JP2011530534A5 - - Google Patents
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- Publication number
- JP2011530534A5 JP2011530534A5 JP2011522274A JP2011522274A JP2011530534A5 JP 2011530534 A5 JP2011530534 A5 JP 2011530534A5 JP 2011522274 A JP2011522274 A JP 2011522274A JP 2011522274 A JP2011522274 A JP 2011522274A JP 2011530534 A5 JP2011530534 A5 JP 2011530534A5
- Authority
- JP
- Japan
- Prior art keywords
- spp
- use according
- infection
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000015181 infectious disease Diseases 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 6
- 241000894006 Bacteria Species 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 2
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 241000588655 Moraxella catarrhalis Species 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 241000589291 Acinetobacter Species 0.000 claims 1
- 241000456624 Actinobacteria bacterium Species 0.000 claims 1
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 241000589876 Campylobacter Species 0.000 claims 1
- 241001185363 Chlamydiae Species 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 241000186216 Corynebacterium Species 0.000 claims 1
- 206010011409 Cross infection Diseases 0.000 claims 1
- 241000588921 Enterobacteriaceae Species 0.000 claims 1
- 241000741267 Enterobacteriaceae bacterium Species 0.000 claims 1
- 241000194033 Enterococcus Species 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 241000194029 Enterococcus hirae Species 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 241000589989 Helicobacter Species 0.000 claims 1
- 201000008225 Klebsiella pneumonia Diseases 0.000 claims 1
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 1
- 241000589248 Legionella Species 0.000 claims 1
- 208000007764 Legionnaires' Disease Diseases 0.000 claims 1
- 241000186781 Listeria Species 0.000 claims 1
- 241000589289 Moraxellaceae Species 0.000 claims 1
- 241000204031 Mycoplasma Species 0.000 claims 1
- 241000588656 Neisseriaceae Species 0.000 claims 1
- 241000187654 Nocardia Species 0.000 claims 1
- 206010029803 Nosocomial infection Diseases 0.000 claims 1
- 206010035717 Pneumonia klebsiella Diseases 0.000 claims 1
- 241000186429 Propionibacterium Species 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241000607493 Vibrionaceae Species 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 206010040872 skin infection Diseases 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18830708P | 2008-08-08 | 2008-08-08 | |
| US61/188,307 | 2008-08-08 | ||
| PCT/US2009/053142 WO2010017470A1 (en) | 2008-08-08 | 2009-08-07 | C7-fluoro substituted tetracycline compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014041460A Division JP5690957B2 (ja) | 2008-08-08 | 2014-03-04 | Ｃ７−フルオロ置換テトラサイクリン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011530534A JP2011530534A (ja) | 2011-12-22 |
| JP2011530534A5 true JP2011530534A5 (enExample) | 2012-09-20 |
| JP5496202B2 JP5496202B2 (ja) | 2014-05-21 |
Family
ID=41110902
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522274A Active JP5496202B2 (ja) | 2008-08-08 | 2009-08-07 | Ｃ７−フルオロ置換テトラサイクリン化合物 |
| JP2014041460A Expired - Fee Related JP5690957B2 (ja) | 2008-08-08 | 2014-03-04 | Ｃ７−フルオロ置換テトラサイクリン化合物 |
| JP2015018405A Expired - Fee Related JP6041911B2 (ja) | 2008-08-08 | 2015-02-02 | Ｃ７−フルオロ置換テトラサイクリン化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014041460A Expired - Fee Related JP5690957B2 (ja) | 2008-08-08 | 2014-03-04 | Ｃ７−フルオロ置換テトラサイクリン化合物 |
| JP2015018405A Expired - Fee Related JP6041911B2 (ja) | 2008-08-08 | 2015-02-02 | Ｃ７−フルオロ置換テトラサイクリン化合物 |
Country Status (31)
| Country | Link |
|---|---|
| US (11) | US8906887B2 (enExample) |
| EP (3) | EP2682387B1 (enExample) |
| JP (3) | JP5496202B2 (enExample) |
| KR (3) | KR101679023B1 (enExample) |
| CN (3) | CN105367440A (enExample) |
| AR (3) | AR072990A1 (enExample) |
| AU (1) | AU2009279473B2 (enExample) |
| BR (1) | BRPI0916985B1 (enExample) |
| CA (1) | CA2732883C (enExample) |
| CO (1) | CO6351777A2 (enExample) |
| CY (3) | CY1114689T1 (enExample) |
| DK (2) | DK2323972T3 (enExample) |
| ES (3) | ES2558512T3 (enExample) |
| FR (1) | FR19C1012I2 (enExample) |
| HR (2) | HRP20130928T1 (enExample) |
| HU (2) | HUE026562T2 (enExample) |
| IL (3) | IL211120A (enExample) |
| LT (1) | LTC2323972I2 (enExample) |
| LU (1) | LUC00107I2 (enExample) |
| MX (2) | MX358961B (enExample) |
| NL (1) | NL300971I2 (enExample) |
| NO (1) | NO2019010I1 (enExample) |
| NZ (3) | NZ603568A (enExample) |
| PL (3) | PL2323972T3 (enExample) |
| PT (2) | PT2323972E (enExample) |
| RS (2) | RS54485B1 (enExample) |
| SG (1) | SG10201806714PA (enExample) |
| SI (2) | SI2682387T1 (enExample) |
| SM (1) | SMT201600045B (enExample) |
| TW (3) | TWI453183B (enExample) |
| WO (1) | WO2010017470A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE026562T2 (hu) * | 2008-08-08 | 2016-06-28 | Tetraphase Pharmaceuticals Inc | C7-fluor-helyettesített tetraciklin vegyületek |
| CN102459153A (zh) | 2009-05-08 | 2012-05-16 | 四相制药公司 | 四环素类化合物 |
| EP2470500B1 (en) * | 2009-08-28 | 2017-10-04 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| WO2012021829A1 (en) * | 2010-08-12 | 2012-02-16 | Tetraphase Pharmaceuticals, Inc. | Methods of treating bacterial infections |
| WO2012021712A1 (en) * | 2010-08-12 | 2012-02-16 | Tetraphase Pharmaceuticals, Inc. | Tetracycline analogs |
| WO2012065028A2 (en) | 2010-11-11 | 2012-05-18 | Concert Pharmaceuticals Inc. | Substituted tetracyclines |
| TR201902057T4 (tr) | 2012-08-31 | 2019-03-21 | Tetraphase Pharmaceuticals Inc | Tetrasiklin bileşikleri. |
| CN104230960B (zh) * | 2013-06-06 | 2017-02-15 | 山东轩竹医药科技有限公司 | 四并环类间变性淋巴瘤激酶抑制剂 |
| MA40836A (fr) | 2014-10-23 | 2017-08-29 | Tetraphase Pharmaceuticals Inc | Procédures de semi-synthèse |
| WO2017097891A1 (en) | 2015-12-10 | 2017-06-15 | Sandoz Ag | Crystalline eravacycline |
| WO2017125557A1 (en) | 2016-01-22 | 2017-07-27 | Sandoz Ag | Crystalline eravacycline bis-hydrochloride |
| CN109414445A (zh) * | 2016-05-02 | 2019-03-01 | 帕拉特克药品公司 | 9-氨基甲基米诺环素化合物及其在泌尿道感染(uti)治疗中的应用方法 |
| CN107759503A (zh) * | 2016-08-16 | 2018-03-06 | 四川科伦博泰生物医药股份有限公司 | 一种四环素衍生物及其用途 |
| MA46102A (fr) | 2016-08-30 | 2019-07-10 | Tetraphase Pharmaceuticals Inc | Composés de tétracycline et méthodes de traitement |
| MA46567A (fr) * | 2016-10-19 | 2019-08-28 | Tetraphase Pharmaceuticals Inc | Formes cristallines de l'éravacycline |
| SG11201903846TA (en) | 2016-11-01 | 2019-05-30 | Paratek Pharm Innc | 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp) |
| WO2020097450A1 (en) | 2018-11-09 | 2020-05-14 | Tetraphase Pharmaceuticals, Inc. | Polymorphic forms of a compound and uses thereof |
| EP4531866A4 (en) * | 2022-05-29 | 2026-06-17 | B G Negev Technologies And Applications Ltd At Ben Gurion Univ | ERAVACYCLINE FOR CANCER TREATMENT |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB935384A (en) * | 1959-03-30 | 1963-08-28 | Pfizer & Co C | Tetracycline derivatives and preparation thereof |
| US3338963A (en) * | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
| GB1034933A (en) | 1962-10-29 | 1966-07-06 | American Cyanamid Co | 4-demethylamino-4-substituted amino 6-demethyl tetracyclines |
| US3304227A (en) | 1965-07-15 | 1967-02-14 | Loyal E Loveless | Antibiotic-containing animal feed |
| US3433709A (en) * | 1965-12-07 | 1969-03-18 | American Cyanamid Co | Biological transformation of alpha-6-deoxytetracyclines to tetracyclines |
| US4666897A (en) | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
| US4704383A (en) | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| USRE34656E (en) | 1983-12-29 | 1994-07-05 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency |
| US4935412A (en) | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4925833A (en) | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
| JP3016587B2 (ja) | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
| US5308839A (en) | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
| US5770588A (en) | 1991-02-11 | 1998-06-23 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions of the prevention and treatment of root caries |
| US5231017A (en) | 1991-05-17 | 1993-07-27 | Solvay Enzymes, Inc. | Process for producing ethanol |
| DK0536515T3 (da) * | 1991-10-04 | 2002-04-08 | American Cyanamid Co | Nye 7-substitueret-9-substitueret amino-6-demethyl-6-deoxytetracycliner |
| USRE40183E1 (en) | 1991-10-04 | 2008-03-25 | Wyeth Holdings Corporation | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| US5494903A (en) | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| US5258371A (en) | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
| US6043225A (en) | 1992-06-12 | 2000-03-28 | Board Of Regents Of The University Of Washington | Diagnosis and treatment of arterial chlamydial granuloma |
| US5328902A (en) | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| SG47520A1 (en) | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
| US5284963A (en) | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
| US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| JPH06256280A (ja) | 1992-11-17 | 1994-09-13 | Univ New York State | 糖尿病における過度のコラーゲン架橋結合を阻害する非抗菌性化学修飾テトラサイクリンを含むテトラサイクリン |
| US6043231A (en) | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| US5523297A (en) | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| US5371076A (en) * | 1993-04-02 | 1994-12-06 | American Cyanamid Company | 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines |
| US5668122A (en) | 1993-07-28 | 1997-09-16 | Fife; Rose S. | Method to treat cancer with tetracyclines |
| WO1995022529A1 (en) | 1994-02-17 | 1995-08-24 | Pfizer Inc. | 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
| US5574026A (en) * | 1994-12-13 | 1996-11-12 | American Cyanamid Company | Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth |
| US5843925A (en) | 1994-12-13 | 1998-12-01 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
| US5495301A (en) * | 1994-12-27 | 1996-02-27 | Zenith Electronics Corporation | Three wire pillow speaker with full television remote control functions |
| US5834449A (en) | 1996-06-13 | 1998-11-10 | The Research Foundation Of State University Of New York | Treatment of aortic and vascular aneurysms with tetracycline compounds |
| US5827840A (en) | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
| US5789395A (en) | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US5919774A (en) | 1996-12-10 | 1999-07-06 | Eli Lilly And Company | Pyrroles as sPLA2 inhibitors |
| US5837696A (en) | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
| US5773430A (en) | 1997-03-13 | 1998-06-30 | Research Foundation Of State University Of New York | Serine proteinase inhibitory activity by hydrophobic tetracycline |
| US5929055A (en) | 1997-06-23 | 1999-07-27 | The Research Foundation Of State University Of New York | Therapeutic method for management of diabetes mellitus |
| US6277061B1 (en) | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
| US6015804A (en) | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
| US5977091A (en) | 1998-09-21 | 1999-11-02 | The Research Foundation Of State University Of New York | Method of preventing acute lung injury |
| US5998390A (en) | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
| EP1124558A4 (en) | 1998-09-28 | 2004-10-27 | Res Foundation Ofstate Univers | NEW INHIBITANT AGAINST CATARACT EDUCATION |
| US6914057B1 (en) | 1998-09-28 | 2005-07-05 | The Research Foundation Of State University Of New York | Inhibitor of cataract formation |
| US6231894B1 (en) | 1999-10-21 | 2001-05-15 | Duke University | Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase |
| AU2000257445A1 (en) | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-n-substituted phenyl tetracycline compounds |
| ATE504562T1 (de) | 2000-07-07 | 2011-04-15 | Tufts College | 7-, 8- und 9-substitutierte tetracyclinverbindungen |
| CZ2003344A3 (cs) * | 2000-07-07 | 2003-05-14 | Trustees Of Tufts College | 9-Substituované minocyklinové sloučeniny |
| EP1381372A2 (en) | 2001-03-14 | 2004-01-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
| US6841546B2 (en) | 2001-03-14 | 2005-01-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as antifungal agents |
| EP1399414B1 (en) | 2001-04-24 | 2010-01-13 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| US8088820B2 (en) | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| US20060194773A1 (en) | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
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| JP2005526754A (ja) | 2002-03-08 | 2005-09-08 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノメチル置換されたテトラサイクリン化合物 |
| EP1503981A4 (en) | 2002-03-21 | 2007-08-15 | Paratek Pharm Innc | SUBSTITUTED TETRACYCLINE COMPOUNDS |
| WO2004006850A2 (en) | 2002-07-12 | 2004-01-22 | Paratek Pharmaceuticals, Inc | 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS |
| JP4686189B2 (ja) | 2002-10-24 | 2011-05-18 | パラテック ファーマシューティカルズ インコーポレイテッド | Ｒｎａを調節するための置換テトラサイクリン化合物の使用方法 |
| WO2004038001A2 (en) | 2002-10-24 | 2004-05-06 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| WO2005009943A2 (en) | 2003-07-09 | 2005-02-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| KR101171408B1 (ko) | 2004-05-21 | 2012-08-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 테트라사이클린 및 이의 유사체의 합성 |
| JP2008518025A (ja) | 2004-10-25 | 2008-05-29 | パラテック ファーマシューティカルズ インコーポレイテッド | ４−アミノテトラサイクリンおよびその使用の方法 |
| AU2006210406C1 (en) | 2005-02-04 | 2013-03-07 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| CN101119964A (zh) * | 2005-02-15 | 2008-02-06 | 惠氏公司 | 9-经取代四环素 |
| CA2616224A1 (en) | 2005-07-21 | 2007-02-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
| EP1991236A2 (en) | 2006-01-24 | 2008-11-19 | Paratek Pharmaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
| JP5335664B2 (ja) | 2006-04-07 | 2013-11-06 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | テトラサイクリンおよびその類似体の合成 |
| WO2007133797A2 (en) | 2006-05-15 | 2007-11-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| EP2479169B1 (en) | 2006-10-11 | 2014-12-03 | President and Fellows of Harvard College | Synthesis of Enone Intermediate |
| WO2008045507A2 (en) | 2006-10-11 | 2008-04-17 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of bacillus anthracis infections |
| EP2144614A1 (en) | 2007-04-12 | 2010-01-20 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| WO2009073056A1 (en) * | 2007-09-07 | 2009-06-11 | Dr. Reddy's Laboratories Ltd. | Novel tetracycline derivatives as antibacterial agents |
| JP2011517697A (ja) | 2008-04-14 | 2011-06-16 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換テトラサイクリン化合物 |
| HUE026562T2 (hu) | 2008-08-08 | 2016-06-28 | Tetraphase Pharmaceuticals Inc | C7-fluor-helyettesített tetraciklin vegyületek |
| WO2010126607A2 (en) | 2009-04-30 | 2010-11-04 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
| CN102459153A (zh) | 2009-05-08 | 2012-05-16 | 四相制药公司 | 四环素类化合物 |
| US8367654B2 (en) | 2009-05-08 | 2013-02-05 | Tetraphase Pharmaceuticals, Inc. | 8-AZA tetracycline compounds |
| EP2470500B1 (en) | 2009-08-28 | 2017-10-04 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| WO2012021712A1 (en) | 2010-08-12 | 2012-02-16 | Tetraphase Pharmaceuticals, Inc. | Tetracycline analogs |
| WO2012047907A1 (en) | 2010-10-04 | 2012-04-12 | President And Fellows Of Harvard College | Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto |
| TR201902057T4 (tr) | 2012-08-31 | 2019-03-21 | Tetraphase Pharmaceuticals Inc | Tetrasiklin bileşikleri. |
-
2009
- 2009-08-07 HU HUE13172357A patent/HUE026562T2/hu unknown
- 2009-08-07 AR ARP090103046A patent/AR072990A1/es active IP Right Grant
- 2009-08-07 PT PT97912901T patent/PT2323972E/pt unknown
- 2009-08-07 EP EP13172357.9A patent/EP2682387B1/en active Active
- 2009-08-07 CA CA2732883A patent/CA2732883C/en active Active
- 2009-08-07 CN CN201510656850.1A patent/CN105367440A/zh active Pending
- 2009-08-07 HR HRP20130928AT patent/HRP20130928T1/hr unknown
- 2009-08-07 MX MX2013009145A patent/MX358961B/es unknown
- 2009-08-07 DK DK09791290.1T patent/DK2323972T3/da active
- 2009-08-07 KR KR1020117005491A patent/KR101679023B1/ko active Active
- 2009-08-07 BR BRPI0916985-7A patent/BRPI0916985B1/pt active IP Right Grant
- 2009-08-07 NZ NZ603568A patent/NZ603568A/en not_active IP Right Cessation
- 2009-08-07 PL PL09791290T patent/PL2323972T3/pl unknown
- 2009-08-07 PL PL13172357T patent/PL2682387T3/pl unknown
- 2009-08-07 SI SI200931338T patent/SI2682387T1/sl unknown
- 2009-08-07 SG SG10201806714PA patent/SG10201806714PA/en unknown
- 2009-08-07 ES ES13172357.9T patent/ES2558512T3/es active Active
- 2009-08-07 ES ES09791290T patent/ES2430254T3/es active Active
- 2009-08-07 ES ES15180611.4T patent/ES2655911T3/es active Active
- 2009-08-07 PL PL15180611T patent/PL3000805T3/pl unknown
- 2009-08-07 RS RS20150879A patent/RS54485B1/sr unknown
- 2009-08-07 MX MX2011001367A patent/MX2011001367A/es active IP Right Grant
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