JP2016511279A5 - - Google Patents
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- JP2016511279A5 JP2016511279A5 JP2015562218A JP2015562218A JP2016511279A5 JP 2016511279 A5 JP2016511279 A5 JP 2016511279A5 JP 2015562218 A JP2015562218 A JP 2015562218A JP 2015562218 A JP2015562218 A JP 2015562218A JP 2016511279 A5 JP2016511279 A5 JP 2016511279A5
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- JP
- Japan
- Prior art keywords
- payload
- immunoligand
- antibody
- complex
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 9
- 239000012634 fragment Substances 0.000 claims description 8
- 239000003053 toxin Substances 0.000 claims description 8
- 231100000765 toxin Toxicity 0.000 claims description 8
- 108700012359 toxins Proteins 0.000 claims description 8
- 108090000279 Peptidyltransferases Proteins 0.000 claims description 7
- 230000003197 catalytic effect Effects 0.000 claims description 5
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 238000012986 modification Methods 0.000 claims description 3
- 230000004048 modification Effects 0.000 claims description 3
- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 230000004640 cellular pathway Effects 0.000 claims description 2
- 239000012228 culture supernatant Substances 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000001613 neoplastic effect Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 230000001575 pathological effect Effects 0.000 claims description 2
- 125000006850 spacer group Chemical group 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims description 2
- 238000001261 affinity purification Methods 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 3
- 150000003384 small molecules Chemical class 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 239000002596 immunotoxin Substances 0.000 claims 1
- 230000003278 mimic effect Effects 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 238000006276 transfer reaction Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000003550 marker Substances 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000006576 Althaea officinalis Nutrition 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 241000208422 Rhododendron Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 230000017730 intein-mediated protein splicing Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020015265A JP7481852B2 (ja) | 2013-03-15 | 2020-01-31 | 免疫リガンド／ペイロード複合体の生産方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361787371P | 2013-03-15 | 2013-03-15 | |
| US61/787,371 | 2013-03-15 | ||
| EP13159484.8A EP2777714A1 (en) | 2013-03-15 | 2013-03-15 | Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme |
| EP13159484.8 | 2013-03-15 | ||
| US201461939754P | 2014-02-14 | 2014-02-14 | |
| US61/939,754 | 2014-02-14 | ||
| PCT/EP2014/055173 WO2014140317A2 (en) | 2013-03-15 | 2014-03-14 | Method of producing an immunoligand/payload conjugate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020015265A Division JP7481852B2 (ja) | 2013-03-15 | 2020-01-31 | 免疫リガンド／ペイロード複合体の生産方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016511279A JP2016511279A (ja) | 2016-04-14 |
| JP2016511279A5 true JP2016511279A5 (enExample) | 2017-02-02 |
| JP7213610B2 JP7213610B2 (ja) | 2023-01-27 |
Family
ID=47900856
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015562218A Active JP7213610B2 (ja) | 2013-03-15 | 2014-03-14 | 免疫リガンド／ペイロード複合体の生産方法 |
| JP2020015265A Active JP7481852B2 (ja) | 2013-03-15 | 2020-01-31 | 免疫リガンド／ペイロード複合体の生産方法 |
| JP2022105670A Pending JP2022130634A (ja) | 2013-03-15 | 2022-06-30 | 免疫リガンド／ペイロード複合体の生産方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020015265A Active JP7481852B2 (ja) | 2013-03-15 | 2020-01-31 | 免疫リガンド／ペイロード複合体の生産方法 |
| JP2022105670A Pending JP2022130634A (ja) | 2013-03-15 | 2022-06-30 | 免疫リガンド／ペイロード複合体の生産方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9872923B2 (enExample) |
| EP (2) | EP2777714A1 (enExample) |
| JP (3) | JP7213610B2 (enExample) |
| CN (3) | CN109260478A (enExample) |
| AU (1) | AU2014230129B2 (enExample) |
| BR (2) | BR112015023589B1 (enExample) |
| CA (1) | CA2903581A1 (enExample) |
| DK (1) | DK2968583T3 (enExample) |
| ES (1) | ES3034413T3 (enExample) |
| HU (1) | HUE072754T2 (enExample) |
| IL (3) | IL240893B (enExample) |
| MX (1) | MX365547B (enExample) |
| PL (1) | PL2968583T3 (enExample) |
| SG (2) | SG10201903962PA (enExample) |
| WO (1) | WO2014140317A2 (enExample) |
| ZA (1) | ZA201506005B (enExample) |
Families Citing this family (82)
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| EP2777714A1 (en) | 2013-03-15 | 2014-09-17 | NBE-Therapeutics LLC | Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme |
| WO2014175690A1 (ko) | 2013-04-25 | 2014-10-30 | (재) 스크립스코리아 항체연구원 | 자가 절단 카세트를 포함하는 단백질 정제방법 및 이의 용도 |
| KR102511249B1 (ko) * | 2014-04-29 | 2023-03-20 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 신규한 안정한 항체-약물 복합체, 이의 제조방법 및 이의 용도 |
| CN107109463B (zh) | 2014-12-17 | 2020-12-29 | 豪夫迈·罗氏有限公司 | 键形成酶的活性测定 |
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| BR112017013661B1 (pt) * | 2014-12-23 | 2023-12-19 | Nbe-Therapeutics Ag | Conjugado de proteína de ligação-fármaco e composição farmacêutica |
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