JP2013253094A5 - - Google Patents
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- Publication number
- JP2013253094A5 JP2013253094A5 JP2013169657A JP2013169657A JP2013253094A5 JP 2013253094 A5 JP2013253094 A5 JP 2013253094A5 JP 2013169657 A JP2013169657 A JP 2013169657A JP 2013169657 A JP2013169657 A JP 2013169657A JP 2013253094 A5 JP2013253094 A5 JP 2013253094A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- carbapenem
- use according
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 8
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 claims 7
- 230000003115 biocidal effect Effects 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 4
- 229960002260 meropenem Drugs 0.000 claims 4
- DMJNNHOOLUXYBV-PQTSNVLCSA-N meropenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](C(=O)N(C)C)C1 DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- JUZNIMUFDBIJCM-ANEDZVCMSA-N Invanz Chemical compound O=C([C@H]1NC[C@H](C1)SC=1[C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)NC1=CC=CC(C(O)=O)=C1 JUZNIMUFDBIJCM-ANEDZVCMSA-N 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 claims 2
- 229960003644 aztreonam Drugs 0.000 claims 2
- 229960000895 doripenem Drugs 0.000 claims 2
- AVAACINZEOAHHE-VFZPANTDSA-N doripenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](CNS(N)(=O)=O)C1 AVAACINZEOAHHE-VFZPANTDSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229960002770 ertapenem Drugs 0.000 claims 2
- 229960002182 imipenem Drugs 0.000 claims 2
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000005646 oximino group Chemical group 0.000 claims 2
- 241001673062 Achromobacter xylosoxidans Species 0.000 claims 1
- 208000008745 Healthcare-Associated Pneumonia Diseases 0.000 claims 1
- 241000588915 Klebsiella aerogenes Species 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 229940092559 enterobacter aerogenes Drugs 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07006053 | 2007-03-23 | ||
| EP07006053.8 | 2007-03-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009554024A Division JP2010521517A (ja) | 2007-03-23 | 2008-03-19 | 細菌感染症を処置するための組合せ薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013253094A JP2013253094A (ja) | 2013-12-19 |
| JP2013253094A5 true JP2013253094A5 (enExample) | 2014-02-06 |
| JP5779209B2 JP5779209B2 (ja) | 2015-09-16 |
Family
ID=38293982
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009554024A Pending JP2010521517A (ja) | 2007-03-23 | 2008-03-19 | 細菌感染症を処置するための組合せ薬 |
| JP2013169657A Expired - Fee Related JP5779209B2 (ja) | 2007-03-23 | 2013-08-19 | 細菌感染症を処置するための組合せ薬 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009554024A Pending JP2010521517A (ja) | 2007-03-23 | 2008-03-19 | 細菌感染症を処置するための組合せ薬 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8486929B2 (enExample) |
| EP (1) | EP2124942B1 (enExample) |
| JP (2) | JP2010521517A (enExample) |
| KR (1) | KR101320718B1 (enExample) |
| CN (1) | CN101641095B (enExample) |
| AU (1) | AU2008231854B2 (enExample) |
| BR (1) | BRPI0809147A2 (enExample) |
| CA (1) | CA2680018C (enExample) |
| MX (1) | MX2009009918A (enExample) |
| NZ (1) | NZ579375A (enExample) |
| RU (1) | RU2488394C2 (enExample) |
| WO (1) | WO2008116813A2 (enExample) |
| ZA (1) | ZA200906349B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2488394C2 (ru) * | 2007-03-23 | 2013-07-27 | Базилеа Фармацойтика Аг | Комбинированные лекарственные средства для лечения бактериальных инфекций |
| TR201102640T1 (tr) * | 2008-12-01 | 2011-08-22 | Glade Organics Private Limited | Aztreonamın meropenem ve ertapenem adlı karbapenemlerle oluşturduğu sinerjik kombinasyonlar. |
| CN102325769A (zh) | 2008-12-19 | 2012-01-18 | 美国辉瑞有限公司 | 单卡波姆 |
| RU2599791C2 (ru) | 2010-08-10 | 2016-10-20 | Ремпекс Фармасьютикэлз, Инч. | Циклические бороновые кислотно-эфирные производные и их использование в терапии |
| KR101315483B1 (ko) * | 2011-06-23 | 2013-10-07 | 주식회사 아리바이오 | 항생제 및 라이소포스파티딜콜린을 포함하는 면역 증강 또는 세균성 감염 질환 치료용 조성물 |
| WO2013033461A1 (en) | 2011-08-31 | 2013-03-07 | Rempex Pharmaceuticals, Inc. | Heterocyclic boronic acid ester derivatives and therapeutic uses thereof |
| UY34585A (es) | 2012-01-24 | 2013-09-02 | Aicuris Gmbh & Co Kg | Compuestos b-lactámicos sustituidos con amidina, su preparación y uso |
| US9156858B2 (en) | 2012-05-23 | 2015-10-13 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US10561675B2 (en) | 2012-06-06 | 2020-02-18 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| MX2015008627A (es) | 2013-01-04 | 2015-09-23 | Rempex Pharmaceuticals Inc | Derivados de acido boronico y usos terapeuticos de los mismos. |
| WO2014107535A1 (en) | 2013-01-04 | 2014-07-10 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9101638B2 (en) | 2013-01-04 | 2015-08-11 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9687497B1 (en) | 2014-05-05 | 2017-06-27 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
| EP3140310B1 (en) | 2014-05-05 | 2019-08-07 | Rempex Pharmaceuticals, Inc. | Synthesis of boronate salts and uses thereof |
| MX2016015093A (es) | 2014-05-19 | 2017-03-27 | Rempex Pharmaceuticals Inc | Derivados de acido boronico y sus usos terapeuticos. |
| KR20170024087A (ko) | 2014-07-01 | 2017-03-06 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
| US10662205B2 (en) | 2014-11-18 | 2020-05-26 | Qpex Biopharma, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| WO2016149393A1 (en) | 2015-03-17 | 2016-09-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| RU2618433C2 (ru) * | 2015-08-10 | 2017-05-03 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) | Антимикробная комбинация в отношении устойчивых к карбапенемам грамотрицательных бактерий вида pseudomonas aeruginosa, продуцирующих металло-β-лактамазу |
| EP3478693B1 (en) | 2016-06-30 | 2021-07-21 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| CN107641119B (zh) * | 2016-07-21 | 2019-11-08 | 中国科学院上海药物研究所 | 单环β-内酰胺-铁载体轭合物及其制备方法和用途 |
| RU2666619C2 (ru) * | 2016-12-01 | 2018-09-11 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет" (СПбГУ) | АНТИМИКРОБНАЯ КОМБИНАЦИЯ В ОТНОШЕНИИ УСТОЙЧИВЫХ К КАРБАПЕНЕМАМ ГРАМОТРИЦАТЕЛЬНЫХ БАКТЕРИЙ ВИДА ACINETOBACTER BAUMANNII, ПРОДУЦИРУЮЩИХ МЕТАЛЛО-β-ЛАКТАМАЗУ |
| WO2018065636A1 (en) | 2016-12-21 | 2018-04-12 | Aicuris Anti-Infective Cures Gmbh | COMBINATION THERAPY WITH AMIDINE SUBSTITUTED ß-LACTAM COMPOUNDS AND ß-LACTAMASE INHIBITORS FOR INFECTIONS WITH ANTIBIOTIC RESISTANT BACTERIAL STRAINS |
| CN111212843B (zh) | 2017-10-11 | 2025-05-16 | Qpex生物制药有限公司 | 硼酸衍生物及其合成 |
| US11459323B2 (en) | 2018-01-29 | 2022-10-04 | Medshine Discovery Inc. | Monocyclic β-lactam compound for treating bacterial infection |
| JP7329260B2 (ja) | 2018-04-20 | 2023-08-18 | キューペックス バイオファーマ， インコーポレイテッド | ボロン酸誘導体およびその治療的使用 |
| JP7179185B2 (ja) | 2018-12-18 | 2022-11-28 | メッドシャイン ディスカバリー インコーポレイテッド | 医薬の製造おける単環式β－ラクタム化合物の使用 |
| WO2020168265A1 (en) | 2019-02-14 | 2020-08-20 | Singapore Eye Research Institute | Antibacterial compositions |
| US12491180B2 (en) | 2019-12-19 | 2025-12-09 | Shenzhen Optimum Biological Technology Co., Ltd | Application of compound in treating pneumonia |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1575803A (en) | 1976-03-09 | 1980-10-01 | Fujisawa Pharmaceutical Co | 3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof |
| CA1283404C (en) | 1986-07-01 | 1991-04-23 | Shigeru Sanai | Cephalosporin compounds, processes for their preparation and antibacterial agents |
| US5888998A (en) * | 1997-04-24 | 1999-03-30 | Synphar Laboratories, Inc. | 2-oxo-1-azetidine sulfonic acid derivatives as potent β-lactamase inhibitors |
| US5994340A (en) | 1997-08-29 | 1999-11-30 | Synphar Laboratories, Inc. | Azetidinone derivatives as β-lactamase inhibitors |
| DE60111757T2 (de) | 2000-09-14 | 2006-04-27 | Pantherix Ltd. | 3-(Heteroarylacetamido)-2-oxoazetidin-1-sulfonsäure-derivate als antibakterielle Mittel |
| US20050065141A1 (en) * | 2003-07-31 | 2005-03-24 | Odink Debra A. | Carbapenems useful in treating and preventing pulmonary infections, pharmaceutical compositions thereof and modes of administration thereof |
| ES2373461T3 (es) * | 2005-12-07 | 2012-02-03 | Basilea Pharmaceutica Ag | Antibióticos útiles de monobactama. |
| RU2488394C2 (ru) * | 2007-03-23 | 2013-07-27 | Базилеа Фармацойтика Аг | Комбинированные лекарственные средства для лечения бактериальных инфекций |
-
2008
- 2008-03-19 RU RU2009139004/15A patent/RU2488394C2/ru not_active IP Right Cessation
- 2008-03-19 NZ NZ579375A patent/NZ579375A/en not_active IP Right Cessation
- 2008-03-19 BR BRPI0809147-1A patent/BRPI0809147A2/pt not_active IP Right Cessation
- 2008-03-19 KR KR1020097019585A patent/KR101320718B1/ko not_active Expired - Fee Related
- 2008-03-19 CN CN2008800093460A patent/CN101641095B/zh not_active Expired - Fee Related
- 2008-03-19 JP JP2009554024A patent/JP2010521517A/ja active Pending
- 2008-03-19 CA CA2680018A patent/CA2680018C/en not_active Expired - Fee Related
- 2008-03-19 AU AU2008231854A patent/AU2008231854B2/en not_active Ceased
- 2008-03-19 WO PCT/EP2008/053336 patent/WO2008116813A2/en not_active Ceased
- 2008-03-19 MX MX2009009918A patent/MX2009009918A/es active IP Right Grant
- 2008-03-19 US US12/532,243 patent/US8486929B2/en not_active Expired - Fee Related
- 2008-03-19 EP EP08718057.6A patent/EP2124942B1/en active Active
-
2009
- 2009-09-11 ZA ZA200906349A patent/ZA200906349B/xx unknown
-
2013
- 2013-06-12 US US13/915,833 patent/US8809315B2/en not_active Expired - Fee Related
- 2013-08-19 JP JP2013169657A patent/JP5779209B2/ja not_active Expired - Fee Related
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