CA2892766A1 - Assays for detecting neutralizing autoantibodies to biologic therapy - Google Patents
Assays for detecting neutralizing autoantibodies to biologic therapy Download PDFInfo
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- CA2892766A1 CA2892766A1 CA2892766A CA2892766A CA2892766A1 CA 2892766 A1 CA2892766 A1 CA 2892766A1 CA 2892766 A CA2892766 A CA 2892766A CA 2892766 A CA2892766 A CA 2892766A CA 2892766 A1 CA2892766 A1 CA 2892766A1
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- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- ACOJCCLIDPZYJC-UHFFFAOYSA-M thiazole orange Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.C1=CC=C2C(C=C3N(C4=CC=CC=C4S3)C)=CC=[N+](C)C2=C1 ACOJCCLIDPZYJC-UHFFFAOYSA-M 0.000 description 1
- IUTNWRFYTFZSEK-UUOKFMHZSA-N thioguanosine 5'-diphosphate Chemical compound C1=NC=2C(=S)NC(N)=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O IUTNWRFYTFZSEK-UUOKFMHZSA-N 0.000 description 1
- QENYANNAQSWPLM-UUOKFMHZSA-N thioguanosine 5'-triphosphate Chemical compound C1=NC=2C(=S)NC(N)=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O QENYANNAQSWPLM-UUOKFMHZSA-N 0.000 description 1
- ODBLHEXUDAPZAU-UHFFFAOYSA-N threo-D-isocitric acid Natural products OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 description 1
- 230000003582 thrombocytopenic effect Effects 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 229950004742 tigatuzumab Drugs 0.000 description 1
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- 230000014616 translation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 229950007217 tremelimumab Drugs 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000002451 tumor necrosis factor inhibitor Substances 0.000 description 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/525—Tumor necrosis factor [TNF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
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- Pathology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261732251P | 2012-11-30 | 2012-11-30 | |
| US61/732,251 | 2012-11-30 | ||
| US13/802,117 | 2013-03-13 | ||
| US13/802,117 US20130266963A1 (en) | 2011-07-06 | 2013-03-13 | Assay for detecting neutralizing autoantibodies to biologic therapy |
| PCT/IB2013/060458 WO2014083520A2 (en) | 2012-11-30 | 2013-11-27 | Assays for detecting neutralizing autoantibodies to biologic therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2892766A1 true CA2892766A1 (en) | 2014-06-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2892766A Abandoned CA2892766A1 (en) | 2012-11-30 | 2013-11-27 | Assays for detecting neutralizing autoantibodies to biologic therapy |
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| Country | Link |
|---|---|
| EP (1) | EP2926136A2 (enExample) |
| JP (1) | JP2016502091A (enExample) |
| KR (1) | KR20150088890A (enExample) |
| CN (1) | CN105074461A (enExample) |
| AU (1) | AU2013350817A1 (enExample) |
| BR (1) | BR112015012482A2 (enExample) |
| CA (1) | CA2892766A1 (enExample) |
| HK (1) | HK1215969A1 (enExample) |
| IL (1) | IL238995A0 (enExample) |
| MX (1) | MX2015006852A (enExample) |
| RU (1) | RU2015125739A (enExample) |
| SG (2) | SG10201703210XA (enExample) |
| WO (1) | WO2014083520A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104634955B (zh) | 2009-10-26 | 2016-09-14 | 雀巢产品技术援助有限公司 | 检测抗-tnf药物和自身抗体的试验 |
| WO2012054532A1 (en) | 2010-10-18 | 2012-04-26 | Prometheus Laboratories Inc. | Methods for determining anti-drug antibody isotypes |
| WO2013006810A1 (en) | 2011-07-06 | 2013-01-10 | Nestec Sa | Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha |
| RU2017122720A (ru) | 2014-12-05 | 2019-01-10 | Нестек С.А. | Непрямые однородные анализы по изменению подвижности для детекции биологических препаратов в образцах пациента |
| US11085931B2 (en) | 2015-01-09 | 2021-08-10 | W. Health L.P. | Universal assay for determining the quantity of TNFα inhibitory drugs and their corresponding anti-drug-antibodies |
| US11119096B2 (en) | 2016-07-08 | 2021-09-14 | W. Health L.P. | Universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples |
| WO2018178307A1 (en) | 2017-03-31 | 2018-10-04 | Ablynx N.V. | Improved immunogenicity assays |
| CN114902052B (zh) * | 2020-01-02 | 2025-07-18 | 豪夫迈·罗氏有限公司 | Ada应答特异性化测定 |
| CN111024958B (zh) * | 2020-03-11 | 2020-06-23 | 同昕生物技术（北京）有限公司 | 用于检测单抗药物和抗单抗药物抗体的试剂及其应用 |
| CN112730846B (zh) * | 2020-12-18 | 2023-12-15 | 安渡生物医药(杭州)有限公司 | 一种用于小鼠血样检测免疫复合物的方法 |
| CN114047343B (zh) * | 2022-01-13 | 2022-05-31 | 美迪西普亚医药科技(上海)有限公司 | 双耐受型抗IgE单抗药物的免疫原性分析试剂盒及其使用方法和应用 |
| CN117871856A (zh) * | 2023-12-15 | 2024-04-12 | 首都医科大学附属北京地坛医院 | 可溶性因子在无症状神经梅毒检测中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104634955B (zh) * | 2009-10-26 | 2016-09-14 | 雀巢产品技术援助有限公司 | 检测抗-tnf药物和自身抗体的试验 |
| PL2564202T3 (pl) * | 2010-04-29 | 2016-04-29 | Theradiag Sa | Sposoby wykrywania przeciwciał przeciw lekowi |
| WO2012054532A1 (en) * | 2010-10-18 | 2012-04-26 | Prometheus Laboratories Inc. | Methods for determining anti-drug antibody isotypes |
| MX343327B (es) * | 2011-02-17 | 2016-11-01 | Nestec Sa | Ensayos para detectar autoanticuerpos contra farmacos anti-tnfa. |
| WO2013006810A1 (en) * | 2011-07-06 | 2013-01-10 | Nestec Sa | Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha |
-
2013
- 2013-11-21 BR BR112015012482A patent/BR112015012482A2/pt not_active IP Right Cessation
- 2013-11-27 HK HK16103834.6A patent/HK1215969A1/zh unknown
- 2013-11-27 SG SG10201703210XA patent/SG10201703210XA/en unknown
- 2013-11-27 MX MX2015006852A patent/MX2015006852A/es unknown
- 2013-11-27 WO PCT/IB2013/060458 patent/WO2014083520A2/en not_active Ceased
- 2013-11-27 JP JP2015544592A patent/JP2016502091A/ja active Pending
- 2013-11-27 CN CN201380071748.4A patent/CN105074461A/zh active Pending
- 2013-11-27 CA CA2892766A patent/CA2892766A1/en not_active Abandoned
- 2013-11-27 EP EP13820955.6A patent/EP2926136A2/en not_active Withdrawn
- 2013-11-27 KR KR1020157017311A patent/KR20150088890A/ko not_active Withdrawn
- 2013-11-27 SG SG11201504097PA patent/SG11201504097PA/en unknown
- 2013-11-27 AU AU2013350817A patent/AU2013350817A1/en not_active Abandoned
- 2013-11-27 RU RU2015125739A patent/RU2015125739A/ru not_active Application Discontinuation
-
2015
- 2015-05-25 IL IL238995A patent/IL238995A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013350817A1 (en) | 2015-06-11 |
| IL238995A0 (en) | 2015-07-30 |
| JP2016502091A (ja) | 2016-01-21 |
| BR112015012482A2 (pt) | 2017-07-11 |
| WO2014083520A2 (en) | 2014-06-05 |
| WO2014083520A3 (en) | 2014-07-31 |
| SG11201504097PA (en) | 2015-06-29 |
| CN105074461A (zh) | 2015-11-18 |
| EP2926136A2 (en) | 2015-10-07 |
| KR20150088890A (ko) | 2015-08-03 |
| SG10201703210XA (en) | 2017-06-29 |
| RU2015125739A (ru) | 2017-01-13 |
| HK1215969A1 (zh) | 2016-09-30 |
| MX2015006852A (es) | 2015-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20191127 |