JP2016510597A5 - - Google Patents

Download PDF

Info

Publication number
JP2016510597A5
JP2016510597A5 JP2015561743A JP2015561743A JP2016510597A5 JP 2016510597 A5 JP2016510597 A5 JP 2016510597A5 JP 2015561743 A JP2015561743 A JP 2015561743A JP 2015561743 A JP2015561743 A JP 2015561743A JP 2016510597 A5 JP2016510597 A5 JP 2016510597A5
Authority
JP
Japan
Prior art keywords
cell
vector
antigen
receptor
specific
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015561743A
Other languages
English (en)
Japanese (ja)
Other versions
JP6409009B2 (ja
JP2016510597A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/022137 external-priority patent/WO2014138704A1/en
Publication of JP2016510597A publication Critical patent/JP2016510597A/ja
Publication of JP2016510597A5 publication Critical patent/JP2016510597A5/ja
Application granted granted Critical
Publication of JP6409009B2 publication Critical patent/JP6409009B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015561743A 2013-03-07 2014-03-07 がんにおけるcd138の標的化 Expired - Fee Related JP6409009B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361774040P 2013-03-07 2013-03-07
US61/774,040 2013-03-07
PCT/US2014/022137 WO2014138704A1 (en) 2013-03-07 2014-03-07 Targeting cd138 in cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018176745A Division JP6678215B2 (ja) 2013-03-07 2018-09-21 がんにおけるcd138の標的化

Publications (3)

Publication Number Publication Date
JP2016510597A JP2016510597A (ja) 2016-04-11
JP2016510597A5 true JP2016510597A5 (enExample) 2017-04-06
JP6409009B2 JP6409009B2 (ja) 2018-10-17

Family

ID=50588798

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015561743A Expired - Fee Related JP6409009B2 (ja) 2013-03-07 2014-03-07 がんにおけるcd138の標的化
JP2018176745A Expired - Fee Related JP6678215B2 (ja) 2013-03-07 2018-09-21 がんにおけるcd138の標的化

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018176745A Expired - Fee Related JP6678215B2 (ja) 2013-03-07 2018-09-21 がんにおけるcd138の標的化

Country Status (9)

Country Link
US (1) US20160017048A1 (enExample)
EP (3) EP3241897B1 (enExample)
JP (2) JP6409009B2 (enExample)
CN (1) CN105339498A (enExample)
AU (2) AU2014225365B2 (enExample)
CA (1) CA2904369A1 (enExample)
ES (1) ES2671004T3 (enExample)
HK (1) HK1245841B (enExample)
WO (1) WO2014138704A1 (enExample)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201505858VA (en) 2013-01-28 2015-09-29 St Jude Childrens Res Hospital A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
SG10201808811QA (en) 2014-04-10 2018-11-29 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Method and compositions for cellular immunotherapy
EP3805371A1 (en) 2014-05-15 2021-04-14 National University of Singapore Modified natural killer cells and uses thereof
US10738278B2 (en) 2014-07-15 2020-08-11 Juno Therapeutics, Inc. Engineered cells for adoptive cell therapy
JP6831777B2 (ja) 2014-07-21 2021-02-17 ノバルティス アーゲー Cd33キメラ抗原受容体を使用する癌の処置
AU2015292744C1 (en) 2014-07-21 2021-01-21 Novartis Ag Treatment of cancer using humanized anti-BCMA chimeric antigen receptor
PT3575315T (pt) * 2014-09-15 2022-12-16 Agc Biologics S P A Recetores de antigénios quiméricos
AU2015330017A1 (en) * 2014-10-07 2017-04-27 Cellectis Method for modulating car-induced immune cells activity
JP6740234B2 (ja) * 2014-11-05 2020-08-12 ジュノー セラピューティクス インコーポレイテッド 形質導入および細胞プロセシングのための方法
HRP20240357T1 (hr) 2014-12-24 2024-06-07 Autolus Limited Stanica
US11497767B2 (en) 2015-02-18 2022-11-15 Enlivex Therapeutics R&D Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11512289B2 (en) 2015-02-18 2022-11-29 Enlivex Therapeutics Rdo Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11596652B2 (en) 2015-02-18 2023-03-07 Enlivex Therapeutics R&D Ltd Early apoptotic cells for use in treating sepsis
US11000548B2 (en) 2015-02-18 2021-05-11 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11318163B2 (en) 2015-02-18 2022-05-03 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11304976B2 (en) 2015-02-18 2022-04-19 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
CN107530424A (zh) 2015-02-20 2018-01-02 俄亥俄州国家创新基金会 针对nkg2d和肿瘤相关抗原的二价抗体
AU2016230828B2 (en) * 2015-03-10 2020-10-22 ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) T-cell receptors directed against the preferentially expressed antigen of melanoma and uses thereof
CN108367057B (zh) 2015-04-06 2022-11-22 赛通免疫股份有限公司 用于胶质母细胞瘤的egfr导向的car疗法
PL3280729T3 (pl) 2015-04-08 2022-08-22 Novartis Ag Terapie cd20, terapie cd22 i terapie skojarzone komórką eksprymującą chimeryczny receptor antygenowy (car) cd19
DE112015006458B4 (de) * 2015-04-17 2019-05-23 Mitsubishi Electric Corporation Anzeigesteuervorrichtung, Anzeigesystem, Anzeigesteuerverfahren und Anzeigesteuerprogramm
WO2016168595A1 (en) 2015-04-17 2016-10-20 Barrett David Maxwell Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
JP6803339B2 (ja) 2015-04-21 2020-12-23 エンリヴェックス セラピューティクス リミテッド 治療用のプールされた血液アポトーシス細胞調製物及びそれらの使用
MA42895A (fr) 2015-07-15 2018-05-23 Juno Therapeutics Inc Cellules modifiées pour thérapie cellulaire adoptive
US10829735B2 (en) * 2015-07-21 2020-11-10 The Trustees Of The University Of Pennsylvania Methods for improving the efficacy and expansion of immune cells
MX2018001568A (es) 2015-08-07 2019-04-25 Seattle Children´S Hospital Dba Seattle Children´S Res Institute Celulas t biespecificas de receptor quimerico de antigeno (car) para focalizacion a tumores solidos.
JP7054924B2 (ja) * 2015-09-23 2022-04-15 サイトイミューン セラピューティクス, インコーポレイテッド 免疫療法のためのflt3指向car細胞
WO2017093969A1 (en) 2015-12-04 2017-06-08 Novartis Ag Compositions and methods for immunooncology
KR20180101540A (ko) * 2016-01-15 2018-09-12 이투빅스 코포레이션 T 세포 면역요법을 위한 방법 및 조성물
US11090334B2 (en) 2016-01-29 2021-08-17 Med Manor Organics (P) Ltd. Chimeric antigen receptor specific to b-cell maturation antigen, a recombinant expression vector and a method thereof
JP6884155B2 (ja) 2016-02-18 2021-06-09 エンリヴェックス セラピューティクス リミテッド 癌治療のための併用免疫療法及びサイトカイン制御療法
WO2017176525A1 (en) * 2016-04-04 2017-10-12 Promab Biotechnologies, Inc. Car having replicated binding motifs in a co-stimulatory domain
US10894093B2 (en) 2016-04-15 2021-01-19 Cellectis Method of engineering drug-specific hypersensitive t-cells for immunotherapy by gene inactivation
WO2017178586A1 (en) * 2016-04-15 2017-10-19 Cellectis A method of engineering prodrug-specific hypersensitive t-cells for immunotherapy by gene expression
JP7467117B2 (ja) 2016-10-07 2024-04-15 ノバルティス アーゲー 癌の治療のためのキメラ抗原受容体
CN110177803A (zh) * 2016-11-22 2019-08-27 T细胞受体治疗公司 用于使用融合蛋白进行tcr重新编程的组合物和方法
CN110352068A (zh) 2016-12-02 2019-10-18 南加利福尼亚大学 合成的免疫受体及其使用方法
EP3581190B1 (en) 2016-12-09 2021-03-10 ONK Therapeutics Limited Engineered natural killer cells and uses thereof
WO2018111763A1 (en) 2016-12-12 2018-06-21 Seattle Children's Hospital (dba Seattle Children's Research Institute) Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells
KR20190130608A (ko) 2017-03-22 2019-11-22 노파르티스 아게 면역종양학을 위한 조성물 및 방법
CN117363636A (zh) 2017-03-27 2024-01-09 新加坡国立大学 一种编码嵌合受体的多核苷酸
MX2019011570A (es) 2017-03-27 2019-11-18 Nat Univ Singapore Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales.
CN107164412B (zh) * 2017-06-30 2020-10-23 山东兴瑞生物科技有限公司 一种安全型抗cea嵌合抗原受体修饰t细胞的制备方法及其应用
US12139522B2 (en) 2017-12-05 2024-11-12 The Medical Research Infrastructure And Heal Serviced Fund Of The Tel Aviv Medecal Center T-cells comprising two different chimeric antigen receptors and uses thereof
WO2019111249A1 (en) * 2017-12-05 2019-06-13 The Medical Research Infrastructure And Health Services Fund Of The Tel Aviv Medical Center T-cells comprising anti-cd38 and anti-cd138 chimeric antigen receptors and uses thereof
JP7360174B2 (ja) 2018-02-09 2023-10-12 ナショナル ユニヴァーシティー オブ シンガポール ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用
US12441787B2 (en) 2018-04-02 2025-10-14 National University Of Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
IL279367B2 (en) 2018-06-13 2026-05-01 Novartis Ag BCMA chimeric antigen receptors and their uses
WO2020044239A1 (en) 2018-08-29 2020-03-05 National University Of Singapore A method to specifically stimulate survival and expansion of genetically-modified immune cells
CN113226340A (zh) 2018-11-26 2021-08-06 恩卡尔塔公司 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途
WO2020160217A1 (en) * 2019-02-01 2020-08-06 Seattle Children's Hospital (dba Seattle Children's Research Institute) Microenvironment sensors to regulate engineered gene expression
GB201902277D0 (en) * 2019-02-19 2019-04-03 King S College London Therapeutic agents
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
AU2020232789B2 (en) * 2019-03-06 2026-04-09 Lentigen Technology, Inc. Compositions and methods for treating cancer with self-driving chimeric antigen receptors
CN111686128A (zh) * 2019-03-12 2020-09-22 重庆精准生物技术有限公司 一种缺氧可调控的启动子在car-t中的应用
JP7391984B2 (ja) * 2019-03-12 2023-12-05 重▲慶▼精准生物技▲術▼有限公司 低酸素調節プロモーター及びその応用
JP7805928B2 (ja) 2019-11-26 2026-01-26 ノバルティス アーゲー Cd19及びcd22キメラ抗原受容体及びその使用
US20230272035A1 (en) * 2019-12-05 2023-08-31 Vycellix, Inc. Modulators of the immune escape mechanism for universal cell therapy
WO2022072990A1 (en) * 2020-09-30 2022-04-07 Baylor College Of Medicine Cytotoxic and costimulatory chimeric antigen receptors
WO2022233956A1 (en) 2021-05-05 2022-11-10 Immatics Biotechnologies Gmbh Antigen binding proteins specifically binding prame
NL2037811B1 (en) 2024-05-29 2025-12-12 Univ Oslo Treatment for Cancer
NL2037929B1 (en) 2024-06-11 2026-01-12 Prinses Maxima Centrum Voor Kinderoncologie B V Brain Organoid
GB202417285D0 (en) 2024-11-25 2025-01-08 Univ Oxford Innovation Ltd Expanded t cell population
GB202418460D0 (en) 2024-12-16 2025-01-29 Univ Oxford Innovation Ltd Multivalent binding proteins

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
GB9304200D0 (en) 1993-03-02 1993-04-21 Sandoz Ltd Improvements in or relating to organic compounds
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5928906A (en) 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
GB9810423D0 (en) * 1998-05-15 1998-07-15 Cancer Res Campaign Tech Ionizing radiation or diathermy-switched gene therapy vectors and their use in antitumour therapy
US20070036773A1 (en) * 2005-08-09 2007-02-15 City Of Hope Generation and application of universal T cells for B-ALL
US9011864B2 (en) * 2007-12-26 2015-04-21 Biotest Ag Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
ES2475201T3 (es) * 2007-12-26 2014-07-10 Biotest Ag Agentes dirigidos contra CD138 y usos de los mismos
EP2198884A1 (en) * 2008-12-18 2010-06-23 Centre National de la Recherche Scientifique (CNRS) Monoclonal antibodies directed against LG4-5 domain of alpha3 chain of human laminin-5
EP3789487A1 (en) * 2013-04-03 2021-03-10 Memorial Sloan Kettering Cancer Center Effective generation of tumor-targeted t-cells derived from pluripotent stem cells

Similar Documents

Publication Publication Date Title
AU2023241321A1 (en) Bispecific car t-cells for solid tumor targeting
Zhukovsky et al. Bispecific antibodies and CARs: generalized immunotherapeutics harnessing T cell redirection
JP6867347B2 (ja) 免疫療法のためのエンゲージャー細胞
Ruella et al. Adoptive immunotherapy for cancer
Ghorashian et al. CD 19 chimeric antigen receptor T cell therapy for haematological malignancies
JP2021522208A5 (enExample)
WO2021129559A1 (zh) T细胞受体融合蛋白及其用途
JP2022510207A5 (enExample)
RU2017121826A (ru) Т-клетки, модифицированные химерным рецептором антигена, нацеленным на cs1
JP2022550899A5 (enExample)
IL276554B1 (en) Non-hla restricted t cell receptors and uses thereof
JP2022548943A5 (enExample)
JP2018532432A5 (enExample)
JP2016508728A5 (enExample)
JP2021505131A5 (enExample)
RU2017111298A (ru) Т-КЛЕТКИ С КОСТИМУЛИРУЮЩИМ ХИМЕРНЫМ АНТИГЕННЫМ РЕЦЕПТОРОМ, НАЦЕЛЕННЫЕ НА IL13Rα2
JP2023512452A5 (enExample)
RU2018118817A (ru) Химерные рецепторы антигена, нацеленные на her2
JP2020530989A5 (enExample)
JP2018532407A5 (enExample)
JP2016513458A5 (enExample)
KR20240018680A (ko) 혈액 악성종양을 표적으로 하는 키메라 항원 수용체(car), 조성물 및 이의 용도
JP2019535262A5 (enExample)
JP2017535284A5 (enExample)
JP2016514457A5 (enExample)