JP2016502091A5 - - Google Patents
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- Publication number
- JP2016502091A5 JP2016502091A5 JP2015544592A JP2015544592A JP2016502091A5 JP 2016502091 A5 JP2016502091 A5 JP 2016502091A5 JP 2015544592 A JP2015544592 A JP 2015544592A JP 2015544592 A JP2015544592 A JP 2015544592A JP 2016502091 A5 JP2016502091 A5 JP 2016502091A5
- Authority
- JP
- Japan
- Prior art keywords
- tnfα
- labeled
- sample
- agents
- autoantibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 28
- 239000000523 sample Substances 0.000 claims 21
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 20
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 20
- 229940079593 drug Drugs 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 20
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 claims 18
- 239000002452 tumor necrosis factor alpha inhibitor Substances 0.000 claims 18
- 239000013068 control sample Substances 0.000 claims 8
- 238000006386 neutralization reaction Methods 0.000 claims 7
- 230000003472 neutralizing effect Effects 0.000 claims 6
- 238000001542 size-exclusion chromatography Methods 0.000 claims 6
- 239000013074 reference sample Substances 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 239000007850 fluorescent dye Substances 0.000 claims 2
- 229960001743 golimumab Drugs 0.000 claims 2
- 230000002123 temporal effect Effects 0.000 claims 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261732251P | 2012-11-30 | 2012-11-30 | |
| US61/732,251 | 2012-11-30 | ||
| US13/802,117 US20130266963A1 (en) | 2011-07-06 | 2013-03-13 | Assay for detecting neutralizing autoantibodies to biologic therapy |
| US13/802,117 | 2013-03-13 | ||
| PCT/IB2013/060458 WO2014083520A2 (en) | 2012-11-30 | 2013-11-27 | Assays for detecting neutralizing autoantibodies to biologic therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016502091A JP2016502091A (ja) | 2016-01-21 |
| JP2016502091A5 true JP2016502091A5 (enExample) | 2017-01-05 |
Family
ID=50828561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015544592A Pending JP2016502091A (ja) | 2012-11-30 | 2013-11-27 | 生物学的治療に対する中和自己抗体の検出のためのアッセイ |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2926136A2 (enExample) |
| JP (1) | JP2016502091A (enExample) |
| KR (1) | KR20150088890A (enExample) |
| CN (1) | CN105074461A (enExample) |
| AU (1) | AU2013350817A1 (enExample) |
| BR (1) | BR112015012482A2 (enExample) |
| CA (1) | CA2892766A1 (enExample) |
| HK (1) | HK1215969A1 (enExample) |
| IL (1) | IL238995A0 (enExample) |
| MX (1) | MX2015006852A (enExample) |
| RU (1) | RU2015125739A (enExample) |
| SG (2) | SG10201703210XA (enExample) |
| WO (1) | WO2014083520A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ621655A (en) | 2009-10-26 | 2015-08-28 | Nestec Sa | Assays for the detection of anti-tnf drugs and autoantibodies |
| CN103299190B (zh) | 2010-10-18 | 2017-02-15 | 雀巢产品技术援助有限公司 | 确定抗药物抗体同种型的方法 |
| JP6181646B2 (ja) | 2011-07-06 | 2017-08-16 | ネステク ソシエテ アノニム | Ｔｎｆアルファによる生物学的治療に対する中和自己抗体の検出のためのアッセイ |
| BR112017011545A2 (pt) | 2014-12-05 | 2018-03-13 | Nestec Sa | ensaio de desvio de mobilidade homogênea indireto para a detecção de produtos biológicos nas amostras do paciente |
| US11085931B2 (en) | 2015-01-09 | 2021-08-10 | W. Health L.P. | Universal assay for determining the quantity of TNFα inhibitory drugs and their corresponding anti-drug-antibodies |
| CN109791142B (zh) * | 2016-07-08 | 2022-11-29 | W 健康公司 | 用于确定样品中治疗性单克隆抗体及其相应抗药物抗体的量的通用测定 |
| US12480957B2 (en) | 2017-03-31 | 2025-11-25 | Ablynx N.V. | Method of screening for anti-drug antibodies against immunoglobulin single variable domain-based drugs |
| EP4085254B1 (en) * | 2020-01-02 | 2024-06-05 | F. Hoffmann-La Roche AG | Ada-response specification assay |
| CN111024958B (zh) * | 2020-03-11 | 2020-06-23 | 同昕生物技术（北京）有限公司 | 用于检测单抗药物和抗单抗药物抗体的试剂及其应用 |
| CN112730846B (zh) * | 2020-12-18 | 2023-12-15 | 安渡生物医药(杭州)有限公司 | 一种用于小鼠血样检测免疫复合物的方法 |
| CN114047343B (zh) * | 2022-01-13 | 2022-05-31 | 美迪西普亚医药科技(上海)有限公司 | 双耐受型抗IgE单抗药物的免疫原性分析试剂盒及其使用方法和应用 |
| CN117871856A (zh) * | 2023-12-15 | 2024-04-12 | 首都医科大学附属北京地坛医院 | 可溶性因子在无症状神经梅毒检测中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ621655A (en) * | 2009-10-26 | 2015-08-28 | Nestec Sa | Assays for the detection of anti-tnf drugs and autoantibodies |
| PT2564202E (pt) * | 2010-04-29 | 2015-10-20 | Theradiag Sa | Métodos de deteção de anticorpos |
| CN103299190B (zh) * | 2010-10-18 | 2017-02-15 | 雀巢产品技术援助有限公司 | 确定抗药物抗体同种型的方法 |
| KR20140008397A (ko) * | 2011-02-17 | 2014-01-21 | 네스텍 소시에테아노님 | 항-ＴＮＦα 약물에 대한 자가항체 검출을 위한 검정법 |
| JP6181646B2 (ja) * | 2011-07-06 | 2017-08-16 | ネステク ソシエテ アノニム | Ｔｎｆアルファによる生物学的治療に対する中和自己抗体の検出のためのアッセイ |
-
2013
- 2013-11-21 BR BR112015012482A patent/BR112015012482A2/pt not_active IP Right Cessation
- 2013-11-27 CN CN201380071748.4A patent/CN105074461A/zh active Pending
- 2013-11-27 SG SG10201703210XA patent/SG10201703210XA/en unknown
- 2013-11-27 KR KR1020157017311A patent/KR20150088890A/ko not_active Withdrawn
- 2013-11-27 HK HK16103834.6A patent/HK1215969A1/zh unknown
- 2013-11-27 EP EP13820955.6A patent/EP2926136A2/en not_active Withdrawn
- 2013-11-27 SG SG11201504097PA patent/SG11201504097PA/en unknown
- 2013-11-27 JP JP2015544592A patent/JP2016502091A/ja active Pending
- 2013-11-27 MX MX2015006852A patent/MX2015006852A/es unknown
- 2013-11-27 CA CA2892766A patent/CA2892766A1/en not_active Abandoned
- 2013-11-27 AU AU2013350817A patent/AU2013350817A1/en not_active Abandoned
- 2013-11-27 WO PCT/IB2013/060458 patent/WO2014083520A2/en not_active Ceased
- 2013-11-27 RU RU2015125739A patent/RU2015125739A/ru not_active Application Discontinuation
-
2015
- 2015-05-25 IL IL238995A patent/IL238995A0/en unknown
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