PL2968583T3 - Sposób wytwarzania koniugatu immunoligand/ładunek przy użyciu sekwencyjnie specyficznego enzymu transpeptydazy - Google Patents

Sposób wytwarzania koniugatu immunoligand/ładunek przy użyciu sekwencyjnie specyficznego enzymu transpeptydazy

Info

Publication number
PL2968583T3
PL2968583T3 PL14710285.9T PL14710285T PL2968583T3 PL 2968583 T3 PL2968583 T3 PL 2968583T3 PL 14710285 T PL14710285 T PL 14710285T PL 2968583 T3 PL2968583 T3 PL 2968583T3
Authority
PL
Poland
Prior art keywords
immunoligand
sequence
producing
payload conjugate
transpeptidase enzyme
Prior art date
Application number
PL14710285.9T
Other languages
English (en)
Polish (pl)
Inventor
Ulf Grawunder
Roger Renzo Beerli
Original Assignee
Nbe-Therapeutics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nbe-Therapeutics Ag filed Critical Nbe-Therapeutics Ag
Publication of PL2968583T3 publication Critical patent/PL2968583T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/50—Other enzymatic activities
    • C12Q2521/537—Protease

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
PL14710285.9T 2013-03-15 2014-03-14 Sposób wytwarzania koniugatu immunoligand/ładunek przy użyciu sekwencyjnie specyficznego enzymu transpeptydazy PL2968583T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361787371P 2013-03-15 2013-03-15
EP13159484.8A EP2777714A1 (en) 2013-03-15 2013-03-15 Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
US201461939754P 2014-02-14 2014-02-14
PCT/EP2014/055173 WO2014140317A2 (en) 2013-03-15 2014-03-14 Method of producing an immunoligand/payload conjugate

Publications (1)

Publication Number Publication Date
PL2968583T3 true PL2968583T3 (pl) 2025-08-11

Family

ID=47900856

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14710285.9T PL2968583T3 (pl) 2013-03-15 2014-03-14 Sposób wytwarzania koniugatu immunoligand/ładunek przy użyciu sekwencyjnie specyficznego enzymu transpeptydazy

Country Status (16)

Country Link
US (4) US9872923B2 (enExample)
EP (2) EP2777714A1 (enExample)
JP (3) JP7213610B2 (enExample)
CN (3) CN109260478A (enExample)
AU (1) AU2014230129B2 (enExample)
BR (2) BR112015023589B1 (enExample)
CA (1) CA2903581A1 (enExample)
DK (1) DK2968583T3 (enExample)
ES (1) ES3034413T3 (enExample)
HU (1) HUE072754T2 (enExample)
IL (3) IL240893B (enExample)
MX (1) MX365547B (enExample)
PL (1) PL2968583T3 (enExample)
SG (2) SG10201903962PA (enExample)
WO (1) WO2014140317A2 (enExample)
ZA (1) ZA201506005B (enExample)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2777714A1 (en) 2013-03-15 2014-09-17 NBE-Therapeutics LLC Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
WO2014175690A1 (ko) 2013-04-25 2014-10-30 (재) 스크립스코리아 항체연구원 자가 절단 카세트를 포함하는 단백질 정제방법 및 이의 용도
KR102511249B1 (ko) * 2014-04-29 2023-03-20 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. 신규한 안정한 항체-약물 복합체, 이의 제조방법 및 이의 용도
CN107109463B (zh) 2014-12-17 2020-12-29 豪夫迈·罗氏有限公司 键形成酶的活性测定
MX376535B (es) 2014-12-17 2025-03-07 Hoffmann La Roche Reacción enzimática en un solo recipiente para conjugación de polipéptido doble en un solo paso usando sortasa.
BR112017013661B1 (pt) * 2014-12-23 2023-12-19 Nbe-Therapeutics Ag Conjugado de proteína de ligação-fármaco e composição farmacêutica
US20180028682A1 (en) 2015-02-09 2018-02-01 Nbe Therapeutics Ag Maytansine-drug conjugates of her-2 specific binding proteins generated by site specific sortase-enzyme mediated conjugation
KR20170129769A (ko) * 2015-03-17 2017-11-27 리제너론 파아마슈티컬스, 인크. 아미노산 아실화 시약 및 이의 사용 방법
EP3353314A1 (en) 2015-09-25 2018-08-01 H. Hoffnabb-La Roche Ag Transamidation employing sortase a in deep eutectic solvents
JP6895953B2 (ja) 2015-09-25 2021-06-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ソルターゼａを利用してチオエステルを作製するための方法
CN108138158B (zh) 2015-09-25 2021-11-09 豪夫迈·罗氏有限公司 可溶性分选酶a
ES2896475T3 (es) * 2015-09-25 2022-02-24 Hoffmann La Roche Cadenas pesadas de inmunoglobulina recombinante que comprenden un bucle de conjugación de sortasa y conjugados de las mismas
US20190112385A1 (en) * 2015-10-30 2019-04-18 Nbe-Therapeutics Ag Anti-mesothelin antibodies
HK1254836A1 (zh) 2015-10-30 2019-07-26 Nbe-Therapeutics Ag 抗-ror1抗体
WO2017127702A1 (en) 2016-01-20 2017-07-27 The Scripps Research Institute Ror2 antibody compositions and related methods
CN108848669B (zh) 2016-01-20 2022-06-07 斯克利普斯研究所 Ror1抗体组合物和相关方法
CN105925596A (zh) * 2016-02-23 2016-09-07 上海交通大学 基于内含肽的药用重组蛋白的合成方法
CN106397598B (zh) * 2016-02-23 2020-07-14 上海交通大学 多价多特异性抗体及免疫杂合蛋白的表达和制备方法
MA45328A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Compositions acide nucléique-polypeptide et utilisations de celles-ci
US20190328901A1 (en) 2016-06-17 2019-10-31 Magenta Therapeutics, Inc. Compositions and methods for the depletion of cells
EP3272864A1 (en) 2016-07-20 2018-01-24 Paul Scherrer Institut Solid-phase immobilization of microbial transglutaminase mtg on microbeads for protein conjugation
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
SG11201906200WA (en) 2017-01-06 2019-08-27 Avidity Biosciences Llc Nucleic acid-polypeptide compositions and methods of inducing exon skipping
SG11201906319XA (en) 2017-01-20 2019-08-27 Magenta Therapeutics Inc Compositions and methods for the depletion of cd137+ cells
US20210139579A1 (en) 2017-07-20 2021-05-13 Nbe-Therapeutics Ag Multispecific antibody product that binds to different ror1 epitopes
EP3655437A1 (en) 2017-07-20 2020-05-27 NBE-Therapeutics AG Human antibodies binding to ror2
GB201711809D0 (en) 2017-07-21 2017-09-06 Governors Of The Univ Of Alberta Antisense oligonucleotide
WO2019023247A1 (en) 2017-07-25 2019-01-31 Immutics, Inc. TREATMENT OF CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND
WO2019030223A1 (en) 2017-08-07 2019-02-14 Nbe-Therapeutics Ag ANTHRACYCLINE ANTIBODY-MEDICINAL CONJUGATES HAVING HIGH IN VIVO TOLERABILITY
AU2018337671B2 (en) 2017-09-19 2021-03-04 Paul Scherrer Institut Transglutaminase conjugation method and linker
WO2019071028A1 (en) 2017-10-04 2019-04-11 Avidity Biosciences Llc NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
CN107759699A (zh) * 2017-10-18 2018-03-06 银丰生物工程集团有限公司 靶向cd30抗原的转基因t细胞及其制备方法与应用
SG11202005022YA (en) 2017-12-06 2020-06-29 Avidity Biosciences Inc Compositions and methods of treating muscle atrophy and myotonic dystrophy
US12037370B2 (en) 2018-02-26 2024-07-16 Research Institute At Nationwide Children's Hospital Split-immunotoxins for boosting oncolytic virus toxicity
EP4253421A3 (en) 2018-03-13 2024-01-03 Zymeworks BC Inc. Anti-her2 biparatopic antibody-drug conjugates and methods of use
CN112088016A (zh) 2018-05-10 2020-12-15 化工研究所有限公司 含有多种活性剂分子的生物相容性共聚物
CN108593909A (zh) * 2018-05-23 2018-09-28 苏州立禾生物医学工程有限公司 一种定点标记免疫试剂的方法、标记免疫试剂及应用
US20210388112A1 (en) * 2018-07-09 2021-12-16 National University Corporation Kumamoto University Cyclic Single-Chain Antibody
US20210246189A1 (en) * 2018-09-03 2021-08-12 Technische Universitaet Muenchen A double peptide tag combining reversibility and flexible functionalization
CN112888710B (zh) 2018-09-30 2023-06-09 美国杰科实验室有限公司 一种多肽组合物
EP3636284A1 (en) 2018-10-11 2020-04-15 NBE Therapeutics AG Binding protein-toxin conjugates comprising anthracyclines, and use thereof in immune-oncological applications
WO2020081493A1 (en) 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
EP3647419A1 (en) 2018-11-02 2020-05-06 NBE Therapeutics AG Sortase f and its use in methods for conjugation
IL319265A (en) 2018-12-21 2025-04-01 Avidity Biosciences Inc Anti-transferrin receptor antibodies and their uses
AU2020214796A1 (en) 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
KR20220144753A (ko) * 2019-03-19 2022-10-27 폴 슈레 앙스띠뛰 글리신 기반 링커를 사용한 트랜스글루타미나제 컨쥬게이션 방법
EP3959319A4 (en) 2019-04-25 2023-06-07 Avidity Biosciences, Inc. NUCLEIC ACID COMPOSITIONS AND METHODS FOR MULTI-EXON SKIPPING
WO2020247782A1 (en) 2019-06-06 2020-12-10 Avidity Biosciences, Inc. Nucleic acid-polypeptide compositions and uses thereof
CN114375297A (zh) 2019-06-06 2022-04-19 艾维迪提生物科学公司 Una亚酰胺及其用途
EP3980080A1 (en) * 2019-06-10 2022-04-13 Sutro Biopharma, Inc. Immunomodulator antibody drug conjugates and uses thereof
US11918649B2 (en) 2019-09-18 2024-03-05 Molecular Templates, Inc. PD-L1-binding molecules comprising Shiga toxin a subunit scaffolds
GB201914468D0 (en) 2019-10-07 2019-11-20 Crescendo Biologics Ltd Binding Molecules
EP4051320A1 (en) 2019-10-30 2022-09-07 CIS Pharma AG Biocompatible polymeric drug carriers for delivering active agents
US12076400B2 (en) 2019-12-06 2024-09-03 Zymeworks Bc Inc. Methods of using a bispecific antigen-binding construct targeting HER2 in combination with CDK4/6 inhibitors for the treatment of breast cancer
JP7788060B2 (ja) 2020-03-19 2025-12-18 アビディティー バイオサイエンシーズ，インク． 顔面肩甲上腕型筋ジストロフィーを処置するための組成物および方法
JP7748962B2 (ja) 2020-03-27 2025-10-03 アビディティー バイオサイエンシーズ，インク． 筋ジストロフィーを処置するための組成物および方法
US12281166B2 (en) 2020-05-26 2025-04-22 Truebinding, Inc. Methods of treating inflammatory diseases by blocking Galectin-3
CA3196218A1 (en) 2020-10-25 2022-04-28 Philipp SPYCHER Means and methods for producing antibody-linker conjugates
WO2022122709A1 (en) 2020-12-07 2022-06-16 Sotio Biotech A.S. Antibody-drug conjugates based on humanized cldn18.2 antibodies
AU2021423664A1 (en) 2021-01-28 2023-09-07 Genequantum Healthcare (Suzhou) Co., Ltd. Ligase fusion proteins and applications thereof
EP4304658A4 (en) 2021-03-08 2025-03-12 Genequantum Healthcare (Suzhou) Co., Ltd. Antibody-immunagonist conjugate and applications thereof
EP4308242A1 (en) 2021-03-17 2024-01-24 Molecular Templates, Inc. Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens
EP4323009A4 (en) 2021-04-14 2025-03-05 Genequantum Healthcare (Suzhou) Co., Ltd. Linkers, conjugates and applications thereof
CN115369127A (zh) * 2021-05-18 2022-11-22 苏州有诺真生物科技有限公司 一种基于基因改造脊椎动物的携带通用定点偶联接口的抗体的制备方法
EP4370555A4 (en) 2021-07-13 2025-11-12 Truebinding Inc METHODS FOR PREVENTING PROTEIN AGGREGATION
US20240350649A1 (en) * 2021-08-05 2024-10-24 Octagon Therapeutics, Inc. Treatment and diagnosis of immune disorders relating to aberrant immune cells
WO2023017191A1 (en) 2021-08-13 2023-02-16 Cytune Pharma Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer
CN113777295B (zh) * 2021-09-15 2024-03-19 江南大学 用于检测肿瘤标志物pd-l1的高灵敏度量子点探针、制备方法及应用
US11912779B2 (en) 2021-09-16 2024-02-27 Avidity Biosciences, Inc. Compositions and methods of treating facioscapulohumeral muscular dystrophy
US20230279120A1 (en) 2021-11-09 2023-09-07 Truebinding, Inc. Methods of treating or inhibiting cardiovascular diseases
KR20240125036A (ko) 2021-12-23 2024-08-19 마이레큘, 인크. 폴리뉴클레오타이드의 전달을 위한 조성물
CN118591394A (zh) * 2022-01-28 2024-09-03 启德医药科技（苏州）有限公司 抗体药物偶联物、药物组合物及用途
CA3243873A1 (en) 2022-02-23 2023-08-31 Bright Peak Therapeutics Ag Immune Antigen-Specific IL-18 Immune Cytokines and Their Uses
US12071621B2 (en) 2022-04-05 2024-08-27 Avidity Biosciences, Inc. Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping
WO2024026474A1 (en) 2022-07-29 2024-02-01 Regeneron Pharmaceuticals, Inc. Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
CA3264112A1 (en) 2022-08-08 2024-02-15 Atb Therapeutics Humanized antibodies directed against CD79B
WO2024107765A2 (en) 2022-11-14 2024-05-23 Regeneron Pharmaceuticals, Inc. Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
US12491257B2 (en) 2023-06-27 2025-12-09 Avidity Biosciences, Inc. Compositions and methods of using PRKAG2-targeting antibody-oligonucleotide conjugates
WO2025007063A1 (en) 2023-06-30 2025-01-02 Avidity Biosciences, Inc. Compositions and methods of using pln-targeting antibody-oligonucleotide conjugates
WO2025041101A1 (en) 2023-08-23 2025-02-27 Bright Peak Therapeutics Ag Activatable il-18 immunocytokines and uses thereof
WO2025041102A1 (en) 2023-08-23 2025-02-27 Bright Peak Therapeutics Ag Targeted immune activation with il-18 immunocytokines
WO2025083208A1 (en) 2023-10-19 2025-04-24 Boehringer Ingelheim International Gmbh Synthesis of morpholine derivatives and compounds therefore

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA932523B (en) 1992-04-10 1994-10-08 Res Dev Foundation Immunotoxins directed against cd33 related surface antigens
WO1996040260A2 (en) 1995-06-07 1996-12-19 Innogenetics N.V. Immunotoxins specific for cd80 and cd86 expressing cells
US7405276B2 (en) * 2000-11-01 2008-07-29 Elusys Therapeutics, Inc. Method of producing bispecific molecules by protein trans-splicing
DE10341812A1 (de) 2003-09-10 2005-04-07 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
WO2005051976A2 (en) * 2003-11-20 2005-06-09 Ansata Therapeutics, Inc. Protein and peptide ligation processes and one-step purification processes
US7579187B2 (en) 2004-09-06 2009-08-25 Kyoma Hakko Kirin Co., Ltd. Anti-A33 antibody
WO2006062779A2 (en) * 2004-12-09 2006-06-15 Centocor, Inc. Anti-integrin immunoconjugates, methods and uses
DE102005061934A1 (de) 2005-12-23 2007-06-28 Philipps-Universität Marburg Verfahren zur Herstellung eines chemisch modifizierten Proteins
WO2007108013A2 (en) 2006-03-22 2007-09-27 National Institute Of Immunology Novel bioconjugates as therapeutic agent and synthesis thereof
EP2046375B1 (en) * 2006-07-20 2017-04-05 The General Hospital Corporation Methods and compositions for the selective activation of protoxins through combinatorial targeting
US20100111851A1 (en) * 2007-01-05 2010-05-06 The University Of Tokyo Diagnosis and treatment of cancer by using anti-prg-3 antibody
PT2211904T (pt) 2007-10-19 2016-11-02 Seattle Genetics Inc Agentes de ligação a cd19 e seus usos
ES2547552T3 (es) 2008-02-01 2015-10-07 Genentech, Inc. Metabolito de nemorrubicina y reactivos análogos, conjugados anticuerpo-fármaco y métodos
CA2715319A1 (en) * 2008-03-14 2009-09-17 Genentech, Inc. Genetic variations associated with drug resistance
US8394604B2 (en) 2008-04-30 2013-03-12 Paul Xiang-Qin Liu Protein splicing using short terminal split inteins
AU2009246516B2 (en) * 2008-05-13 2015-03-05 Genentech, Inc. Analysis of antibody drug conjugates by bead-based affinity capture and mass spectrometry
JP6067222B2 (ja) 2008-07-15 2017-01-25 ジェネンテック， インコーポレイテッド アントラサイクリン誘導体コンジュゲート、その調製方法及び抗腫瘍化合物としてのその用途
EP2391714B2 (en) * 2009-01-30 2019-07-24 Whitehead Institute for Biomedical Research Methods for ligation and uses thereof
CN102448486A (zh) * 2009-03-06 2012-05-09 艾更斯司股份有限公司 结合于24p4c12蛋白的抗体药物偶联物(adc)
MX2011010469A (es) 2009-04-08 2012-03-14 Deutsches Krebsforsch Radicales de enlace al objetivo, armados con amatoxina para el tratamiento del cancer.
UY32665A (es) 2009-05-28 2010-12-31 Glaxo Group Ltd Proteinas de union al antigeno
EP2593469A4 (en) * 2010-04-20 2015-07-15 Whitehead Biomedical Inst MODIFIED POLYPEPTIDES AND PROTEINS AND ITS APPLICATION
MX2013005972A (es) 2010-12-02 2013-08-09 Nerviano Medical Sciences Srl Proceso para la preparacion de derivados de morfolinil antraciclina.
EP2670440B1 (en) * 2011-02-01 2018-09-05 Genmab A/S Human antibodies and antibody-drug conjugates against cd74
WO2012142659A1 (en) * 2011-04-19 2012-10-26 Baker Idi Heart And Diabetes Institute Holdings Limited Site-selective modification of proteins
EP2524929A1 (en) * 2011-05-17 2012-11-21 Sanofi Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms
WO2013022808A2 (en) * 2011-08-05 2013-02-14 The University Of Chicago Immunogenic protein conjugates and methods for making and using the same
KR20130046322A (ko) 2011-10-27 2013-05-07 한국외국어대학교 연구산학협력단 식중독 세균 Salmonella enterica 탐지용 탐침자 및 그를 포함한 DNA 칩
US9731029B2 (en) * 2012-05-21 2017-08-15 Massachusetts Institute Of Technology Protein retrosplicing enabled by a double ligation reaction
EA201491947A1 (ru) 2012-05-21 2015-05-29 Дженентек, Инк. Антитела и иммуноконъюгаты к ly6e и способы применения
AU2013271952A1 (en) * 2012-06-04 2014-11-13 Irm Llc Site-specific labeling methods and molecules produced thereby
WO2014088928A1 (en) 2012-12-03 2014-06-12 President And Fellows Of Harvard College Methods for making targeted protein toxins by sortase-mediated protein ligation
EP2777714A1 (en) 2013-03-15 2014-09-17 NBE-Therapeutics LLC Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
WO2014175690A1 (ko) 2013-04-25 2014-10-30 (재) 스크립스코리아 항체연구원 자가 절단 카세트를 포함하는 단백질 정제방법 및 이의 용도
US20180104349A9 (en) 2013-04-28 2018-04-19 Gang Qin Novel linker, preparation method, and application thereof

Also Published As

Publication number Publication date
IL284979A (en) 2021-08-31
BR112015023589B1 (pt) 2023-10-03
US20190262461A1 (en) 2019-08-29
ZA201506005B (en) 2016-10-26
JP7213610B2 (ja) 2023-01-27
CN105142675B (zh) 2021-08-20
EP2968583A2 (en) 2016-01-20
SG11201507385YA (en) 2015-10-29
IL240893B (en) 2019-08-29
US10864277B2 (en) 2020-12-15
WO2014140317A8 (en) 2014-11-06
EP2968583B1 (en) 2025-06-04
DK2968583T3 (da) 2025-07-14
CN105142675A (zh) 2015-12-09
SG10201903962PA (en) 2019-05-30
BR112015023589A8 (pt) 2022-03-08
IL268423B (en) 2021-08-31
HUE072754T2 (hu) 2025-12-28
WO2014140317A2 (en) 2014-09-18
MX365547B (es) 2019-06-07
AU2014230129B2 (en) 2019-03-28
MX2015012983A (es) 2016-04-04
WO2014140317A3 (en) 2014-12-24
US20210015936A1 (en) 2021-01-21
BR112015023589A2 (pt) 2017-10-24
JP7481852B2 (ja) 2024-05-13
NZ711762A (en) 2021-04-30
JP2022130634A (ja) 2022-09-06
IL284979B (en) 2022-06-01
CN109260478A (zh) 2019-01-25
BR122021025118B1 (pt) 2023-10-10
IL240893A0 (en) 2015-10-29
US9872923B2 (en) 2018-01-23
US20220378927A1 (en) 2022-12-01
US11364301B2 (en) 2022-06-21
CN113908291A (zh) 2022-01-11
EP2777714A1 (en) 2014-09-17
US20160136298A1 (en) 2016-05-19
JP2020089383A (ja) 2020-06-11
US11986535B2 (en) 2024-05-21
CA2903581A1 (en) 2014-09-18
JP2016511279A (ja) 2016-04-14
HK1217296A1 (zh) 2017-01-06
ES3034413T3 (en) 2025-08-18
IL268423A (en) 2019-09-26
AU2014230129A8 (en) 2016-04-14
AU2014230129A1 (en) 2015-09-24

Similar Documents

Publication Publication Date Title
IL284979B (en) A method for producing an immunoligand/charge conjugate using a sequence-specific transpeptidase enzyme
EP3006568A4 (en) Production method for tagatose
EP3056469A4 (en) Production method for graphene
EP3060646A4 (en) Process for biosensor well formation
EP3006622A4 (en) Production method for fine-fibre-containing sheet
EP3061828A4 (en) Method for producing target substance
EP3006135A4 (en) Method of thickening and forming by spinning and device for thickening and forming by spinning
EP3042960A4 (en) Method for producing ambrein
ZA201600018B (en) Method for improving adherence
EP3088530A4 (en) Method for producing sugar solution
EP3020820A4 (en) Method for producing saccharide solution
GB201412190D0 (en) Method of optimization for an application
EP3048095A4 (en) Bis(amino-methyl)cyclohexane isomerization method
PL2920317T3 (pl) Sposób otrzymywania pochodnych cukrowych
EP3061352A4 (en) Method for producing kakiage
EP3053882A4 (en) Method for producing trichlorosilane
SG11201506828WA (en) Process for producing butadiene
EP3045437A4 (en) Method for producing butadiene
EP3000606A4 (en) Printing method
EP2963048A4 (en) Method for producing -halo-tetraacyl glucose
PL3017051T3 (pl) Sposób enzymatycznego wytwarzania 3-buten-2-onu
EP2835194A3 (en) Method of supporting a part
EP3033946A4 (en) Method for producing chocolate and chocolate produced by said method
EP2943436B8 (fr) Procédé de production d'hydrogene
EP3053907A4 (en) Selective production method for d-mannitol -form crystal using spray-drying method