|
GB2036891B
(en)
|
1978-12-05 |
1983-05-05 |
Windsor Smith C |
Change speed gear
|
|
CA1213229A
(en)
|
1982-04-12 |
1986-10-28 |
Gary S. David |
Antibodies having dual specificities, their preparation and uses therefor
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
|
CA1282069C
(en)
|
1985-09-12 |
1991-03-26 |
Damon L. Meyer |
Antibody complexes of hapten-modified diagnostic or therapeutic agents
|
|
WO1987002671A1
(en)
|
1985-11-01 |
1987-05-07 |
International Genetic Engineering, Inc. |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5053394A
(en)
|
1988-09-21 |
1991-10-01 |
American Cyanamid Company |
Targeted forms of methyltrithio antitumor agents
|
|
IL89220A
(en)
|
1988-02-11 |
1994-02-27 |
Bristol Myers Squibb Co |
Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them
|
|
US5006652A
(en)
|
1988-08-08 |
1991-04-09 |
Eli Lilly And Company |
Intermediates for antibody-vinca drug conjugates
|
|
US5094849A
(en)
|
1988-08-08 |
1992-03-10 |
Eli Lilly And Company |
Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers
|
|
US5028697A
(en)
|
1988-08-08 |
1991-07-02 |
Eli Lilly And Company |
Cytotoxic antibody conjugates of hydrazide derivatized methotrexate analogs via simple organic linkers
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5137877B1
(en)
|
1990-05-14 |
1996-01-30 |
Bristol Myers Squibb Co |
Bifunctional linking compounds conjugates and methods for their production
|
|
GB9017024D0
(en)
|
1990-08-03 |
1990-09-19 |
Erba Carlo Spa |
New linker for bioactive agents
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
DE69127627T2
(de)
|
1990-08-29 |
1998-02-19 |
Genpharm Int |
Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
JPH08500017A
(ja)
|
1992-08-17 |
1996-01-09 |
ジェネンテク,インコーポレイテッド |
二特異的免疫アドヘジン
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
US6569834B1
(en)
|
1992-12-03 |
2003-05-27 |
George R. Pettit |
Elucidation and synthesis of antineoplastic tetrapeptide w-aminoalkyl-amides
|
|
AU679479B2
(en)
|
1992-12-16 |
1997-07-03 |
Basf Aktiengesellschaft |
Dolostatin analog
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
US5556623A
(en)
|
1993-03-30 |
1996-09-17 |
Eli Lilly And Company |
Antibody-drug conjugates
|
|
US6214345B1
(en)
*
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
CA2173150C
(en)
|
1993-10-01 |
2004-11-30 |
Kyoichi Sakakibara |
Novel peptide derivatives
|
|
US5599902A
(en)
|
1994-11-10 |
1997-02-04 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Cancer inhibitory peptides
|
|
US5663149A
(en)
|
1994-12-13 |
1997-09-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
|
|
GB9508195D0
(en)
|
1995-04-20 |
1995-06-07 |
Univ British Columbia |
Novel biologically active compounds and compositions,their use and derivation
|
|
CA2220339C
(en)
|
1995-05-10 |
2009-10-13 |
Kyowa Hakko Kogyo Co., Ltd. |
Toxin conjugates having a spacer comprising polyalkylene glycol and peptide
|
|
CA2249195A1
(en)
|
1996-03-18 |
1997-09-25 |
Board Of Regents, The University Of Texas System |
Immunoglobin-like domains with increased half lives
|
|
US6759509B1
(en)
|
1996-11-05 |
2004-07-06 |
Bristol-Myers Squibb Company |
Branched peptide linkers
|
|
CA2225325A1
(en)
|
1997-12-19 |
1999-06-19 |
The University Of British Columbia |
Hemiasterlin analogs
|
|
US8097648B2
(en)
|
1998-06-17 |
2012-01-17 |
Eisai R&D Management Co., Ltd. |
Methods and compositions for use in treating cancer
|
|
CA2359030A1
(en)
|
1999-01-28 |
2000-08-03 |
Chugai Seiyaku Kabushiki Kaisha |
Substituted phenethylamine derivatives
|
|
US6468522B1
(en)
|
1999-07-22 |
2002-10-22 |
University Of Medicine And Dentistry Of New Jersey |
Controlled release of thioamide moiety-containing therapeutic agents
|
|
US6323315B1
(en)
|
1999-09-10 |
2001-11-27 |
Basf Aktiengesellschaft |
Dolastatin peptides
|
|
US6756037B2
(en)
|
2000-03-31 |
2004-06-29 |
Enzon, Inc. |
Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups
|
|
US7214663B2
(en)
|
2000-06-14 |
2007-05-08 |
Medarex, Inc. |
Tripeptide prodrug compounds
|
|
TWI245034B
(en)
|
2000-07-24 |
2005-12-11 |
Matsushita Electric Industrial Co Ltd |
Capacitor
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
US6737409B2
(en)
|
2001-07-19 |
2004-05-18 |
Hoffmann-La Roche Inc. |
Dolastatin 10 derivatives
|
|
WO2003026577A2
(en)
|
2001-09-24 |
2003-04-03 |
Seattle Genetics, Inc. |
P-amidobenzylethers in drug delivery agents
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
AU2003224644A1
(en)
|
2002-02-27 |
2003-09-09 |
The Government Of The United States Of America, Represented By The Secretary, Department Of Healtan |
Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
|
|
US7064211B2
(en)
|
2002-03-22 |
2006-06-20 |
Eisai Co., Ltd. |
Hemiasterlin derivatives and uses thereof
|
|
CA2479764C
(en)
|
2002-03-22 |
2013-07-30 |
Eisai Co., Ltd. |
Hemiasterlin derivatives and uses thereof
|
|
WO2003090678A2
(en)
|
2002-04-23 |
2003-11-06 |
Ohio State University |
Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin
|
|
ITMI20021391A1
(it)
|
2002-06-25 |
2003-12-29 |
Nicox Sa |
Nitroderivati di inibitori della cicloossigenasi-2
|
|
CA2494104A1
(en)
*
|
2002-07-31 |
2004-04-22 |
Seattle Genetics, Inc. |
Anti-cd20 antibody-drug conjugates for the treatment of cancer and immune disorders
|
|
CA2802205C
(en)
|
2002-07-31 |
2016-01-19 |
Seattle Genetics, Inc. |
Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
|
|
US7087229B2
(en)
|
2003-05-30 |
2006-08-08 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US7122189B2
(en)
|
2002-08-13 |
2006-10-17 |
Enzon, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
JP2006500364A
(ja)
|
2002-08-16 |
2006-01-05 |
イムノージェン インコーポレーテッド |
高い反応性と溶解度を有する架橋剤および小分子薬物の標的化送達用コンジュゲートの調製におけるそれらの使用
|
|
WO2004026814A2
(en)
|
2002-09-20 |
2004-04-01 |
Wyeth Holdings Corporation |
Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors
|
|
US20040121965A1
(en)
|
2002-09-20 |
2004-06-24 |
Wyeth Holdings Corporation |
Method of treating resistant tumors
|
|
EP1560599A1
(en)
|
2002-11-14 |
2005-08-10 |
Syntarga B.V. |
Prodrugs built as multiple self-elimination-release spacers
|
|
WO2004047615A2
(en)
|
2002-11-21 |
2004-06-10 |
Wyeth |
Hemiasterlin affinity probes and their uses
|
|
US7332164B2
(en)
|
2003-03-21 |
2008-02-19 |
Enzon Pharmaceuticals, Inc. |
Heterobifunctional polymeric bioconjugates
|
|
US7390910B2
(en)
|
2003-08-08 |
2008-06-24 |
Wyeth |
Compounds for treating tumors
|
|
US7576206B2
(en)
|
2003-08-14 |
2009-08-18 |
Cephalon, Inc. |
Proteasome inhibitors and methods of using the same
|
|
US20080255090A1
(en)
|
2003-09-15 |
2008-10-16 |
The University Of British Columbia |
Ceratamines A and B, and Analogues, Syntheses and Pharmaceutical Compositions Thereof
|
|
US8007782B2
(en)
|
2003-10-22 |
2011-08-30 |
The Johns Hopkins University |
Combination bacteriolytic therapy for the treatment of tumors
|
|
CN103394083B
(zh)
|
2003-11-06 |
2017-07-18 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
|
US7078562B2
(en)
|
2004-01-19 |
2006-07-18 |
Mitsubishi Gas Chemical Company, Inc. |
Adamantane derivatives and resin compositions using the same as raw material
|
|
US20050175619A1
(en)
|
2004-02-05 |
2005-08-11 |
Robert Duffy |
Methods of producing antibody conjugates
|
|
AU2005216251B2
(en)
|
2004-02-23 |
2011-03-10 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
NZ550934A
(en)
|
2004-05-19 |
2010-05-28 |
Medarex Inc |
Chemical linkers and conjugates thereof
|
|
NZ579482A
(en)
*
|
2004-06-01 |
2011-02-25 |
Genentech Inc |
Antibody drug conjugates and methods
|
|
JP5198063B2
(ja)
*
|
2004-08-26 |
2013-05-15 |
アッパラオ・サティアム |
新規バイオ開裂性リンカー
|
|
CN101039701A
(zh)
*
|
2004-08-26 |
2007-09-19 |
尼古拉斯皮拉马尔印度有限公司 |
含有生物可裂解二硫化物连接物的前药和共药
|
|
US20090130136A1
(en)
|
2004-09-30 |
2009-05-21 |
Miller Louis H |
Chondroitin Sulphate a Binding Domains
|
|
ES2715776T3
(es)
|
2004-11-12 |
2019-06-06 |
Seattle Genetics Inc |
Auristatinas que tienen una unidad de ácido aminobenzoico en el extremo N
|
|
WO2006065533A2
(en)
|
2004-11-29 |
2006-06-22 |
Seattle Genetics, Inc. |
Engineered antibodies and immunoconjugates
|
|
KR20070086123A
(ko)
|
2004-12-13 |
2007-08-27 |
에프. 호프만-라 로슈 아게 |
하나 이상의 돌라스타틴 10 유도체를 포함하는 신규 약학조성물
|
|
UY29300A1
(es)
|
2004-12-22 |
2006-07-31 |
Astrazeneca Ab |
Compuestos quimicos
|
|
US7714016B2
(en)
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
WO2007008848A2
(en)
|
2005-07-07 |
2007-01-18 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
|
|
ES2585357T3
(es)
|
2005-07-07 |
2016-10-05 |
Seattle Genetics, Inc. |
Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
|
|
DK1912671T3
(da)
|
2005-07-18 |
2017-11-27 |
Seattle Genetics Inc |
Beta-glucuronid-linker-lægemiddelkonjugater
|
|
US8158590B2
(en)
|
2005-08-05 |
2012-04-17 |
Syntarga B.V. |
Triazole-containing releasable linkers, conjugates thereof, and methods of preparation
|
|
EP1940470B1
(en)
|
2005-09-26 |
2013-04-17 |
Medarex, Inc. |
Antibody-drug conjugates and their use
|
|
CA2627190A1
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
WO2007103288A2
(en)
|
2006-03-02 |
2007-09-13 |
Seattle Genetics, Inc. |
Engineered antibody drug conjugates
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
Medarex Llc |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
TW200900059A
(en)
|
2007-02-21 |
2009-01-01 |
Medarex Inc |
Chemical linkers with single amino acids and conjugates thereof
|
|
US8476451B2
(en)
|
2007-07-20 |
2013-07-02 |
The Regents Of The University Of California |
Tubulysin D analogues
|
|
BRPI0817881A2
(pt)
|
2007-10-10 |
2015-03-31 |
Novartis Ag |
Compostos orgânicos e seus usos
|
|
US20090155289A1
(en)
|
2007-11-01 |
2009-06-18 |
Steve Roberts |
Furin-cleavable peptide linkers for drug-ligand conjugates
|
|
CN106986926A
(zh)
|
2008-01-30 |
2017-07-28 |
皮里斯股份公司 |
具有对人c‑met受体酪氨酸激酶的亲和性的泪脂质运载蛋白的突变蛋白及其获得方法
|
|
DK2842575T3
(da)
|
2008-03-18 |
2017-11-27 |
Seattle Genetics Inc |
Auristatin-lægemiddel-linker-konjugater
|
|
MX2010011808A
(es)
|
2008-04-30 |
2011-03-04 |
Immunogen Inc |
Conjugados potentes y enlazadores hidrofilicos.
|
|
KR20210005318A
(ko)
|
2008-04-30 |
2021-01-13 |
이뮤노젠 아이엔씨 |
가교제 및 그 용도
|
|
CA2729095C
(en)
|
2008-06-27 |
2018-12-04 |
Merus B.V. |
Method for producing a transgenic murine mammal
|
|
GB2461546B
(en)
|
2008-07-02 |
2010-07-07 |
Argen X Bv |
Antigen binding polypeptides
|
|
EP2374481B1
(en)
|
2008-07-21 |
2015-11-04 |
Polytherics Limited |
Novel reagents and method for conjugating biological molecules
|
|
AU2009292643B2
(en)
|
2008-09-19 |
2016-02-18 |
Nektar Therapeutics |
Polymer conjugates of therapeutic peptides
|
|
LT2865387T
(lt)
|
2008-11-21 |
2019-09-25 |
Kobenhavns Universitet (University Of Copenhagen) |
Imuninio atsako sužadinimas
|
|
US20110182850A1
(en)
|
2009-04-10 |
2011-07-28 |
Trixi Brandl |
Organic compounds and their uses
|
|
WO2010138719A1
(en)
|
2009-05-28 |
2010-12-02 |
Mersana Therapeutics, Inc. |
Polyal drug conjugates comprising variable rate-releasing linkers
|
|
US8394922B2
(en)
|
2009-08-03 |
2013-03-12 |
Medarex, Inc. |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
|
|
SG10201404925TA
(en)
|
2009-08-28 |
2014-10-30 |
Arena Pharm Inc |
Cannabinoid receptor modulators
|
|
MX2012003560A
(es)
|
2009-09-25 |
2012-10-05 |
Astellas Pharma Inc |
Compuesto de amida sustituida.
|
|
EP3208281A1
(en)
|
2010-03-29 |
2017-08-23 |
Zymeworks, Inc. |
Antibodies with enhanced or suppressed effector function
|
|
EP4477668A3
(en)
|
2010-04-20 |
2025-03-19 |
Genmab A/S |
Heterodimeric antibody fc-containing proteins and methods for production thereof
|
|
ES2528956T3
(es)
|
2010-06-10 |
2015-02-13 |
Seattle Genetics, Inc. |
Nuevos derivados de auristatina y su uso
|
|
WO2012032080A1
(en)
|
2010-09-07 |
2012-03-15 |
F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H |
Stabilised human fc
|
|
PH12012500542A1
(en)
|
2010-09-24 |
2012-11-12 |
Astellas Pharma Inc |
Substituted amide compound
|
|
CA2930801C
(en)
|
2010-11-05 |
2019-05-28 |
Rinat Neuroscience Corporation |
Engineered polypeptide conjugates and methods for making thereof using transglutaminase
|
|
US10294270B2
(en)
|
2011-02-25 |
2019-05-21 |
Lonza Ltd |
Branched linker for protein drug conjugates
|
|
CA2828811C
(en)
|
2011-03-03 |
2021-09-21 |
Zymeworks Inc. |
Multivalent heteromultimer scaffold design and constructs
|
|
US9200034B2
(en)
|
2011-03-16 |
2015-12-01 |
Council Of Scientific & Industrial Research |
Oligopeptides and process for preparation thereof
|
|
JP6023097B2
(ja)
|
2011-03-16 |
2016-11-09 |
シアトル ジェネティックス, インコーポレイテッド |
Nカルボキシアルキルオーリスタチンおよびその使用
|
|
JP6161592B2
(ja)
|
2011-03-30 |
2017-07-12 |
アリゾナ・ボード・オブ・リージェンツ, フォー・アンド・オン・ビハーフ・オブ・アリゾナ・ステート・ユニバーシティArizona Board Of Regents, For And On Behalf Of Arizona State University |
オーリスタチンチラミンリン酸塩およびオーリスタチンアミノキノリン誘導体ならびにそのプロドラッグ
|
|
KR20140122649A
(ko)
|
2011-04-21 |
2014-10-20 |
시애틀 지네틱스, 인크. |
신규 결합제-약물 콘주게이트 (ADCs) 및 그의 용도
|
|
EP2714684B1
(en)
|
2011-05-27 |
2018-09-05 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
|
|
JP6215197B2
(ja)
|
2011-05-27 |
2017-10-18 |
アンブルックス, インコーポレイテッドAmbrx, Inc. |
非天然アミノ酸結合ドラスタチン誘導体を含有する化合物、またはその塩
|
|
MX2013014583A
(es)
|
2011-06-10 |
2014-03-31 |
Mersana Therapeutics Inc |
Conjugados de proteina-polimero-farmaco.
|
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
US20130190248A1
(en)
|
2011-07-26 |
2013-07-25 |
Agensys, Inc. |
Substituted peptide analogs
|
|
EP2776409B1
(en)
|
2011-11-09 |
2016-02-03 |
Ensemble Therapeutics Corporation |
Macrocyclic compounds for inhibition of inhibitors of apoptosis
|
|
WO2013068874A1
(en)
|
2011-11-11 |
2013-05-16 |
Pfizer Inc. |
Antibody-drug conjugates
|
|
HUE053589T2
(hu)
|
2011-11-17 |
2021-07-28 |
Pfizer |
Citotoxikus peptidek és azok antitest-hatóanyag konjugátumai
|
|
US20130224228A1
(en)
|
2011-12-05 |
2013-08-29 |
Igenica, Inc. |
Antibody-Drug Conjugates and Related Compounds, Compositions, and Methods
|
|
US9061000B2
(en)
|
2012-01-19 |
2015-06-23 |
Chao-Han LAI |
Pharmacological treatment of aortic aneurysm development
|
|
BR112014018630A2
(pt)
|
2012-02-09 |
2017-07-04 |
Var2 Pharmaceuticals Aps |
alvejamento de glicanos de sulfato de condroitina
|
|
EP2850059A4
(en)
|
2012-05-15 |
2016-06-29 |
Concortis Biosystems Corp |
CONJUGATES OF MEDICATION, METHODS OF CONJUGATION AND USE THEREOF
|
|
MX363116B
(es)
|
2012-06-07 |
2019-03-11 |
Ambrx Inc |
Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata.
|
|
EP4406612A3
(en)
|
2012-06-19 |
2024-10-16 |
Ambrx, Inc. |
Anti-cd70 antibody drug conjugates
|
|
MX367055B
(es)
*
|
2012-06-26 |
2019-08-02 |
Del Mar Pharmaceuticals |
El uso de una composición que comprende dianhidrogalactitol, diacetildianhidrogalactitol, y dibromodulcitol, y análogos o derivados de cada uno para el tratamiento de malignidades resistentes a inhibidores de tirosina cinasa.
|
|
US10501412B2
(en)
|
2012-07-12 |
2019-12-10 |
Hangzhou Dac Biotech Co., Ltd. |
Conjugates of cell binding molecules with cytotoxic agents
|
|
EP2917218B1
(en)
|
2012-11-09 |
2017-01-04 |
Ensemble Therapeutics Corporation |
Macrocyclic compounds for inhibition of inhibitors of apoptosis
|
|
JP6133431B2
(ja)
|
2012-11-24 |
2017-05-24 |
ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. |
親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用
|
|
EP2740493A1
(en)
|
2012-12-05 |
2014-06-11 |
Institut Curie |
Conjugates of the B-subunit of Shiga toxin for anticancer therapies
|
|
EP2740491A1
(en)
|
2012-12-05 |
2014-06-11 |
Institut Curie |
Conjugates of the B-subunit of shiga toxin for use as contrasting agents for imaging and therapy
|
|
CN108546283A
(zh)
|
2012-12-21 |
2018-09-18 |
荷商台医(有限合伙)公司 |
亲水性自消耗连接子及其缀合物
|
|
KR102215954B1
(ko)
|
2013-02-14 |
2021-02-15 |
브리스톨-마이어스 스큅 컴퍼니 |
튜부리신 화합물, 그의 제조 및 사용 방법
|
|
US9644028B2
(en)
|
2013-02-15 |
2017-05-09 |
Perseus Proteomics Inc. |
Anti-CDH3 humanized antibody, drug conjugate thereof, and use thereof
|
|
TR201911139T4
(tr)
|
2013-03-15 |
2019-08-21 |
Zymeworks Inc |
Sitotoksik ve anti-mitotik bileşikler ve bunları kullanmanın yöntemleri.
|
|
EP3057610B1
(en)
|
2013-10-15 |
2021-09-22 |
Sorrento Therapeutics, Inc. |
Drug-conjugates with a targeting molecule and two different drugs
|
|
US9988420B2
(en)
|
2013-12-17 |
2018-06-05 |
Novartis Ag |
Cytotoxic peptides and conjugates thereof
|
|
ES2916722T3
(es)
|
2013-12-27 |
2022-07-05 |
Zymeworks Inc |
Sistemas de enlace que contienen sulfonamida para conjugados de fármacos
|
|
AU2014373640B2
(en)
|
2013-12-27 |
2018-08-30 |
Var2 Pharmaceuticals Aps |
VAR2CSA-drug conjugates
|
|
HRP20220123T1
(hr)
*
|
2014-09-17 |
2022-04-15 |
Zymeworks Inc. |
Citotoksični i antimitotički spojevi, te postupci njihove uporabe
|
|
CA2975383C
(en)
|
2015-01-28 |
2023-09-12 |
Sorrento Therapeutics, Inc. |
Antibody drug conjugates comprising dolastatin derivatives
|
|
US10975112B2
(en)
|
2015-06-16 |
2021-04-13 |
Hangzhou Dac Biotech Co., Ltd. |
Linkers for conjugation of cell-binding molecules
|