JP2017503867A5 - - Google Patents

Download PDF

Info

Publication number
JP2017503867A5
JP2017503867A5 JP2016566857A JP2016566857A JP2017503867A5 JP 2017503867 A5 JP2017503867 A5 JP 2017503867A5 JP 2016566857 A JP2016566857 A JP 2016566857A JP 2016566857 A JP2016566857 A JP 2016566857A JP 2017503867 A5 JP2017503867 A5 JP 2017503867A5
Authority
JP
Japan
Prior art keywords
fluoro
ethenopyrazolo
methyl
tetrahydro
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016566857A
Other languages
English (en)
Japanese (ja)
Other versions
JP6490713B2 (ja
JP2017503867A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/012597 external-priority patent/WO2015112806A2/en
Publication of JP2017503867A publication Critical patent/JP2017503867A/ja
Publication of JP2017503867A5 publication Critical patent/JP2017503867A5/ja
Application granted granted Critical
Publication of JP6490713B2 publication Critical patent/JP6490713B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016566857A 2014-01-24 2015-01-23 タンパク質キナーゼのモジュレータとしてのジアリール大環状化合物 Active JP6490713B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461931506P 2014-01-24 2014-01-24
US61/931,506 2014-01-24
US201462049326P 2014-09-11 2014-09-11
US62/049,326 2014-09-11
US201562106301P 2015-01-22 2015-01-22
US62/106,301 2015-01-22
PCT/US2015/012597 WO2015112806A2 (en) 2014-01-24 2015-01-23 Diaryl macrocycles as modulators of protein kinases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019034652A Division JP2019104748A (ja) 2014-01-24 2019-02-27 タンパク質キナーゼのモジュレータとしてのジアリール大環状化合物

Publications (3)

Publication Number Publication Date
JP2017503867A JP2017503867A (ja) 2017-02-02
JP2017503867A5 true JP2017503867A5 (enExample) 2018-03-08
JP6490713B2 JP6490713B2 (ja) 2019-03-27

Family

ID=53682127

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2016566857A Active JP6490713B2 (ja) 2014-01-24 2015-01-23 タンパク質キナーゼのモジュレータとしてのジアリール大環状化合物
JP2019034652A Withdrawn JP2019104748A (ja) 2014-01-24 2019-02-27 タンパク質キナーゼのモジュレータとしてのジアリール大環状化合物
JP2021001588A Pending JP2021063121A (ja) 2014-01-24 2021-01-07 タンパク質キナーゼのモジュレータとしてのジアリール大環状化合物
JP2022110613A Active JP7356546B2 (ja) 2014-01-24 2022-07-08 タンパク質キナーゼのモジュレータとしてのジアリール大環状化合物
JP2023158350A Ceased JP2023179539A (ja) 2014-01-24 2023-09-22 タンパク質キナーゼのモジュレータとしてのジアリール大環状化合物

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2019034652A Withdrawn JP2019104748A (ja) 2014-01-24 2019-02-27 タンパク質キナーゼのモジュレータとしてのジアリール大環状化合物
JP2021001588A Pending JP2021063121A (ja) 2014-01-24 2021-01-07 タンパク質キナーゼのモジュレータとしてのジアリール大環状化合物
JP2022110613A Active JP7356546B2 (ja) 2014-01-24 2022-07-08 タンパク質キナーゼのモジュレータとしてのジアリール大環状化合物
JP2023158350A Ceased JP2023179539A (ja) 2014-01-24 2023-09-22 タンパク質キナーゼのモジュレータとしてのジアリール大環状化合物

Country Status (35)

Country Link
US (7) US9714258B2 (enExample)
EP (6) EP3636648A1 (enExample)
JP (5) JP6490713B2 (enExample)
KR (1) KR102402179B1 (enExample)
CN (3) CN110317213B (enExample)
AP (1) AP2016009383A0 (enExample)
AU (1) AU2019279951B2 (enExample)
CA (1) CA2936079C (enExample)
CL (1) CL2016001876A1 (enExample)
CY (1) CY1121850T1 (enExample)
DK (3) DK3572416T3 (enExample)
EA (2) EA201892241A1 (enExample)
ES (3) ES2933350T3 (enExample)
FI (2) FI3636649T3 (enExample)
FR (1) FR25C1013I2 (enExample)
HR (3) HRP20221518T1 (enExample)
HU (4) HUE066590T2 (enExample)
IL (2) IL246860B (enExample)
LT (4) LT3636649T (enExample)
MX (2) MX392904B (enExample)
MY (1) MY193524A (enExample)
NL (1) NL301322I2 (enExample)
NO (1) NO2025015I1 (enExample)
NZ (2) NZ722375A (enExample)
PE (1) PE20160931A1 (enExample)
PH (1) PH12016501463A1 (enExample)
PL (3) PL3097107T3 (enExample)
PT (3) PT3097107T (enExample)
RS (3) RS59059B1 (enExample)
SG (2) SG11201605929RA (enExample)
SI (3) SI3636649T1 (enExample)
SM (3) SMT202400175T1 (enExample)
UA (1) UA121206C2 (enExample)
WO (1) WO2015112806A2 (enExample)
ZA (2) ZA201604654B (enExample)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2350075T1 (sl) 2008-09-22 2014-06-30 Array Biopharma, Inc. Substituirane imidazo (1,2b)piridazinske spojine kot Trk kinazni inhibitorji
BRPI0919873B8 (pt) 2008-10-22 2021-05-25 Array Biopharma Inc compostos de pirazol[1,5-a]pirimidina substituídos como inibidores da trk quinase, seus processos de preparação e composições farmacêuticas
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
SMT201700372T1 (it) 2010-05-20 2017-09-07 Array Biopharma Inc Composti macrociclici come inibitori di trk chinasi
RS59059B1 (sr) 2014-01-24 2019-08-30 Turning Point Therapeutics Inc Diaril makrociklična jedinjenja kao modulatori protein kinaza
CA2967951C (en) 2014-11-16 2023-11-07 Array Biopharma, Inc. Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
US10758525B2 (en) 2015-01-22 2020-09-01 MyoKardia, Inc. 4-methylsulfonyl-substituted piperidine urea compounds
EP3722441A1 (en) 2015-06-01 2020-10-14 Loxo Oncology Inc. Method of diagnosing a cancer for a treatment with a trk inhibitor
CN107735399B (zh) * 2015-07-02 2021-01-26 特普医药公司 作为蛋白质激酶的调节剂的手性二芳基大环
PL3319969T3 (pl) * 2015-07-06 2024-06-24 Turning Point Therapeutics, Inc. Diarylowe polimorfy makrocykliczne
HRP20210177T1 (hr) 2015-07-16 2021-03-19 Array Biopharma, Inc. Supstituirani spojevi pirazolo[1,5-a]piridina kao inhibitori ret kinaze
RU2020123800A (ru) 2015-07-21 2020-10-02 Тёрнинг Поинт Терапьютикс, Инк. Хиральные диарильные макроциклы и их применение
EP3368039A1 (en) 2015-10-26 2018-09-05 The Regents of The University of Colorado, A Body Corporate Point mutations in trk inhibitor-resistant cancer and methods relating to the same
WO2017106505A1 (en) * 2015-12-15 2017-06-22 University Of South Florida Gas5 binding compounds, formulations, and uses thereof
BR112018070017A2 (pt) 2016-04-04 2019-02-05 Loxo Oncology Inc métodos de tratamento de cânceres pediátricos
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
PT3439662T (pt) 2016-04-04 2024-09-30 Loxo Oncology Inc Formulações líquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida
PT3458456T (pt) 2016-05-18 2020-12-07 Array Biopharma Inc Preparação de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidino-1-carboxamida
AU2017302019A1 (en) 2016-07-28 2019-02-07 Turning Point Therapeutics, Inc. Macrocycle kinase inhibitors
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
CN110267960B (zh) 2017-01-18 2022-04-26 阿雷生物药品公司 作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
TWI808958B (zh) * 2017-01-25 2023-07-21 美商特普醫葯公司 涉及二芳基巨環化合物之組合療法
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
CN107586796B (zh) * 2017-07-20 2021-08-06 暨明医药科技(苏州)有限公司 (r)-2-(1-氨基乙基)-4-氟苯酚的合成方法
KR102645316B1 (ko) 2017-07-28 2024-03-07 터닝 포인트 테라퓨틱스, 인크. 거대환형 화합물 및 이의 용도
TWI876442B (zh) 2017-10-10 2025-03-11 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
CA3080157A1 (en) 2017-10-26 2019-05-02 Array Biopharma Inc. Formulations of a macrocyclic trk kinase inhibitor
CN109516999B (zh) * 2017-11-01 2021-08-17 郑州泰基鸿诺医药股份有限公司 用作蛋白质激酶调节剂的化合物及其应用
US11098046B2 (en) 2017-11-10 2021-08-24 Angex Pharmaceutical, Inc. Macrocyclic compounds as TRK kinase inhibitors and uses thereof
WO2019126122A1 (en) 2017-12-19 2019-06-27 Tp Therapeutics, Inc. Macrocyclic kinase inhibitors and their use
JP7194188B2 (ja) * 2017-12-19 2022-12-21 ターニング・ポイント・セラピューティクス・インコーポレイテッド 疾患を治療するための大環状化合物
JP7150356B2 (ja) * 2017-12-22 2022-10-11 深▲チェン▼市塔吉瑞生物医薬有限公司 置換ピラゾロ[1,5-a]ピリミジン化合物並びにその医薬組成物および使用
CA3087972C (en) 2018-01-18 2023-01-10 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
CN111630054B (zh) 2018-01-18 2023-05-09 奥瑞生物药品公司 作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物
CN111971286B (zh) 2018-01-18 2023-04-14 阿雷生物药品公司 作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物
EP3744723B1 (en) 2018-01-23 2023-10-18 Shenzhen TargetRx, Inc. Substituted pyrazolo[1,5-a]pyrimidine macrocyclic compound
WO2019149131A1 (zh) * 2018-01-30 2019-08-08 上海吉倍生物技术有限公司 具有大环分子结构的化合物及其用途
CN110156813B (zh) * 2018-02-13 2023-07-25 北京诺诚健华医药科技有限公司 作为trk抑制剂的杂环化合物
KR20200141041A (ko) * 2018-03-28 2020-12-17 포천 파마슈티컬즈, 엘티디. Trk 키나제 억제제로서의 마크로사이클릭 화합물
WO2019191659A1 (en) 2018-03-29 2019-10-03 Loxo Oncology, Inc. Treatment of trk-associated cancers
CN110386944B (zh) * 2018-04-16 2021-10-29 深圳市塔吉瑞生物医药有限公司 用于抑制蛋白激酶活性的二(杂)芳基大环化合物
ES2989075T3 (es) * 2018-04-25 2024-11-25 Primegene Beijing Co Ltd Compuesto macrocíclico diarílico y composición farmacéutica y uso del mismo
CN111918868B (zh) * 2018-05-04 2022-12-30 正大天晴药业集团股份有限公司 作为蛋白激酶调节剂的二芳基大环化合物
CN110627812B (zh) 2018-06-25 2022-10-11 北京诺诚健华医药科技有限公司 作为trk抑制剂的杂环化合物
KR102612513B1 (ko) 2018-07-31 2023-12-12 록쏘 온콜로지, 인코포레이티드 (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의 분무-건조된 분산물 및 제제
US11964988B2 (en) 2018-09-10 2024-04-23 Array Biopharma Inc. Fused heterocyclic compounds as RET kinase inhibitors
CN110950889B (zh) * 2018-09-27 2022-04-05 北京赛林泰医药技术有限公司 一种多靶点激酶抑制剂及其制备方法和用途
US20210403485A1 (en) * 2018-09-29 2021-12-30 Shandong Luye Pharmaceutical Co., Ltd. Pyrazolopyrimidine derivative as selective trk inhibitor
CA3117200A1 (en) 2018-10-22 2020-04-30 Esker Therapeutics, Inc. Tyk2 inhibitors and uses thereof
KR20210088675A (ko) * 2018-11-09 2021-07-14 산동 수안주 파마 코포레이션 리미티드 마크로사이클릭 타이로신 키나아제 억제제 및 그 용도
CN111171049B (zh) * 2018-11-09 2021-06-04 山东轩竹医药科技有限公司 酪氨酸激酶抑制剂及其用途
CA3119638A1 (en) * 2018-11-19 2020-05-28 Dana-Farber Cancer Institute, Inc. Macrocyclic inhibitors of dyrk1a
JP2022515198A (ja) 2018-12-19 2022-02-17 アレイ バイオファーマ インコーポレイテッド FGFRチロシンキナーゼの阻害剤としての置換ピラゾロ[1,5-a]ピリジン化合物
WO2020131674A1 (en) 2018-12-19 2020-06-25 Array Biopharma Inc. 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer
CN111592541B (zh) * 2019-02-21 2021-09-10 山东轩竹医药科技有限公司 大环类激酶抑制剂及其用途
IL286248B2 (en) * 2019-03-11 2025-12-01 Alumis Inc Tyk2 inhibitors and uses thereof
EA202192625A1 (ru) * 2019-03-26 2022-03-21 Вентикс Байосайенсес, Инк. Лиганды псевдокиназы tyk2
EP3974434B1 (en) * 2019-05-21 2025-11-19 Zhejiang Hisun Pharmaceutical Co., Ltd. Macrolide derivatives, preparation method and application thereof
JP2022537385A (ja) * 2019-06-19 2022-08-25 ターニング・ポイント・セラピューティクス・インコーポレイテッド 大環状キナーゼ阻害剤の多形
WO2020257189A1 (en) * 2019-06-19 2020-12-24 Turning Point Therapeutics, Inc. Macrocycles for treating disease
WO2020257165A1 (en) * 2019-06-19 2020-12-24 Turning Point Therapeutics, Inc. Macrocycles for use in treating disease
CN112110938B (zh) * 2019-06-21 2021-11-09 成都海博为药业有限公司 一种作为蛋白质激酶抑制剂的化合物及其制备方法和用途
MA56505A (fr) * 2019-06-21 2022-04-27 Janssen Pharmaceutica Nv Inhibiteurs macrocycliques de mcl-1
JP2022540678A (ja) 2019-07-16 2022-09-16 マイオカーディア,インク (r)-4-(1-((3-(ジフルオロメチル)-1-メチル-1h-ピラゾール-4-イル)スルホニル)-1-フルオロエチル)-n-(イソキサゾール-3-イル)ピペリジン-1-カルボキシアミドの多形体
WO2021027503A1 (zh) * 2019-08-12 2021-02-18 罗欣药业(上海)有限公司 三环类化合物、其制备方法、中间体及应用
CN114423762B (zh) * 2019-09-30 2024-03-29 浙江海正药业股份有限公司 大环类衍生物及其制备方法和用途
IL293208A (en) 2019-11-27 2022-07-01 Turning Point Therapeutics Inc Combination therapy involving diaryl macrocyclic compounds
CA3162632A1 (en) 2019-11-27 2021-06-03 Turning Point Therapeutics, Inc. Combination therapy involving diaryl macrocyclic compounds
JP7641965B2 (ja) 2019-12-03 2025-03-07 ターニング・ポイント・セラピューティクス・インコーポレイテッド 疾患処置に使用するための大環状分子
US20230101747A1 (en) 2019-12-06 2023-03-30 Schrödinger, Inc. Cyclic compounds and methods of using same
BR112022012684A2 (pt) 2019-12-27 2023-03-07 Schroedinger Inc Compostos cíclicos e métodos de uso dos mesmos
CN113045587A (zh) * 2019-12-27 2021-06-29 成都倍特药业股份有限公司 一种大环结构化合物的晶型及其制备方法
CN113135938B (zh) * 2020-01-19 2022-06-14 山东轩竹医药科技有限公司 取代的大环类酪氨酸激酶抑制剂及其用途
EP4114530A4 (en) * 2020-03-02 2024-04-17 Turning Point Therapeutics, Inc. THERAPEUTIC USES OF MACROCYCLIC COMPOUNDS
EP4146220A4 (en) 2020-05-04 2024-05-29 Amgen Inc. HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTORS EXPRESSED ON MYELOID CELL 2 AGONISTS AND METHODS OF USE
KR20230008767A (ko) * 2020-05-08 2023-01-16 산동 수안주 파마 코포레이션 리미티드 거대고리형 티로신 키나제 억제제의 결정형 및 그의 제조 방법
CN113754682B (zh) * 2020-06-04 2023-01-06 赛诺哈勃药业(成都)有限公司 具有大环结构的化合物及其用途
WO2022011123A1 (en) * 2020-07-10 2022-01-13 Blossomhill Therapeutics, Inc. Macrocycles and their use
US20230365584A1 (en) 2020-09-10 2023-11-16 Schrödinger, Inc. Heterocyclic pericondensed cdc7 kinase inhibitors for the treatment of cancer
EP4284804A1 (en) 2021-01-26 2023-12-06 Schrödinger, Inc. Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disorders
WO2022182845A1 (en) * 2021-02-25 2022-09-01 Blossomhill Therapeutics, Inc. Macrocycles and their use
TW202300150A (zh) 2021-03-18 2023-01-01 美商薛定諤公司 環狀化合物及其使用方法
CN113754657B (zh) * 2021-09-22 2023-01-17 广州白云山医药集团股份有限公司白云山制药总厂 大环类化合物的晶型及其制备方法和应用
CN116063326B (zh) * 2021-11-02 2025-08-05 赛诺哈勃药业(成都)有限公司 作为蛋白激酶调节剂的含氨基大环化合物
CN116514813A (zh) * 2021-12-31 2023-08-01 轩竹生物科技股份有限公司 酪氨酸激酶抑制剂及其中间体的制备方法
CA3246487A1 (en) * 2022-01-05 2023-07-13 Blossomhill Therapeutics, Inc. MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS
CN115746023B (zh) * 2022-10-27 2024-08-09 复旦大学 一种作为蛋白激酶抑制剂的含吲唑结构的杂环大环化合物及其制备方法
WO2025059027A1 (en) 2023-09-11 2025-03-20 Schrödinger, Inc. Cyclopenta[e]pyrazolo[1,5-a]pyrimidine derivatives as malt1 inhibitors
WO2025217347A2 (en) 2024-04-11 2025-10-16 Bristol-Myers Squibb Company Process of preparing repotrectinib
WO2025235733A1 (en) * 2024-05-09 2025-11-13 Blossomhill Therapeutics, Inc. Bis-bicycloheteroaryl macrocycles and their use

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4838925A (en) 1986-04-25 1989-06-13 E. I. Du Pont De Nemours And Company Heterocyclic acyl sulfonamides
ES2021105B3 (es) 1987-03-07 1991-10-16 Bayer Ag Procedimiento para la obtencion de 5-amino-4,6-dihalogeno piridinas.
DE69425736T2 (de) 1993-03-25 2001-04-12 Pharmacia & Upjohn Co., Kalamazoo Formyl- oder Cyano- substituierte Indolderivate mit dopaminergischer Wirkung
CZ291950B6 (cs) 1993-12-07 2003-06-18 Eli Lilly And Company Bis-indolmaleinimidy, jako inhibitory proteinové kinázy C, léčivo, farmaceutický prostředek s jejich obsahem a jejich použití
FR2746309B1 (fr) 1996-03-22 1998-04-17 Oreal Composition de teinture des fibres keratiniques contenant des pyrazolopyrimidineoxo ; leur utilisation pour la teinture comme coupleurs, procedes de teinture
RS49779B (sr) 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
FR2793791B1 (fr) 1999-05-19 2002-01-25 Univ Paris 7 Denis Diderot Nouveaux composes inhibiteurs specifiques de phospholipases a2
AU2001283955B2 (en) 2000-07-31 2006-05-18 F. Hoffmann-La Roche Ag Piperazine derivatives
AU2002227371B2 (en) 2000-12-08 2007-05-10 Ortho-Mcneil Pharmaceutical, Inc. Macroheterocylic compounds useful as kinase inhibitors
AU2002254114A1 (en) 2001-03-23 2002-10-08 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses
WO2004052315A2 (en) 2002-12-11 2004-06-24 Merck & Co., Inc. Tyrosine kinase inhibitors
US7970766B1 (en) 2007-07-23 2011-06-28 Google Inc. Entity type assignment
ES2668834T3 (es) 2008-09-08 2018-05-22 Merck Serono Sa Pirimidinas macrociclicas como inhibidores de proteína quinasas
SI2350075T1 (sl) 2008-09-22 2014-06-30 Array Biopharma, Inc. Substituirane imidazo (1,2b)piridazinske spojine kot Trk kinazni inhibitorji
BRPI0919873B8 (pt) 2008-10-22 2021-05-25 Array Biopharma Inc compostos de pirazol[1,5-a]pirimidina substituídos como inibidores da trk quinase, seus processos de preparação e composições farmacêuticas
MX2011004494A (es) 2008-10-31 2011-05-24 Genentech Inc Compuestos de pirazolopirimidina inhibidores de jak y metodos.
WO2010063487A1 (en) 2008-12-05 2010-06-10 Merz Pharma Gmbh & Co. Kgaa Pyrazolopyrimidines, a process for their preparation and their use as medicine
WO2010086040A1 (en) 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
US20110029480A1 (en) * 2009-08-03 2011-02-03 IntelliCubes, Inc. Method of Compiling Multiple Data Sources into One Dataset
KR20120087916A (ko) 2009-10-13 2012-08-07 엘랑코 애니멀 헬쓰 아일랜드 리미티드 마크로시클릭 인테그라제 억제제
WO2011071716A1 (en) 2009-12-07 2011-06-16 Boehringer Ingelheim International Gmbh Heterocyclic compounds containing an indole core
JP5643332B2 (ja) 2009-12-07 2014-12-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ピロロピリジンまたはベンゾイミダゾールコアを含有する複素環化合物
SA111320200B1 (ar) 2010-02-17 2014-02-16 ديبيوفارم اس ايه مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة
SMT201700372T1 (it) 2010-05-20 2017-09-07 Array Biopharma Inc Composti macrociclici come inibitori di trk chinasi
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
WO2012075393A2 (en) 2010-12-02 2012-06-07 President And Fellows Of Harvard College Activators of proteasomal degradation and uses thereof
EP2508607A1 (en) * 2011-04-07 2012-10-10 Helmholtz-Zentrum für Infektionsforschung GmbH Medicament for liver regeneration and for treatment of liver failure
WO2013001310A1 (en) 2011-06-30 2013-01-03 Centro Nacional De Investigaciones Oncológicas (Cnio) Macrocyclic compounds and their use as cdk8 inhibitors
WO2013028470A1 (en) 2011-08-19 2013-02-28 Merck Sharp & Dohme Corp. Process and intermediates for preparing macrolactams
WO2013045701A2 (en) 2011-09-29 2013-04-04 L'oreal Dyeing process using a composition comprising a glycosyl iridoid compound and a nucleophile or an amino or thio polymer, composition and devices therefor
WO2013045702A2 (en) 2011-09-29 2013-04-04 L'oreal Dye composition comprising a non-glycosyl iridoid compound and a specific nucleophile or an amino or thio polymer, dyeing process, and device therefor
HUE027318T2 (en) * 2011-09-30 2016-10-28 Oncodesign Sa Macrocyclic FLT3 kinase inhibitors
GB2495134B (en) 2011-09-30 2014-06-11 Tridonic Uk Ltd Power supply apparatus
JP6073343B2 (ja) 2011-10-20 2017-02-01 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ
CN104169286B (zh) 2012-03-06 2016-06-08 辉瑞大药厂 用于治疗增殖性疾病的大环衍生物
BR112014022000A8 (pt) 2012-03-09 2021-06-15 Lexicon Pharmaceuticals Inc compostos à base de pirazol[1,5-a]pirimidina, seu uso e composições que os compreende
EP2822559B1 (en) * 2012-03-09 2018-05-02 Lexicon Pharmaceuticals, Inc. Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and uses thereof
EP2645540A1 (de) 2012-03-28 2013-10-02 Siemens Aktiengesellschaft Glimmschutzwerkstoff für eine elektrische Maschine
GB201205669D0 (en) 2012-03-30 2012-05-16 Agency Science Tech & Res Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof
WO2014118186A1 (en) 2013-01-30 2014-08-07 Bayer Pharma Aktiengesellschaft Amino-substituted isothiazoles
EP2989082A1 (en) 2013-04-23 2016-03-02 LEK Pharmaceuticals d.d. Novel synthetic process to 8-chloro-1-methyl-benzo[d]azepine, novel intermediates and the production thereof
JPWO2015012328A1 (ja) 2013-07-24 2017-03-02 武田薬品工業株式会社 複素環化合物
WO2015073267A1 (en) 2013-11-15 2015-05-21 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
RS59059B1 (sr) 2014-01-24 2019-08-30 Turning Point Therapeutics Inc Diaril makrociklična jedinjenja kao modulatori protein kinaza
WO2016070241A1 (en) 2014-11-03 2016-05-12 Ctxt Pty Ltd Triazine compounds, compositions and synthesis
HUE067779T2 (hu) 2014-12-15 2024-11-28 Cmg Pharmaceutical Co Ltd Kondenzált gyûrûs heteroaril vegyületek és azok felhasználása TRK inhibitorokként
US9981944B2 (en) 2015-02-20 2018-05-29 Rigel Pharmaceuticals, Inc GDF-8 inhibitors
EP3267996B1 (en) 2015-03-12 2020-11-11 Merck Sharp & Dohme Corp. Pyrazolopyrimidine inhibitors of irak4 activity
US10155765B2 (en) 2015-03-12 2018-12-18 Merck Sharp & Dohme Corp. Carboxamide inhibitors of IRAK4 activity
CA2984848A1 (en) 2015-05-05 2016-11-10 Bayer Pharma Aktiengesellschaft Amido-substituted cyclohexane derivatives
CN108289610A (zh) 2015-06-29 2018-07-17 Q-科雷医疗有限公司 用于感测和分析医疗装置的导管内的流体和其中的气泡的特性的方法、电路、装置、组件、系统和相关联的计算机可执行代码
CN107735399B (zh) 2015-07-02 2021-01-26 特普医药公司 作为蛋白质激酶的调节剂的手性二芳基大环
PL3319969T3 (pl) 2015-07-06 2024-06-24 Turning Point Therapeutics, Inc. Diarylowe polimorfy makrocykliczne
RU2020123800A (ru) 2015-07-21 2020-10-02 Тёрнинг Поинт Терапьютикс, Инк. Хиральные диарильные макроциклы и их применение
EP3368039A1 (en) 2015-10-26 2018-09-05 The Regents of The University of Colorado, A Body Corporate Point mutations in trk inhibitor-resistant cancer and methods relating to the same
EP3423435B1 (en) 2016-03-04 2023-08-23 Vanderbilt University Substituted indole mcl-1 inhibitors
AU2017302019A1 (en) 2016-07-28 2019-02-07 Turning Point Therapeutics, Inc. Macrocycle kinase inhibitors
JP2020533269A (ja) 2016-12-14 2020-11-19 デベロップメント センター フォー バイオテクノロジー 抗体−薬物複合体およびその使用
TWI808958B (zh) 2017-01-25 2023-07-21 美商特普醫葯公司 涉及二芳基巨環化合物之組合療法
KR102645316B1 (ko) 2017-07-28 2024-03-07 터닝 포인트 테라퓨틱스, 인크. 거대환형 화합물 및 이의 용도

Similar Documents

Publication Publication Date Title
JP2017503867A5 (enExample)
HRP20191283T1 (hr) Diaril makrocikli kao modulatori protein kinaze
RU2370496C2 (ru) Конденсированные производные пиридина, применимые в качестве антагонистов аденозинового рецептора a2b
JP2018522869A5 (enExample)
HRP20211864T1 (hr) Inhibitori hetero-halo histonske deacetilaze
AP762A (en) Substituted 6,5-hetero-bicyclic derivatives.
RU2015131148A (ru) СОЕДИНЕНИЯ, ГЕТЕРОБИЦИКЛО-ЗАМЕЩЕННЫЕ-[1, 2, 4]ТРИАЗОЛО[1, 5c]ХИНАЗОЛИН-5-АМИНА, ОБЛАДАЮЩИЕ СВОЙСТВАМИ А2А АНТАГОНИСТОВ
JP2016504363A5 (enExample)
JP2016523270A5 (enExample)
HRP20190748T1 (hr) Derivati policikličkog amida kao inhibitori cdk9
JP2014513139A5 (enExample)
NZ586579A (en) Fused heterocyclic derivatives and methods of use as c-met inhibitors
JP2001097889A (ja) Crfアンタゴニストおよび関連組成物の使用
JP2014533734A5 (enExample)
JOP20190144A1 (ar) إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
TN2016000271A1 (en) Heteroaryl substituted nicotinamide compounds.
RU2007107910A (ru) Гетероциклические соединения
JP2018501315A5 (enExample)
HRP20170349T1 (hr) Novi derivati pirola, postupak njihove priprave i farmaceutski pripravci koji ih sadrže
RU2014115478A (ru) Новые гетероциклические производные и их применения
JP2011500774A5 (enExample)
RU2014115227A (ru) Производные бензотиазол-6-ил уксусной кислоты и их примение для лечения вич-инфекции
JP2012515205A5 (enExample)
RU2016111675A (ru) Соединения биарилацетамида и способы их применения
RU2015148189A (ru) ПРОИЗВОДНЫЕ 2-АМИДОПИРИДО[4, 3-d]ПИРИМИДИН-5-ОНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ WEE-1