JP2014508930A5 - - Google Patents
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- Publication number
- JP2014508930A5 JP2014508930A5 JP2013554602A JP2013554602A JP2014508930A5 JP 2014508930 A5 JP2014508930 A5 JP 2014508930A5 JP 2013554602 A JP2013554602 A JP 2013554602A JP 2013554602 A JP2013554602 A JP 2013554602A JP 2014508930 A5 JP2014508930 A5 JP 2014508930A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- tnfα drug
- labeled
- therapy
- tnfα
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161444097P | 2011-02-17 | 2011-02-17 | |
| US61/444,097 | 2011-02-17 | ||
| US201161484594P | 2011-05-10 | 2011-05-10 | |
| US61/484,594 | 2011-05-10 | ||
| US201161496501P | 2011-06-13 | 2011-06-13 | |
| US61/496,501 | 2011-06-13 | ||
| PCT/US2012/025437 WO2012154253A1 (en) | 2011-02-17 | 2012-02-16 | ASSAYS FOR DETECTING AUTOANTIBODIES TO ANTI-TNFα DRUGS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014508930A JP2014508930A (ja) | 2014-04-10 |
| JP2014508930A5 true JP2014508930A5 (enExample) | 2015-03-19 |
| JP6063398B2 JP6063398B2 (ja) | 2017-01-18 |
Family
ID=45809635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013554602A Expired - Fee Related JP6063398B2 (ja) | 2011-02-17 | 2012-02-16 | 抗ＴＮＦα薬に対する自己抗体を検出するためのアッセイ |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20140045276A1 (enExample) |
| EP (1) | EP2676137B1 (enExample) |
| JP (1) | JP6063398B2 (enExample) |
| KR (1) | KR20140008397A (enExample) |
| CN (1) | CN103502815B (enExample) |
| AU (1) | AU2012254150B2 (enExample) |
| BR (1) | BR112013020981A2 (enExample) |
| CA (1) | CA2827609A1 (enExample) |
| DK (1) | DK2676137T3 (enExample) |
| ES (1) | ES2530175T3 (enExample) |
| IL (1) | IL227853A (enExample) |
| MX (1) | MX343327B (enExample) |
| RU (1) | RU2013142278A (enExample) |
| SG (1) | SG192770A1 (enExample) |
| WO (1) | WO2012154253A1 (enExample) |
| ZA (1) | ZA201306950B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| CN104634955B (zh) | 2009-10-26 | 2016-09-14 | 雀巢产品技术援助有限公司 | 检测抗-tnf药物和自身抗体的试验 |
| WO2012054532A1 (en) | 2010-10-18 | 2012-04-26 | Prometheus Laboratories Inc. | Methods for determining anti-drug antibody isotypes |
| WO2013006810A1 (en) | 2011-07-06 | 2013-01-10 | Nestec Sa | Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha |
| WO2014055025A1 (en) * | 2012-10-03 | 2014-04-10 | Gyros Patent Ab | Method and kit for analyte determination at acidic conditions |
| ES2638971T3 (es) | 2012-10-05 | 2017-10-24 | Nestec S.A. | Métodos para predecir y monitorizar la cicatrización de la mucosa |
| BR112015012482A2 (pt) * | 2012-11-30 | 2017-07-11 | Nestec Sa | ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicos |
| WO2014122600A1 (en) | 2013-02-05 | 2014-08-14 | Nestec S.A. | Methods of selecting combination therapy for colorectal cancer patients |
| PT3387898T (pt) | 2013-03-15 | 2020-06-17 | Mayo Found Medical Education & Res | Identificação e monitorização de imunoglobulinas monoclonais pela massa molecular |
| KR20240122922A (ko) | 2013-03-27 | 2024-08-13 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전 |
| KR20210107176A (ko) | 2013-05-17 | 2021-08-31 | 세다르스-신나이 메디칼 센터 | 크론병과 연관된 tnfsf15와 dcr3의 변이체 |
| EP3022295A4 (en) | 2013-07-19 | 2017-03-01 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| EP3654037A1 (en) | 2013-12-03 | 2020-05-20 | Prometheus Biosciences, Inc. | Methods for predicting post-operative recurrence of crohn's disease |
| WO2015110989A1 (en) | 2014-01-23 | 2015-07-30 | Nestec S.A. | Biomarker panel for assessment of mucosal healing |
| EP4137816B1 (en) | 2014-02-11 | 2025-03-19 | Genzyme Corporation | Assays for detecting the presence or amount of an anti-drug antibody |
| JP6759104B2 (ja) | 2014-04-04 | 2020-09-23 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 精密分子質量を用いた免疫グロブリンのアイソタイピング |
| CN104034896A (zh) * | 2014-06-19 | 2014-09-10 | 华北制药集团新药研究开发有限责任公司 | 一种双抗体夹心elisa检测方法 |
| US10690676B2 (en) | 2014-07-29 | 2020-06-23 | Mayo Roundation for Medical Education and Research | Quantifying monoclonal antibody therapeutics by LC-MS/MS |
| MX2017004742A (es) * | 2014-10-20 | 2017-07-20 | Nestec Sa | Métodos para la predicción de niveles de farmacos anti-tnf alfa y formación de autoanticuerpos. |
| CN107076761B (zh) * | 2014-11-05 | 2020-05-05 | 豪夫迈·罗氏有限公司 | 用于测定针对效应子功能抑制的人或人源化药物抗体的抗药物抗体的方法 |
| RU2017122720A (ru) | 2014-12-05 | 2019-01-10 | Нестек С.А. | Непрямые однородные анализы по изменению подвижности для детекции биологических препаратов в образцах пациента |
| US11085931B2 (en) | 2015-01-09 | 2021-08-10 | W. Health L.P. | Universal assay for determining the quantity of TNFα inhibitory drugs and their corresponding anti-drug-antibodies |
| WO2016135707A1 (en) | 2015-02-27 | 2016-09-01 | Nestec S.A. | Diagnosis of major depressive disorder, mild cognitive impairment, and alzheimer's disease and other neurologic and psychiatric disorders |
| JP6968058B2 (ja) | 2015-09-24 | 2021-11-17 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 質量分析法による免疫グロブリン遊離軽鎖の同定 |
| ES2815224T3 (es) * | 2015-11-06 | 2021-03-29 | Promise Proteomics | Un método para cuantificar anticuerpos terapéuticos |
| CN109462996A (zh) | 2016-03-17 | 2019-03-12 | 西达-赛奈医疗中心 | 通过rnaset2诊断炎性肠病的方法 |
| US11119096B2 (en) | 2016-07-08 | 2021-09-14 | W. Health L.P. | Universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples |
| CN118443922A (zh) * | 2016-09-06 | 2024-08-06 | 富士瑞必欧株式会社 | 肿瘤标记物的测定方法及测定试剂 |
| US10955420B2 (en) | 2016-09-07 | 2021-03-23 | Mayo Foundation For Medical Education And Research | Identification and monitoring of cleaved immunoglobulins by molecular mass |
| EP3681528B1 (en) | 2017-09-13 | 2025-07-23 | Mayo Foundation for Medical Education and Research | Identification and monitoring of apoptosis inhibitor of macrophage |
| WO2019055632A1 (en) | 2017-09-13 | 2019-03-21 | Mayo Foundation For Medical Education And Research | IDENTIFICATION AND MONITORING OF IMMUNOGLOBULIN CHAINS J |
| JP7161534B2 (ja) * | 2017-11-29 | 2022-10-26 | エフ．ホフマン－ラ ロシュ アーゲー | 標的による干渉が抑制された抗薬物抗体アッセイ |
| JP7474240B2 (ja) * | 2018-08-03 | 2024-04-24 | ブリストル－マイヤーズ スクイブ カンパニー | 抗薬物抗体を検出するための方法 |
| WO2020112890A1 (en) | 2018-11-29 | 2020-06-04 | Cedars-Sinai Medical Center | Rnaset2 compositions and methods of treatment therewith |
| US12378245B2 (en) | 2019-02-11 | 2025-08-05 | Phoenix Molecular Designs | Crystalline forms of an RSK inhibitor |
| JP2020115139A (ja) * | 2020-03-11 | 2020-07-30 | 国立大学法人千葉大学 | 血管炎の検査方法 |
| CN112362649B (zh) * | 2020-11-09 | 2024-07-12 | 长春金赛药业有限责任公司 | 一种rhGH中和抗体的检测方法 |
| KR102562006B1 (ko) | 2020-11-09 | 2023-08-02 | 바디텍메드(주) | 항tnf-알파 약물 모니터링을 위한 신속 검출 키트 |
| KR102568430B1 (ko) * | 2020-11-16 | 2023-08-24 | 바디텍메드(주) | 항 약물 항체의 신속 검출 방법 |
| CN114236139A (zh) * | 2021-12-30 | 2022-03-25 | 苏州和锐生物科技有限公司 | 一种TNF-α生物制剂的抗体检测试剂盒、制备方法 |
Family Cites Families (38)
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| US4459359A (en) * | 1981-11-19 | 1984-07-10 | New York Blood Center, Inc. | Sensitive immunoassays of antigens or antibodies sequestered within immune complexes |
| FR2590674B1 (fr) * | 1985-11-25 | 1989-03-03 | Inst Nat Sante Rech Med | Nouveaux reactifs de diagnostic |
| DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
| US5094740A (en) * | 1990-02-16 | 1992-03-10 | Glycomed, Inc. | Two-dimensional electrophoretic separation of carbohydrates |
| GB9028123D0 (en) * | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
| US6074835A (en) | 1996-04-12 | 2000-06-13 | Regents Of The Univ. Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1 |
| US6033864A (en) | 1996-04-12 | 2000-03-07 | The Regents Of The University Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens |
| US6406862B1 (en) | 1998-10-06 | 2002-06-18 | The United States Of America As Represented By The Secretary Of The Army | Dip-stick assay for C-reactive protein |
| PT1159003E (pt) * | 1999-03-02 | 2011-02-22 | Centocor Inc | Anti-tnf alfa na terapêutica da asma resistente a esteróides |
| US6309643B1 (en) | 1999-04-30 | 2001-10-30 | The Regents Of The University Of California | IBD-associated microbial antigens and methods of using same |
| FR2802536B1 (fr) | 1999-11-23 | 2003-06-13 | Chru Lille | Oligomannosides de synthese, leur preparation et leur utilisation a la detection d'anticorps et a la prevention d'infections |
| FR2806739B1 (fr) | 2000-03-27 | 2005-02-18 | Fond Jean Dausset Ceph | Genes impliques dans les maladies inflammatoires de l'intestin et leur utilisation |
| US6838250B2 (en) | 2000-03-31 | 2005-01-04 | Ortho-Clinical Diagnostics, Inc. | Immunoassay for C-reactive protein |
| US7138237B1 (en) | 2000-05-19 | 2006-11-21 | Cedars-Sinai Medical Center | Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen |
| DK1330525T3 (da) | 2000-10-30 | 2013-03-04 | Univ Michigan | NOD2-nukleinsyrer og proteiner |
| CA2427471C (en) | 2000-10-30 | 2010-12-21 | The Regents Of The University Of Michigan | Nod2 nucleic acids and proteins |
| ES2325059T3 (es) | 2000-11-14 | 2009-08-25 | Techlab, Inc. | Metodo para diferenciar el sindrome del intestino irritable de la enfermedad inflamatoria intestinal (ibd) y para seguir personas con ibd usando la lactoferrina endogena total como marcador. |
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| US20040053263A1 (en) | 2002-08-30 | 2004-03-18 | Abreu Maria T. | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
| DE60321027D1 (de) | 2002-10-25 | 2008-06-26 | Techlab Inc | Diagnostisches panel ibd-first chek fur entzundliche darmerkrankung (ibd) und reizkolon |
| US7662569B2 (en) | 2003-04-11 | 2010-02-16 | Cedars-Sinai Medical Center | Methods of assessing Crohn's disease patient phenotype by I2 serologic response |
| CA2549971A1 (en) | 2003-11-03 | 2005-05-12 | Duke University | Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke |
| EP1769244A4 (en) * | 2004-06-30 | 2008-05-14 | Dow Kenneth Centocor Inc | DETECTION OR MEASUREMENT OF ANTIGEN PROTEIN ANTIBODIES IN BIOLOGICAL TISSUE OR SAMPLES |
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| US20110066624A1 (en) | 2006-08-01 | 2011-03-17 | Divyank Turakhia | system and method of generating related words and word concepts |
| CN104198705B (zh) | 2006-09-21 | 2017-06-09 | 雀巢产品技术援助有限公司 | 检测稀有循环细胞内多种信号转导分子的基于抗体的阵列 |
| NZ582618A (en) | 2007-07-13 | 2012-07-27 | Prometheus Lab Inc | Drug selection for lung cancer therapy using antibody-based arrays |
| US20090035216A1 (en) * | 2007-08-03 | 2009-02-05 | Biomonitor Aps | Method for determining in vivo biopharmaceutical concentration or bioavailability |
| WO2009022001A1 (en) * | 2007-08-16 | 2009-02-19 | Novartis Ag | Improvement of drug tolerance in immunogenicity testing |
| WO2009091240A1 (en) * | 2008-01-15 | 2009-07-23 | Stichting Sanquin Bloedvoorziening | Method and kits for detecting antibodies against therapeutic antibodies |
| ES2553390T3 (es) | 2008-02-25 | 2015-12-09 | Nestec S.A. | Método para la detección de receptores truncados intracelulares |
| US20110195524A1 (en) * | 2008-10-07 | 2011-08-11 | Mats Inganas | Semi-sequential assay for detection of an analyte in a sample |
| NZ596468A (en) | 2009-05-14 | 2013-11-29 | Nestec Sa | Biomarkers for determining sensitivity of breast cancer cells to her2-targeted therapy |
| JP5795311B2 (ja) | 2009-07-15 | 2015-10-14 | ネステク ソシエテ アノニム | 抗体ベースのアレイを使用する胃癌療法のための薬物選択 |
| US8408369B2 (en) | 2009-09-08 | 2013-04-02 | GM Global Technology Operations LLC | Bimetallic brake rotor |
| DK2491385T3 (en) | 2009-10-20 | 2017-08-28 | Diatech Holdings Inc | PROXIMITY-MEDIED ASSAYS FOR DETECTING ONCOGEN FUSION PROTEINS |
| CN104634955B (zh) * | 2009-10-26 | 2016-09-14 | 雀巢产品技术援助有限公司 | 检测抗-tnf药物和自身抗体的试验 |
-
2012
- 2012-02-16 MX MX2013009570A patent/MX343327B/es active IP Right Grant
- 2012-02-16 ES ES12707193.4T patent/ES2530175T3/es active Active
- 2012-02-16 BR BR112013020981A patent/BR112013020981A2/pt not_active Application Discontinuation
- 2012-02-16 JP JP2013554602A patent/JP6063398B2/ja not_active Expired - Fee Related
- 2012-02-16 DK DK12707193.4T patent/DK2676137T3/en active
- 2012-02-16 EP EP12707193.4A patent/EP2676137B1/en active Active
- 2012-02-16 AU AU2012254150A patent/AU2012254150B2/en not_active Ceased
- 2012-02-16 SG SG2013061692A patent/SG192770A1/en unknown
- 2012-02-16 CN CN201280018741.1A patent/CN103502815B/zh not_active Expired - Fee Related
- 2012-02-16 WO PCT/US2012/025437 patent/WO2012154253A1/en not_active Ceased
- 2012-02-16 KR KR1020137024583A patent/KR20140008397A/ko not_active Ceased
- 2012-02-16 RU RU2013142278/15A patent/RU2013142278A/ru not_active Application Discontinuation
- 2012-02-16 CA CA2827609A patent/CA2827609A1/en not_active Abandoned
-
2013
- 2013-08-07 US US13/961,841 patent/US20140045276A1/en not_active Abandoned
- 2013-09-03 IL IL227853A patent/IL227853A/en active IP Right Grant
- 2013-09-16 ZA ZA2013/06950A patent/ZA201306950B/en unknown
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