JP2016128441A5 - - Google Patents
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- Publication number
- JP2016128441A5 JP2016128441A5 JP2016001684A JP2016001684A JP2016128441A5 JP 2016128441 A5 JP2016128441 A5 JP 2016128441A5 JP 2016001684 A JP2016001684 A JP 2016001684A JP 2016001684 A JP2016001684 A JP 2016001684A JP 2016128441 A5 JP2016128441 A5 JP 2016128441A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antagonist antibody
- binding portion
- madcam antagonist
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000005557 antagonist Substances 0.000 claims 28
- 239000000427 antigen Substances 0.000 claims 25
- 108091007433 antigens Proteins 0.000 claims 25
- 102000036639 antigens Human genes 0.000 claims 25
- 239000003814 drug Substances 0.000 claims 20
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 20
- 239000000090 biomarker Substances 0.000 claims 17
- 206010009900 Colitis ulcerative Diseases 0.000 claims 10
- 208000011231 Crohn disease Diseases 0.000 claims 10
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 239000012472 biological sample Substances 0.000 claims 6
- -1 sMAdCAM Proteins 0.000 claims 6
- 102100022718 Atypical chemokine receptor 2 Human genes 0.000 claims 5
- 108010074051 C-Reactive Protein Proteins 0.000 claims 5
- 101000678892 Homo sapiens Atypical chemokine receptor 2 Proteins 0.000 claims 5
- 101000716070 Homo sapiens C-C chemokine receptor type 9 Proteins 0.000 claims 5
- 102000001109 Leukocyte L1 Antigen Complex Human genes 0.000 claims 5
- 108010069316 Leukocyte L1 Antigen Complex Proteins 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 230000002550 fecal effect Effects 0.000 claims 5
- VKUYLANQOAKALN-UHFFFAOYSA-N 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-n-hydroxy-4-methylpentanamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N(C(CC(C)C)C(=O)NO)CC1=CC=CC=C1 VKUYLANQOAKALN-UHFFFAOYSA-N 0.000 claims 4
- 102400000667 Brain natriuretic peptide 32 Human genes 0.000 claims 4
- 101800000407 Brain natriuretic peptide 32 Proteins 0.000 claims 4
- 101800002247 Brain natriuretic peptide 45 Proteins 0.000 claims 4
- 102100025279 C-X-C motif chemokine 11 Human genes 0.000 claims 4
- 102100025277 C-X-C motif chemokine 13 Human genes 0.000 claims 4
- 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims 4
- 108010066813 Chitinase-3-Like Protein 1 Proteins 0.000 claims 4
- 102000018704 Chitinase-3-Like Protein 1 Human genes 0.000 claims 4
- 102100030074 Dickkopf-related protein 1 Human genes 0.000 claims 4
- 101710099518 Dickkopf-related protein 1 Proteins 0.000 claims 4
- 108010092408 Eosinophil Peroxidase Proteins 0.000 claims 4
- 102100028471 Eosinophil peroxidase Human genes 0.000 claims 4
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 4
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 claims 4
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 claims 4
- 102100034221 Growth-regulated alpha protein Human genes 0.000 claims 4
- 101000858060 Homo sapiens C-X-C motif chemokine 11 Proteins 0.000 claims 4
- 101000858064 Homo sapiens C-X-C motif chemokine 13 Proteins 0.000 claims 4
- 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 claims 4
- 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 claims 4
- 101001082142 Homo sapiens Pentraxin-related protein PTX3 Proteins 0.000 claims 4
- 101000686909 Homo sapiens Resistin Proteins 0.000 claims 4
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 4
- 101001135589 Homo sapiens Tyrosine-protein phosphatase non-receptor type 22 Proteins 0.000 claims 4
- 108050003558 Interleukin-17 Proteins 0.000 claims 4
- 102000013691 Interleukin-17 Human genes 0.000 claims 4
- 108090001005 Interleukin-6 Proteins 0.000 claims 4
- 108010002586 Interleukin-7 Proteins 0.000 claims 4
- 108090001007 Interleukin-8 Proteins 0.000 claims 4
- 102000004890 Interleukin-8 Human genes 0.000 claims 4
- 102100027998 Macrophage metalloelastase Human genes 0.000 claims 4
- 101710187853 Macrophage metalloelastase Proteins 0.000 claims 4
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims 4
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 claims 4
- 108090000630 Oncostatin M Proteins 0.000 claims 4
- 102100031942 Oncostatin-M Human genes 0.000 claims 4
- BFHAYPLBUQVNNJ-UHFFFAOYSA-N Pectenotoxin 3 Natural products OC1C(C)CCOC1(O)C1OC2C=CC(C)=CC(C)CC(C)(O3)CCC3C(O3)(O4)CCC3(C=O)CC4C(O3)C(=O)CC3(C)C(O)C(O3)CCC3(O3)CCCC3C(C)C(=O)OC2C1 BFHAYPLBUQVNNJ-UHFFFAOYSA-N 0.000 claims 4
- 102100027351 Pentraxin-related protein PTX3 Human genes 0.000 claims 4
- 101710098940 Pro-epidermal growth factor Proteins 0.000 claims 4
- 101710110949 Protein S100-A12 Proteins 0.000 claims 4
- 102000014128 RANK Ligand Human genes 0.000 claims 4
- 108010025832 RANK Ligand Proteins 0.000 claims 4
- 102100037889 Regenerating islet-derived protein 4 Human genes 0.000 claims 4
- 101710193245 Regenerating islet-derived protein 4 Proteins 0.000 claims 4
- 102100024735 Resistin Human genes 0.000 claims 4
- 102000058242 S100A12 Human genes 0.000 claims 4
- 102100030416 Stromelysin-1 Human genes 0.000 claims 4
- 101710108790 Stromelysin-1 Proteins 0.000 claims 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 4
- 102100033138 Tyrosine-protein phosphatase non-receptor type 22 Human genes 0.000 claims 4
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 4
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 108700028369 Alleles Proteins 0.000 claims 3
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 3
- 102100028848 Stromelysin-2 Human genes 0.000 claims 3
- 101710108792 Stromelysin-2 Proteins 0.000 claims 3
- 230000009286 beneficial effect Effects 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 230000004044 response Effects 0.000 claims 3
- 206010003267 Arthritis reactive Diseases 0.000 claims 2
- 108700012434 CCL3 Proteins 0.000 claims 2
- 102000000013 Chemokine CCL3 Human genes 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 2
- 102000000704 Interleukin-7 Human genes 0.000 claims 2
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
- 101710151805 Mitochondrial intermediate peptidase 1 Proteins 0.000 claims 2
- 208000002574 reactive arthritis Diseases 0.000 claims 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000005024 Castleman disease Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 208000004575 Infectious Arthritis Diseases 0.000 claims 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010036030 Polyarthritis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000020410 Psoriasis-related juvenile idiopathic arthritis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000006045 Spondylarthropathies Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 230000000366 juvenile effect Effects 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 208000023002 juvenile spondyloarthropathy Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 208000030428 polyarticular arthritis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000001223 septic arthritis Diseases 0.000 claims 1
- 201000005671 spondyloarthropathy Diseases 0.000 claims 1
- 230000004797 therapeutic response Effects 0.000 claims 1
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 claims 1
- 239000002451 tumor necrosis factor inhibitor Substances 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562101877P | 2015-01-09 | 2015-01-09 | |
| US62/101,877 | 2015-01-09 | ||
| US201562263197P | 2015-12-04 | 2015-12-04 | |
| US62/263,197 | 2015-12-04 | ||
| US201562263910P | 2015-12-07 | 2015-12-07 | |
| US62/263,910 | 2015-12-07 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020173121A Division JP7142200B2 (ja) | 2015-01-09 | 2020-10-14 | ＭＡｄＣＡＭアンタゴニストの投与レジメン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016128441A JP2016128441A (ja) | 2016-07-14 |
| JP2016128441A5 true JP2016128441A5 (enExample) | 2019-08-29 |
| JP6779621B2 JP6779621B2 (ja) | 2020-11-04 |
Family
ID=55275128
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016001684A Active JP6779621B2 (ja) | 2015-01-09 | 2016-01-07 | ＭＡｄＣＡＭアンタゴニストの投与レジメン |
| JP2020173121A Active JP7142200B2 (ja) | 2015-01-09 | 2020-10-14 | ＭＡｄＣＡＭアンタゴニストの投与レジメン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020173121A Active JP7142200B2 (ja) | 2015-01-09 | 2020-10-14 | ＭＡｄＣＡＭアンタゴニストの投与レジメン |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10851163B2 (enExample) |
| EP (2) | EP4112079A1 (enExample) |
| JP (2) | JP6779621B2 (enExample) |
| KR (1) | KR102756784B1 (enExample) |
| CN (3) | CN107427576A (enExample) |
| AU (2) | AU2016205852B2 (enExample) |
| BR (1) | BR112017014793A2 (enExample) |
| CA (1) | CA2916283C (enExample) |
| CL (1) | CL2017001756A1 (enExample) |
| EA (1) | EA037288B1 (enExample) |
| ES (1) | ES2927958T3 (enExample) |
| IL (1) | IL253247B (enExample) |
| MA (1) | MA41314A (enExample) |
| MX (1) | MX385589B (enExample) |
| SG (1) | SG11201705604WA (enExample) |
| WO (1) | WO2016110806A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6904905B2 (ja) * | 2014-12-24 | 2021-07-21 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 抗α４β７インテグリン抗体による治療の結果の予測 |
| CA2916283C (en) * | 2015-01-09 | 2024-07-02 | Pfizer Inc. | MADCAM ANTAGONIST DOSING REGIMEN |
| CA3064435A1 (en) * | 2017-05-24 | 2018-11-29 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| TW201920266A (zh) | 2017-07-14 | 2019-06-01 | 美商輝瑞大藥廠 | Madcam 抗體 |
| CN108118093A (zh) * | 2018-03-06 | 2018-06-05 | 谢琳 | Linc00426在制备骨肉瘤转移诊断产品中的用途 |
| CN112805566A (zh) * | 2019-07-29 | 2021-05-14 | 上海谷森医药有限公司 | 用于吸入治疗肺癌的抗体类药物制剂 |
| CN113789328A (zh) * | 2021-09-16 | 2021-12-14 | 中国人民解放军海军军医大学 | lncRNA及其在免疫调控及免疫相关疾病诊治中的应用 |
| CN114164211B (zh) * | 2021-09-16 | 2024-02-27 | 中国人民解放军海军军医大学 | lncRNA及其在肿瘤诊断、治疗和预后判断中的应用 |
| CN116631510B (zh) * | 2022-10-28 | 2024-01-12 | 中国人民解放军军事科学院军事医学研究院 | 一种用于鉴别诊断克罗恩病和溃疡性结肠炎的装置 |
| JP2025538586A (ja) | 2022-11-22 | 2025-11-28 | 武田薬品工業株式会社 | 非アルコール性脂肪性肝炎の治療のためのＭＡｄＣＡＭ－１抗体の投薬レジメン |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US5698679A (en) * | 1994-09-19 | 1997-12-16 | National Jewish Center For Immunology And Respiratory Medicine | Product and process for targeting an immune response |
| US7803904B2 (en) | 1995-09-01 | 2010-09-28 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressing and uses thereof |
| US6551593B1 (en) | 1995-02-10 | 2003-04-22 | Millennium Pharmaceuticals, Inc. | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam |
| CA2290485C (en) | 1997-05-21 | 2008-08-05 | Biovation Limited | Method for the production of non-immunogenic proteins |
| US6217552B1 (en) | 1999-03-01 | 2001-04-17 | Coaxia, Inc. | Medical device for selective intrathecal spinal cooling in aortic surgery and spinal trauma |
| WO2004081049A1 (en) * | 2003-03-10 | 2004-09-23 | Auckland Uniservices Limited | Monoclonal antibodies that recognise mucosal addressin cell adhesion molecule-1 (madcam-1), soluble madcam-1 and uses thereof |
| DE602005026779D1 (de) | 2004-01-09 | 2011-04-21 | Pfizer | ANTIKÖRPER GEGEN MAdCAM |
| US20090110681A1 (en) * | 2005-03-08 | 2009-04-30 | Pfizer, Inc. | Anti-M-CSF Antibody Compositions |
| WO2007007145A2 (en) | 2005-07-08 | 2007-01-18 | Pfizer Limited | Use of anti-madcam antibodies for the treatment of coeliac disease and tropical sprue |
| WO2007007173A2 (en) | 2005-07-08 | 2007-01-18 | Pfizer Limited | Human anti-madcam antibodies |
| WO2007007159A2 (en) | 2005-07-11 | 2007-01-18 | Pfizer Limited | Anti-madcam antibodies to treat uterine disorders |
| WO2007007160A2 (en) | 2005-07-11 | 2007-01-18 | Pfizer Limited | Anti-madcam antibodies to treat fever |
| WO2007007151A2 (en) | 2005-07-11 | 2007-01-18 | Pfizer Limited | Use of anti-mad-cam antibody for the treatment of emphysema |
| WO2007007152A2 (en) | 2005-07-11 | 2007-01-18 | Pfizer Limited | Anti-madcam antibodies to treat metastatic cancers and chloroma |
| US8188235B2 (en) | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
| DE102010013830A1 (de) * | 2010-03-26 | 2011-09-29 | Carl Zeiss Microlmaging Gmbh | Mikroskop und Verfahren zur mikroskopischen Erfassung von Licht einer Probe |
| RU2015145610A (ru) * | 2013-03-27 | 2017-05-04 | Дженентек, Инк. | Применение биомаркеров для оценки лечения желудочно-кишечных воспалительных расстройств антагонистами бета7 интегрина |
| CA2916283C (en) * | 2015-01-09 | 2024-07-02 | Pfizer Inc. | MADCAM ANTAGONIST DOSING REGIMEN |
-
2015
- 2015-12-23 CA CA2916283A patent/CA2916283C/en active Active
-
2016
- 2016-01-05 MA MA041314A patent/MA41314A/fr unknown
- 2016-01-06 CN CN201680014443.3A patent/CN107427576A/zh active Pending
- 2016-01-06 EA EA201791227A patent/EA037288B1/ru unknown
- 2016-01-06 EP EP22179107.2A patent/EP4112079A1/en active Pending
- 2016-01-06 BR BR112017014793A patent/BR112017014793A2/pt not_active Application Discontinuation
- 2016-01-06 EP EP16702586.5A patent/EP3242684B1/en active Active
- 2016-01-06 CN CN202111331779.1A patent/CN114732899A/zh active Pending
- 2016-01-06 CN CN202111331776.8A patent/CN114377125A/zh active Pending
- 2016-01-06 US US15/542,110 patent/US10851163B2/en active Active
- 2016-01-06 AU AU2016205852A patent/AU2016205852B2/en active Active
- 2016-01-06 KR KR1020177021819A patent/KR102756784B1/ko active Active
- 2016-01-06 MX MX2017009047A patent/MX385589B/es unknown
- 2016-01-06 SG SG11201705604WA patent/SG11201705604WA/en unknown
- 2016-01-06 ES ES16702586T patent/ES2927958T3/es active Active
- 2016-01-06 WO PCT/IB2016/050047 patent/WO2016110806A2/en not_active Ceased
- 2016-01-07 JP JP2016001684A patent/JP6779621B2/ja active Active
-
2017
- 2017-06-29 IL IL253247A patent/IL253247B/en unknown
- 2017-07-03 CL CL2017001756A patent/CL2017001756A1/es unknown
-
2020
- 2020-10-14 JP JP2020173121A patent/JP7142200B2/ja active Active
- 2020-11-30 US US17/107,228 patent/US11884726B2/en active Active
-
2021
- 2021-10-12 AU AU2021250850A patent/AU2021250850B2/en active Active
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