MA56505A - Inhibiteurs macrocycliques de mcl-1 - Google Patents

Inhibiteurs macrocycliques de mcl-1

Info

Publication number
MA56505A
MA56505A MA056505A MA56505A MA56505A MA 56505 A MA56505 A MA 56505A MA 056505 A MA056505 A MA 056505A MA 56505 A MA56505 A MA 56505A MA 56505 A MA56505 A MA 56505A
Authority
MA
Morocco
Prior art keywords
inhibitors
mcl
macrocyclic
macrocyclic mcl
Prior art date
Application number
MA056505A
Other languages
English (en)
Inventor
Aldo Peschiulli
Frederik Jan Rita Rombouts
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MA56505A publication Critical patent/MA56505A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41621,2-Diazoles condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA056505A 2019-06-21 2020-06-18 Inhibiteurs macrocycliques de mcl-1 MA56505A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19181605 2019-06-21

Publications (1)

Publication Number Publication Date
MA56505A true MA56505A (fr) 2022-04-27

Family

ID=67001598

Family Applications (1)

Application Number Title Priority Date Filing Date
MA056505A MA56505A (fr) 2019-06-21 2020-06-18 Inhibiteurs macrocycliques de mcl-1

Country Status (11)

Country Link
US (1) US20220306653A1 (fr)
EP (1) EP3986902B1 (fr)
JP (1) JP2022537393A (fr)
KR (1) KR20220024694A (fr)
CN (1) CN114641481A (fr)
AU (1) AU2020296918A1 (fr)
BR (1) BR112021025732A2 (fr)
CA (1) CA3143613A1 (fr)
MA (1) MA56505A (fr)
MX (1) MX2021015770A (fr)
WO (1) WO2020254471A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220041623A1 (en) * 2018-09-30 2022-02-10 Jiangsu Hengrui Medicine Co., Ltd. Indole macrocyclic derivative, preparation method thereof and application thereof in medicine
TWI749404B (zh) 2018-11-22 2021-12-11 大陸商蘇州亞盛藥業有限公司 作為mcl-1抑制劑的大環吲哚
CA3168355A1 (fr) * 2020-02-21 2021-08-26 Frederik Jan Rita Rombouts Derives d'indole macrocycliques en tant qu'inhibiteurs de mcl-1
MX2023009475A (es) * 2021-02-12 2023-08-22 Janssen Pharmaceutica Nv Derivados macrociclicos 1,3-con puente 6-cloro-7-pirazol-4-il-1h-i ndol-2-carboxilato y 6-cloro-7-pirimidina-5-il-1h-indol-2-carboxil ato como inhibidores de mcl-1 para el tratamiento del cancer.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY193524A (en) * 2014-01-24 2022-10-18 Turning Point Therapeutics Inc Diaryl macrocycles as modulators of protein kinases
JO3474B1 (ar) * 2014-08-29 2020-07-05 Amgen Inc مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
CO2018008759A2 (es) 2016-04-22 2018-09-20 Astrazeneca Ab Inhibidores de mcl-1 y métodos de uso de los mismos
TW201904976A (zh) * 2017-03-31 2019-02-01 瑞典商阿斯特捷利康公司 Mcl-1抑制劑及其使用方法
TWI781996B (zh) 2017-03-31 2022-11-01 瑞典商阿斯特捷利康公司 合成mcl-1抑制劑之方法
BR112020003200A2 (pt) * 2017-08-15 2020-10-06 AbbVie Deutschland GmbH & Co. KG inibidores macrocíclicos de mcl-1 e métodos de uso
US20220041623A1 (en) 2018-09-30 2022-02-10 Jiangsu Hengrui Medicine Co., Ltd. Indole macrocyclic derivative, preparation method thereof and application thereof in medicine
TWI749404B (zh) 2018-11-22 2021-12-11 大陸商蘇州亞盛藥業有限公司 作為mcl-1抑制劑的大環吲哚

Also Published As

Publication number Publication date
US20220306653A1 (en) 2022-09-29
WO2020254471A1 (fr) 2020-12-24
BR112021025732A2 (pt) 2022-04-12
CA3143613A1 (fr) 2020-12-24
MX2021015770A (es) 2022-04-12
EP3986902A1 (fr) 2022-04-27
AU2020296918A1 (en) 2022-02-17
EP3986902B1 (fr) 2024-01-24
JP2022537393A (ja) 2022-08-25
KR20220024694A (ko) 2022-03-03
CN114641481A (zh) 2022-06-17

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