JP2016539180A5 - - Google Patents

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JP2016539180A5
JP2016539180A5 JP2016547985A JP2016547985A JP2016539180A5 JP 2016539180 A5 JP2016539180 A5 JP 2016539180A5 JP 2016547985 A JP2016547985 A JP 2016547985A JP 2016547985 A JP2016547985 A JP 2016547985A JP 2016539180 A5 JP2016539180 A5 JP 2016539180A5
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phenyl
group
benzothiazole
enantiomer
enantiomers
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JP2016547985A
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JP6463366B2 (ja
JP2016539180A (ja
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Priority claimed from PCT/US2014/060174 external-priority patent/WO2015054662A1/en
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JP2016547985A 2013-10-10 2014-10-10 １２−リポキシゲナーゼ阻害物質としての４−（（２−ヒドロキシ−３−メトキシベンジル）アミノ）ベンゼンスルホンアミド誘導体 Active JP6463366B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361889396P 2013-10-10 2013-10-10
US61/889,396 2013-10-10
US201461987129P 2014-05-01 2014-05-01
US61/987,129 2014-05-01
PCT/US2014/060174 WO2015054662A1 (en) 2013-10-10 2014-10-10 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as 12-lipoxygenase inhibitors

Publications (3)

Publication Number Publication Date
JP2016539180A JP2016539180A (ja) 2016-12-15
JP2016539180A5 true JP2016539180A5 (enExample) 2018-04-26
JP6463366B2 JP6463366B2 (ja) 2019-01-30

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JP2016547985A Active JP6463366B2 (ja) 2013-10-10 2014-10-10 １２−リポキシゲナーゼ阻害物質としての４−（（２−ヒドロキシ−３−メトキシベンジル）アミノ）ベンゼンスルホンアミド誘導体

Country Status (7)

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US (3) US10266488B2 (enExample)
EP (1) EP3054936B1 (enExample)
JP (1) JP6463366B2 (enExample)
CA (1) CA2926950C (enExample)
DK (1) DK3054936T5 (enExample)
ES (1) ES2968371T3 (enExample)
WO (1) WO2015054662A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10266488B2 (en) 2013-10-10 2019-04-23 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
GB201419579D0 (en) * 2014-11-03 2014-12-17 Iomet Pharma Ltd Pharmaceutical compound
WO2017223447A1 (en) * 2016-06-23 2017-12-28 The Regents Of The University Of Michigan 12(s)-hydroxyeicosatrienoic acid compounds and their use as therapeutic agents
RU2665411C1 (ru) * 2017-03-30 2018-08-29 Александр Александрович Кролевец Способ получения нанокапсул стрептоцида в ксантановой камеди
CN107441100B (zh) * 2017-08-21 2020-08-28 武汉惠康达科技有限公司 治疗缺血再灌注损伤的化合物
CN109694395B (zh) * 2017-10-23 2020-08-28 武汉惠康达科技有限公司 一种用于缺血再灌注损伤的化合物及其制备方法
US11236044B2 (en) 2018-04-17 2022-02-01 The Regents Of The University Of Michigan Selective inhibitors of 12(S)-lipoxygenase (12-LOX) and methods for use of the same
EA202193251A1 (ru) 2019-06-05 2022-03-10 Эмори Юниверсити Пептидомиметики для лечения коронавирусной и пикорнавирусной инфекций
CN110256305B (zh) * 2019-07-24 2020-05-26 中国药科大学 一种萘磺酰胺类化合物、制备方法和应用
JP2023508952A (ja) * 2019-12-23 2023-03-06 エスアールアイ インターナショナル リポキシゲナーゼ阻害剤
CN111184864B (zh) * 2020-01-20 2022-01-14 武汉大学 Alox12特异性抑制剂在制备治疗非酒精性脂肪肝病和/或ⅱ型糖尿病的药物中的应用
US20230381202A1 (en) * 2020-10-20 2023-11-30 The Regents Of The University Of Michigan Compositions and methods for treating cardiovascular related disorders
WO2022236086A1 (en) * 2021-05-07 2022-11-10 The Regents Of The University Of California Compounds for modulating platelet-type 12-(s)-lipoxygenase and methods of use for same
CN113861130A (zh) * 2021-09-29 2021-12-31 守恒(厦门)医疗科技有限公司 联苯磺胺噻二唑类衍生物及其在抗肿瘤药物的应用
CN113698357A (zh) * 2021-09-29 2021-11-26 守恒(厦门)医疗科技有限公司 磺胺嘧啶类衍生物及其在抗肿瘤药物的应用
CN116370407A (zh) * 2021-12-22 2023-07-04 维拉洛斯治疗公司 包含4-((2-羟基-3-甲氧基苯甲醇)氨基)苯磺酰胺衍生物的水性肠道外药物制剂
MX2024007858A (es) * 2021-12-23 2024-09-04 Veralox Therapeutics Composiciones y metodos de uso para tratar enfermedades mediadas por 12-lipoxigenasa (12-lox).
EP4558508A1 (en) * 2022-07-18 2025-05-28 The Regents of the University of California Compositions for modulating lipoxygenase and methods of using same
KR20250099148A (ko) * 2022-11-02 2025-07-01 베라록스 테라퓨틱스 인코포레이티드 4-((2-하이드록시-3-메톡시벤질)아미노)벤젠설폰아마이드 유도체를 함유하는 경구용 약제학적 제형
CN120529902A (zh) * 2022-11-11 2025-08-22 维拉洛斯治疗公司 用于治疗狼疮的12-脂氧合酶抑制剂
TW202504598A (zh) * 2023-06-22 2025-02-01 美商維拉洛斯醫療股份有限公司 用於治療１２－脂肪加氧酶（１２－ｌｏｘ）介導之疾病的組成物及方法
WO2025207887A1 (en) * 2024-03-27 2025-10-02 Veralox Therapeutics Inc. Methods for treating heparin-induced thrombocytopenia

Family Cites Families (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4089809A (en) 1976-03-01 1978-05-16 The United States Of America As Represented By The United States Department Of Energy Regenerable sorbent and method for removing hydrogen sulfide from hot gaseous mixtures
US4233871A (en) 1978-04-26 1980-11-18 Alessi Anthony A Notching tool
ATE8584T1 (de) 1980-01-16 1984-08-15 Hans Georg Prof. Dr. Weder Verfahren und dialysiereinrichtung zur herstellung von bilayer-vesikeln und verwendung der bilayer-vesikel.
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4438253A (en) 1982-11-12 1984-03-20 American Cyanamid Company Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4532089A (en) 1984-01-14 1985-07-30 Northwestern University Method of preparing giant size liposomes
US4897269A (en) 1984-09-24 1990-01-30 Mezei Associates Limited Administration of drugs with multiphase liposomal delivery system
US4623661A (en) 1985-04-26 1986-11-18 Abbott Laboratories Lipoxygenase inhibiting compounds
US4605669A (en) 1985-04-26 1986-08-12 Abbott Laboratories Lipoxygenase inhibiting naphthohydroxamic acids
US4761403A (en) 1986-04-09 1988-08-02 Abbott Laboratories Lipoxygenase inhibiting compounds
US4897422A (en) 1987-02-10 1990-01-30 Abbott Laboratories Lipoxygenase inhibiting compounds
EP0279263B1 (en) 1987-02-10 1993-08-04 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US5571821A (en) 1993-05-20 1996-11-05 Texas Biotechnology Corporation Sulfonamides and derivatives thereof that modulate the activity of endothelin
CA1334975C (en) 1987-11-13 1995-03-28 James H. Holms Furan and pyrrole containing lipoxygenase inhibiting compounds
US4822811A (en) 1987-11-13 1989-04-18 Abbott Laboratories Carbazole lipoxygenase inhibiting compounds, compositions and use
JP2670680B2 (ja) 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
WO1990008545A1 (en) 1989-02-01 1990-08-09 Abbott Laboratories Lipoxygenase inhibiting compounds
WO1990012008A1 (en) 1989-03-30 1990-10-18 Abbott Laboratories Urea based lipoxygenase inhibiting compounds
PH30133A (en) 1989-09-07 1997-01-21 Abbott Lab Indole-, benzofuran-, and benzothiophene-containing lipoxygenase inhibiting compounds
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5120752A (en) 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
EP0645382B1 (en) 1993-04-13 2000-07-12 Morinaga Milk Industry Co., Ltd. Coumarin derivative and use thereof
DK77393D0 (da) 1993-06-29 1993-06-29 Novo Nordisk As Aktivering af enzymer
AU3577995A (en) 1994-10-04 1996-04-26 Fujisawa Pharmaceutical Co., Ltd. Urea derivatives and their use as acat-inhibitors
CA2184826A1 (en) 1994-10-25 1996-05-02 Bruce A. Kottke Direct fluorescence-conjugated immunoassay for platelet activation
US5710171A (en) 1995-05-24 1998-01-20 Merck & Co., Inc. Bisphenyl inhibitors of farnesyl-protein transferase
US5820880A (en) 1995-06-07 1998-10-13 The United States Of America As Represented By The Secretary Of The Army Liposomal formulation
WO1997001275A1 (en) 1995-06-29 1997-01-16 Merck & Co., Inc. Combinations of inhibitors of farnesyl-protein transferase
US5665428A (en) 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
CA2268916A1 (en) 1996-10-30 1998-05-07 Merck & Co., Inc. Integrin antagonists
US5919792A (en) 1996-10-30 1999-07-06 Merck & Co., Inc. Integrin antagonists
WO1998018461A1 (en) 1996-10-30 1998-05-07 Merck & Co., Inc. Integrin antagonists
DE19740785A1 (de) 1997-02-21 1998-08-27 Bayer Ag Arylsulfonamide und Analoga
IL131010A (en) 1997-02-21 2004-03-28 Bayer Ag Aryl sulfonamides and analogues thereof, processes for their preparation and pharmaceutical compositions comprising them in the treatment of neurodegenerative diseases
GB9703756D0 (en) 1997-02-24 1997-04-16 British Steel Plc Composite structures
JP4231559B2 (ja) 1997-04-23 2009-03-04 オリザ油化株式会社 リポキシゲナーゼ阻害剤
US6140351A (en) 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
AU751856B2 (en) 1997-12-19 2002-08-29 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
CA2321142A1 (en) * 1998-02-27 1999-09-02 Regents Of The University Of California Protease-activated receptor 4 and uses thereof
US6225329B1 (en) 1998-03-12 2001-05-01 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (PTPases)
WO1999046236A1 (en) 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
ZA992029B (en) 1998-03-12 1999-09-27 Novo Nordisk As Modulators of protein tyrosine phosphates (PTYases).
US6391568B1 (en) 1998-07-15 2002-05-21 Lionheart Technologies, Inc. Method for determining platelet reactivity in a whole blood sample
JP2000212076A (ja) 1998-11-20 2000-08-02 Takeda Chem Ind Ltd βアミロイド蛋白産生・分泌阻害剤
US6586475B1 (en) 1998-11-20 2003-07-01 Takeda Chemical Industries, Ltd. β-amyloid protein production/secretion inhibitors
US6287588B1 (en) 1999-04-29 2001-09-11 Macromed, Inc. Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
WO2000067776A1 (en) 1999-05-11 2000-11-16 Ortho-Mcneil Pharmaceuticals, Inc. Pharmacokinetic and pharmacodynamic modeling of erythropoietin administration
WO2001004159A1 (en) 1999-07-13 2001-01-18 Science & Technology Corporation @Unm Compositions and methods useful for the diagnosis and treatment of heparin induced thrombocytopenia/thrombosis
MX228790B (es) 1999-09-17 2005-06-30 Millennium Pharm Inc Inhibidores del factor xa.
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
US6720317B1 (en) 1999-09-17 2004-04-13 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
EP1259485B1 (en) 2000-02-29 2005-11-30 Millennium Pharmaceuticals, Inc. BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa
CA2405832A1 (en) 2000-04-28 2001-11-08 F. Hoffmann-La Roche Ag P-(sulfonyl)aryl and heteroaryls
GB0027309D0 (en) 2000-11-08 2000-12-27 Barts And The London Nat Healt Method of measuring measuring platlet activation
WO2002039987A2 (en) 2000-11-14 2002-05-23 Neurosearch A/S Use of malaria parasite anion channel blockers for treating malaria
JP2004523490A (ja) 2000-11-28 2004-08-05 ギルフォード ファーマシュウティカルズ インコーポレイテッド 二置換カルボサイクリックサイクロフィリン結合化合物とその用途
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
ES2200617B1 (es) 2001-01-19 2005-05-01 Almirall Prodesfarma, S.A. Derivados de urea como antagonistas de integrinas alfa 4.
US6670364B2 (en) 2001-01-31 2003-12-30 Telik, Inc. Antagonists of MCP-1 function and methods of use thereof
DE10105754A1 (de) 2001-02-08 2002-08-14 Werner P Berwald Reibungsschloß aus Systemteilen mit Mehrfachfunktionen für eine offene Profilverbindung eines Gleitbogenausbaus aus gewalzten Rinnenprofilen
DE10105751B4 (de) 2001-02-08 2005-09-29 Oxeno Olefinchemie Gmbh Verfahren zur Herstellung von 1-Octen
WO2003007955A2 (en) 2001-07-20 2003-01-30 Cancer Research Technology Limited Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer
FI116940B (fi) 2001-07-20 2006-04-13 Juvantia Pharma Ltd Oy Alfa-2B-adrenoseptorivälitteisen sairauden hoitoon tai ehkäisyyn käyttökelpoiset yhdisteet
SE0102716D0 (sv) 2001-08-14 2001-08-14 Astrazeneca Ab Novel compounds
AUPR738301A0 (en) 2001-08-30 2001-09-20 Starpharma Limited Chemotherapeutic agents
AU2002348533A1 (en) 2001-10-09 2003-05-26 Vertex Pharmaceuticals Incorporated Process for synthesizing aspartic and glutamic acid derivatives and diazoketone intermediates thereof
AU2002353147A1 (en) 2001-12-13 2003-06-30 Abbott Laboratories 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
TWI320409B (en) 2002-01-18 2010-02-11 Almirall Lab Urea derivatives as integrin 4 antagonists
WO2004000318A2 (en) 2002-06-21 2003-12-31 Cellular Genomics, Inc. Certain amino-substituted monocycles as kinase modulators
KR101124245B1 (ko) 2002-06-27 2012-07-02 노보 노르디스크 에이/에스 치료제로서 아릴 카르보닐 유도체
PL215132B1 (pl) 2002-06-27 2013-10-31 Novo Nordisk As Pochodna arylokarbonylowa jako srodek terapeutyczny, jej zastosowanie i kompozycja farmaceutyczna ja zawierajaca
CN101130526B (zh) 2002-06-27 2013-07-10 诺沃挪第克公司 用作治疗剂的芳基羰基衍生物
CA2497060C (en) 2002-08-29 2014-05-20 Temple University - Of The Commonwealth System Of Higher Education Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof
AU2003292625B2 (en) 2002-12-26 2008-07-24 Eisai R & D Management Co., Ltd. Selective estrogen receptor modulators
DE10300098A1 (de) 2003-01-07 2004-07-15 Bayer Ag Kupfer-Carben-Komplexe und ihre Verwendung
DE10300097A1 (de) 2003-01-07 2004-07-22 Bayer Ag Kupfer-Komplexe und ihre Verwendung
US7320989B2 (en) 2003-02-28 2008-01-22 Encysive Pharmaceuticals, Inc. Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists
WO2004078114A2 (en) 2003-02-28 2004-09-16 Encysive Pharmaceuticals Inc. Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-ii receptor antagonists.
TW200505902A (en) 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
WO2004099127A1 (en) 2003-05-07 2004-11-18 Novo Nordisk A/S Novel compounds as kinase inhibitors
US7015233B2 (en) 2003-06-12 2006-03-21 Abbott Laboratories Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
AU2011244937A1 (en) 2003-06-12 2011-11-24 Abbott Laboratories Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7375126B2 (en) 2003-06-12 2008-05-20 Abbott Laboratories Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
AR044694A1 (es) 2003-06-17 2005-09-21 Schering Corp Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo
WO2005000309A2 (en) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
JPWO2005012221A1 (ja) 2003-08-04 2006-09-14 小野薬品工業株式会社 ジフェニルエーテル化合物、その製造方法および用途
WO2005065074A2 (en) 2003-09-09 2005-07-21 Temple University Of The Commonwealth System Of Higher Education Protection of tissues and cells from cytotoxic effects of ionizing radiation by abl inhibitors
CN1878769A (zh) 2003-09-11 2006-12-13 凯米亚公司 细胞因子抑制剂
EP1670787B1 (en) 2003-09-11 2012-05-30 iTherX Pharma, Inc. Cytokine inhibitors
GB0321710D0 (en) 2003-09-16 2003-10-15 Novartis Ag Organic compounds
WO2005037223A2 (en) 2003-10-15 2005-04-28 Brigham And Women's Hospital, Inc. Methods and compositions for immunomodulation
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
CN1660811A (zh) 2004-02-27 2005-08-31 中国科学院上海药物研究所 1，4－二取代苯类化合物及其制备方法和用途
EP1722789A2 (en) 2004-03-08 2006-11-22 Amgen Inc. Therapeutic modulation of ppar (gamma) activity
KR100541110B1 (ko) 2004-06-25 2006-01-11 삼성전기주식회사 다파장 반도체 레이저 제조방법
US7671077B2 (en) 2004-07-19 2010-03-02 Leu-Fen Hou Lin Neuroprotective small organic molecules, compositions and uses related thereto
WO2006038594A1 (ja) 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. Ｎ型カルシウムチャネル阻害薬
US20060074103A1 (en) 2004-10-06 2006-04-06 Corte James R Cyclic beta-amino acid derivatives as factor Xa inhibitors
DE102004051277A1 (de) 2004-10-21 2006-04-27 Merck Patent Gmbh Heterocyclische Carbonylverbindungen
WO2006078941A2 (en) 2005-01-20 2006-07-27 Sirtris Pharmaceuticals, Inc. Novel sirtuin activating compounds and methods of use thereof
BRPI0519979A2 (pt) 2005-02-25 2009-08-18 Lilly Co Eli composto ou estereoisÈmeros, misturas de estereoisÈmeros ou sais farmaceuticamente aceitáveis dos mesmos, composição farmacêutica, e, uso de um composto
WO2006138418A2 (en) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators
CN100343236C (zh) * 2005-09-02 2007-10-17 中国科学院上海有机化学研究所 [n－(2－嘧啶氧基)苄氨基苯基]磺酰胺类化合物、制备方法及其用途
EP1934171A1 (en) 2005-10-13 2008-06-25 Wyeth a Corporation of the State of Delaware Methods for preparing glutamic acid derivatives
WO2007048042A2 (en) 2005-10-21 2007-04-26 University Of Alabama At Birmingham Small molecule inhibitors of hiv-1 capsid assembly
GB0522061D0 (en) 2005-10-28 2005-12-07 Glaxo Group Ltd Chemical process
CN101309707A (zh) 2005-11-15 2008-11-19 巴克斯特国际公司 含有脂氧化酶抑制剂和环糊精的组合物
GB0526240D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
AU2013254904A1 (en) 2006-03-02 2014-02-20 The Uab Research Foundation Mycobacterial disease detection, treatment, and drug discovery
WO2007101274A2 (en) 2006-03-02 2007-09-07 The Uab Research Foundation Mycobacterial disease detection, treatment, and drug discovery
GB0606283D0 (en) 2006-03-29 2006-05-10 Cyclacel Ltd Process
US8129357B2 (en) 2006-04-07 2012-03-06 Academia Sinica Method of making and using an adenosine analogue
US7351434B2 (en) 2006-04-07 2008-04-01 Academia Sinica Therapeutic Gastrodia extracts
CA2656067C (en) 2006-06-23 2014-08-12 Radius Health, Inc. Treatment of vasomotor symptoms with selective estrogen receptor modulators
US20080227799A1 (en) 2006-07-11 2008-09-18 Liotta Dennis C CXCR4 Antagonists Including Heteroatoms for the Treatment of Medical Disorders
EP2101760B1 (en) 2006-12-08 2013-02-27 Millennium Pharmaceuticals, Inc. Unit dose formulations and methods of treating thrombosis with an oral factor xa inhibitor
CN101652136A (zh) 2006-12-08 2010-02-17 米伦纽姆医药公司 使用经口因子xa抑制剂治疗血栓形成的单位剂量调配物和方法
JPWO2008072341A1 (ja) 2006-12-15 2010-03-25 パイオニア株式会社 描画装置及び方法、並びにコンピュータプログラム
US20080200458A1 (en) 2007-01-18 2008-08-21 Joseph Barbosa Methods and compositions for the treatment of body composition disorders
WO2008089307A2 (en) 2007-01-18 2008-07-24 Lexicon Pharmaceuticals, Inc. Delta 5 desaturase inhibitors for the treatment of pain, inflammation and cancer
EP2131848A4 (en) 2007-02-16 2012-06-27 Merck Sharp & Dohme COMPOSITIONS AND METHODS FOR REINFORCED ACTIVITY OF BIOLOGICAL ACTIVE MOLECULES
CA2679185A1 (en) 2007-02-28 2008-09-04 Advinus Therapeutics Private Limited 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application
WO2008109154A1 (en) 2007-03-08 2008-09-12 Altiris Therapeutics, Inc. Chemokine receptor modulators
WO2008112156A1 (en) 2007-03-08 2008-09-18 Altiris Therapeutics Chemokine receptor modulators
US8633186B2 (en) 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
US9603848B2 (en) 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
AU2013202912B2 (en) 2007-06-08 2016-10-27 Firmenich Incorporated Modulation of chemosensory receptors and ligands associated therewith
WO2009012242A2 (en) 2007-07-13 2009-01-22 Icagen, Inc. Sodium channel inhibitors
AU2008289485B2 (en) 2007-08-21 2014-08-14 Senomyx, Inc. Human T2R bitterness receptors and uses thereof
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
JP2009209090A (ja) 2008-03-04 2009-09-17 Mitsui Chemicals Inc 殺虫剤及び該殺虫剤に含まれる化合物、並びに該化合物の使用方法
CL2009000600A1 (es) 2008-03-20 2010-05-07 Bayer Cropscience Ag Uso de compuestos de diaminopirimidina como agentes fitosanitarios; compuestos de diaminopirimidina; su procedimiento de preparacion; agente que los contiene; procedimiento para la preparacion de dicho agente; y procedimiento para combatir plagas de animales y/u hongos dañinos patogenos de plantas.
WO2009118596A2 (en) 2008-03-26 2009-10-01 Glenmark Pharmaceuticals, S. A. Phthalimide derivatives as trpa1 modulators
MX2010011258A (es) 2008-04-14 2011-06-20 Univ Texas Inhibidores de molecula pequeña del dominio de homologia de pleckstrin y metodos para usar los mismos.
GB0810011D0 (en) 2008-06-02 2008-07-09 Jackson William P 5-Lipoxygenase inhibitors
US20110294853A1 (en) 2008-09-12 2011-12-01 Benjamin Pelcman Bis Aromatic Compounds for Use in the Treatment of Inflammation
CN101759683B (zh) 2008-12-25 2011-12-28 哈尔滨誉衡药业股份有限公司 二氢化茚酰胺化合物制备方法、包含其的药物组合物、及其作为蛋白激酶抑制剂的应用
WO2010123139A1 (ja) 2009-04-24 2010-10-28 持田製薬株式会社 スルファモイル基を有するアリールカルボキサミド誘導体
KR101804588B1 (ko) 2009-10-13 2017-12-04 리간드 파마슈티칼스 인코포레이티드 조혈 성장 인자 모방체 소분자 화합물 및 이의 용도
WO2011070444A2 (en) 2009-12-07 2011-06-16 Roberto Testi Compositions and methods for treating friedreich's ataxia
WO2011082400A2 (en) 2010-01-04 2011-07-07 President And Fellows Of Harvard College Modulators of immunoinhibitory receptor pd-1, and methods of use thereof
US20130131140A1 (en) 2010-01-14 2013-05-23 Jerry L. Nadler Treatment of diabetes and disorders associated with visceral obesity with inhibitors of human arachidonate 12 lipoxygenase and arachidonate 15-lipoxygenase
CN102206172B (zh) 2010-03-30 2015-02-25 中国医学科学院医药生物技术研究所 一组取代双芳基化合物及其制备方法和抗病毒应用
EP2560636A4 (en) 2010-04-23 2013-11-27 Kineta Inc ANTIVIRAL CONNECTIONS
JP2013526576A (ja) * 2010-05-18 2013-06-24 アメリカ合衆国 ヒト１２−リポキシゲナーゼ阻害剤
US8993622B2 (en) 2010-06-11 2015-03-31 Eirium Ab Antiviral compounds
WO2012016133A2 (en) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Ros1 kinase inhibitors for the treatment of glioblastoma and other p53-deficient cancers
WO2012021395A1 (en) 2010-08-12 2012-02-16 Novozymes, Inc. Compositions comprising a polypeptide having cellulolytic enhancing activity and a sulfur-containing compound and uses thereof
EP2642994A2 (en) 2010-11-18 2013-10-02 Ligand Pharmaceuticals Incorporated Use of hematopoietic growth factor mimetics
US20130310379A1 (en) 2010-11-19 2013-11-21 Constellation Pharmaceuticals Modulators of methyl modifying enzymes, compositions and uses thereof
ES2734878T3 (es) 2011-02-01 2019-12-12 Univ Illinois Derivados de N-hidroxibenzamida como inhibidores de HDAC y métodos terapéuticos que utilizan los mismos
EP2683682A1 (de) 2011-03-07 2014-01-15 Basf Se Verfahren zur synthese von aminobiphenylen
EP2546229A1 (de) 2011-07-15 2013-01-16 Friedrich-Alexander-Universität Erlangen-Nürnberg Verfahren zur Synthese von Aminobiphenylen
WO2012129562A2 (en) 2011-03-24 2012-09-27 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
ES2634716T3 (es) 2011-05-31 2017-09-28 Celgene International Ii Sàrl Nuevos estabilizantes y moduladores del receptor GLP-1
WO2013036869A2 (en) 2011-09-09 2013-03-14 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
WO2013050441A1 (en) 2011-10-05 2013-04-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for inhibiting or preventing platelet aggregation
BR112014022053B1 (pt) 2012-03-07 2020-12-08 Basf Se processo para a preparação de um composto
WO2013165969A2 (en) 2012-05-01 2013-11-07 The Trustees Of The University Of Pennsylvania Methods and kits for diagnosing heparin-induced thrombocytopenia
US10198163B2 (en) 2012-06-08 2019-02-05 Nec Corporation Electronic device and controlling method and program therefor
US10273234B2 (en) 2012-08-06 2019-04-30 Biogen Ma Inc. Compounds that are S1P modulating agents and/or ATX modulating agents
US9115122B2 (en) 2012-12-20 2015-08-25 University Of Maryland, Baltimore Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK)
WO2014144952A2 (en) 2013-03-15 2014-09-18 Peter Walter Modulators of the eif2alpha pathway
US9938204B2 (en) 2013-09-06 2018-04-10 The Regents Of The University Of California Intermolecular C-H silylation of unactivated arenes
CA2924527C (en) 2013-09-20 2022-07-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compounds for treating prostate cancer
US10266488B2 (en) 2013-10-10 2019-04-23 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
CN104163794A (zh) 2013-10-17 2014-11-26 中国药科大学 2-氨基芳环类血管内皮生长因子受体(vegfr)抑制剂及其制备方法和用途
US20170029366A1 (en) 2014-03-07 2017-02-02 The Johns Hopkins University Inhibitors of histone lysine specific demethylase (lsd1) and histone deacetylases (hdacs)

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