JP2016511279A5 - - Google Patents
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- JP2016511279A5 JP2016511279A5 JP2015562218A JP2015562218A JP2016511279A5 JP 2016511279 A5 JP2016511279 A5 JP 2016511279A5 JP 2015562218 A JP2015562218 A JP 2015562218A JP 2015562218 A JP2015562218 A JP 2015562218A JP 2016511279 A5 JP2016511279 A5 JP 2016511279A5
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- Japan
- Prior art keywords
- payload
- immunoligand
- antibody
- complex
- molecular weight
- Prior art date
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- 238000000034 method Methods 0.000 claims description 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 9
- 239000012634 fragment Substances 0.000 claims description 8
- 239000003053 toxin Substances 0.000 claims description 8
- 231100000765 toxin Toxicity 0.000 claims description 8
- 108700012359 toxins Proteins 0.000 claims description 8
- 108090000279 Peptidyltransferases Proteins 0.000 claims description 7
- 230000003197 catalytic effect Effects 0.000 claims description 5
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 238000012986 modification Methods 0.000 claims description 3
- 230000004048 modification Effects 0.000 claims description 3
- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 230000004640 cellular pathway Effects 0.000 claims description 2
- 239000012228 culture supernatant Substances 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000001613 neoplastic effect Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 230000001575 pathological effect Effects 0.000 claims description 2
- 125000006850 spacer group Chemical group 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims description 2
- 238000001261 affinity purification Methods 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 3
- 150000003384 small molecules Chemical class 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 239000002596 immunotoxin Substances 0.000 claims 1
- 230000003278 mimic effect Effects 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 238000006276 transfer reaction Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000003550 marker Substances 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000006576 Althaea officinalis Nutrition 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 241000208422 Rhododendron Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 230000017730 intein-mediated protein splicing Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020015265A JP7481852B2 (ja) | 2013-03-15 | 2020-01-31 | 免疫リガンド／ペイロード複合体の生産方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361787371P | 2013-03-15 | 2013-03-15 | |
| US61/787,371 | 2013-03-15 | ||
| EP13159484.8 | 2013-03-15 | ||
| EP13159484.8A EP2777714A1 (en) | 2013-03-15 | 2013-03-15 | Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme |
| US201461939754P | 2014-02-14 | 2014-02-14 | |
| US61/939,754 | 2014-02-14 | ||
| PCT/EP2014/055173 WO2014140317A2 (en) | 2013-03-15 | 2014-03-14 | Method of producing an immunoligand/payload conjugate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020015265A Division JP7481852B2 (ja) | 2013-03-15 | 2020-01-31 | 免疫リガンド／ペイロード複合体の生産方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016511279A JP2016511279A (ja) | 2016-04-14 |
| JP2016511279A5 true JP2016511279A5 (enExample) | 2017-02-02 |
| JP7213610B2 JP7213610B2 (ja) | 2023-01-27 |
Family
ID=47900856
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015562218A Active JP7213610B2 (ja) | 2013-03-15 | 2014-03-14 | 免疫リガンド／ペイロード複合体の生産方法 |
| JP2020015265A Active JP7481852B2 (ja) | 2013-03-15 | 2020-01-31 | 免疫リガンド／ペイロード複合体の生産方法 |
| JP2022105670A Pending JP2022130634A (ja) | 2013-03-15 | 2022-06-30 | 免疫リガンド／ペイロード複合体の生産方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020015265A Active JP7481852B2 (ja) | 2013-03-15 | 2020-01-31 | 免疫リガンド／ペイロード複合体の生産方法 |
| JP2022105670A Pending JP2022130634A (ja) | 2013-03-15 | 2022-06-30 | 免疫リガンド／ペイロード複合体の生産方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9872923B2 (enExample) |
| EP (2) | EP2777714A1 (enExample) |
| JP (3) | JP7213610B2 (enExample) |
| CN (3) | CN109260478A (enExample) |
| AU (1) | AU2014230129B2 (enExample) |
| BR (2) | BR122021025118B1 (enExample) |
| CA (1) | CA2903581A1 (enExample) |
| DK (1) | DK2968583T3 (enExample) |
| ES (1) | ES3034413T3 (enExample) |
| HU (1) | HUE072754T2 (enExample) |
| IL (3) | IL240893B (enExample) |
| MX (1) | MX365547B (enExample) |
| PL (1) | PL2968583T3 (enExample) |
| SG (2) | SG11201507385YA (enExample) |
| WO (1) | WO2014140317A2 (enExample) |
| ZA (1) | ZA201506005B (enExample) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2777714A1 (en) | 2013-03-15 | 2014-09-17 | NBE-Therapeutics LLC | Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme |
| NZ713602A (en) | 2013-04-25 | 2016-09-30 | Scripps Korea Antibody Inst | Method for refining protein including self-cutting cassette and use thereof |
| EP3138568B1 (en) | 2014-04-29 | 2019-04-17 | Genequantum Healthcare (Suzhou) Co., Ltd. | New stable antibody-drug conjugate, preparation method therefor, and use thereof |
| EP3234177A1 (en) | 2014-12-17 | 2017-10-25 | F. Hoffmann-La Roche AG | Activity assay for bond forming enzymes |
| JP6605606B2 (ja) | 2014-12-17 | 2019-11-13 | エフ．ホフマン−ラ ロシュ アーゲー | ソルターゼを使用した単一工程での二重ポリペプチドコンジュゲーションのための酵素ワンポット反応 |
| CN107750169B (zh) | 2014-12-23 | 2022-02-08 | 恩比伊治疗股份公司 | 包含蒽环类衍生物的结合蛋白药物缀合物 |
| US20180028682A1 (en) | 2015-02-09 | 2018-02-01 | Nbe Therapeutics Ag | Maytansine-drug conjugates of her-2 specific binding proteins generated by site specific sortase-enzyme mediated conjugation |
| KR20170129769A (ko) * | 2015-03-17 | 2017-11-27 | 리제너론 파아마슈티컬스, 인크. | 아미노산 아실화 시약 및 이의 사용 방법 |
| CN108271375A (zh) * | 2015-09-25 | 2018-07-10 | 豪夫迈·罗氏有限公司 | 包含分选酶缀合环的重组免疫球蛋白重链及其缀合物 |
| CN108138158B (zh) | 2015-09-25 | 2021-11-09 | 豪夫迈·罗氏有限公司 | 可溶性分选酶a |
| WO2017050874A1 (en) | 2015-09-25 | 2017-03-30 | F. Hoffmann-La Roche Ag | Process for producing thioesters employing a sortase a |
| WO2017050872A1 (en) | 2015-09-25 | 2017-03-30 | F. Hoffmann-La Roche Ag | Transamidation employing sortase a in deep eutectic solvents |
| WO2017072366A1 (en) * | 2015-10-30 | 2017-05-04 | Nbe-Therapeutics Ag | Anti-mesothelin antibodies |
| HK1254836A1 (zh) | 2015-10-30 | 2019-07-26 | Nbe-Therapeutics Ag | 抗-ror1抗体 |
| CN109311982A (zh) | 2016-01-20 | 2019-02-05 | 斯克利普斯研究所 | Ror2抗体组合物和相关方法 |
| MX2018008926A (es) | 2016-01-20 | 2019-01-10 | Scripps Research Inst | Composiciones de anticuerpo contra ror1 y métodos relacionados. |
| CN105925596A (zh) * | 2016-02-23 | 2016-09-07 | 上海交通大学 | 基于内含肽的药用重组蛋白的合成方法 |
| CN106397598B (zh) * | 2016-02-23 | 2020-07-14 | 上海交通大学 | 多价多特异性抗体及免疫杂合蛋白的表达和制备方法 |
| KR102775461B1 (ko) | 2016-04-01 | 2025-02-28 | 어비디티 바이오사이언시스 인크. | 핵산-폴리펩타이드 조성물 및 이의 용도 |
| AU2017204139B2 (en) | 2016-06-17 | 2018-08-09 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for the depletion of cells |
| EP3272864A1 (en) | 2016-07-20 | 2018-01-24 | Paul Scherrer Institut | Solid-phase immobilization of microbial transglutaminase mtg on microbeads for protein conjugation |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| SG10202107429WA (en) | 2017-01-06 | 2021-08-30 | Avidity Biosciences Inc | Nucleic acid-polypeptide compositions and methods of inducing exon skipping |
| WO2018134787A2 (en) | 2017-01-20 | 2018-07-26 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd137+ cells |
| WO2019016392A1 (en) * | 2017-07-20 | 2019-01-24 | Nbe-Therapeutics Ag | HUMAN ANTIBODIES BINDING TO ROR2 |
| US20210139579A1 (en) | 2017-07-20 | 2021-05-13 | Nbe-Therapeutics Ag | Multispecific antibody product that binds to different ror1 epitopes |
| GB201711809D0 (en) | 2017-07-21 | 2017-09-06 | Governors Of The Univ Of Alberta | Antisense oligonucleotide |
| JP7368856B2 (ja) | 2017-07-25 | 2023-10-25 | トゥルーバインディング，インコーポレイテッド | Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療 |
| EP3665193A1 (en) | 2017-08-07 | 2020-06-17 | NBE Therapeutics AG | Anthracycline-based antibody drug conjugates having high in vivo tolerability |
| NZ762376A (en) | 2017-09-19 | 2022-08-26 | Scherrer Inst Paul | Transglutaminase conjugation method and linker |
| CN111655268B (zh) | 2017-10-04 | 2024-03-26 | 艾维迪提生物科学公司 | 核酸-多肽组合物及其用途 |
| CN107759699A (zh) * | 2017-10-18 | 2018-03-06 | 银丰生物工程集团有限公司 | 靶向cd30抗原的转基因t细胞及其制备方法与应用 |
| CN118638787A (zh) | 2017-12-06 | 2024-09-13 | 艾维迪提生物科学公司 | 治疗肌萎缩和强直性肌营养不良的组合物和方法 |
| WO2019165444A1 (en) * | 2018-02-26 | 2019-08-29 | Ohio State Innovation Foundation | Split-immunotoxins for boosting oncolytic virus toxicity |
| IL277049B2 (en) | 2018-03-13 | 2024-02-01 | Zymeworks Bc Inc | Conjugates of biparatopic anti-HER2 antibody and drug and methods of use |
| US20210128735A1 (en) | 2018-05-10 | 2021-05-06 | Cis Pharma Ag | Biocompatible copolymer containing multiple active agent molecules |
| CN108593909A (zh) * | 2018-05-23 | 2018-09-28 | 苏州立禾生物医学工程有限公司 | 一种定点标记免疫试剂的方法、标记免疫试剂及应用 |
| JP7427253B2 (ja) * | 2018-07-09 | 2024-02-05 | 国立大学法人 熊本大学 | 環状一本鎖抗体 |
| WO2020048876A1 (en) * | 2018-09-03 | 2020-03-12 | Technische Universitaet Muenchen | A double peptide tag combining reversibility and flexible functionalization |
| US12305202B2 (en) | 2018-09-30 | 2025-05-20 | Jecho Laboratories, Inc. | Polypeptide composition |
| EP3636284A1 (en) | 2018-10-11 | 2020-04-15 | NBE Therapeutics AG | Binding protein-toxin conjugates comprising anthracyclines, and use thereof in immune-oncological applications |
| WO2020081493A1 (en) | 2018-10-16 | 2020-04-23 | Molecular Templates, Inc. | Pd-l1 binding proteins |
| EP3647419A1 (en) | 2018-11-02 | 2020-05-06 | NBE Therapeutics AG | Sortase f and its use in methods for conjugation |
| IL319265A (en) | 2018-12-21 | 2025-04-01 | Avidity Biosciences Inc | Anti-transferrin receptor antibodies and their uses |
| CN120058944A (zh) | 2019-01-30 | 2025-05-30 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| WO2020188061A1 (en) * | 2019-03-19 | 2020-09-24 | Paul Scherrer Institut | Transglutaminase conjugation method with a glycine based linker |
| EP3959319A4 (en) | 2019-04-25 | 2023-06-07 | Avidity Biosciences, Inc. | NUCLEIC ACID COMPOSITIONS AND METHODS FOR MULTI-EXON SKIPPING |
| US11578090B2 (en) | 2019-06-06 | 2023-02-14 | Avidity Biosciences, Inc. | Nucleic acid-polypeptide compositions and uses thereof |
| JP7581252B2 (ja) | 2019-06-06 | 2024-11-12 | アビディティー バイオサイエンシーズ，インク． | Ｕｎａアミダイトおよびその使用 |
| EP3980080A1 (en) * | 2019-06-10 | 2022-04-13 | Sutro Biopharma, Inc. | Immunomodulator antibody drug conjugates and uses thereof |
| US11918649B2 (en) | 2019-09-18 | 2024-03-05 | Molecular Templates, Inc. | PD-L1-binding molecules comprising Shiga toxin a subunit scaffolds |
| GB201914468D0 (en) | 2019-10-07 | 2019-11-20 | Crescendo Biologics Ltd | Binding Molecules |
| JP2023500112A (ja) | 2019-10-30 | 2023-01-04 | シーアイエス ファーマ アクツィエンゲゼルシャフト | 活性剤を送達する生体適合ポリマー薬物担体 |
| CA3164060A1 (en) | 2019-12-06 | 2021-06-10 | Truebinding, Inc. | Antibodies that disrupt the interaction of gal3 and insulin receptor or integrins and methods of use thereof |
| CA3081503A1 (en) | 2019-12-06 | 2021-06-06 | Zymeworks Inc. | Methods of using a bispecific antigen-binding construct targeting her2 in combination with cdk4/6 inhibitors for the treatment of breast cancer |
| AU2021237465A1 (en) | 2020-03-19 | 2022-10-13 | Avidity Biosciences, Inc. | Compositions and methods of treating Facioscapulohumeral muscular dystrophy |
| IL296393B1 (en) | 2020-03-27 | 2025-12-01 | Avidity Biosciences Inc | Compositions and methods of treating muscle dystrophy |
| JP2023528797A (ja) | 2020-05-26 | 2023-07-06 | トゥルーバインディング，インコーポレイテッド | ガレクチン－３を遮断することにより炎症性疾患を処置する方法 |
| PE20231512A1 (es) | 2020-10-25 | 2023-09-26 | Araris Biotech Ag | Medios y metodos para producir conjugados de ligador-anticuerpo |
| WO2022122709A1 (en) | 2020-12-07 | 2022-06-16 | Sotio Biotech A.S. | Antibody-drug conjugates based on humanized cldn18.2 antibodies |
| CN116917484A (zh) | 2021-01-28 | 2023-10-20 | 启德医药科技（苏州）有限公司 | 连接酶融合蛋白及其应用 |
| WO2022188740A1 (en) | 2021-03-08 | 2022-09-15 | Genequantum Healthcare (Suzhou) Co., Ltd. | Antibody-immune agonist conjugate and applications thereof |
| EP4308242A1 (en) | 2021-03-17 | 2024-01-24 | Molecular Templates, Inc. | Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens |
| US20240158435A1 (en) * | 2021-03-18 | 2024-05-16 | Inofea Ag | Biocatalytical composition and use for generation of immunoligand-payload conjugates |
| JP2024514174A (ja) | 2021-04-14 | 2024-03-28 | ジーンクアンタム ヘルスケア （スーチョウ） シーオー．， エルティーディー． | リンカー、コンジュゲート及びその用途 |
| CN115369127A (zh) * | 2021-05-18 | 2022-11-22 | 苏州有诺真生物科技有限公司 | 一种基于基因改造脊椎动物的携带通用定点偶联接口的抗体的制备方法 |
| US20250026838A1 (en) | 2021-07-13 | 2025-01-23 | Truebinding, Inc. | Methods of preventing protein aggregation |
| WO2023014360A1 (en) * | 2021-08-05 | 2023-02-09 | Octagon Therapeutics, Inc. | Treatment and diagnosis of immune disorders relating to aberrant immune cells |
| WO2023017191A1 (en) | 2021-08-13 | 2023-02-16 | Cytune Pharma | Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer |
| CN113777295B (zh) * | 2021-09-15 | 2024-03-19 | 江南大学 | 用于检测肿瘤标志物pd-l1的高灵敏度量子点探针、制备方法及应用 |
| CN118265544A (zh) | 2021-09-16 | 2024-06-28 | 艾维迪提生物科学公司 | 治疗面肩肱型肌营养不良的组合物和方法 |
| CN118524852A (zh) | 2021-11-09 | 2024-08-20 | 真和制药有限公司 | 治疗或抑制心血管疾病的方法 |
| CN118660722A (zh) | 2021-12-23 | 2024-09-17 | 米雷楚来有限公司 | 用于递送多核苷酸的组合物 |
| WO2023143319A1 (zh) * | 2022-01-28 | 2023-08-03 | 启德医药科技（苏州）有限公司 | 抗体药物偶联物、药物组合物及用途 |
| EP4482531A1 (en) | 2022-02-23 | 2025-01-01 | Bright Peak Therapeutics AG | Immune antigen specific il-18 immunocytokines and uses thereof |
| US12071621B2 (en) | 2022-04-05 | 2024-08-27 | Avidity Biosciences, Inc. | Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping |
| IL318296A (en) | 2022-07-15 | 2025-03-01 | Genequantum Healthcare Suzhou Co Ltd | Anti-TROP2 antibody and its conjugate |
| AU2023314808A1 (en) | 2022-07-29 | 2025-03-20 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle |
| WO2024033362A1 (en) | 2022-08-08 | 2024-02-15 | Atb Therapeutics | Humanized antibodies against cd79b |
| WO2024107765A2 (en) | 2022-11-14 | 2024-05-23 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes |
| WO2025006639A2 (en) | 2023-06-27 | 2025-01-02 | Avidity Biosciences, Inc. | Compositions and methods of using prkag2-targeting antibody-oligonucleotide conjugates abstract |
| US12409230B2 (en) | 2023-06-30 | 2025-09-09 | Avidity Biosciences, Inc. | Compositions comprising PLN-targeting anti-transferrin receptor antibody-polynucleotides and methods of use thereof to treat cardiomyopathy |
| US20250197467A1 (en) | 2023-08-23 | 2025-06-19 | Bright Peak Therapeutics Ag | Activatable il-18 immunocytokines and uses thereof |
| WO2025041102A1 (en) | 2023-08-23 | 2025-02-27 | Bright Peak Therapeutics Ag | Targeted immune activation with il-18 immunocytokines |
| WO2025083208A1 (en) | 2023-10-19 | 2025-04-24 | Boehringer Ingelheim International Gmbh | Synthesis of morpholine derivatives and compounds therefore |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA932523B (en) | 1992-04-10 | 1994-10-08 | Res Dev Foundation | Immunotoxins directed against cd33 related surface antigens |
| EP0831917A2 (en) | 1995-06-07 | 1998-04-01 | Innogenetics N.V. | Immunotoxins specific for cd80 and cd86 expressing cells |
| US7405276B2 (en) * | 2000-11-01 | 2008-07-29 | Elusys Therapeutics, Inc. | Method of producing bispecific molecules by protein trans-splicing |
| DE10341812A1 (de) | 2003-09-10 | 2005-04-07 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| WO2005051976A2 (en) * | 2003-11-20 | 2005-06-09 | Ansata Therapeutics, Inc. | Protein and peptide ligation processes and one-step purification processes |
| AU2005280975B2 (en) | 2004-09-06 | 2009-06-18 | Kyowa Hakko Kirin Co., Ltd. | Anti-A33 antibody |
| CA2591148A1 (en) | 2004-12-09 | 2006-06-15 | Centocor, Inc. | Anti-integrin immunoconjugates, methods and uses |
| DE102005061934A1 (de) | 2005-12-23 | 2007-06-28 | Philipps-Universität Marburg | Verfahren zur Herstellung eines chemisch modifizierten Proteins |
| EP1996236A2 (en) | 2006-03-22 | 2008-12-03 | National Institute of Immunology | Novel bioconjugates as therapeutic agent and synthesis thereof |
| JP2010500967A (ja) * | 2006-07-20 | 2010-01-14 | ザ ジェネラル ホスピタル コーポレイション | コンビナトリアルターゲティングを通じたプロトキシンの選択的活性化のための方法、組成物、およびキット |
| US20100111851A1 (en) * | 2007-01-05 | 2010-05-06 | The University Of Tokyo | Diagnosis and treatment of cancer by using anti-prg-3 antibody |
| DK2211904T3 (en) | 2007-10-19 | 2016-10-24 | Seattle Genetics Inc | Cd19-binding agents and uses thereof |
| ES2547552T3 (es) | 2008-02-01 | 2015-10-07 | Genentech, Inc. | Metabolito de nemorrubicina y reactivos análogos, conjugados anticuerpo-fármaco y métodos |
| MX2010009940A (es) * | 2008-03-14 | 2010-09-28 | Genentech Inc | Variaciones geneticas asociadas con resistencia a drogas. |
| WO2009132455A1 (en) | 2008-04-30 | 2009-11-05 | Paul Xiang-Qin Liu | Protein splicing using short terminal split inteins |
| WO2009140242A1 (en) * | 2008-05-13 | 2009-11-19 | Genentech, Inc. | Analysis of antibody drug conjugates by bead-based affinity capture and mass spectrometry |
| JP6067222B2 (ja) | 2008-07-15 | 2017-01-25 | ジェネンテック， インコーポレイテッド | アントラサイクリン誘導体コンジュゲート、その調製方法及び抗腫瘍化合物としてのその用途 |
| EP2391714B2 (en) * | 2009-01-30 | 2019-07-24 | Whitehead Institute for Biomedical Research | Methods for ligation and uses thereof |
| EP2403524A4 (en) | 2009-03-06 | 2012-09-26 | Agensys Inc | CONJUGATES ANTIBODY-DRUG (ADC) BINDING PROTEINS 24P4C12 |
| US20120213805A1 (en) | 2009-04-08 | 2012-08-23 | Heinz Faulstich | Amatoxin-Armed Tartget-Binding Moieties for the Treatment of Cancer |
| US20120076787A1 (en) | 2009-05-28 | 2012-03-29 | Peter Adamson | Combination of a tnf-alpha antagonist and a vegf antagonist for use in the treatment or prevention of diseases of the eye |
| WO2011133704A2 (en) * | 2010-04-20 | 2011-10-27 | Whitehead Institute For Biomedical Researh | Modified polypeptides and proteins and uses thereof |
| BR112013013127B1 (pt) | 2010-12-02 | 2021-06-22 | Nerviano Medical Sciences S.R.L. | Processo para a preparação de derivados de morfolinil antraciclina, compostos derivados de morfolinil antraciclina e composição farmacêutica compreendendo estes compostos |
| ES2700514T3 (es) * | 2011-02-01 | 2019-02-18 | Genmab As | Anticuerpos humanos y conjugados de anticuerpo-fármaco contra CD74 |
| WO2012142659A1 (en) * | 2011-04-19 | 2012-10-26 | Baker Idi Heart And Diabetes Institute Holdings Limited | Site-selective modification of proteins |
| EP2524929A1 (en) * | 2011-05-17 | 2012-11-21 | Sanofi | Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms |
| US20140302084A1 (en) | 2011-08-05 | 2014-10-09 | The University Of Chicago | Immunogenic protein conjugates and method for making and using the same |
| KR20130046322A (ko) | 2011-10-27 | 2013-05-07 | 한국외국어대학교 연구산학협력단 | 식중독 세균 Salmonella enterica 탐지용 탐침자 및 그를 포함한 DNA 칩 |
| PE20150025A1 (es) | 2012-05-21 | 2015-02-09 | Genentech Inc | Anticuerpos e inmunoconjugados contra ly6e y metodos de uso |
| WO2013177231A1 (en) | 2012-05-21 | 2013-11-28 | Massachusetts Institute Of Technology | Translocation of non-natural chemical entities through anthrax protective antigen pore |
| MX2014014894A (es) * | 2012-06-04 | 2015-02-20 | Irm Llc | Metodos de marcado especifico del sitio y moleculas producidas mediante los mismos. |
| WO2014088928A1 (en) | 2012-12-03 | 2014-06-12 | President And Fellows Of Harvard College | Methods for making targeted protein toxins by sortase-mediated protein ligation |
| EP2777714A1 (en) | 2013-03-15 | 2014-09-17 | NBE-Therapeutics LLC | Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme |
| NZ713602A (en) | 2013-04-25 | 2016-09-30 | Scripps Korea Antibody Inst | Method for refining protein including self-cutting cassette and use thereof |
| GB2529356B (en) | 2013-04-28 | 2020-12-23 | Genequantum Healthcare Co Ltd | Novel linkers, coupling intermediates, conjugates, preparation method and application thereof |
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