CA2936079C - Diaryl macrocycles as modulators of protein kinases - Google Patents
Diaryl macrocycles as modulators of protein kinases Download PDFInfo
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- CA2936079C CA2936079C CA2936079A CA2936079A CA2936079C CA 2936079 C CA2936079 C CA 2936079C CA 2936079 A CA2936079 A CA 2936079A CA 2936079 A CA2936079 A CA 2936079A CA 2936079 C CA2936079 C CA 2936079C
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- Prior art keywords
- fluoro
- ethenopyrazolo
- tetrahydro
- methy1
- chloro
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 53
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- 229910052736 halogen Inorganic materials 0.000 claims description 46
- 150000002367 halogens Chemical group 0.000 claims description 44
- 125000002950 monocyclic group Chemical group 0.000 claims description 42
- 238000011282 treatment Methods 0.000 claims description 37
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 36
- 125000001072 heteroaryl group Chemical group 0.000 claims description 36
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 30
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- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
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Applications Claiming Priority (7)
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| US201461931506P | 2014-01-24 | 2014-01-24 | |
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| US201462049326P | 2014-09-11 | 2014-09-11 | |
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| US201562106301P | 2015-01-22 | 2015-01-22 | |
| US62/106,301 | 2015-01-22 | ||
| PCT/US2015/012597 WO2015112806A2 (en) | 2014-01-24 | 2015-01-23 | Diaryl macrocycles as modulators of protein kinases |
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| BRPI0919873B8 (pt) | 2008-10-22 | 2021-05-25 | Array Biopharma Inc | compostos de pirazol[1,5-a]pirimidina substituídos como inibidores da trk quinase, seus processos de preparação e composições farmacêuticas |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| SMT201700372T1 (it) | 2010-05-20 | 2017-09-07 | Array Biopharma Inc | Composti macrociclici come inibitori di trk chinasi |
| RS59059B1 (sr) | 2014-01-24 | 2019-08-30 | Turning Point Therapeutics Inc | Diaril makrociklična jedinjenja kao modulatori protein kinaza |
| CA2967951C (en) | 2014-11-16 | 2023-11-07 | Array Biopharma, Inc. | Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
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- 2019-02-27 JP JP2019034652A patent/JP2019104748A/ja not_active Withdrawn
- 2019-07-17 CY CY20191100764T patent/CY1121850T1/el unknown
- 2019-08-21 IL IL268820A patent/IL268820B/en unknown
- 2019-12-10 AU AU2019279951A patent/AU2019279951B2/en active Active
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2020
- 2020-02-21 US US16/797,866 patent/US20200216465A1/en not_active Abandoned
- 2020-07-06 ZA ZA2020/04100A patent/ZA202004100B/en unknown
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2021
- 2021-01-07 JP JP2021001588A patent/JP2021063121A/ja active Pending
- 2021-09-27 US US17/485,942 patent/US20220112213A1/en not_active Abandoned
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2022
- 2022-07-08 JP JP2022110613A patent/JP7356546B2/ja active Active
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2023
- 2023-07-28 US US18/227,561 patent/US12404281B2/en active Active
- 2023-09-22 JP JP2023158350A patent/JP2023179539A/ja not_active Ceased
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2025
- 2025-03-12 NL NL301322C patent/NL301322I2/nl unknown
- 2025-03-13 NO NO2025015C patent/NO2025015I1/no unknown
- 2025-03-20 HU HUS2500016C patent/HUS2500016I1/hu unknown
- 2025-03-20 FI FIC20250015C patent/FIC20250015I1/fi unknown
- 2025-04-08 LT LTPA2025513C patent/LTPA2025513I1/lt unknown
- 2025-04-09 FR FR25C1013C patent/FR25C1013I2/fr active Active
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