CY1123509T1 - Αλατα και στερεες μορφες ενος αντιβιοτικου μονοβακταμης - Google Patents

Αλατα και στερεες μορφες ενος αντιβιοτικου μονοβακταμης

Info

Publication number
CY1123509T1
CY1123509T1 CY20201100840T CY201100840T CY1123509T1 CY 1123509 T1 CY1123509 T1 CY 1123509T1 CY 20201100840 T CY20201100840 T CY 20201100840T CY 201100840 T CY201100840 T CY 201100840T CY 1123509 T1 CY1123509 T1 CY 1123509T1
Authority
CY
Cyprus
Prior art keywords
salts
solid forms
monobactam
antibiotic
oxo
Prior art date
Application number
CY20201100840T
Other languages
English (en)
Inventor
Eric Aubin
Andreas Fisch
Michael Mutz
Marc SCHOENHENTZ
Anthony Casarez
Zaixing LI
Mika Lindvall
Heinz Ernst Moser
Folkert Reck
Vijay SETHURAMAN
Robert Lowell Simmons
Bernd Ulrich Riebesehl
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1123509T1 publication Critical patent/CY1123509T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Παρέχονται νέες στερεές μορφές, άλατα και πολύμορφα του 1-(((Ζ)-(1-(2-αμινοθειαζολ-4-υλο}-2-οξο-2-(((3S,4R)-2-οξο-4-((2-οξοοξαζολιδιν-3-υλο)μεθυλ)-1-σουλφοαζετιδιν-3-υλο)αμινο)αιθυλιδενο)αμινο)οξυ)-κυκλοπροπανοκαρβοξυλικού οξέος (αναφέρεται εδώ ως ένωση Χ), φαρμακευτικές συνθέσεις που τα περιέχουν, και διαδικασίες για την παρασκευή και χρήση τους στη θεραπεία.
CY20201100840T 2015-09-23 2020-09-07 Αλατα και στερεες μορφες ενος αντιβιοτικου μονοβακταμης CY1123509T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562222430P 2015-09-23 2015-09-23
PCT/CN2016/099482 WO2017050218A1 (en) 2015-09-23 2016-09-20 Salts and solid forms of monobactam antibiotic

Publications (1)

Publication Number Publication Date
CY1123509T1 true CY1123509T1 (el) 2022-03-24

Family

ID=58385723

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100840T CY1123509T1 (el) 2015-09-23 2020-09-07 Αλατα και στερεες μορφες ενος αντιβιοτικου μονοβακταμης

Country Status (25)

Country Link
US (1) US10919887B2 (el)
EP (1) EP3353175B1 (el)
JP (1) JP6837480B2 (el)
KR (1) KR20180054816A (el)
CN (1) CN108137573B (el)
AU (1) AU2016327264B2 (el)
CA (1) CA2999794C (el)
CL (2) CL2018000745A1 (el)
CY (1) CY1123509T1 (el)
DK (1) DK3353175T3 (el)
EA (2) EA202092620A1 (el)
ES (1) ES2817537T3 (el)
HK (1) HK1257271A1 (el)
HR (1) HRP20201423T1 (el)
HU (1) HUE050849T2 (el)
IL (1) IL258254B (el)
LT (1) LT3353175T (el)
MA (1) MA42946B1 (el)
MX (1) MX2018003592A (el)
PH (1) PH12018500653A1 (el)
PT (1) PT3353175T (el)
RS (1) RS60805B1 (el)
RU (1) RU2754180C2 (el)
SI (1) SI3353175T1 (el)
WO (1) WO2017050218A1 (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11414411B2 (en) 2017-08-02 2022-08-16 Novartis Ag Chemical process for manufacturing monobactam antibiotic and intermediates thereof
US11760866B2 (en) * 2017-08-16 2023-09-19 Lg Chem, Ltd. White pigment comprising ZIF-based powder, polymer resin film and method for changing color of medium using white pigment
EP3706738A1 (en) * 2017-11-10 2020-09-16 Novartis AG Administration of monobactam for the treatment of urinary tract infection
US11459323B2 (en) 2018-01-29 2022-10-04 Medshine Discovery Inc. Monocyclic β-lactam compound for treating bacterial infection
WO2020125670A1 (zh) 2018-12-18 2020-06-25 南京明德新药研发有限公司 单环β-内酰胺化合物在制药中的应用
JP7446424B2 (ja) * 2019-11-22 2024-03-08 スージョウ アーイェ ファーマシューティカル カンパニー リミテッド スルホニル尿素環置換単環式β－ラクタム系抗生物質
EP4079305A4 (en) 2019-12-19 2024-01-10 Shenzhen Optimum Biological Technology Co., Ltd APPLICATION OF A COMPOUND IN THE PREPARATION OF DRUG
CN113754651B (zh) 2020-06-02 2023-04-18 中国医学科学院医药生物技术研究所 一种β-内酰胺化合物、其用途及其制备方法
US20230150996A1 (en) * 2020-08-06 2023-05-18 Ningxia Academy Of Agriculture And Forestry Sciences B-lactam compounds, their preparation and use as antibacterial agents
WO2022185240A1 (en) 2021-03-04 2022-09-09 Bp Asset Vi, Inc. Formulation of a monobactam antibiotic
WO2022185241A1 (en) 2021-03-04 2022-09-09 Bp Asset Vi, Inc. Process for manufacturing a monobactam antibiotic
CN115304594B (zh) * 2022-10-12 2023-02-14 苏州二叶制药有限公司 磺酰脲环取代的化合物的盐型及其晶型

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NZ205240A (en) 1980-02-07 1984-07-31 Squibb & Sons Inc Sulphonamide derivatives,being starting materials for producing beta-lactams
US4775670A (en) 1980-09-29 1988-10-04 E. R. Squibb & Sons, Inc. 2-oxo-1-azetidinesulfonic acid salts
EP0048953B1 (en) 1980-09-29 1988-03-09 E.R. Squibb & Sons, Inc. Beta-lactam antibiotics
WO1982001873A1 (en) 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
US4782147A (en) 1980-12-05 1988-11-01 Takeda Chemical Industries, Ltd. 1-sulfo-2-oxoazetidine derivatives and their production
CA1262128A (en) 1981-08-27 1989-10-03 Christian N. Hubschwerlen .beta.-lactams
IL67451A (en) 1981-12-25 1987-10-20 Takeda Chemical Industries Ltd 4-cyano-2-azetidinones and production thereof and process for the preparation of 4-carbamoyl-2-azetidinones using them
AU564150B2 (en) * 1982-04-30 1987-08-06 Takeda Chemical Industries Ltd. 1-sulfo-2-azetidinone derivatives
SU1195908A3 (ru) 1982-05-31 1985-11-30 Баниу Фармасьютикал Ко.,Лтд.(Фирма) Способ получени производных 2-оксо-1-азетидинсульфокислоты или их солей с щелочными металлами
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JPS6153282A (ja) 1984-08-22 1986-03-17 Banyu Pharmaceut Co Ltd 単環β−ラクタム誘導体
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Also Published As

Publication number Publication date
US20180273522A1 (en) 2018-09-27
EA037569B1 (ru) 2021-04-15
CN108137573A (zh) 2018-06-08
EP3353175B1 (en) 2020-08-12
AU2016327264B2 (en) 2019-06-27
IL258254B (en) 2021-02-28
CL2018000745A1 (es) 2018-06-22
PH12018500653A1 (en) 2018-10-01
MX2018003592A (es) 2018-06-18
JP2018528241A (ja) 2018-09-27
ES2817537T3 (es) 2021-04-07
DK3353175T3 (da) 2020-09-14
EA201890771A1 (ru) 2018-09-28
HK1257271A1 (zh) 2019-10-18
JP6837480B2 (ja) 2021-03-03
RU2754180C2 (ru) 2021-08-30
BR112018005805A2 (pt) 2018-10-16
WO2017050218A1 (en) 2017-03-30
HRP20201423T1 (hr) 2020-12-11
PT3353175T (pt) 2020-09-10
AU2016327264A1 (en) 2018-05-10
LT3353175T (lt) 2020-10-12
EP3353175A1 (en) 2018-08-01
RU2018114480A (ru) 2019-10-23
CA2999794A1 (en) 2017-03-30
EP3353175A4 (en) 2019-06-26
CN108137573B (zh) 2021-06-11
MA42946A (fr) 2018-08-01
SI3353175T1 (sl) 2020-11-30
EA202092620A1 (ru) 2021-06-30
HUE050849T2 (hu) 2021-01-28
RU2018114480A3 (el) 2020-06-09
IL258254A (en) 2018-05-31
RS60805B1 (sr) 2020-10-30
CL2019003324A1 (es) 2020-04-17
US10919887B2 (en) 2021-02-16
CA2999794C (en) 2023-08-15
KR20180054816A (ko) 2018-05-24
MA42946B1 (fr) 2020-10-28

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