EA201490832A1 - Биомаркеры, имеющие прогностическое значение в отношении ответа на лечение активатором альфа 7 никотиновых ацетилхолиновых рецепторов - Google Patents

Биомаркеры, имеющие прогностическое значение в отношении ответа на лечение активатором альфа 7 никотиновых ацетилхолиновых рецепторов

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Publication number
EA201490832A1
EA201490832A1 EA201490832A EA201490832A EA201490832A1 EA 201490832 A1 EA201490832 A1 EA 201490832A1 EA 201490832 A EA201490832 A EA 201490832A EA 201490832 A EA201490832 A EA 201490832A EA 201490832 A1 EA201490832 A1 EA 201490832A1
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EA
Eurasian Patent Office
Prior art keywords
response
treatment
biomarkers
respect
acetyl choline
Prior art date
Application number
EA201490832A
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English (en)
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EA034964B1 (ru
Inventor
Доминик Фойербах
Бальтазар Гомес-Манкилла
Юньшэн Хэ
Доналд Джонс
Кристина Лопес-Лопес
Кевин Холл Макаллистер
Николь Пезу
Лиза Сэндфорд
Маркус Вайсс
Original Assignee
Новартис Аг
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Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201490832A1 publication Critical patent/EA201490832A1/ru
Publication of EA034964B1 publication Critical patent/EA034964B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

Изобретение относится к способам прогнозирования способности индивида, страдающего когнитивными нарушениями или дисфункциями, психотическими и/или нейродегенеративными расстройствами, к ответу на лечение активатором альфа 7 никотиновых ацетилхолиновых рецепторов.
EA201490832A 2011-10-20 2012-10-18 Биомаркеры, имеющие прогностическое значение в отношении ответа на лечение активатором альфа 7 никотиновых ацетилхолиновых рецепторов EA034964B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161549319P 2011-10-20 2011-10-20
PCT/IB2012/055692 WO2013057687A2 (en) 2011-10-20 2012-10-18 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment

Publications (2)

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EA201490832A1 true EA201490832A1 (ru) 2015-12-30
EA034964B1 EA034964B1 (ru) 2020-04-13

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EA201490832A EA034964B1 (ru) 2011-10-20 2012-10-18 Биомаркеры, имеющие прогностическое значение в отношении ответа на лечение активатором альфа 7 никотиновых ацетилхолиновых рецепторов

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EP (1) EP2768507B1 (ru)
JP (1) JP6162705B2 (ru)
KR (1) KR102043077B1 (ru)
CN (1) CN103930112B (ru)
AU (1) AU2012324458B2 (ru)
BR (1) BR112014007485B1 (ru)
CA (2) CA2852268C (ru)
EA (1) EA034964B1 (ru)
ES (1) ES2776996T3 (ru)
IN (1) IN2014CN03647A (ru)
JO (1) JO3766B1 (ru)
MX (1) MX2014004621A (ru)
TW (1) TWI635861B (ru)
WO (1) WO2013057687A2 (ru)

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EP2791160B1 (en) 2011-12-16 2022-03-02 ModernaTX, Inc. Modified mrna compositions
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WO2013057687A2 (en) 2013-04-25
EA034964B1 (ru) 2020-04-13
BR112014007485B1 (pt) 2022-05-31
JP6162705B2 (ja) 2017-07-12
CA2852268A1 (en) 2013-04-25
CN103930112A (zh) 2014-07-16
CA3083244C (en) 2023-01-03
IN2014CN03647A (ru) 2015-10-09
AU2012324458B2 (en) 2016-05-19
ES2776996T3 (es) 2020-08-03
JO3766B1 (ar) 2021-01-31
EP2768507B1 (en) 2019-12-11
KR102043077B1 (ko) 2019-11-11
CA3083244A1 (en) 2013-04-25
JP2015501306A (ja) 2015-01-15
BR112014007485A2 (pt) 2017-04-04
WO2013057687A3 (en) 2013-07-11
KR20140081822A (ko) 2014-07-01
CA2852268C (en) 2020-08-25
TW201322980A (zh) 2013-06-16
CN103930112B (zh) 2018-11-09
EP2768507A2 (en) 2014-08-27
TWI635861B (zh) 2018-09-21
MX2014004621A (es) 2014-08-22
AU2012324458A1 (en) 2014-05-01

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