BR112014007485A2 - biomarcadores preditivos de sensibilidade a tratamento com ativador de receptor de acetilcolina nicotínico alfa 7 - Google Patents

biomarcadores preditivos de sensibilidade a tratamento com ativador de receptor de acetilcolina nicotínico alfa 7

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Publication number
BR112014007485A2
BR112014007485A2 BR112014007485A BR112014007485A BR112014007485A2 BR 112014007485 A2 BR112014007485 A2 BR 112014007485A2 BR 112014007485 A BR112014007485 A BR 112014007485A BR 112014007485 A BR112014007485 A BR 112014007485A BR 112014007485 A2 BR112014007485 A2 BR 112014007485A2
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BR
Brazil
Prior art keywords
treatment
sensitivity
acetylcholine receptor
nicotinic acetylcholine
receptor activator
Prior art date
Application number
BR112014007485A
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English (en)
Other versions
BR112014007485B1 (pt
Inventor
Gomez-Mancilla Baltazar
Lopez-Lopez Cristina
Feuerbach Dominik
Johns Donald
Hall Mcallister Kevin
Sandford Lisa
Weiss Markus
Pezous Nicole
He Yunsheng
Original Assignee
Novartis Ag
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112014007485A2 publication Critical patent/BR112014007485A2/pt
Publication of BR112014007485B1 publication Critical patent/BR112014007485B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
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  • Immunology (AREA)
  • Microbiology (AREA)
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  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
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Abstract

resumo patente de invenção: "biomarcadores preditivos de sensibilidade a tratamento com ativador de receptor de acetilcolina nicotínico alfa 7". a presente invenção refere-se a uma invenção que fornece métodos para prever a sensibilidade terapêutica de um indivíduo sofrendo de danos ou disfunções cognitivas, distúrbios psicóticos e/ou neurodegenerativos a um tratamento por ativador de receptor de acetilcolina nicotínico alfa 7.
BR112014007485-2A 2011-10-20 2012-10-18 Métodos para prever responsividade terapêutica de um indivíduo a tratamento com um ativador do receptor de acetilcolina nicotínico alfa 7, e usos do referido ativador BR112014007485B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161549319P 2011-10-20 2011-10-20
US61/549,319 2011-10-20
PCT/IB2012/055692 WO2013057687A2 (en) 2011-10-20 2012-10-18 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment

Publications (2)

Publication Number Publication Date
BR112014007485A2 true BR112014007485A2 (pt) 2017-04-04
BR112014007485B1 BR112014007485B1 (pt) 2022-05-31

Family

ID=47297333

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014007485-2A BR112014007485B1 (pt) 2011-10-20 2012-10-18 Métodos para prever responsividade terapêutica de um indivíduo a tratamento com um ativador do receptor de acetilcolina nicotínico alfa 7, e usos do referido ativador

Country Status (14)

Country Link
EP (1) EP2768507B1 (pt)
JP (1) JP6162705B2 (pt)
KR (1) KR102043077B1 (pt)
CN (1) CN103930112B (pt)
AU (1) AU2012324458B2 (pt)
BR (1) BR112014007485B1 (pt)
CA (2) CA2852268C (pt)
EA (1) EA034964B1 (pt)
ES (1) ES2776996T3 (pt)
IN (1) IN2014CN03647A (pt)
JO (1) JO3766B1 (pt)
MX (1) MX2014004621A (pt)
TW (1) TWI635861B (pt)
WO (1) WO2013057687A2 (pt)

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AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9428535B2 (en) 2011-10-03 2016-08-30 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
EP2791160B1 (en) 2011-12-16 2022-03-02 ModernaTX, Inc. Modified mrna compositions
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
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Also Published As

Publication number Publication date
EP2768507B1 (en) 2019-12-11
TWI635861B (zh) 2018-09-21
CA3083244A1 (en) 2013-04-25
EA034964B1 (ru) 2020-04-13
WO2013057687A3 (en) 2013-07-11
AU2012324458B2 (en) 2016-05-19
JP2015501306A (ja) 2015-01-15
WO2013057687A2 (en) 2013-04-25
KR20140081822A (ko) 2014-07-01
EA201490832A1 (ru) 2015-12-30
TW201322980A (zh) 2013-06-16
EP2768507A2 (en) 2014-08-27
MX2014004621A (es) 2014-08-22
BR112014007485B1 (pt) 2022-05-31
CA3083244C (en) 2023-01-03
JO3766B1 (ar) 2021-01-31
KR102043077B1 (ko) 2019-11-11
IN2014CN03647A (pt) 2015-10-09
CA2852268C (en) 2020-08-25
CN103930112B (zh) 2018-11-09
CA2852268A1 (en) 2013-04-25
AU2012324458A1 (en) 2014-05-01
ES2776996T3 (es) 2020-08-03
CN103930112A (zh) 2014-07-16
JP6162705B2 (ja) 2017-07-12

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