성 및 선택성을 개선한 캠필로박터 선택증균용 배지 조성물 및 이를 이용한 캠필로박터 검출방법 |
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| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| WO2020098635A1 (zh) | 2018-11-13 | 2020-05-22 | 南京圣和药业股份有限公司 | 单环内酰胺化合物及其应用 |
| US12310948B2 (en) | 2018-12-18 | 2025-05-27 | Shenzhen Optimum Biological Technology Co., Ltd | Application of monocyclic β-lactam compound in pharmacy |
| EP4046998B1 (en) * | 2019-11-22 | 2024-02-28 | Suzhou Erye Pharmaceutical Co., Ltd. | Sulfonylurea ring substituted monocyclic beta-lactam antibiotics |
| CN111303144B (zh) * | 2019-12-13 | 2020-11-27 | 苏州信诺维医药科技有限公司 | 一种治疗细菌感染的化合物 |
| EP4079305A4 (en) | 2019-12-19 | 2024-01-10 | Shenzhen Optimum Biological Technology Co., Ltd | APPLICATION OF A COMPOUND IN THE PREPARATION OF DRUG |
| EP3838266A1 (en) | 2019-12-20 | 2021-06-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Microfluidic production of biofunctionalized giant unilamellar vesicles for targeted intracellular cargo delivery |
| CN113754651B (zh) * | 2020-06-02 | 2023-04-18 | 中国医学科学院医药生物技术研究所 | 一种β-内酰胺化合物、其用途及其制备方法 |
| WO2022011626A1 (en) * | 2020-07-16 | 2022-01-20 | Ningxia Academy Of Agriculture And Forestry Sciences | Novel monobactam compounds, their preparation and use as antibacterial agents |
| WO2022185240A1 (en) | 2021-03-04 | 2022-09-09 | Bp Asset Vi, Inc. | Formulation of a monobactam antibiotic |
| WO2022185241A1 (en) | 2021-03-04 | 2022-09-09 | Bp Asset Vi, Inc. | Process for manufacturing a monobactam antibiotic |
| US20250019376A1 (en) | 2021-11-18 | 2025-01-16 | Merck Sharp & Dohme Llc | Chromane amidine monobactam antibiotics |
| CN115304594B (zh) * | 2022-10-12 | 2023-02-14 | 苏州二叶制药有限公司 | 磺酰脲环取代的化合物的盐型及其晶型 |
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2015
- 2015-03-23 SI SI201530680T patent/SI3122745T1/sl unknown
- 2015-03-23 KR KR1020167024716A patent/KR101733441B1/ko active Active
- 2015-03-23 EP EP15714147.4A patent/EP3122745B1/en active Active
- 2015-03-23 JP JP2016558569A patent/JP6153674B2/ja active Active
- 2015-03-23 HU HUE15714147A patent/HUE042134T2/hu unknown
- 2015-03-23 AU AU2015236369A patent/AU2015236369B2/en active Active
- 2015-03-23 TW TW104109243A patent/TWI714525B/zh active
- 2015-03-23 PE PE2016001601A patent/PE20161371A1/es unknown
- 2015-03-23 MX MX2016011822A patent/MX373444B/es active IP Right Grant
- 2015-03-23 DK DK18215940.0T patent/DK3511328T3/da active
- 2015-03-23 RS RS20190406A patent/RS58509B1/sr unknown
- 2015-03-23 PH PH1/2016/501577A patent/PH12016501577B1/en unknown
- 2015-03-23 EA EA201691766A patent/EA030850B1/ru not_active IP Right Cessation
- 2015-03-23 CU CU2016000131A patent/CU24441B1/es unknown
- 2015-03-23 CN CN201580015867.7A patent/CN106164072B/zh active Active
- 2015-03-23 PT PT15714147T patent/PT3122745T/pt unknown
- 2015-03-23 SG SG11201606711UA patent/SG11201606711UA/en unknown
- 2015-03-23 BR BR112016020333-0A patent/BR112016020333B1/pt active IP Right Grant
- 2015-03-23 MY MYPI2016702871A patent/MY179292A/en unknown
- 2015-03-23 UA UAA201608977A patent/UA121383C2/uk unknown
- 2015-03-23 ES ES18215940T patent/ES2862203T3/es active Active
- 2015-03-23 MA MA39777A patent/MA39777B1/fr unknown
- 2015-03-23 CA CA2939254A patent/CA2939254C/en active Active
- 2015-03-23 HR HRP20190501TT patent/HRP20190501T1/hr unknown
- 2015-03-23 PL PL15714147T patent/PL3122745T3/pl unknown
- 2015-03-23 AP AP2016009374A patent/AP2016009374A0/en unknown
- 2015-03-23 WO PCT/US2015/022011 patent/WO2015148379A1/en not_active Ceased
- 2015-03-23 EP EP18215940.0A patent/EP3511328B1/en active Active
- 2015-03-23 LT LTEP15714147.4T patent/LT3122745T/lt unknown
- 2015-03-23 ES ES15714147T patent/ES2719136T3/es active Active
- 2015-03-23 SM SM20190218T patent/SMT201900218T1/it unknown
- 2015-03-23 US US14/665,245 patent/US9174978B2/en active Active
- 2015-03-23 DK DK15714147.4T patent/DK3122745T3/en active
- 2015-09-22 US US14/861,797 patent/US10369138B2/en active Active
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2016
- 2016-08-11 ZA ZA2016/05565A patent/ZA201605565B/en unknown
- 2016-08-14 IL IL247259A patent/IL247259B/en active IP Right Grant
- 2016-09-09 CL CL2016002285A patent/CL2016002285A1/es unknown
- 2016-09-12 SV SV2016005274A patent/SV2016005274A/es unknown
- 2016-09-12 EC ECIEPI201673620A patent/ECSP16073620A/es unknown
- 2016-09-12 GT GT201600183A patent/GT201600183A/es unknown
-
2019
- 2019-04-03 CY CY20191100371T patent/CY1121701T1/el unknown
- 2019-04-10 US US16/380,243 patent/US20190231752A1/en not_active Abandoned
-
2020
- 2020-03-19 US US16/823,485 patent/US20200276169A1/en not_active Abandoned
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