BR112015012482A2 - ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicos - Google Patents
ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicosInfo
- Publication number
- BR112015012482A2 BR112015012482A2 BR112015012482A BR112015012482A BR112015012482A2 BR 112015012482 A2 BR112015012482 A2 BR 112015012482A2 BR 112015012482 A BR112015012482 A BR 112015012482A BR 112015012482 A BR112015012482 A BR 112015012482A BR 112015012482 A2 BR112015012482 A2 BR 112015012482A2
- Authority
- BR
- Brazil
- Prior art keywords
- neutralizing
- therapy
- assays
- present
- biological
- Prior art date
Links
- 230000003472 neutralizing effect Effects 0.000 title abstract 7
- 238000003556 assay Methods 0.000 title abstract 3
- 238000001815 biotherapy Methods 0.000 title abstract 3
- 239000003814 drug Substances 0.000 abstract 4
- 238000002560 therapeutic procedure Methods 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 3
- 238000012544 monitoring process Methods 0.000 abstract 2
- 239000003124 biologic agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000009260 cross reactivity Effects 0.000 abstract 1
- 238000005457 optimization Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/525—Tumor necrosis factor [TNF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261732251P | 2012-11-30 | 2012-11-30 | |
| US13/802,117 US20130266963A1 (en) | 2011-07-06 | 2013-03-13 | Assay for detecting neutralizing autoantibodies to biologic therapy |
| PCT/IB2013/060458 WO2014083520A2 (en) | 2012-11-30 | 2013-11-27 | Assays for detecting neutralizing autoantibodies to biologic therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015012482A2 true BR112015012482A2 (pt) | 2017-07-11 |
Family
ID=50828561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015012482A BR112015012482A2 (pt) | 2012-11-30 | 2013-11-21 | ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicos |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2926136A2 (enExample) |
| JP (1) | JP2016502091A (enExample) |
| KR (1) | KR20150088890A (enExample) |
| CN (1) | CN105074461A (enExample) |
| AU (1) | AU2013350817A1 (enExample) |
| BR (1) | BR112015012482A2 (enExample) |
| CA (1) | CA2892766A1 (enExample) |
| HK (1) | HK1215969A1 (enExample) |
| IL (1) | IL238995A0 (enExample) |
| MX (1) | MX2015006852A (enExample) |
| RU (1) | RU2015125739A (enExample) |
| SG (2) | SG11201504097PA (enExample) |
| WO (1) | WO2014083520A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012004877A (es) | 2009-10-26 | 2012-05-23 | Prometheus Lab Inc | Analisis para la deteccion de farmacos anti-tnf y autoanticuerpos. |
| SG189391A1 (en) | 2010-10-18 | 2013-05-31 | Nestec Sa | Methods for determining anti-drug antibody isotypes |
| AU2012278802B2 (en) | 2011-07-06 | 2015-11-26 | Société des Produits Nestlé S.A. | Assays for detecting neutralizing autoantibodies to biologic therapy with TNF alpha |
| JP2018500553A (ja) | 2014-12-05 | 2018-01-11 | ネステク ソシエテ アノニム | 患者試料における生物製剤の検出のための間接的均一移動度シフトアッセイ |
| CN107110853A (zh) | 2015-01-09 | 2017-08-29 | 阿通诺米斯公司 | 确定TNFα抑制药及其相应抗药抗体的量的通用测定法 |
| US11119096B2 (en) | 2016-07-08 | 2021-09-14 | W. Health L.P. | Universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples |
| CN110546506B (zh) * | 2017-03-31 | 2023-04-04 | 埃博灵克斯股份有限公司 | 改进的免疫原性测定法 |
| CN114902052B (zh) * | 2020-01-02 | 2025-07-18 | 豪夫迈·罗氏有限公司 | Ada应答特异性化测定 |
| CN111024958B (zh) * | 2020-03-11 | 2020-06-23 | 同昕生物技术（北京）有限公司 | 用于检测单抗药物和抗单抗药物抗体的试剂及其应用 |
| CN112730846B (zh) * | 2020-12-18 | 2023-12-15 | 安渡生物医药(杭州)有限公司 | 一种用于小鼠血样检测免疫复合物的方法 |
| CN114047343B (zh) * | 2022-01-13 | 2022-05-31 | 美迪西普亚医药科技(上海)有限公司 | 双耐受型抗IgE单抗药物的免疫原性分析试剂盒及其使用方法和应用 |
| CN117871856A (zh) * | 2023-12-15 | 2024-04-12 | 首都医科大学附属北京地坛医院 | 可溶性因子在无症状神经梅毒检测中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012004877A (es) * | 2009-10-26 | 2012-05-23 | Prometheus Lab Inc | Analisis para la deteccion de farmacos anti-tnf y autoanticuerpos. |
| JP2013527444A (ja) * | 2010-04-29 | 2013-06-27 | テラディアグ・ソシエテ・アノニム | 抗体を検出するための方法 |
| SG189391A1 (en) * | 2010-10-18 | 2013-05-31 | Nestec Sa | Methods for determining anti-drug antibody isotypes |
| WO2012154253A1 (en) * | 2011-02-17 | 2012-11-15 | Prometheus Laboratories Inc. | ASSAYS FOR DETECTING AUTOANTIBODIES TO ANTI-TNFα DRUGS |
| AU2012278802B2 (en) * | 2011-07-06 | 2015-11-26 | Société des Produits Nestlé S.A. | Assays for detecting neutralizing autoantibodies to biologic therapy with TNF alpha |
-
2013
- 2013-11-21 BR BR112015012482A patent/BR112015012482A2/pt not_active IP Right Cessation
- 2013-11-27 CN CN201380071748.4A patent/CN105074461A/zh active Pending
- 2013-11-27 RU RU2015125739A patent/RU2015125739A/ru not_active Application Discontinuation
- 2013-11-27 AU AU2013350817A patent/AU2013350817A1/en not_active Abandoned
- 2013-11-27 KR KR1020157017311A patent/KR20150088890A/ko not_active Withdrawn
- 2013-11-27 SG SG11201504097PA patent/SG11201504097PA/en unknown
- 2013-11-27 JP JP2015544592A patent/JP2016502091A/ja active Pending
- 2013-11-27 SG SG10201703210XA patent/SG10201703210XA/en unknown
- 2013-11-27 CA CA2892766A patent/CA2892766A1/en not_active Abandoned
- 2013-11-27 EP EP13820955.6A patent/EP2926136A2/en not_active Withdrawn
- 2013-11-27 WO PCT/IB2013/060458 patent/WO2014083520A2/en not_active Ceased
- 2013-11-27 HK HK16103834.6A patent/HK1215969A1/zh unknown
- 2013-11-27 MX MX2015006852A patent/MX2015006852A/es unknown
-
2015
- 2015-05-25 IL IL238995A patent/IL238995A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN105074461A (zh) | 2015-11-18 |
| CA2892766A1 (en) | 2014-06-05 |
| WO2014083520A3 (en) | 2014-07-31 |
| EP2926136A2 (en) | 2015-10-07 |
| MX2015006852A (es) | 2015-09-16 |
| SG11201504097PA (en) | 2015-06-29 |
| HK1215969A1 (zh) | 2016-09-30 |
| KR20150088890A (ko) | 2015-08-03 |
| WO2014083520A2 (en) | 2014-06-05 |
| IL238995A0 (en) | 2015-07-30 |
| SG10201703210XA (en) | 2017-06-29 |
| RU2015125739A (ru) | 2017-01-13 |
| JP2016502091A (ja) | 2016-01-21 |
| AU2013350817A1 (en) | 2015-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |