DK3353175T3 - Salte og faste former af et monobactam-antibiotikum - Google Patents

Salte og faste former af et monobactam-antibiotikum Download PDF

Info

Publication number
DK3353175T3
DK3353175T3 DK16848099.4T DK16848099T DK3353175T3 DK 3353175 T3 DK3353175 T3 DK 3353175T3 DK 16848099 T DK16848099 T DK 16848099T DK 3353175 T3 DK3353175 T3 DK 3353175T3
Authority
DK
Denmark
Prior art keywords
salts
solid forms
monobactam antibiotic
monobactam
antibiotic
Prior art date
Application number
DK16848099.4T
Other languages
English (en)
Inventor
Eric Aubin
Andreas Fisch
Michael Mutz
Bernd Ulrich Riebesehl
Marc Schoenhentz
Anthony Casarez
Zaixing Li
Mika Lindvall
Heinz Ernst Moser
Folkert Reck
Vijay Sethuraman
Robert Lowell Simmons
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK3353175T3 publication Critical patent/DK3353175T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK16848099.4T 2015-09-23 2016-09-20 Salte og faste former af et monobactam-antibiotikum DK3353175T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562222430P 2015-09-23 2015-09-23
PCT/CN2016/099482 WO2017050218A1 (en) 2015-09-23 2016-09-20 Salts and solid forms of monobactam antibiotic

Publications (1)

Publication Number Publication Date
DK3353175T3 true DK3353175T3 (da) 2020-09-14

Family

ID=58385723

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16848099.4T DK3353175T3 (da) 2015-09-23 2016-09-20 Salte og faste former af et monobactam-antibiotikum

Country Status (25)

Country Link
US (1) US10919887B2 (da)
EP (1) EP3353175B1 (da)
JP (1) JP6837480B2 (da)
KR (1) KR20180054816A (da)
CN (1) CN108137573B (da)
AU (1) AU2016327264B2 (da)
CA (1) CA2999794C (da)
CL (2) CL2018000745A1 (da)
CY (1) CY1123509T1 (da)
DK (1) DK3353175T3 (da)
EA (2) EA037569B1 (da)
ES (1) ES2817537T3 (da)
HK (1) HK1257271A1 (da)
HR (1) HRP20201423T1 (da)
HU (1) HUE050849T2 (da)
IL (1) IL258254B (da)
LT (1) LT3353175T (da)
MA (1) MA42946B1 (da)
MX (1) MX2018003592A (da)
PH (1) PH12018500653A1 (da)
PT (1) PT3353175T (da)
RS (1) RS60805B1 (da)
RU (1) RU2754180C2 (da)
SI (1) SI3353175T1 (da)
WO (1) WO2017050218A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3063649A1 (en) * 2017-08-02 2019-02-07 Novartis Ag Chemical process for manufacturing monobactam antibiotic and intermediates thereof
US11760866B2 (en) * 2017-08-16 2023-09-19 Lg Chem, Ltd. White pigment comprising ZIF-based powder, polymer resin film and method for changing color of medium using white pigment
WO2019092180A1 (en) * 2017-11-10 2019-05-16 Novartis Ag Administration of monobactam for the treatment of urinary tract infection
JP7280273B2 (ja) * 2018-01-29 2023-05-23 メッドシャイン ディスカバリー インコーポレイテッド 細菌感染を治療するための単環β-ラクタム化合物
CN113227088B (zh) * 2018-12-18 2022-05-31 南京明德新药研发有限公司 单环β-内酰胺化合物在制药中的应用
JP7446424B2 (ja) * 2019-11-22 2024-03-08 スージョウ アーイェ ファーマシューティカル カンパニー リミテッド スルホニル尿素環置換単環式β-ラクタム系抗生物質
EP4079305A4 (en) 2019-12-19 2024-01-10 Shenzhen Optimum Biological Technology Co., Ltd APPLICATION OF A COMPOUND IN THE PREPARATION OF DRUG
CN113754651B (zh) 2020-06-02 2023-04-18 中国医学科学院医药生物技术研究所 一种β-内酰胺化合物、其用途及其制备方法
WO2022027439A1 (en) * 2020-08-06 2022-02-10 Ningxia Academy Of Agriculture And Forestry Sciences β-LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS
WO2022185240A1 (en) 2021-03-04 2022-09-09 Bp Asset Vi, Inc. Formulation of a monobactam antibiotic
WO2022185241A1 (en) 2021-03-04 2022-09-09 Bp Asset Vi, Inc. Process for manufacturing a monobactam antibiotic
CN115304594B (zh) * 2022-10-12 2023-02-14 苏州二叶制药有限公司 磺酰脲环取代的化合物的盐型及其晶型

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ205240A (en) 1980-02-07 1984-07-31 Squibb & Sons Inc Sulphonamide derivatives,being starting materials for producing beta-lactams
EP0048953B1 (en) 1980-09-29 1988-03-09 E.R. Squibb & Sons, Inc. Beta-lactam antibiotics
US4775670A (en) 1980-09-29 1988-10-04 E. R. Squibb & Sons, Inc. 2-oxo-1-azetidinesulfonic acid salts
WO1982001873A1 (en) 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
US4782147A (en) 1980-12-05 1988-11-01 Takeda Chemical Industries, Ltd. 1-sulfo-2-oxoazetidine derivatives and their production
CA1262128A (en) 1981-08-27 1989-10-03 Christian N. Hubschwerlen .beta.-lactams
IL67451A (en) 1981-12-25 1987-10-20 Takeda Chemical Industries Ltd 4-cyano-2-azetidinones and production thereof and process for the preparation of 4-carbamoyl-2-azetidinones using them
AU564150B2 (en) * 1982-04-30 1987-08-06 Takeda Chemical Industries Ltd. 1-sulfo-2-azetidinone derivatives
SU1195908A3 (ru) 1982-05-31 1985-11-30 Баниу Фармасьютикал Ко.,Лтд.(Фирма) Способ получени производных 2-оксо-1-азетидинсульфокислоты или их солей с щелочными металлами
EP0096297B1 (de) 1982-06-03 1988-06-15 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von 1-Sulfo-2-oxoazetidinderivaten
JPS6153282A (ja) 1984-08-22 1986-03-17 Banyu Pharmaceut Co Ltd 単環β−ラクタム誘導体
JPS6153283A (ja) 1984-08-24 1986-03-17 Banyu Pharmaceut Co Ltd 2−オキソ−1−アゼチジンスルホン酸誘導体
US4610824A (en) 1984-10-09 1986-09-09 E. R. Squibb & Sons, Inc. Hydrazide derivatives of monocyclic beta-lactam antibiotics
US5112968A (en) 1989-07-28 1992-05-12 E. R. Squibb & Sons, Inc. Monobactam hydrazide derivatives
ES2602969T3 (es) 2008-10-31 2017-02-23 Shionogi & Co., Ltd. Cefalosporinas que tienen un grupo catecol
JP2012512863A (ja) * 2008-12-19 2012-06-07 ファイザー・インク モノカルバム
CN103228652B (zh) 2010-11-29 2015-02-18 辉瑞大药厂 单环内酰胺类
UY34585A (es) * 2012-01-24 2013-09-02 Aicuris Gmbh & Co Kg Compuestos b-lactámicos sustituidos con amidina, su preparación y uso
CN103044416A (zh) 2012-12-17 2013-04-17 浙江华方药业有限责任公司 一种卡芦莫南钠的合成方法
US20160326157A1 (en) 2014-01-06 2016-11-10 President And Fellows Of Harvard College Monobactams and methods of their synthesis and use
SI3122745T1 (sl) 2014-03-24 2019-05-31 Novartis Ag Organske spojine monobaktama za zdravljenje bakterijskih infekcij

Also Published As

Publication number Publication date
RU2018114480A (ru) 2019-10-23
IL258254A (en) 2018-05-31
CL2019003324A1 (es) 2020-04-17
CA2999794C (en) 2023-08-15
ES2817537T3 (es) 2021-04-07
MA42946B1 (fr) 2020-10-28
HRP20201423T1 (hr) 2020-12-11
SI3353175T1 (sl) 2020-11-30
JP2018528241A (ja) 2018-09-27
HK1257271A1 (zh) 2019-10-18
JP6837480B2 (ja) 2021-03-03
RU2754180C2 (ru) 2021-08-30
EP3353175B1 (en) 2020-08-12
EA037569B1 (ru) 2021-04-15
CL2018000745A1 (es) 2018-06-22
EP3353175A1 (en) 2018-08-01
EA202092620A1 (ru) 2021-06-30
US20180273522A1 (en) 2018-09-27
EP3353175A4 (en) 2019-06-26
AU2016327264A1 (en) 2018-05-10
IL258254B (en) 2021-02-28
MX2018003592A (es) 2018-06-18
HUE050849T2 (hu) 2021-01-28
RS60805B1 (sr) 2020-10-30
CN108137573B (zh) 2021-06-11
CA2999794A1 (en) 2017-03-30
LT3353175T (lt) 2020-10-12
CY1123509T1 (el) 2022-03-24
RU2018114480A3 (da) 2020-06-09
KR20180054816A (ko) 2018-05-24
WO2017050218A1 (en) 2017-03-30
BR112018005805A2 (pt) 2018-10-16
AU2016327264B2 (en) 2019-06-27
PH12018500653A1 (en) 2018-10-01
MA42946A (fr) 2018-08-01
PT3353175T (pt) 2020-09-10
CN108137573A (zh) 2018-06-08
US10919887B2 (en) 2021-02-16
EA201890771A1 (ru) 2018-09-28

Similar Documents

Publication Publication Date Title
DK3353175T3 (da) Salte og faste former af et monobactam-antibiotikum
DK3371171T3 (da) Inhibitorer af RET
DK3302565T3 (da) Faste doseringsformer af palbociclib
DK3262046T3 (da) Salte af pi3k-inhibitor og fremgangsmåder til fremstilling deraf
DK3442972T3 (da) Bromdomænehæmmere
DK3102576T3 (da) Dihydropyrrolopyridininhibitorer af ror-gamma
DK3160956T3 (da) Inhibitorer af lysin-specifik demethylase-1
ES2577288B8 (es) Dispositivo para trombectomía
DK3164380T3 (da) Hæmmere af lysinspecifik demethylase-1
FR3042634B1 (fr) Point memoire magnetique
FR3031622B1 (fr) Point memoire magnetique
DK3365323T3 (da) Salte af tetracycliner
DK3215493T3 (da) Syntese af copanlisib og dihydrochloridsalt deraf
DK3571192T3 (da) Jak1-selektive inhibitorer
DK3341379T3 (da) EZH2-hæmmere
DK3390422T3 (da) Krystalformer af lnt
DK3204352T3 (da) Hæmmere af lysin-gingipain
DK3097313T3 (da) Skrue, fastgørelsesanordning og anvendelse af en skrue
DK3247711T3 (da) Hidtil ukendte salte og polymorfer af scy-078
DK3189045T3 (da) Hidtil ukendte salte af nilotinib og polymorfer deraf
DK3418273T3 (da) Derivater af flavagliner
DK3016414T3 (da) Konfiguration af en indretning
DK3519419T3 (da) Beta-lactamase-inhibitorer
DK3481826T3 (da) Tyrosinkinaseinhibitorer
DK3380465T3 (da) Diaminopyridinderivativer