MA56505A - Inhibiteurs macrocycliques de mcl-1 - Google Patents

Inhibiteurs macrocycliques de mcl-1

Info

Publication number
MA56505A
MA56505A MA056505A MA56505A MA56505A MA 56505 A MA56505 A MA 56505A MA 056505 A MA056505 A MA 056505A MA 56505 A MA56505 A MA 56505A MA 56505 A MA56505 A MA 56505A
Authority
MA
Morocco
Prior art keywords
inhibitors
mcl
macrocyclic
macrocyclic mcl
Prior art date
Application number
MA056505A
Other languages
English (en)
Inventor
Aldo Peschiulli
Frederik Jan Rita Rombouts
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MA56505A publication Critical patent/MA56505A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41621,2-Diazoles condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA056505A 2019-06-21 2020-06-18 Inhibiteurs macrocycliques de mcl-1 MA56505A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19181605 2019-06-21

Publications (1)

Publication Number Publication Date
MA56505A true MA56505A (fr) 2022-04-27

Family

ID=67001598

Family Applications (1)

Application Number Title Priority Date Filing Date
MA056505A MA56505A (fr) 2019-06-21 2020-06-18 Inhibiteurs macrocycliques de mcl-1

Country Status (12)

Country Link
US (1) US20220306653A1 (fr)
EP (1) EP3986902B1 (fr)
JP (1) JP2022537393A (fr)
KR (1) KR20220024694A (fr)
CN (1) CN114641481A (fr)
AU (1) AU2020296918A1 (fr)
BR (1) BR112021025732A2 (fr)
CA (1) CA3143613A1 (fr)
ES (1) ES2975083T3 (fr)
MA (1) MA56505A (fr)
MX (1) MX2021015770A (fr)
WO (1) WO2020254471A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019347963A1 (en) * 2018-09-30 2021-05-27 Jiangsu Hengrui Medicine Co., Ltd. Indole macrocyclic derivative, preparation method therefor and application thereof in medicine
US11691989B2 (en) 2018-11-22 2023-07-04 Ascentage Pharma (Suzhou) Co., Ltd. Macrocyclic indoles as Mcl-1 inhibitors
CN115151551A (zh) * 2020-02-21 2022-10-04 詹森药业有限公司 作为mcl-1抑制剂的大环吲哚衍生物
KR20230145079A (ko) * 2021-02-12 2023-10-17 얀센 파마슈티카 엔브이 암의 치료를 위한 mcl-1 억제제로서의 마크로사이클릭1,3-브릿지된 6-클로로-7-피라졸-4-일-1h-인돌-2-카르복실레이트 및 6-클로로-7-피리미딘-5-일-1h-인돌-2-카르복실레이트 유도체

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3636649T (pt) * 2014-01-24 2024-04-09 Turning Point Therapeutics Inc Diaril macrociclos como moduladores das proteínas quinases
JO3474B1 (ar) * 2014-08-29 2020-07-05 Amgen Inc مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
KR102388208B1 (ko) 2016-04-22 2022-04-18 아스트라제네카 아베 암을 치료하기 위한 거대 환형 mcl1 억제제
TW201904976A (zh) 2017-03-31 2019-02-01 瑞典商阿斯特捷利康公司 Mcl-1抑制劑及其使用方法
TWI781996B (zh) 2017-03-31 2022-11-01 瑞典商阿斯特捷利康公司 合成mcl-1抑制劑之方法
JP2020531457A (ja) * 2017-08-15 2020-11-05 アッヴィ・インコーポレイテッド 大環状mcl−1阻害剤及び使用の方法
AU2019347963A1 (en) 2018-09-30 2021-05-27 Jiangsu Hengrui Medicine Co., Ltd. Indole macrocyclic derivative, preparation method therefor and application thereof in medicine
US11691989B2 (en) * 2018-11-22 2023-07-04 Ascentage Pharma (Suzhou) Co., Ltd. Macrocyclic indoles as Mcl-1 inhibitors

Also Published As

Publication number Publication date
CN114641481A (zh) 2022-06-17
CA3143613A1 (fr) 2020-12-24
EP3986902A1 (fr) 2022-04-27
JP2022537393A (ja) 2022-08-25
ES2975083T3 (es) 2024-07-03
WO2020254471A1 (fr) 2020-12-24
EP3986902B1 (fr) 2024-01-24
KR20220024694A (ko) 2022-03-03
US20220306653A1 (en) 2022-09-29
BR112021025732A2 (pt) 2022-04-12
MX2021015770A (es) 2022-04-12
AU2020296918A1 (en) 2022-02-17

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