|
DE3922444A1
(de)
|
1988-03-01 |
1991-01-10 |
Deutsches Krebsforsch |
Virusmodifizierte tumorvakzine fuer die immuntherapie von tumormetastasen
|
|
DE3806565A1
(de)
|
1988-03-01 |
1989-09-14 |
Deutsches Krebsforsch |
Virusmodifizierte tumorvakzinen fuer die immuntherapie von tumormetastasen
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5166057A
(en)
|
1989-08-28 |
1992-11-24 |
The Mount Sinai School Of Medicine Of The City University Of New York |
Recombinant negative strand rna virus expression-systems
|
|
US5786199A
(en)
|
1989-08-28 |
1998-07-28 |
The Mount Sinai School Of Medicine Of The City University Of New York |
Recombinant negative strand RNA virus expression systems and vaccines
|
|
US5854037A
(en)
|
1989-08-28 |
1998-12-29 |
The Mount Sinai School Of Medicine Of The City University Of New York |
Recombinant negative strand RNA virus expression systems and vaccines
|
|
EP1486211B1
(en)
|
1993-04-30 |
2008-10-22 |
Wellstat Biologics Corporation |
Compositions for treating cancer using viruses
|
|
PT702085E
(pt)
|
1994-07-18 |
2004-04-30 |
Karl Klaus Conzelmann |
Virus de arn de cadeia negativa nao segmentada infeccioso recombinante
|
|
US5891680A
(en)
|
1995-02-08 |
1999-04-06 |
Whitehead Institute For Biomedical Research |
Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
|
|
US7153510B1
(en)
|
1995-05-04 |
2006-12-26 |
Yale University |
Recombinant vesiculoviruses and their uses
|
|
DE69510207T3
(de)
|
1995-08-09 |
2007-02-15 |
Schweiz. Serum- & Impfinstitut Bern |
Verfahren zur Herstellung von infektiösen minussträngigen RNA-Viren
|
|
CA2230033C
(en)
|
1995-09-27 |
2010-01-26 |
Peter L. Collins |
Production of infectious respiratory syncytial virus from cloned nucleotide sequences
|
|
JP4128625B2
(ja)
|
1995-10-17 |
2008-07-30 |
ウェイン ステイト ユニヴァーシティ |
チキンインターロイキン−15及びその使用
|
|
BR9710363A
(pt)
|
1996-07-15 |
2000-01-11 |
Us Gov Health & Human Serv |
"vìrus sincicial respirátorio recombinante infeccioso isolado, partìcula do mesmo, processos para estimular o sistema imunológico de um indivìduo para induzir proteção contra o vìrus sincicial respiratório e para produzir uma partìcula de vìrus sincicial respiratório recombinante, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante composição e ceta de vìrus sincicial respiratório recombinante"
|
|
EP0932684A2
(en)
|
1996-09-27 |
1999-08-04 |
American Cyanamid Company |
3' genomic promoter region and polymerase gene mutations responsible for attenuation in viruses of the order designated mononegavirales
|
|
KR100702523B1
(ko)
|
1997-05-23 |
2007-04-04 |
더 가번먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 에즈 레프리젠티드 바이 더 디파트먼트 오브 헬쓰 앤드 휴먼 서비시즈 |
클로닝된 뉴클레오타이드 서열로부터 약독화된파라인플루엔자 바이러스를 제조하는 방법
|
|
JP4434478B2
(ja)
|
1997-07-11 |
2010-03-17 |
イエール ユニバーシティー |
リエンジニアリングされた外被を有するラブドウイルス
|
|
CA2302867A1
(en)
|
1997-09-19 |
1999-04-01 |
American Cyanamid Company |
Attenuated respiratory syncytial viruses
|
|
AU9603898A
(en)
|
1997-10-09 |
1999-05-03 |
Pro-Virus, Inc. |
Treatment of neoplasms with viruses
|
|
US7470426B1
(en)
|
1997-10-09 |
2008-12-30 |
Wellstat Biologics Corporation |
Treatment of neoplasms with viruses
|
|
US20030044384A1
(en)
|
1997-10-09 |
2003-03-06 |
Pro-Virus, Inc. |
Treatment of neoplasms with viruses
|
|
US7780962B2
(en)
|
1997-10-09 |
2010-08-24 |
Wellstat Biologics Corporation |
Treatment of neoplasms with RNA viruses
|
|
PT1085904E
(pt)
|
1998-06-12 |
2013-03-05 |
Sinai School Medicine |
Vírus de cadeia negativa atenuados com actividade antagonista do interferão alterada, para utilização como vacinas e produtos farmacêuticos
|
|
EP0974660A1
(en)
|
1998-06-19 |
2000-01-26 |
Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) |
Newcastle disease virus infectious clones, vaccines and diagnostic assays
|
|
US6544785B1
(en)
|
1998-09-14 |
2003-04-08 |
Mount Sinai School Of Medicine Of New York University |
Helper-free rescue of recombinant negative strand RNA viruses
|
|
US6146642A
(en)
|
1998-09-14 |
2000-11-14 |
Mount Sinai School Of Medicine, Of The City University Of New York |
Recombinant new castle disease virus RNA expression systems and vaccines
|
|
US7052685B1
(en)
|
1998-10-15 |
2006-05-30 |
Trustees Of The University Of Pennsylvania |
Methods for treatment of cutaneous T-cell lymphoma
|
|
CA2370187C
(en)
|
1999-04-15 |
2011-08-02 |
Pro-Virus, Inc. |
Treatment of neoplasms with viruses
|
|
US20030224017A1
(en)
|
2002-03-06 |
2003-12-04 |
Samal Siba K. |
Recombinant Newcastle disease viruses useful as vaccines or vaccine vectors
|
|
AU4971500A
(en)
|
1999-05-05 |
2000-11-21 |
University Of Maryland |
Production of novel newcastle disease virus strains from cdnas and improved liveattenuated newcastle disease vaccines
|
|
DE122007000070I1
(de)
|
1999-07-14 |
2008-01-31 |
Sinai School Medicine |
In Vitro-rekonstitution von segmentierten Negativstrang-Rna-Viren
|
|
EP1217891B1
(en)
|
1999-09-24 |
2009-12-16 |
Mayo Foundation For Medical Education And Research |
Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family
|
|
US6896881B1
(en)
|
1999-09-24 |
2005-05-24 |
Mayo Foundation For Medical Education And Research |
Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family
|
|
AUPQ425699A0
(en)
|
1999-11-25 |
1999-12-23 |
University Of Newcastle Research Associates Limited, The |
A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
|
|
JP2003525222A
(ja)
|
2000-01-20 |
2003-08-26 |
ウニベルジテート チューリッヒ インスティチュート フューア メディツィニーチェ ビロロギー |
Il−12をコードする核酸分子の腫瘍内投与
|
|
WO2001077394A1
(en)
|
2000-04-10 |
2001-10-18 |
Mount Sinai School Of Medicine Of New York University |
Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents
|
|
US6818444B2
(en)
|
2000-08-04 |
2004-11-16 |
Heska Corporation |
Canine and feline proteins, nucleic acid molecules and uses thereof
|
|
FR2823222B1
(fr)
|
2001-04-06 |
2004-02-06 |
Merial Sas |
Vaccin contre le virus de la fievre du nil
|
|
US7740863B2
(en)
|
2001-04-06 |
2010-06-22 |
Merial |
Recombinant vaccine against West Nile Virus
|
|
WO2002102404A1
(en)
|
2001-06-18 |
2002-12-27 |
Institut National De La Recherche Agronomique |
Uses of cytokines
|
|
WO2003092579A2
(en)
|
2002-04-29 |
2003-11-13 |
Hadasit Medical Research Services And Development Company Ltd. |
Compositions and methods for treating cancer with an oncolytic viral agent
|
|
JPWO2003102183A1
(ja)
|
2002-06-03 |
2005-09-29 |
株式会社ディナベック研究所 |
抗体をコードするパラミクソウイルスベクターおよびその利用
|
|
WO2004015572A1
(en)
|
2002-08-07 |
2004-02-19 |
Mmagix Technology Limited |
Apparatus, method and system for a synchronicity independent, resource delegating, power and instruction optimizing processor
|
|
SE0203159D0
(sv)
|
2002-10-25 |
2002-10-25 |
Electrolux Ab |
Handtag till ett motordrivet handhållet verktyg
|
|
AU2002953436A0
(en)
|
2002-12-18 |
2003-01-09 |
The University Of Newcastle Research Associates Limited |
A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
|
|
US20040197312A1
(en)
|
2003-04-02 |
2004-10-07 |
Marina Moskalenko |
Cytokine-expressing cellular vaccine combinations
|
|
EP1718670B1
(en)
|
2004-02-27 |
2011-07-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Il-15 binding site for il 15-ralpha and specific il-15 mutants having agonist/antagonist activity
|
|
AU2005221725B2
(en)
|
2004-03-11 |
2010-06-24 |
Viralytics Limited |
Modified oncolytic viruses
|
|
JP5054522B2
(ja)
*
|
2004-08-20 |
2012-10-24 |
ヴィラリティクス リミテッド |
血液ガンを治療するための方法および組成物
|
|
CN101065144B
(zh)
*
|
2004-08-20 |
2012-06-13 |
溶瘤病毒有限公司 |
治疗血液癌症的方法和组合物
|
|
BRPI0517834A
(pt)
|
2004-11-12 |
2008-10-21 |
Bayer Schering Pharma Ag |
vìrus da doença de newcastle recombinante
|
|
US20080160031A1
(en)
|
2005-01-17 |
2008-07-03 |
Viralytics Limited |
Method and Composition for Treatment of Neoplasms
|
|
MX2007014474A
(es)
|
2005-05-17 |
2008-02-07 |
Univ Connecticut |
Composiciones y metodos para inmunomodulacion en un organismo.
|
|
US20090214590A1
(en)
|
2005-07-08 |
2009-08-27 |
Wayne State University |
Virus Vaccines Comprising Envelope-Bound Immunomodulatory Proteins and Methods of Use Thereof
|
|
MX2008002743A
(es)
*
|
2005-08-31 |
2008-03-26 |
Oncolytics Biotech Inc |
Potenciacion in vivo del reconocimiento de neoplasmas por el sistema inmunitario posterior a viroterapia oncolitica o vector para terapia genica.
|
|
EP1777294A1
(en)
|
2005-10-20 |
2007-04-25 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
|
|
TWI531652B
(zh)
|
2005-12-02 |
2016-05-01 |
美國紐約大學西奈山醫學院 |
表現非原生表面蛋白質之嵌合病毒及其用途
|
|
US9303080B2
(en)
|
2006-01-13 |
2016-04-05 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health |
Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells
|
|
EP2007423A2
(en)
|
2006-04-05 |
2008-12-31 |
Pfizer Products Incorporated |
Ctla4 antibody combination therapy
|
|
US20090175826A1
(en)
|
2006-06-05 |
2009-07-09 |
Elankumaran Subbiah |
Genetically-engineered newcastle disease virus as an oncolytic agent, and methods of using same
|
|
CA2658584A1
(en)
|
2006-07-27 |
2008-01-31 |
Ottawa Health Research Institute |
Staged immune-response modulation in oncolytic therapy
|
|
CA2723320C
(en)
|
2007-05-04 |
2019-06-11 |
University Health Network |
Il-12 immunotherapy for cancer
|
|
EP2160401B1
(en)
|
2007-05-11 |
2014-09-24 |
Altor BioScience Corporation |
Fusion molecules and il-15 variants
|
|
EP2535354B1
(en)
|
2007-06-18 |
2017-01-11 |
Merck Sharp & Dohme B.V. |
Antibodies to human programmed death receptor pd-1
|
|
NZ703668A
(en)
|
2007-06-27 |
2016-07-29 |
Us Sec Dep Of Health And Human Services |
Complexes of il-15 and il-15ralpha and uses thereof
|
|
EP2085092A1
(en)
|
2008-01-29 |
2009-08-05 |
Bayer Schering Pharma Aktiengesellschaft |
Attenuated oncolytic paramyxoviruses encoding avian cytokines
|
|
EA023148B1
(ru)
|
2008-08-25 |
2016-04-29 |
Эмплиммьюн, Инк. |
Композиции на основе антагонистов pd-1 и их применение
|
|
WO2010042433A1
(en)
|
2008-10-06 |
2010-04-15 |
Bristol-Myers Squibb Company |
Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases
|
|
CN101787373B
(zh)
|
2009-01-23 |
2013-06-19 |
中国人民解放军第二军医大学东方肝胆外科医院 |
一种携带外源基因在包装细胞中高效生产的重组病毒载体、其构建方法及其用途
|
|
ES2550179T3
(es)
|
2009-02-05 |
2015-11-05 |
Icahn School Of Medicine At Mount Sinai |
Virus quiméricos de la enfermedad de Newcastle y usos de los mismos
|
|
AU2010241864B2
(en)
|
2009-04-30 |
2014-02-20 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Inducible interleukin-12
|
|
US20100297072A1
(en)
|
2009-05-19 |
2010-11-25 |
Depinho Ronald A |
Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy
|
|
EP2464377B1
(en)
|
2009-08-14 |
2016-07-27 |
The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services |
Use of il-15 to increase thymic output and to treat lymphopenia
|
|
RU2592544C2
(ru)
|
2009-08-21 |
2016-07-20 |
Мериал, Инк. |
Способ получения рекомбинантного вирусного вектора apmv-8
|
|
EP2482849B1
(en)
|
2009-09-30 |
2018-06-06 |
Memorial Sloan-Kettering Cancer Center |
Combination immunotherapy for the treatment of cancer
|
|
WO2011119628A2
(en)
|
2010-03-23 |
2011-09-29 |
The Regents Of The University Of California |
Compositions and methods for self-adjuvanting vaccines against microbes and tumors
|
|
WO2012000188A1
(en)
|
2010-06-30 |
2012-01-05 |
Tot Shanghai Rd Center Co., Ltd. |
Recombinant tumor vaccine and method of producing such
|
|
CN105017429B
(zh)
|
2010-09-21 |
2021-04-06 |
阿尔托生物科学有限公司 |
多聚体il-15可溶性融合分子与其制造与使用方法
|
|
ES2733211T3
(es)
|
2011-04-15 |
2019-11-28 |
Genelux Corp |
Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas
|
|
EP2537933A1
(en)
|
2011-06-24 |
2012-12-26 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
An IL-15 and IL-15Ralpha sushi domain based immunocytokines
|
|
AU2012322999B2
(en)
|
2011-10-11 |
2017-08-10 |
Universitat Zurich Prorektorat Mnw |
Combination medicament comprising IL-12 and an agent for blockade of T-cell inhibitory molecules for tumour therapy
|
|
DK2806883T3
(da)
|
2012-01-25 |
2019-07-22 |
Dnatrix Inc |
Biomarkører og kombinationsterapier under anvendelse af onkolytisk virus og immunomodulation
|
|
EP2669381A1
(en)
|
2012-05-30 |
2013-12-04 |
AmVac AG |
Method for expression of heterologous proteins using a recombinant negative-strand RNA virus vector comprising a mutated P protein
|
|
US20150250837A1
(en)
|
2012-09-20 |
2015-09-10 |
Morningside Technology Ventures Ltd. |
Oncolytic virus encoding pd-1 binding agents and uses of the same
|
|
NZ630790A
(en)
|
2012-10-24 |
2016-11-25 |
Admune Therapeutics Llc |
Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes
|
|
NZ711946A
(en)
|
2013-03-14 |
2020-05-29 |
Icahn School Med Mount Sinai |
Newcastle disease viruses and uses thereof
|
|
EP4032540A1
(en)
|
2013-04-19 |
2022-07-27 |
Cytune Pharma |
Cytokine derived treatment with reduced vascular leak syndrome
|
|
US20160136211A1
(en)
|
2013-06-17 |
2016-05-19 |
Viralytics Limited |
Methods for the treatment of bladder cancer
|
|
LT3030262T
(lt)
|
2013-08-08 |
2020-03-10 |
Cytune Pharma |
Kombinuota farmacinė kompozicija
|
|
EP3995507B1
(en)
|
2013-08-08 |
2023-10-04 |
Cytune Pharma |
Il-15 and il-15ralpha sushi domain based on modulokines
|
|
EA039404B1
(ru)
|
2013-09-03 |
2022-01-24 |
Медиммун Лимитед |
Аттенуированный вирус ньюкаслской болезни (ndv) штамма 73т для лечения неоплазии, способ селективного цитолиза опухолевых клеток и способ индуцирования регресса опухоли с его использованием
|
|
CA2940570A1
(en)
*
|
2014-02-27 |
2015-09-03 |
Viralytics Limited |
Combination method for treatment of cancer
|
|
EP2915569A1
(en)
|
2014-03-03 |
2015-09-09 |
Cytune Pharma |
IL-15/IL-15Ralpha based conjugates purification method
|
|
WO2016018920A1
(en)
|
2014-07-29 |
2016-02-04 |
Admune Therapeutics Llc |
Il-15 and il-15ralpha heterodimer dose escalation regimens for treating conditions
|
|
SG11201702295UA
(en)
|
2014-09-22 |
2017-04-27 |
Intrexon Corp |
Improved therapeutic control of heterodimeric and single chain forms of interleukin-12
|
|
RU2017123117A
(ru)
|
2014-12-09 |
2019-01-10 |
Мерк Шарп И Доум Корп. |
Система и способы получения биомаркеров генных сигнатур ответа на антагонисты pd-1
|
|
CN106166294A
(zh)
|
2015-05-18 |
2016-11-30 |
国科丹蓝生物科技(北京)有限公司 |
一种用于术前介入放疗治疗肿瘤的化合物
|
|
US10344067B2
(en)
|
2016-02-25 |
2019-07-09 |
Deutsches Krebsforschungszentrum |
RNA viruses expressing IL-12 for immunovirotherapy
|
|
CN105734023B
(zh)
|
2016-03-28 |
2019-04-26 |
江苏康缘瑞翱生物医药科技有限公司 |
一种重组新城疫病毒在制备抗肝癌药物中的应用
|