JP2014508930A5 - - Google Patents
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- Publication number
- JP2014508930A5 JP2014508930A5 JP2013554602A JP2013554602A JP2014508930A5 JP 2014508930 A5 JP2014508930 A5 JP 2014508930A5 JP 2013554602 A JP2013554602 A JP 2013554602A JP 2013554602 A JP2013554602 A JP 2013554602A JP 2014508930 A5 JP2014508930 A5 JP 2014508930A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- tnfα drug
- labeled
- therapy
- tnfα
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161444097P | 2011-02-17 | 2011-02-17 | |
| US61/444,097 | 2011-02-17 | ||
| US201161484594P | 2011-05-10 | 2011-05-10 | |
| US61/484,594 | 2011-05-10 | ||
| US201161496501P | 2011-06-13 | 2011-06-13 | |
| US61/496,501 | 2011-06-13 | ||
| PCT/US2012/025437 WO2012154253A1 (en) | 2011-02-17 | 2012-02-16 | ASSAYS FOR DETECTING AUTOANTIBODIES TO ANTI-TNFα DRUGS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014508930A JP2014508930A (ja) | 2014-04-10 |
| JP2014508930A5 true JP2014508930A5 (enExample) | 2015-03-19 |
| JP6063398B2 JP6063398B2 (ja) | 2017-01-18 |
Family
ID=45809635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013554602A Expired - Fee Related JP6063398B2 (ja) | 2011-02-17 | 2012-02-16 | 抗ＴＮＦα薬に対する自己抗体を検出するためのアッセイ |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20140045276A1 (enExample) |
| EP (1) | EP2676137B1 (enExample) |
| JP (1) | JP6063398B2 (enExample) |
| KR (1) | KR20140008397A (enExample) |
| CN (1) | CN103502815B (enExample) |
| AU (1) | AU2012254150B2 (enExample) |
| BR (1) | BR112013020981A2 (enExample) |
| CA (1) | CA2827609A1 (enExample) |
| DK (1) | DK2676137T3 (enExample) |
| ES (1) | ES2530175T3 (enExample) |
| IL (1) | IL227853A (enExample) |
| MX (1) | MX343327B (enExample) |
| RU (1) | RU2013142278A (enExample) |
| SG (1) | SG192770A1 (enExample) |
| WO (1) | WO2012154253A1 (enExample) |
| ZA (1) | ZA201306950B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010062960A2 (en) | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE |
| KR101881714B1 (ko) | 2009-10-26 | 2018-07-24 | 네스텍 소시에테아노님 | 항-ｔｎｆ 약물 및 자가항체의 검출을 위한 검정법 |
| JP5960707B2 (ja) | 2010-10-18 | 2016-08-02 | ネステク ソシエテ アノニム | 抗薬物抗体アイソタイプを決定するための方法 |
| EP3130921B1 (en) | 2011-07-06 | 2018-09-12 | Nestec S.A. | Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha |
| CN104718453B (zh) | 2012-10-03 | 2017-03-08 | Gyros专利公司 | 酸性条件下分析物测定用方法和试剂盒 |
| ES2638971T3 (es) | 2012-10-05 | 2017-10-24 | Nestec S.A. | Métodos para predecir y monitorizar la cicatrización de la mucosa |
| BR112015012482A2 (pt) * | 2012-11-30 | 2017-07-11 | Nestec Sa | ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicos |
| EP2954329A1 (en) | 2013-02-05 | 2015-12-16 | Nestec S.A. | Methods of selecting combination therapy for colorectal cancer patients |
| DK3387898T3 (da) | 2013-03-15 | 2020-08-03 | Mayo Found Medical Education & Res | Identificering og monitorering af monoklonale immunglobuliner ved hjælp af molekylvægt |
| KR20230109779A (ko) | 2013-03-27 | 2023-07-20 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 |
| CN105358713B (zh) | 2013-05-17 | 2020-02-28 | 雪松-西奈医学中心 | 与克罗恩病相关的tnfsf15和dcr3的变体 |
| EP4105236A1 (en) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease |
| CA2932571A1 (en) | 2013-12-03 | 2015-06-11 | Nestec S.A. | Methods for predicting post-operative recurrence of crohn's disease |
| WO2015110989A1 (en) | 2014-01-23 | 2015-07-30 | Nestec S.A. | Biomarker panel for assessment of mucosal healing |
| MX374652B (es) | 2014-02-11 | 2025-03-06 | Genzyme Corp | Ensayos para detectar la presencia o la cantidad de un anticuerpo antifármaco. |
| CA2944767C (en) | 2014-04-04 | 2022-07-12 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
| CN104034896A (zh) * | 2014-06-19 | 2014-09-10 | 华北制药集团新药研究开发有限责任公司 | 一种双抗体夹心elisa检测方法 |
| WO2016018978A1 (en) * | 2014-07-29 | 2016-02-04 | Mayo Foundation For Medical Education And Research | Quantifying monoclonal antibody therapeutics by lc-ms/ms |
| MX2017004742A (es) * | 2014-10-20 | 2017-07-20 | Nestec Sa | Métodos para la predicción de niveles de farmacos anti-tnf alfa y formación de autoanticuerpos. |
| BR112017004810A2 (pt) * | 2014-11-05 | 2017-12-12 | Hoffmann La Roche | imunoensaio |
| EP3536705A1 (en) | 2014-12-05 | 2019-09-11 | Société des Produits Nestlé S.A. | Isolated soluble alpha-4 integrin, beta-7 integrin and alpha-4/beta-7 heterodimer integrin |
| CN107110853A (zh) | 2015-01-09 | 2017-08-29 | 阿通诺米斯公司 | 确定TNFα抑制药及其相应抗药抗体的量的通用测定法 |
| WO2016135707A1 (en) | 2015-02-27 | 2016-09-01 | Nestec S.A. | Diagnosis of major depressive disorder, mild cognitive impairment, and alzheimer's disease and other neurologic and psychiatric disorders |
| EP3353200A4 (en) | 2015-09-24 | 2019-06-26 | Mayo Foundation for Medical Education and Research | IDENTIFICATION OF FREE LIGHT CHAINS FROM IMMOBILIZED LOBULIN BY MASS SPECTROMETRY |
| EP3165922B1 (en) * | 2015-11-06 | 2020-06-17 | Promise Proteomics | A method for quantifying therapeutic antibodies |
| KR20180127416A (ko) | 2016-03-17 | 2018-11-28 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
| EP3482199A1 (en) | 2016-07-08 | 2019-05-15 | Atonomics A/S | A universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples |
| JP7060510B2 (ja) * | 2016-09-06 | 2022-04-26 | 富士レビオ株式会社 | 腫瘍マーカーの測定方法及び測定試薬 |
| EP3523647B1 (en) | 2016-09-07 | 2024-06-26 | Mayo Foundation for Medical Education and Research | Identification and monitoring of cleaved immunoglobulins by molecular mass |
| EP3681528B1 (en) | 2017-09-13 | 2025-07-23 | Mayo Foundation for Medical Education and Research | Identification and monitoring of apoptosis inhibitor of macrophage |
| EP3681907A4 (en) | 2017-09-13 | 2021-07-07 | Mayo Foundation for Medical Education and Research | IDENTIFICATION AND MONITORING OF IMMUNOGLOBULIN J-CHAINS |
| MX2020004921A (es) * | 2017-11-29 | 2020-08-27 | Hoffmann La Roche | Ensayo de anticuerpo antifarmaco con supresion de interferencia del objetivo. |
| US12385913B2 (en) * | 2018-08-03 | 2025-08-12 | Bristol-Myers Squibb Company | Methods for detecting anti-drug antibodies |
| CA3121162A1 (en) | 2018-11-29 | 2020-06-04 | Cedars-Sinai Medical Center | Rnaset2 compositions and methods of treatment therewith |
| KR20210126077A (ko) | 2019-02-11 | 2021-10-19 | 피닉스 몰레큘라 디자인스 | Rsk 억제제의 결정형 |
| JP2020115139A (ja) * | 2020-03-11 | 2020-07-30 | 国立大学法人千葉大学 | 血管炎の検査方法 |
| CN112362649B (zh) * | 2020-11-09 | 2024-07-12 | 长春金赛药业有限责任公司 | 一种rhGH中和抗体的检测方法 |
| KR102562006B1 (ko) | 2020-11-09 | 2023-08-02 | 바디텍메드(주) | 항tnf-알파 약물 모니터링을 위한 신속 검출 키트 |
| KR102568430B1 (ko) * | 2020-11-16 | 2023-08-24 | 바디텍메드(주) | 항 약물 항체의 신속 검출 방법 |
| CN114236139A (zh) * | 2021-12-30 | 2022-03-25 | 苏州和锐生物科技有限公司 | 一种TNF-α生物制剂的抗体检测试剂盒、制备方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4459359A (en) * | 1981-11-19 | 1984-07-10 | New York Blood Center, Inc. | Sensitive immunoassays of antigens or antibodies sequestered within immune complexes |
| FR2590674B1 (fr) * | 1985-11-25 | 1989-03-03 | Inst Nat Sante Rech Med | Nouveaux reactifs de diagnostic |
| DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
| US5094740A (en) * | 1990-02-16 | 1992-03-10 | Glycomed, Inc. | Two-dimensional electrophoretic separation of carbohydrates |
| GB9028123D0 (en) * | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
| US6033864A (en) | 1996-04-12 | 2000-03-07 | The Regents Of The University Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens |
| US6074835A (en) | 1996-04-12 | 2000-06-13 | Regents Of The Univ. Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1 |
| US6406862B1 (en) | 1998-10-06 | 2002-06-18 | The United States Of America As Represented By The Secretary Of The Army | Dip-stick assay for C-reactive protein |
| WO2000051637A1 (en) * | 1999-03-02 | 2000-09-08 | Centocor, Inc. | ANTI-TNFα ANTIBODIES IN THERAPY OF ASTHMA |
| US6309643B1 (en) | 1999-04-30 | 2001-10-30 | The Regents Of The University Of California | IBD-associated microbial antigens and methods of using same |
| FR2802536B1 (fr) | 1999-11-23 | 2003-06-13 | Chru Lille | Oligomannosides de synthese, leur preparation et leur utilisation a la detection d'anticorps et a la prevention d'infections |
| FR2806739B1 (fr) | 2000-03-27 | 2005-02-18 | Fond Jean Dausset Ceph | Genes impliques dans les maladies inflammatoires de l'intestin et leur utilisation |
| US6838250B2 (en) | 2000-03-31 | 2005-01-04 | Ortho-Clinical Diagnostics, Inc. | Immunoassay for C-reactive protein |
| US7138237B1 (en) | 2000-05-19 | 2006-11-21 | Cedars-Sinai Medical Center | Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen |
| AU2002227350B2 (en) | 2000-10-30 | 2007-03-22 | Regents Of The University Of Michigan | Nod2 nucleic acids and proteins |
| EP1404712B1 (en) | 2000-10-30 | 2014-06-18 | The Regents Of The University Of Michigan | Nod2 nucleic acids and proteins |
| EP2071332A1 (en) | 2000-11-14 | 2009-06-17 | Techlab, Inc. | Method for monitoring persons with IBD using total endogeneous lactoferrin as a marker |
| EP1581119B1 (en) | 2001-12-17 | 2013-01-30 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of inflammatory bowel disease |
| US20040053263A1 (en) | 2002-08-30 | 2004-03-18 | Abreu Maria T. | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
| ATE395596T1 (de) | 2002-10-25 | 2008-05-15 | Techlab Inc | Diagnostisches panel ibd-first chek fur entzundliche darmerkrankung (ibd) und reizkolon |
| US7662569B2 (en) | 2003-04-11 | 2010-02-16 | Cedars-Sinai Medical Center | Methods of assessing Crohn's disease patient phenotype by I2 serologic response |
| CA2549971A1 (en) | 2003-11-03 | 2005-05-12 | Duke University | Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke |
| WO2006004958A2 (en) * | 2004-06-30 | 2006-01-12 | Centocor, Inc. | Detection or measurement of antibodies to antigenic proteins in biological tissues or samples |
| WO2006012472A1 (en) | 2004-07-21 | 2006-02-02 | Qualyst, Inc. | Apparatus, kits and methods for evaluating binding interactions, for detecting and quantifying binding molecules, and for sample preparation |
| JP2007147367A (ja) * | 2005-11-25 | 2007-06-14 | Sekisui Chem Co Ltd | サイトカイン産生能の測定方法 |
| WO2008059515A2 (en) | 2006-08-01 | 2008-05-22 | Divyank Turakhia | A system and method of generating related words and word concepts |
| WO2008036802A2 (en) | 2006-09-21 | 2008-03-27 | Prometheus Laboratories Inc. | Antibody-based arrays for detecting multiple signal transducers in rare circulating cells |
| BRPI0813583A2 (pt) | 2007-07-13 | 2014-12-30 | Prometheus Lab Inc | Métodos para selecionar um medicamento anticâncer, para identificar a resposta de um tumor pulmonar, e para prognosticar a resposta de um paciente, e, arranjo |
| US20090035216A1 (en) * | 2007-08-03 | 2009-02-05 | Biomonitor Aps | Method for determining in vivo biopharmaceutical concentration or bioavailability |
| WO2009022001A1 (en) * | 2007-08-16 | 2009-02-19 | Novartis Ag | Improvement of drug tolerance in immunogenicity testing |
| WO2009091240A1 (en) * | 2008-01-15 | 2009-07-23 | Stichting Sanquin Bloedvoorziening | Method and kits for detecting antibodies against therapeutic antibodies |
| NZ600339A (en) | 2008-02-25 | 2013-12-20 | Nestec Sa | Drug selection for breast cancer therapy using antibody-based arrays |
| JP5634405B2 (ja) * | 2008-10-07 | 2014-12-03 | ユィロス・パテント・アクチボラグＧｙｒｏｓ Ｐａｔｅｎｔ ＡＢ | 試料中のアナライトの検出のための半逐次アッセイ |
| EP2430443B1 (en) | 2009-05-14 | 2018-06-27 | Pierian Holdings, Inc. | Biomarkers for determining sensitivity of breast cancer cells to her2-targeted therapy |
| AU2010273319B2 (en) | 2009-07-15 | 2015-01-22 | Nestec S.A. | Drug selection for gastric cancer therapy using antibody-based arrays |
| US8408369B2 (en) | 2009-09-08 | 2013-04-02 | GM Global Technology Operations LLC | Bimetallic brake rotor |
| MX337666B (es) | 2009-10-20 | 2016-03-14 | Nestec Sa | Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas. |
| KR101881714B1 (ko) * | 2009-10-26 | 2018-07-24 | 네스텍 소시에테아노님 | 항-ｔｎｆ 약물 및 자가항체의 검출을 위한 검정법 |
-
2012
- 2012-02-16 ES ES12707193.4T patent/ES2530175T3/es active Active
- 2012-02-16 SG SG2013061692A patent/SG192770A1/en unknown
- 2012-02-16 BR BR112013020981A patent/BR112013020981A2/pt not_active Application Discontinuation
- 2012-02-16 WO PCT/US2012/025437 patent/WO2012154253A1/en not_active Ceased
- 2012-02-16 EP EP12707193.4A patent/EP2676137B1/en active Active
- 2012-02-16 AU AU2012254150A patent/AU2012254150B2/en not_active Ceased
- 2012-02-16 MX MX2013009570A patent/MX343327B/es active IP Right Grant
- 2012-02-16 CN CN201280018741.1A patent/CN103502815B/zh not_active Expired - Fee Related
- 2012-02-16 KR KR1020137024583A patent/KR20140008397A/ko not_active Ceased
- 2012-02-16 JP JP2013554602A patent/JP6063398B2/ja not_active Expired - Fee Related
- 2012-02-16 DK DK12707193.4T patent/DK2676137T3/en active
- 2012-02-16 CA CA2827609A patent/CA2827609A1/en not_active Abandoned
- 2012-02-16 RU RU2013142278/15A patent/RU2013142278A/ru not_active Application Discontinuation
-
2013
- 2013-08-07 US US13/961,841 patent/US20140045276A1/en not_active Abandoned
- 2013-09-03 IL IL227853A patent/IL227853A/en active IP Right Grant
- 2013-09-16 ZA ZA2013/06950A patent/ZA201306950B/en unknown
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