|
US3480613A
(en)
|
1967-07-03 |
1969-11-25 |
Merck & Co Inc |
2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
|
|
US3792039A
(en)
|
1971-12-27 |
1974-02-12 |
Miles Lab |
Poly 2'-fluoro-2'-deoxyuridylic acid
|
|
US5449664A
(en)
|
1988-11-21 |
1995-09-12 |
Syntex (U.S.A.) Inc. |
Antiviral agents
|
|
US6391542B1
(en)
|
1992-09-10 |
2002-05-21 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for treatment of Hepatitis C virus-associated diseases
|
|
US6174868B1
(en)
|
1992-09-10 |
2001-01-16 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for treatment of hepatitis C virus-associated diseases
|
|
US6433159B1
(en)
|
1992-09-10 |
2002-08-13 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for treatment of Hepatitis C virus associated diseases
|
|
JPH08506479A
(ja)
|
1992-09-10 |
1996-07-16 |
財団法人化学及血清療法研究所 |
C型肝炎ウイルス関連疾患の治療のための組成物および方法
|
|
US6423489B1
(en)
|
1992-09-10 |
2002-07-23 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for treatment of Hepatitis C virus-associated diseases
|
|
AU691527B2
(en)
|
1993-09-17 |
1998-05-21 |
Gilead Sciences, Inc. |
Nucleotide analogs
|
|
US5798340A
(en)
|
1993-09-17 |
1998-08-25 |
Gilead Sciences, Inc. |
Nucleotide analogs
|
|
US5656745A
(en)
|
1993-09-17 |
1997-08-12 |
Gilead Sciences, Inc. |
Nucleotide analogs
|
|
CA2267279A1
(en)
|
1996-10-16 |
1998-04-23 |
Devron Averett |
Monocyclic l-nucleosides, analogs and uses thereof
|
|
US6316612B1
(en)
|
1997-08-22 |
2001-11-13 |
Ribozyme Pharmaceuticals, Inc. |
Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides
|
|
US6054576A
(en)
|
1997-10-02 |
2000-04-25 |
Ribozyme Pharmaceuticals, Inc. |
Deprotection of RNA
|
|
US6127535A
(en)
|
1997-11-05 |
2000-10-03 |
Ribozyme Pharmaceuticals, Inc. |
Nucleoside triphosphates and their incorporation into oligonucleotides
|
|
US6482932B1
(en)
|
1997-11-05 |
2002-11-19 |
Ribozyme Pharmaceuticals, Incorporated |
Nucleoside triphosphates and their incorporation into oligonucleotides
|
|
US6617438B1
(en)
|
1997-11-05 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Oligoribonucleotides with enzymatic activity
|
|
US6528640B1
(en)
|
1997-11-05 |
2003-03-04 |
Ribozyme Pharmaceuticals, Incorporated |
Synthetic ribonucleic acids with RNAse activity
|
|
US6245750B1
(en)
|
1998-01-23 |
2001-06-12 |
Newbiotics, Inc. |
Enzyme catalyzed therapeutic agents
|
|
US6030957A
(en)
|
1998-06-29 |
2000-02-29 |
Wayne Hughes Institute |
Aryl phosphate derivatives of d4T having anti-HIV activity
|
|
MY164523A
(en)
|
2000-05-23 |
2017-12-29 |
Univ Degli Studi Cagliari |
Methods and compositions for treating hepatitis c virus
|
|
AU2001272923A1
(en)
|
2000-05-26 |
2001-12-11 |
Idenix (Cayman) Limited |
Methods and compositions for treating flaviviruses and pestiviruses
|
|
US20030008841A1
(en)
|
2000-08-30 |
2003-01-09 |
Rene Devos |
Anti-HCV nucleoside derivatives
|
|
EP1411954B1
(en)
|
2000-10-18 |
2010-12-15 |
Pharmasset, Inc. |
Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
|
|
US7105499B2
(en)
|
2001-01-22 |
2006-09-12 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
|
|
US8481712B2
(en)
|
2001-01-22 |
2013-07-09 |
Merck Sharp & Dohme Corp. |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
|
|
JP2004532184A
(ja)
|
2001-01-22 |
2004-10-21 |
メルク エンド カムパニー インコーポレーテッド |
Rna依存性rnaウィルスポリメラーゼ阻害薬としてのヌクレオシド誘導体
|
|
GB2392157B
(en)
|
2001-05-16 |
2005-12-21 |
Micrologix Biotech Inc |
Nucleic acid-based compounds and methods of use thereof
|
|
GB0114286D0
(en)
|
2001-06-12 |
2001-08-01 |
Hoffmann La Roche |
Nucleoside Derivatives
|
|
WO2003062256A1
(en)
|
2002-01-17 |
2003-07-31 |
Ribapharm Inc. |
2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
|
|
EP1480982A4
(en)
|
2002-02-14 |
2007-08-01 |
Pharmasset Inc |
MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES
|
|
CA2484921A1
(en)
|
2002-05-06 |
2003-11-13 |
Genelabs Technologies, Inc. |
Nucleoside derivatives for treating hepatitis c virus infection
|
|
AU2003237249A1
(en)
|
2002-05-24 |
2003-12-12 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having modified nucleoside units
|
|
CA2490191C
(en)
|
2002-06-28 |
2010-08-03 |
Idenix (Cayman) Limited |
Modified 2' and 3' -nucleoside prodrugs for treating flaviviridae infections
|
|
US7608600B2
(en)
|
2002-06-28 |
2009-10-27 |
Idenix Pharmaceuticals, Inc. |
Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
|
|
NZ537662A
(en)
|
2002-06-28 |
2007-10-26 |
Idenix Cayman Ltd |
2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
|
|
KR20050035194A
(ko)
|
2002-06-28 |
2005-04-15 |
이데닉스 (케이만) 리미티드 |
플라비비리다에 감염 치료용 2'-c-메틸-3'-o-l-발린에스테르 리보푸라노실 사이티딘
|
|
EP1545558A4
(en)
|
2002-09-24 |
2010-02-17 |
Koronis Pharmaceuticals Inc |
1, 3, 5-TRIAZINES FOR THE TREATMENT OF VIRAL DISEASES
|
|
KR20050109918A
(ko)
|
2002-12-12 |
2005-11-22 |
이데닉스 (케이만) 리미티드 |
2'-분지형 뉴클레오시드의 제조 방법
|
|
AR043006A1
(es)
|
2003-02-12 |
2005-07-13 |
Merck & Co Inc |
Proceso para preparar ribonucleosidos ramificados
|
|
US20040229839A1
(en)
|
2003-05-14 |
2004-11-18 |
Biocryst Pharmaceuticals, Inc. |
Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
|
|
WO2004106356A1
(en)
|
2003-05-27 |
2004-12-09 |
Syddansk Universitet |
Functionalized nucleotide derivatives
|
|
KR100883703B1
(ko)
|
2003-05-30 |
2009-02-12 |
파마셋 인코포레이티드 |
변형 불소화 뉴클레오시드 유사체
|
|
GB0317009D0
(en)
|
2003-07-21 |
2003-08-27 |
Univ Cardiff |
Chemical compounds
|
|
JP2007509939A
(ja)
|
2003-10-27 |
2007-04-19 |
ジェネラブズ テクノロジーズ インコーポレーティッド |
ウイルス感染を治療するためのヌクレオシド化合物
|
|
KR100570697B1
(ko)
|
2004-09-24 |
2006-04-12 |
삼성에스디아이 주식회사 |
연료 전지 시스템 및 이에 사용되는 개질기
|
|
WO2006121820A1
(en)
|
2005-05-05 |
2006-11-16 |
Valeant Research & Development |
Phosphoramidate prodrugs for treatment of viral infection
|
|
WO2007027248A2
(en)
|
2005-05-16 |
2007-03-08 |
Valeant Research & Development |
3', 5' - cyclic nucleoside analogues for treatment of hcv
|
|
EP1893192A4
(en)
|
2005-06-08 |
2010-03-31 |
Univ North Carolina |
METHOD FOR ENABLING SURVIVAL OF NERVE CELLS BASED ON NON-PEPTIDIC AND PEPTIDIC BDNF NEUROTROPHINE MIMETICS
|
|
CN101287472B
(zh)
|
2005-08-15 |
2011-10-12 |
弗·哈夫曼-拉罗切有限公司 |
抗病毒的4'-取代前核苷酸的氨基磷酸酯类化合物
|
|
WO2007056596A2
(en)
|
2005-11-09 |
2007-05-18 |
Wayne State University |
Phosphoramidate derivatives of fau
|
|
US8236904B2
(en)
|
2005-12-28 |
2012-08-07 |
Ethicon, Inc. |
Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates
|
|
WO2007095269A2
(en)
|
2006-02-14 |
2007-08-23 |
Merck & Co., Inc. |
Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection
|
|
US7842672B2
(en)
|
2006-07-07 |
2010-11-30 |
Gilead Sciences, Inc. |
Phosphonate inhibitors of HCV
|
|
EP2041156B1
(en)
|
2006-07-13 |
2013-11-20 |
Achillion Pharmaceuticals, Inc. |
4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
|
|
GB0623493D0
(en)
|
2006-11-24 |
2007-01-03 |
Univ Cardiff |
Chemical compounds
|
|
JP2010513484A
(ja)
|
2006-12-20 |
2010-04-30 |
メルク・シャープ・エンド・ドーム・コーポレイション |
Rna依存性rnaウイルス感染治療用ヌクレオシド環状ホスホロアミデート
|
|
AU2007337983A1
(en)
|
2006-12-22 |
2008-07-03 |
Ablynx N.V. |
Anti-chemokine (CCL2, CCL3, CCL5, CXCL11, CXCL12) single-domain antibodies
|
|
US20080261913A1
(en)
|
2006-12-28 |
2008-10-23 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of liver disorders
|
|
CA2673649A1
(en)
|
2007-01-05 |
2008-07-17 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection
|
|
AU2008210411A1
(en)
|
2007-01-31 |
2008-08-07 |
Alios Biopharma, Inc. |
2-5A derivatives and their use as anti-cancer, anti-viral and anti-parasitic agents
|
|
US8324179B2
(en)
|
2007-02-09 |
2012-12-04 |
Gilead Sciences, Inc. |
Nucleoside analogs for antiviral treatment
|
|
US7964580B2
(en)
|
2007-03-30 |
2011-06-21 |
Pharmasset, Inc. |
Nucleoside phosphoramidate prodrugs
|
|
EP1980568A1
(de)
|
2007-04-13 |
2008-10-15 |
Eberhard Karls Universität Tübingen |
Ethinylierte Heterodinucleosidphosphatanaloga, Verfahren zu deren Herstellung und deren Verwendung
|
|
GB0709791D0
(en)
|
2007-05-22 |
2007-06-27 |
Angeletti P Ist Richerche Bio |
Antiviral agents
|
|
WO2009058800A2
(en)
|
2007-10-29 |
2009-05-07 |
President And Fellows Of Harvard College |
Synthesis of nucleosides
|
|
US20090318380A1
(en)
|
2007-11-20 |
2009-12-24 |
Pharmasset, Inc. |
2',4'-substituted nucleosides as antiviral agents
|
|
WO2009086201A1
(en)
|
2007-12-21 |
2009-07-09 |
Alios Biopharma, Inc. |
2-5a analogs and their use as anti-cancer, anti-viral and anti- paras iti c agents
|
|
WO2009086192A1
(en)
|
2007-12-21 |
2009-07-09 |
Alios Biopharma, Inc. |
Biodegradable phosphate protected nucleotide derivatives and their use as cancer, anti viral and anti parasitic agents
|
|
CA2722308C
(en)
|
2008-04-15 |
2024-02-27 |
Rfs Pharma, Llc. |
Nucleoside derivatives for treatment of caliciviridae infections, including norovirus infections
|
|
KR20110065440A
(ko)
|
2008-07-02 |
2011-06-15 |
아이데닉스 파마슈티칼스, 인코포레이티드 |
바이러스 감염의 치료를 위한 화합물 및 제약 조성물
|
|
CA2733591C
(en)
|
2008-08-08 |
2016-06-28 |
Scinopharm Taiwan Ltd. |
Process for making 5-azacytosine nucleosides and their derivatives
|
|
GB0815968D0
(en)
|
2008-09-03 |
2008-10-08 |
Angeletti P Ist Richerche Bio |
Antiviral agents
|
|
US8163707B2
(en)
|
2008-09-15 |
2012-04-24 |
Enanta Pharmaceuticals, Inc. |
4′-allene-substituted nucleoside derivatives
|
|
PA8852101A1
(es)
|
2008-12-08 |
2010-07-27 |
Medivir Ab |
Nucleótidos uracil ciclopropílicos
|
|
WO2010068760A2
(en)
|
2008-12-10 |
2010-06-17 |
Achillion Pharmaceuticals, Inc. |
New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
|
|
US20100152103A1
(en)
|
2008-12-10 |
2010-06-17 |
Achillion Pharmaceuticals, Inc. |
4-amino-4-oxobutanoyl peptide cyclic analogues, inhibitors of viral replication
|
|
BRPI1004575A2
(pt)
|
2009-01-09 |
2016-04-05 |
Inhibitex Inc |
composto, composição farmacêutica, método de tratamento de infecções virais, método de separação dos diaestereômeros de fósforo
|
|
BRPI1005401A2
(pt)
|
2009-02-06 |
2019-04-02 |
Rfs Pharma, Llc |
pro-farmácos de purina nucleosídeo monofosfato para o tratamento de câncer e infecções virais
|
|
AP2011005929A0
(en)
|
2009-03-20 |
2011-10-31 |
Alios Biopharma Inc |
Substituted nucleoside and nucleotide analogs.
|
|
US20100240604A1
(en)
|
2009-03-20 |
2010-09-23 |
Alios Biopharma, Inc. |
Protected nucleotide analogs
|
|
JO3027B1
(ar)
|
2009-05-14 |
2016-09-05 |
Janssen Products Lp |
نيوكليوسيدات يوراسيل سبيرواوكسيتان
|
|
WO2010135520A1
(en)
|
2009-05-20 |
2010-11-25 |
Chimerix, Inc. |
Compounds, compositions and methods for treating viral infection
|
|
TWI583692B
(zh)
|
2009-05-20 |
2017-05-21 |
基利法瑪席特有限責任公司 |
核苷磷醯胺
|
|
US8618076B2
(en)
|
2009-05-20 |
2013-12-31 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
|
WO2011097607A1
(en)
|
2010-02-08 |
2011-08-11 |
Southern Research Institute |
Anti-viral treatment and assay to screen for anti-viral agent
|
|
EA026341B9
(ru)
|
2010-03-31 |
2021-12-27 |
ГАЙЛИД ФАРМАССЕТ ЭлЭлСи |
Кристаллическая форма нуклеозидфосфорамидата
|
|
PL3290428T3
(pl)
|
2010-03-31 |
2022-02-07 |
Gilead Pharmasset Llc |
Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
|
|
AR094621A1
(es)
|
2010-04-01 |
2015-08-19 |
Idenix Pharmaceuticals Inc |
Compuestos y composiciones farmacéuticas para el tratamiento de infecciones virales
|
|
PH12013500033A1
(en)
*
|
2010-07-19 |
2017-07-26 |
Gilead Sciences Inc |
Methods for the preparation of diasteromerically pure phosphoramidate prodrugs
|
|
CA2806829C
(en)
|
2010-08-04 |
2018-10-16 |
Herbert Schott |
Bone-targeting bisphosphonate duplex drugs
|
|
AU2011305652B2
(en)
|
2010-09-22 |
2016-10-20 |
Janssen Biopharma, Inc. |
Azido nucleosides and nucleotide analogs
|
|
WO2012040126A1
(en)
|
2010-09-22 |
2012-03-29 |
Alios Biopharma, Inc. |
Substituted nucleotide analogs
|
|
SG188497A1
(en)
|
2010-09-22 |
2013-05-31 |
Alios Biopharma Inc |
Substituted nucleotide analogs
|
|
AR083221A1
(es)
|
2010-09-29 |
2013-02-06 |
Univ Nac Quilmes |
Proceso para producir dialquilfosfotriesteres de nucleosidos mediante transesterificacion enzimatica y desproteccion de los mismos para producir nucleosidos monofosfato
|
|
WO2012062869A1
(en)
|
2010-11-10 |
2012-05-18 |
Janssen Products, Lp |
Uracyl spirooxetane nucleoside phosphoramidates
|
|
US8841275B2
(en)
|
2010-11-30 |
2014-09-23 |
Gilead Pharmasset Llc |
2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
|
|
EP2655392B1
(en)
|
2010-12-22 |
2018-04-18 |
Alios Biopharma, Inc. |
Cyclic nucleotide analogs
|
|
WO2012092484A2
(en)
|
2010-12-29 |
2012-07-05 |
Inhibitex, Inc. |
Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
|
|
US9095599B2
(en)
|
2011-01-03 |
2015-08-04 |
Nanjing Molecular Research, Inc. |
O-(substituted benzyl) phosphoramidate compounds and therapeutic use
|
|
US9156874B2
(en)
|
2011-01-03 |
2015-10-13 |
Nanjing Molecular Research, Inc. |
Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs
|
|
WO2012125900A1
(en)
|
2011-03-16 |
2012-09-20 |
Enanta Pharmaceuticals, Inc. |
2'-allene-substituted nucleoside derivatives
|
|
CA2843324A1
(en)
|
2011-03-31 |
2012-11-15 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
|
EA201391519A1
(ru)
|
2011-04-13 |
2014-03-31 |
Мерк Шарп И Доум Корп. |
2'-замещенные нуклеозидные производные и способы их применения для лечения вирусных заболеваний
|
|
WO2012142075A1
(en)
|
2011-04-13 |
2012-10-18 |
Merck Sharp & Dohme Corp. |
2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
|
|
EP2697241B1
(en)
|
2011-04-13 |
2019-06-12 |
Gilead Sciences, Inc. |
1'-substituted pyrimidine n-nucleoside analogs for antiviral treatment
|
|
WO2012158811A2
(en)
|
2011-05-19 |
2012-11-22 |
Rfs Pharma, Llc |
Purine monophosphate prodrugs for treatment of viral infections
|
|
PH12013502455A1
(en)
|
2011-05-27 |
2014-01-20 |
Achillion Pharmaceuticals Inc |
Substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for treating hcv infections
|
|
JP2014520772A
(ja)
|
2011-06-30 |
2014-08-25 |
ステラ・アンパルトセルスカブ |
Hcv併用療法
|
|
WO2013009735A1
(en)
|
2011-07-13 |
2013-01-17 |
Merck Sharp & Dohme Corp. |
5'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
|
|
EP2731433A4
(en)
|
2011-07-13 |
2014-12-31 |
Merck Sharp & Dohme |
5'-SUBSTITUTED NUCLEOSIDE ANALOGA AND METHOD FOR THEIR USE FOR THE TREATMENT OF VIRUS DISEASES
|
|
WO2013024155A1
(en)
|
2011-08-17 |
2013-02-21 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Combinations of anti-hcv-entry factor antibodies and direct acting antivirals for the treatment and the prevention of hcv infection
|
|
EA201490254A1
(ru)
|
2011-08-24 |
2014-07-30 |
ГЛАКСОСМИТКЛАЙН ЭлЭлСи |
Комбинированное лечение гепатита с
|
|
JP2014526474A
(ja)
|
2011-09-12 |
2014-10-06 |
アイディニックス ファーマシューティカルズ インコーポレイテッド |
ウイルス感染の治療のための化合物および薬学的組成物
|
|
TW201329096A
(zh)
|
2011-09-12 |
2013-07-16 |
Idenix Pharmaceuticals Inc |
經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物
|
|
MX2014003180A
(es)
|
2011-09-16 |
2014-04-25 |
Abbvie Inc |
Metodos para tratar vhc.
|
|
WO2013044030A1
(en)
|
2011-09-23 |
2013-03-28 |
Enanta Pharmaceuticals, Inc. |
2'-chloroacetylenyl substituted nucleoside derivatives
|
|
WO2013056046A1
(en)
|
2011-10-14 |
2013-04-18 |
Idenix Pharmaceuticals, Inc. |
Substituted 3',5'-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
|
|
WO2013066991A1
(en)
|
2011-10-31 |
2013-05-10 |
Inhibitex, Inc. |
Crystalline solvates of nucleoside phosphoroamidates, their stereoselective preparation, novel intermediates thereof, and their use in the treatment of viral disease
|
|
WO2013090420A2
(en)
|
2011-12-12 |
2013-06-20 |
Catabasis Pharmaceuticals, Inc. |
Fatty acid antiviral conjugates and their uses
|
|
EP2797594A1
(en)
|
2011-12-28 |
2014-11-05 |
AbbVie Inc. |
Methods for treating hcv
|
|
WO2013101550A1
(en)
|
2011-12-29 |
2013-07-04 |
Abbvie Inc. |
Solid compositions comprising an hcv inhibitor
|
|
US20130217644A1
(en)
|
2012-02-13 |
2013-08-22 |
Idenix Pharmaceuticals, Inc. |
Pharmaceutical Compositions of 2'-C-Methyl-Guanosine, 5'-[2[(3-Hydroxy-2,2-Dimethyl-1-Oxopropyl)Thio]Ethyl N-(Phenylmethyl)Phosphoramidate]
|