JP2017501680A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017501680A5 JP2017501680A5 JP2016526089A JP2016526089A JP2017501680A5 JP 2017501680 A5 JP2017501680 A5 JP 2017501680A5 JP 2016526089 A JP2016526089 A JP 2016526089A JP 2016526089 A JP2016526089 A JP 2016526089A JP 2017501680 A5 JP2017501680 A5 JP 2017501680A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- pathway inhibitor
- patient
- seq
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003112 inhibitor Substances 0.000 claims 105
- 230000037361 pathway Effects 0.000 claims 50
- 238000002560 therapeutic procedure Methods 0.000 claims 34
- 108020004999 messenger RNA Proteins 0.000 claims 30
- 238000000034 method Methods 0.000 claims 17
- 102100036850 C-C motif chemokine 23 Human genes 0.000 claims 14
- 101000713081 Homo sapiens C-C motif chemokine 23 Proteins 0.000 claims 14
- 101000868391 Homo sapiens Voltage-dependent calcium channel gamma-6 subunit Proteins 0.000 claims 14
- 102100024218 Prostaglandin D2 receptor 2 Human genes 0.000 claims 14
- 102100032335 Voltage-dependent calcium channel gamma-8 subunit Human genes 0.000 claims 14
- 102100024824 3 beta-hydroxysteroid dehydrogenase type 7 Human genes 0.000 claims 13
- 101000761592 Homo sapiens 3 beta-hydroxysteroid dehydrogenase type 7 Proteins 0.000 claims 13
- -1 OLIG2 Proteins 0.000 claims 13
- 208000006673 asthma Diseases 0.000 claims 13
- 101001037256 Homo sapiens Indoleamine 2,3-dioxygenase 1 Proteins 0.000 claims 12
- 101001117314 Homo sapiens Prostaglandin D2 receptor 2 Proteins 0.000 claims 12
- 101000863884 Homo sapiens Sialic acid-binding Ig-like lectin 8 Proteins 0.000 claims 12
- 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 claims 12
- 102100029964 Sialic acid-binding Ig-like lectin 8 Human genes 0.000 claims 12
- 102100034826 Homeobox protein Meis2 Human genes 0.000 claims 11
- 101001019057 Homo sapiens Homeobox protein Meis2 Proteins 0.000 claims 11
- 102100023287 2-acylglycerol O-acyltransferase 3 Human genes 0.000 claims 10
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 claims 10
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 claims 10
- 108091011896 CSF1 Proteins 0.000 claims 10
- 102100024632 Galectin-12 Human genes 0.000 claims 10
- 101001115709 Homo sapiens 2-acylglycerol O-acyltransferase 3 Proteins 0.000 claims 10
- 101001052060 Homo sapiens Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Proteins 0.000 claims 10
- 101001051083 Homo sapiens Galectin-12 Proteins 0.000 claims 10
- 101001064853 Homo sapiens Polyunsaturated fatty acid lipoxygenase ALOX15 Proteins 0.000 claims 10
- 101001082342 Homo sapiens Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 Proteins 0.000 claims 10
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 10
- 102100031950 Polyunsaturated fatty acid lipoxygenase ALOX15 Human genes 0.000 claims 10
- 102100027335 Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 Human genes 0.000 claims 10
- 102100026974 Sorbitol dehydrogenase Human genes 0.000 claims 10
- 101710184713 Sorbitol dehydrogenase Proteins 0.000 claims 10
- 208000023504 respiratory system disease Diseases 0.000 claims 10
- 102100021626 Ankyrin repeat and SOCS box protein 2 Human genes 0.000 claims 9
- 101000754299 Homo sapiens Ankyrin repeat and SOCS box protein 2 Proteins 0.000 claims 9
- 101000633617 Homo sapiens Thrombospondin-4 Proteins 0.000 claims 9
- 102000004388 Interleukin-4 Human genes 0.000 claims 9
- 108090000978 Interleukin-4 Proteins 0.000 claims 9
- 102100029219 Thrombospondin-4 Human genes 0.000 claims 9
- 239000003550 marker Substances 0.000 claims 9
- 102100040434 Ankyrin repeat and BTB/POZ domain-containing protein 2 Human genes 0.000 claims 8
- 101000964346 Homo sapiens Ankyrin repeat and BTB/POZ domain-containing protein 2 Proteins 0.000 claims 8
- 102100032877 Multidrug and toxin extrusion protein 1 Human genes 0.000 claims 8
- 108091007574 SLC47A1 Proteins 0.000 claims 8
- 239000012472 biological sample Substances 0.000 claims 8
- 102100024918 Cytochrome P450 4F12 Human genes 0.000 claims 7
- 101000909108 Homo sapiens Cytochrome P450 4F12 Proteins 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 7
- 101001108755 Homo sapiens Sphingomyelin phosphodiesterase 3 Proteins 0.000 claims 6
- 102100021461 Sphingomyelin phosphodiesterase 3 Human genes 0.000 claims 6
- 102000003816 Interleukin-13 Human genes 0.000 claims 5
- 108090000176 Interleukin-13 Proteins 0.000 claims 5
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims 4
- 102100032976 CCR4-NOT transcription complex subunit 6 Human genes 0.000 claims 4
- 101000845170 Homo sapiens Thymic stromal lymphopoietin Proteins 0.000 claims 4
- 102100039897 Interleukin-5 Human genes 0.000 claims 4
- 108010002616 Interleukin-5 Proteins 0.000 claims 4
- 102100031294 Thymic stromal lymphopoietin Human genes 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 4
- 229940125386 long-acting bronchodilator Drugs 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 230000003321 amplification Effects 0.000 claims 3
- 239000003246 corticosteroid Substances 0.000 claims 3
- 230000005713 exacerbation Effects 0.000 claims 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims 3
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 3
- PFWVGKROPKKEDW-UHFFFAOYSA-N 2-[4-[4-(tert-butylcarbamoyl)-2-[(2-chloro-4-cyclopropylphenyl)sulfonylamino]phenoxy]-5-chloro-2-fluorophenyl]acetic acid Chemical compound C=1C=C(C2CC2)C=C(Cl)C=1S(=O)(=O)NC1=CC(C(=O)NC(C)(C)C)=CC=C1OC1=CC(F)=C(CC(O)=O)C=C1Cl PFWVGKROPKKEDW-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 101150104383 ALOX5AP gene Proteins 0.000 claims 2
- 229940124291 BTK inhibitor Drugs 0.000 claims 2
- PJFHZKIDENOSJB-UHFFFAOYSA-N Budesonide/formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1.C1CC2=CC(=O)C=CC2(C)C2C1C1CC3OC(CCC)OC3(C(=O)CO)C1(C)CC2O PJFHZKIDENOSJB-UHFFFAOYSA-N 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- 102100034477 H(+)/Cl(-) exchange transporter 3 Human genes 0.000 claims 2
- 101000906633 Homo sapiens Chloride channel protein 2 Proteins 0.000 claims 2
- 101000710223 Homo sapiens H(+)/Cl(-) exchange transporter 3 Proteins 0.000 claims 2
- 101001019600 Homo sapiens Interleukin-17 receptor B Proteins 0.000 claims 2
- 101001033279 Homo sapiens Interleukin-3 Proteins 0.000 claims 2
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 claims 2
- 101000620620 Homo sapiens Placental protein 13-like Proteins 0.000 claims 2
- 108010073816 IgE Receptors Proteins 0.000 claims 2
- 102000009438 IgE Receptors Human genes 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 102000007482 Interleukin-13 Receptor alpha2 Subunit Human genes 0.000 claims 2
- 108010085418 Interleukin-13 Receptor alpha2 Subunit Proteins 0.000 claims 2
- 102000004559 Interleukin-13 Receptors Human genes 0.000 claims 2
- 108010017511 Interleukin-13 Receptors Proteins 0.000 claims 2
- 102100035014 Interleukin-17 receptor B Human genes 0.000 claims 2
- 102100039064 Interleukin-3 Human genes 0.000 claims 2
- 102000010787 Interleukin-4 Receptors Human genes 0.000 claims 2
- 108010038486 Interleukin-4 Receptors Proteins 0.000 claims 2
- 102000010786 Interleukin-5 Receptors Human genes 0.000 claims 2
- 108010038484 Interleukin-5 Receptors Proteins 0.000 claims 2
- 102000000585 Interleukin-9 Human genes 0.000 claims 2
- 108010002335 Interleukin-9 Proteins 0.000 claims 2
- 102000010682 Interleukin-9 Receptors Human genes 0.000 claims 2
- 108010038414 Interleukin-9 Receptors Proteins 0.000 claims 2
- 229940110339 Long-acting muscarinic antagonist Drugs 0.000 claims 2
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 claims 2
- 101100236114 Mus musculus Lrrfip1 gene Proteins 0.000 claims 2
- 108010042215 OX40 Ligand Proteins 0.000 claims 2
- 102100022336 Placental protein 13-like Human genes 0.000 claims 2
- 108050000258 Prostaglandin D receptors Proteins 0.000 claims 2
- IHAXLPDVOWLUOS-UHFFFAOYSA-N Setipiprant Chemical compound C1=CC=C2C(C(=O)N3CCC=4N(C5=CC=C(F)C=C5C=4C3)CC(=O)O)=CC=CC2=C1 IHAXLPDVOWLUOS-UHFFFAOYSA-N 0.000 claims 2
- 102000000551 Syk Kinase Human genes 0.000 claims 2
- 108010016672 Syk Kinase Proteins 0.000 claims 2
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 claims 2
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims 2
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 claims 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 229950003468 dupilumab Drugs 0.000 claims 2
- 230000002327 eosinophilic effect Effects 0.000 claims 2
- DFQGDHBGRSTTHX-UHFFFAOYSA-N fiboflapon Chemical compound C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C(O)=O DFQGDHBGRSTTHX-UHFFFAOYSA-N 0.000 claims 2
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 229940043355 kinase inhibitor Drugs 0.000 claims 2
- 229950002183 lebrikizumab Drugs 0.000 claims 2
- 229940065725 leukotriene receptor antagonists for obstructive airway diseases Drugs 0.000 claims 2
- 239000003199 leukotriene receptor blocking agent Substances 0.000 claims 2
- 229940127212 long-acting beta 2 agonist Drugs 0.000 claims 2
- 229960005108 mepolizumab Drugs 0.000 claims 2
- 229940124624 oral corticosteroid Drugs 0.000 claims 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 2
- 108091006082 receptor inhibitors Proteins 0.000 claims 2
- 229940035073 symbicort Drugs 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 2
- 229940099073 xolair Drugs 0.000 claims 2
- FCSXYHUNDAXDRH-OKMNHOJOSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;n-[2-hydroxy-5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(OC)=CC=C1C[C@@H](C)NC[C@H](O)C1=CC=C(O)C(NC=O)=C1 FCSXYHUNDAXDRH-OKMNHOJOSA-N 0.000 claims 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 102100036597 Basement membrane-specific heparan sulfate proteoglycan core protein Human genes 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 101710161551 Pectate lyase 3 Proteins 0.000 claims 1
- 101710124951 Phospholipase C Proteins 0.000 claims 1
- 101710179609 Probable pectin lyase C Proteins 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 229940031472 brovana Drugs 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 229940033835 flonase Drugs 0.000 claims 1
- 229940085861 flovent Drugs 0.000 claims 1
- 229940125369 inhaled corticosteroids Drugs 0.000 claims 1
- 210000004180 plasmocyte Anatomy 0.000 claims 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 claims 1
- 238000003753 real-time PCR Methods 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000013517 stratification Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361894831P | 2013-10-23 | 2013-10-23 | |
| US61/894,831 | 2013-10-23 | ||
| PCT/US2014/061759 WO2015061441A1 (en) | 2013-10-23 | 2014-10-22 | Methods of diagnosing and treating eosinophilic disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020099159A Division JP2020178692A (ja) | 2013-10-23 | 2020-06-08 | 好酸球性疾患の診断及び治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501680A JP2017501680A (ja) | 2017-01-19 |
| JP2017501680A5 true JP2017501680A5 (enExample) | 2017-11-30 |
| JP6715767B2 JP6715767B2 (ja) | 2020-07-01 |
Family
ID=52993499
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016526089A Expired - Fee Related JP6715767B2 (ja) | 2013-10-23 | 2014-10-22 | 好酸球性疾患の診断及び治療方法 |
| JP2020099159A Pending JP2020178692A (ja) | 2013-10-23 | 2020-06-08 | 好酸球性疾患の診断及び治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020099159A Pending JP2020178692A (ja) | 2013-10-23 | 2020-06-08 | 好酸球性疾患の診断及び治療方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20170067108A1 (enExample) |
| EP (1) | EP3060685B1 (enExample) |
| JP (2) | JP6715767B2 (enExample) |
| KR (1) | KR20160068802A (enExample) |
| CN (1) | CN105849280B (enExample) |
| AR (1) | AR098155A1 (enExample) |
| AU (1) | AU2014340129A1 (enExample) |
| BR (1) | BR112016008694A2 (enExample) |
| CA (1) | CA2924873A1 (enExample) |
| IL (1) | IL244709A0 (enExample) |
| MX (1) | MX2016005159A (enExample) |
| RU (1) | RU2016119425A (enExample) |
| SG (1) | SG11201603127WA (enExample) |
| WO (1) | WO2015061441A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI682781B (zh) | 2013-07-11 | 2020-01-21 | 美商再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| AU2015204674B2 (en) | 2014-01-10 | 2020-09-03 | Anaptysbio, Inc. | Antibodies directed against interleukin-33 (IL-33) |
| CN107109494B (zh) | 2014-11-10 | 2023-10-27 | 豪夫迈·罗氏有限公司 | Il-33介导型疾病的治疗方法和诊断方法 |
| CA2960297A1 (en) | 2014-11-10 | 2016-05-19 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| MX2018004170A (es) | 2015-10-06 | 2018-06-06 | Regeneron Pharma | Biomarcadores relacionados con enfermedades mediadas por interleucina-33 (il-33) y usos de los mismos. |
| WO2017189805A1 (en) | 2016-04-27 | 2017-11-02 | Abbvie Inc. | Methods of treatment of diseases in which il-13 activity is detrimental using anti-il-13 antibodies |
| WO2017197360A1 (en) * | 2016-05-13 | 2017-11-16 | The Regents Of The University Of California | Airway mucus impaction |
| PE20191548A1 (es) | 2017-02-10 | 2019-10-24 | Genentech Inc | Anticuerpos contra triptasa, composiciones de estos y usos de estos |
| JOP20190243A1 (ar) * | 2017-04-12 | 2019-10-13 | Medimmune Llc | علاج الربو بجسم مضاد لـ tslp |
| EP3624820A1 (en) | 2017-04-21 | 2020-03-25 | H. Hoffnabb-La Roche Ag | Use of klk5 antagonists for treatment of a disease |
| US20200132691A1 (en) * | 2017-04-24 | 2020-04-30 | The General Hospital Corporation | Detection and targeting of tumor-promoting neutrophils |
| US10676522B2 (en) * | 2017-05-05 | 2020-06-09 | Novartis Ag | Methods of selectively treating asthma using IL-17 antagonists |
| EA201992626A1 (ru) | 2017-05-05 | 2020-04-24 | Аллакос Инк. | Способы и композиции для лечения аллергических заболеваний глаз |
| IL315556A (en) * | 2017-08-04 | 2024-11-01 | Regeneron Pharma | Methods for treating active eosinophilic esophagitis |
| GB201718667D0 (en) * | 2017-11-10 | 2017-12-27 | Mologic Ltd | Monitoring inflammation status |
| US20210361693A1 (en) * | 2018-02-09 | 2021-11-25 | Empirico Inc. | Process to inhibit or eliminate eosinophilic diseases of the airway and related conditions |
| PE20211304A1 (es) | 2018-02-09 | 2021-07-20 | Genentech Inc | Metodos terapeuticos y diagnosticos para enfermedades inflamatorias mediadas por mastocitos |
| US20200040103A1 (en) | 2018-03-14 | 2020-02-06 | Genentech, Inc. | Anti-klk5 antibodies and methods of use |
| AU2019262167A1 (en) * | 2018-05-04 | 2020-12-10 | Allakos Inc. | Methods and compositions for treating chronic urticaria |
| CN108949954A (zh) * | 2018-07-03 | 2018-12-07 | 张罗 | 用于检测慢性鼻窦炎伴鼻息肉亚型的试剂盒及alox15基因作为生物标志物的应用 |
| WO2020007227A1 (zh) * | 2018-07-03 | 2020-01-09 | 首都医科大学附属北京同仁医院 | 检测慢性鼻窦炎伴鼻息肉亚型的方法和试剂盒及alox15基因作为生物标志物的应用 |
| CN108913764A (zh) * | 2018-07-03 | 2018-11-30 | 张罗 | 检测鼻腔脱落细胞中alox15基因表达量的方法及应用 |
| CN113195738B (zh) * | 2018-08-04 | 2025-01-28 | 帝国理工学院创新有限公司 | 识别患有川崎病的受试者的方法 |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| WO2020117840A2 (en) * | 2018-12-05 | 2020-06-11 | Empirico Inc. | Process to inhibit or eliminate eosinophilic diseases of the airway and related conditions |
| EP3911632A1 (en) | 2019-01-15 | 2021-11-24 | Empirico Inc. | Prodrugs of alox-15 inhibitors and methods of using the same |
| US20220170944A1 (en) * | 2019-01-31 | 2022-06-02 | The Regents Of The University Of California | Materials and methods for identifying and treating eosinophilic disorders |
| US20220259656A1 (en) * | 2019-05-03 | 2022-08-18 | Merck Sharp & Dohme Corp. | Blood biomarker and genetic markers associated with response to crth2 receptor antagonists |
| JP7704740B2 (ja) | 2019-09-16 | 2025-07-08 | アムジエン・インコーポレーテツド | 薬物送達デバイスの外部滅菌の方法 |
| CR20220156A (es) | 2019-09-18 | 2022-05-23 | Genentech Inc | Anticuerpos anti-klk7, anticuerpos anti-klk5, anticuerpos multiespecíficos anti-klk5/klk7 y métodos de uso |
| TW202144410A (zh) | 2020-03-13 | 2021-12-01 | 美商建南德克公司 | 抗介白素－３３抗體及其用途 |
| JP7572835B2 (ja) | 2020-10-26 | 2024-10-24 | 株式会社三井ハイテック | 分割型積層鉄心及び分割型積層鉄心の製造方法 |
| WO2023056254A1 (en) * | 2021-09-30 | 2023-04-06 | Regeneron Pharmaceuticals, Inc. | Reticulocalbin-3 (rcn3) variants and treatment of asthma with interleukin-4 receptor alpha (il4r) antagonists |
| WO2023091479A1 (en) * | 2021-11-17 | 2023-05-25 | AmMax Bio, Inc. | Detection and treatment of idiopathic pulmonary fibrosis |
| EP4540284A2 (en) | 2022-06-17 | 2025-04-23 | Apogee Therapeutics, Inc. | Antibodies that bind interleukin 13 and methods of use |
| DE102023114008B3 (de) | 2023-05-26 | 2024-09-12 | Precision For Medicine Gmbh | CRTH2 (PTGDR2) als epigenetischer Marker zur Identifizierung von Immunzellen |
| KR20250017928A (ko) * | 2023-07-28 | 2025-02-04 | 재단법인 아산사회복지재단 | 객담 단백체를 이용한 생물학적 제제에 대한 천식 치료 반응성 예측을 위한 바이오마커 및 이의 용도 |
| WO2025032112A1 (en) * | 2023-08-08 | 2025-02-13 | Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of type 2-mediated diseases |
| WO2025117848A1 (en) | 2023-12-01 | 2025-06-05 | Genentech, Inc. | Low-viscosity variants of antibodies |
| WO2025147585A1 (en) * | 2024-01-03 | 2025-07-10 | The Regents Of The University Of California | Use of epigenetic and genomic biomarkers for assessing drug response to type 2 inflammatory diseases |
Family Cites Families (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4018653A (en) | 1971-10-29 | 1977-04-19 | U.S. Packaging Corporation | Instrument for the detection of Neisseria gonorrhoeae without culture |
| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
| US4424279A (en) | 1982-08-12 | 1984-01-03 | Quidel | Rapid plunger immunoassay method and apparatus |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| WO1993006217A1 (en) | 1991-09-19 | 1993-04-01 | Genentech, Inc. | EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| ATE419355T1 (de) | 1992-02-06 | 2009-01-15 | Novartis Vaccines & Diagnostic | Marker für krebs und biosynthetisches bindeprotein dafür |
| WO1994029351A2 (en) | 1993-06-16 | 1994-12-22 | Celltech Limited | Antibodies |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| EP0994903B1 (en) | 1997-06-24 | 2005-05-25 | Genentech, Inc. | Methods and compositions for galactosylated glycoproteins |
| US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
| AU759779B2 (en) | 1997-10-31 | 2003-05-01 | Genentech Inc. | Methods and compositions comprising glycoprotein glycoforms |
| US6610833B1 (en) | 1997-11-24 | 2003-08-26 | The Institute For Human Genetics And Biochemistry | Monoclonal human natural antibodies |
| JP4460155B2 (ja) | 1997-12-05 | 2010-05-12 | ザ・スクリプス・リサーチ・インステイチユート | マウス抗体のヒト化 |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| DE69937291T2 (de) | 1998-04-02 | 2008-07-10 | Genentech, Inc., South San Francisco | Antikörpervarianten und fragmente davon |
| JP4334141B2 (ja) | 1998-04-20 | 2009-09-30 | グリカート バイオテクノロジー アクチェンゲゼルシャフト | 抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作 |
| BR0008758A (pt) | 1999-01-15 | 2001-12-04 | Genentech Inc | Variantes de polipeptìdeos parentais com funçãoefetora alterada, polipeptìdeos, composição ácidonucleico isolado, vetor, célula hospedeira,método para produzir uma variante depolipeptìdeo, método para o tratamento de umadesordem em mamìferos e método para produziruma região fc variante |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| CA2369292C (en) | 1999-04-09 | 2010-09-21 | Kyowa Hakko Kogyo Co. Ltd. | Method of modulating the activity of functional immune molecules |
| JP2003512821A (ja) | 1999-10-04 | 2003-04-08 | メディカゴ インコーポレイテッド | 外来性遺伝子の転写調節方法 |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| WO2001029246A1 (fr) | 1999-10-19 | 2001-04-26 | Kyowa Hakko Kogyo Co., Ltd. | Procede de production d'un polypeptide |
| US20030180714A1 (en) | 1999-12-15 | 2003-09-25 | Genentech, Inc. | Shotgun scanning |
| IL151865A0 (en) | 2000-03-31 | 2003-04-10 | Genentech Inc | Compositions and methods for detecting and quantifying gene expression |
| DK1272647T3 (en) | 2000-04-11 | 2014-12-15 | Genentech Inc | Multivalent antibodies and uses thereof |
| US7064191B2 (en) | 2000-10-06 | 2006-06-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
| EA013563B1 (ru) | 2000-10-06 | 2010-06-30 | Киова Хакко Кирин Ко., Лтд. | Трансгенное животное, продуцирующее антитела с измененными углеводными цепями, способ получения антител и содержащее антитела лекарственное средство |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| DK1354034T3 (da) | 2000-11-30 | 2008-03-25 | Medarex Inc | Transgene transchromosomale gnavere til fremstilling af humane antistoffer |
| CA2455365C (en) | 2001-08-03 | 2014-07-29 | Glycart Biotechnology Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| ATE430580T1 (de) | 2001-10-25 | 2009-05-15 | Genentech Inc | Glycoprotein-zusammensetzungen |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| CN1930288B (zh) | 2002-04-09 | 2012-08-08 | 协和发酵麒麟株式会社 | 基因组被修饰的细胞 |
| WO2003085119A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcϜ RECEPTOR IIIa |
| WO2003084570A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | DRUG CONTAINING ANTIBODY COMPOSITION APPROPRIATE FOR PATIENT SUFFERING FROM FcϜRIIIa POLYMORPHISM |
| CA2481920A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Antibody composition-containing medicament |
| ES2362419T3 (es) | 2002-04-09 | 2011-07-05 | Kyowa Hakko Kirin Co., Ltd. | Células con depresión o deleción de la actividad de la proteína que participa en el transporte de gdp-fucosa. |
| JPWO2003085118A1 (ja) | 2002-04-09 | 2005-08-11 | 協和醗酵工業株式会社 | 抗体組成物の製造方法 |
| CA2488441C (en) | 2002-06-03 | 2015-01-27 | Genentech, Inc. | Synthetic antibody phage libraries |
| US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| PT1572744E (pt) | 2002-12-16 | 2010-09-07 | Genentech Inc | Variantes de imunoglobulina e utilizações destas |
| US20050079574A1 (en) | 2003-01-16 | 2005-04-14 | Genentech, Inc. | Synthetic antibody phage libraries |
| US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| AU2004229501B2 (en) | 2003-04-11 | 2011-08-18 | Medimmune, Llc | Recombinant IL-9 antibodies and uses thereof |
| GB0407315D0 (en) | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
| AU2004279742A1 (en) | 2003-10-08 | 2005-04-21 | Kyowa Hakko Kirin Co., Ltd. | Fused protein composition |
| EP1705251A4 (en) | 2003-10-09 | 2009-10-28 | Kyowa Hakko Kirin Co Ltd | PROCESS FOR PRODUCING ANTIBODY COMPOSITION BY RNA INHIBITION OF FUNCTION OF $ G (A) 1,6-FUCOSYLTRANSFERASE |
| ME01775B (me) | 2003-11-05 | 2011-02-28 | Glycart Biotechnology Ag | Cd20 antitijela sa povećanim afinitetom vezivanja za fc receptor i efektornom funkcijom |
| JPWO2005053742A1 (ja) | 2003-12-04 | 2007-06-28 | 協和醗酵工業株式会社 | 抗体組成物を含有する医薬 |
| WO2005093092A2 (en) * | 2004-03-26 | 2005-10-06 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 44 (gpr44) |
| CA2561686C (en) | 2004-03-31 | 2014-12-02 | Genentech, Inc. | Humanized anti-tgf-beta antibodies |
| US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| BR122019012028B1 (pt) | 2004-04-13 | 2023-09-26 | F. Hoffmann-La Roche Ag | Anticorpos anti-p-selectina, molécula de ácido nucléico, vetor, e composição |
| US7745421B2 (en) * | 2004-05-25 | 2010-06-29 | The Johns Hopkins University | Methods and compositions for treating diseases and disorders associated with Siglec-8 expressing cells |
| US20070048785A1 (en) | 2004-06-09 | 2007-03-01 | Lin Laura L | Anti-IL-13 antibodies and complexes |
| AR049390A1 (es) | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
| US7501121B2 (en) | 2004-06-17 | 2009-03-10 | Wyeth | IL-13 binding agents |
| TWI307630B (en) | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
| TWI380996B (zh) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | 抗ｏｘ４０ｌ抗體 |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| JP2009510046A (ja) | 2005-09-30 | 2009-03-12 | メドイミューン・リミテッド | インターロイキン−１３抗体組成物 |
| ATE514793T1 (de) | 2005-09-30 | 2011-07-15 | Centocor Ortho Biotech Inc | Zusammensetzungen und verfahren für il13- biomarker |
| MY144906A (en) | 2005-10-21 | 2011-11-30 | Novartis Ag | Human antibodies against il13 and therapeutic uses |
| EP2465870A1 (en) | 2005-11-07 | 2012-06-20 | Genentech, Inc. | Binding polypeptides with diversified and consensus VH/VL hypervariable sequences |
| US20070237764A1 (en) | 2005-12-02 | 2007-10-11 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| MX2008008968A (es) | 2006-01-11 | 2008-09-10 | Aerovance Inc | Metodos y composiciones para tratar asma en primates humanos y no humanos. |
| GB0600488D0 (en) | 2006-01-11 | 2006-02-22 | Glaxo Group Ltd | Immunoglobulins |
| WO2007134050A2 (en) | 2006-05-09 | 2007-11-22 | Genentech, Inc. | Binding polypeptides with optimized scaffolds |
| ES2399075T3 (es) | 2006-08-30 | 2013-03-25 | Genentech, Inc. | Anticuerpos multiespecíficos |
| MY161894A (en) | 2006-09-08 | 2017-05-15 | Abbvie Bahamas Ltd | Interleukin-13 binding proteins |
| US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
| CN101600457B (zh) | 2007-01-09 | 2014-01-08 | 惠氏公司 | 抗il-13抗体调配物和其用途 |
| WO2008086043A2 (en) | 2007-01-10 | 2008-07-17 | Wyeth | Methods and compositions for assessment and treatment of asthma |
| WO2008091814A2 (en) * | 2007-01-22 | 2008-07-31 | Wyeth | Assessment of asthma and allergen-dependent gene expression |
| HRP20140661T1 (hr) | 2007-03-22 | 2014-10-10 | Genentech, Inc. | Apoptotiäśka protutijela anti-ige koja vežu ige spojen s membranom |
| PT2152290E (pt) | 2007-04-30 | 2014-09-03 | Glaxosmithkline Llc | Métodos para administrar anticorpos anti-il-5 |
| CN100592373C (zh) | 2007-05-25 | 2010-02-24 | 群康科技(深圳)有限公司 | 液晶显示面板驱动装置及其驱动方法 |
| EP2178547A4 (en) | 2007-07-11 | 2011-02-16 | Aerovance Inc | PHARMACEUTICAL FORMULATION OF POLYPEPTIDE DRY POWDER AEROSOL AND PROCESS FOR PREPARING THE SAME |
| PT2235064E (pt) | 2008-01-07 | 2016-03-01 | Amgen Inc | Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática |
| RU2607569C2 (ru) * | 2008-03-31 | 2017-01-10 | Дженентек, Инк. | Композиции и способы для лечения и диагностики астмы |
| FR2944448B1 (fr) | 2008-12-23 | 2012-01-13 | Adocia | Composition pharmaceutique stable comprenant au moins un anticorps monodonal et au moins un polysacharide amphiphile comprenant des substituants derives d'alcools hydrofobes ou d'amines hydrophobes. |
| KR101615474B1 (ko) | 2010-12-16 | 2016-04-25 | 제넨테크, 인크. | Th2 억제에 관한 진단 및 치료 |
| JP2015506950A (ja) | 2012-01-31 | 2015-03-05 | ジェネンテック， インコーポレイテッド | 抗ｉｇ−ｅｍ１’抗体およびそれを用いる方法 |
| MX370486B (es) * | 2012-03-27 | 2019-12-16 | Genentech Inc | Composiciones, métodos y usos para asistir en el diagnóstico, pronóstico y tratamiento de la fibrosis pulmonar idiopática. |
-
2014
- 2014-10-22 AR ARP140103970A patent/AR098155A1/es unknown
- 2014-10-22 MX MX2016005159A patent/MX2016005159A/es unknown
- 2014-10-22 WO PCT/US2014/061759 patent/WO2015061441A1/en not_active Ceased
- 2014-10-22 BR BR112016008694A patent/BR112016008694A2/pt not_active IP Right Cessation
- 2014-10-22 CN CN201480070162.0A patent/CN105849280B/zh not_active Expired - Fee Related
- 2014-10-22 KR KR1020167010399A patent/KR20160068802A/ko not_active Withdrawn
- 2014-10-22 JP JP2016526089A patent/JP6715767B2/ja not_active Expired - Fee Related
- 2014-10-22 CA CA2924873A patent/CA2924873A1/en not_active Abandoned
- 2014-10-22 AU AU2014340129A patent/AU2014340129A1/en not_active Abandoned
- 2014-10-22 RU RU2016119425A patent/RU2016119425A/ru not_active Application Discontinuation
- 2014-10-22 SG SG11201603127WA patent/SG11201603127WA/en unknown
- 2014-10-22 EP EP14856518.7A patent/EP3060685B1/en not_active Not-in-force
-
2016
- 2016-03-22 IL IL244709A patent/IL244709A0/en unknown
- 2016-04-22 US US15/136,677 patent/US20170067108A1/en not_active Abandoned
-
2018
- 2018-10-09 US US16/155,706 patent/US20190024178A1/en not_active Abandoned
-
2019
- 2019-11-01 US US16/671,903 patent/US20200165679A1/en not_active Abandoned
-
2020
- 2020-06-08 JP JP2020099159A patent/JP2020178692A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017501680A5 (enExample) | ||
| Agache et al. | Advances and highlights in asthma in 2021 | |
| RU2016119425A (ru) | Способы диагностики и лечения эозинофильных заболеваний | |
| Hinks et al. | Treatment options in type-2 low asthma | |
| Behrens et al. | MOR103, a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial | |
| Burmester et al. | Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis | |
| US9475872B2 (en) | Nucleic acid molecules encoding moonoclonal antibodies speceific for IL17F | |
| RU2013132733A (ru) | Способы диагностики и лечения, связанные с ингибированием th2 | |
| US10875916B2 (en) | Nucleic acid molecules encoding monoclonal antibodies specific for IL-17F | |
| Holgate | Asthma: a simple concept but in reality a complex disease | |
| Zheng et al. | Expression of interleukin‐22 in myasthenia gravis | |
| Zeng et al. | Antibody therapies in autoimmune inflammatory myopathies: promising treatment options | |
| JP6923215B2 (ja) | 抗ｈｔｌｖ−１剤、ｈｔｌｖ−１関連脊髄症（ｈａｍ／ｔｓｐ）治療薬 | |
| US11156600B2 (en) | Assay for detecting TH1 and TH2 cell populations | |
| Giovannini-Chami et al. | New insights into the treatment of severe asthma in children | |
| Chimenti et al. | Remission of psoriatic arthritis after etanercept discontinuation: analysis of patients' clinical characteristics leading to disease relapse | |
| Guida et al. | Eosinophilic phenotype: the lesson from research models to severe asthma | |
| JP7193054B2 (ja) | 自己免疫疾患の臨床転帰を評価するための方法及びキット | |
| Rupani et al. | Eosinophilic asthma | |
| Clienti et al. | Monoclonal antibodies for the treatment of severe asthma | |
| Cobo-Ibanez et al. | Etanercept: long-term clinical experience in rheumatoid arthritis and other arthritis | |
| Mohan et al. | Biomarkers, targeted therapies, biologics, and bronchial thermoplasty | |
| HK40006590A (en) | Assay for detecting th1 and th2 cell populations | |
| Mease et al. | IL-17 inhibition in spondyloarthritis: a targeted approach in psoriatic arthritis | |
| Webb | Immunopharmacology |