RU2013142278A - ТЕСТЫ ДЛЯ ДЕТЕКЦИИ АУТОАНТИТЕЛ К АНТИ-TNFα ЛЕКАРСТВЕННЫМ СРЕДСТВАМ - Google Patents
ТЕСТЫ ДЛЯ ДЕТЕКЦИИ АУТОАНТИТЕЛ К АНТИ-TNFα ЛЕКАРСТВЕННЫМ СРЕДСТВАМ Download PDFInfo
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- RU2013142278A RU2013142278A RU2013142278/15A RU2013142278A RU2013142278A RU 2013142278 A RU2013142278 A RU 2013142278A RU 2013142278/15 A RU2013142278/15 A RU 2013142278/15A RU 2013142278 A RU2013142278 A RU 2013142278A RU 2013142278 A RU2013142278 A RU 2013142278A
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- Prior art keywords
- tnfα drug
- sample
- autoantibody
- labeled
- acid
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Links
- 239000003814 drug Substances 0.000 title claims abstract 38
- 238000001514 detection method Methods 0.000 title claims 2
- 229940079593 drug Drugs 0.000 claims abstract 37
- 238000000034 method Methods 0.000 claims abstract 35
- 239000002253 acid Substances 0.000 claims abstract 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract 6
- 229960001743 golimumab Drugs 0.000 claims abstract 6
- 108010008165 Etanercept Proteins 0.000 claims abstract 5
- 150000007524 organic acids Chemical class 0.000 claims abstract 5
- 238000001542 size-exclusion chromatography Methods 0.000 claims abstract 5
- 230000003472 neutralizing effect Effects 0.000 claims abstract 4
- 229960002964 adalimumab Drugs 0.000 claims abstract 3
- 229960003115 certolizumab pegol Drugs 0.000 claims abstract 3
- 238000010494 dissociation reaction Methods 0.000 claims abstract 3
- 230000005593 dissociations Effects 0.000 claims abstract 3
- 229960000403 etanercept Drugs 0.000 claims abstract 3
- 229940048921 humira Drugs 0.000 claims abstract 3
- 229960000598 infliximab Drugs 0.000 claims abstract 3
- 150000007522 mineralic acids Chemical class 0.000 claims abstract 3
- 239000000203 mixture Substances 0.000 claims abstract 3
- 229940116176 remicade Drugs 0.000 claims abstract 3
- 229940068638 simponi Drugs 0.000 claims abstract 3
- 238000002560 therapeutic procedure Methods 0.000 claims 11
- 238000003998 size exclusion chromatography high performance liquid chromatography Methods 0.000 claims 4
- 241001325209 Nama Species 0.000 claims 2
- 238000002651 drug therapy Methods 0.000 claims 2
- 229940073621 enbrel Drugs 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 230000001988 toxicity Effects 0.000 claims 2
- 231100000419 toxicity Toxicity 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- WVCHIGAIXREVNS-UHFFFAOYSA-N 2-hydroxy-1,4-naphthoquinone Chemical compound C1=CC=C2C(O)=CC(=O)C(=O)C2=C1 WVCHIGAIXREVNS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161444097P | 2011-02-17 | 2011-02-17 | |
| US61/444,097 | 2011-02-17 | ||
| US201161484594P | 2011-05-10 | 2011-05-10 | |
| US61/484,594 | 2011-05-10 | ||
| US201161496501P | 2011-06-13 | 2011-06-13 | |
| US61/496,501 | 2011-06-13 | ||
| PCT/US2012/025437 WO2012154253A1 (en) | 2011-02-17 | 2012-02-16 | ASSAYS FOR DETECTING AUTOANTIBODIES TO ANTI-TNFα DRUGS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013142278A true RU2013142278A (ru) | 2015-03-27 |
Family
ID=45809635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013142278/15A RU2013142278A (ru) | 2011-02-17 | 2012-02-16 | ТЕСТЫ ДЛЯ ДЕТЕКЦИИ АУТОАНТИТЕЛ К АНТИ-TNFα ЛЕКАРСТВЕННЫМ СРЕДСТВАМ |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20140045276A1 (enExample) |
| EP (1) | EP2676137B1 (enExample) |
| JP (1) | JP6063398B2 (enExample) |
| KR (1) | KR20140008397A (enExample) |
| CN (1) | CN103502815B (enExample) |
| AU (1) | AU2012254150B2 (enExample) |
| BR (1) | BR112013020981A2 (enExample) |
| CA (1) | CA2827609A1 (enExample) |
| DK (1) | DK2676137T3 (enExample) |
| ES (1) | ES2530175T3 (enExample) |
| IL (1) | IL227853A (enExample) |
| MX (1) | MX343327B (enExample) |
| RU (1) | RU2013142278A (enExample) |
| SG (1) | SG192770A1 (enExample) |
| WO (1) | WO2012154253A1 (enExample) |
| ZA (1) | ZA201306950B (enExample) |
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| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| AU2010315547C1 (en) | 2009-10-26 | 2015-06-04 | Société des Produits Nestlé S.A. | Assays for the detection of anti-TNF drugs and autoantibodies |
| AU2011317149B2 (en) | 2010-10-18 | 2015-05-07 | Société des Produits Nestlé S.A. | Methods for determining anti-drug antibody isotypes |
| RU2013158256A (ru) | 2011-07-06 | 2015-07-10 | Нестек С.А. | АНАЛИЗЫ ДЛЯ ОБНАРУЖЕНИЯ НЕЙТРАЛИЗУЮЩИХ АУТОАНТИТЕЛ ДЛЯ БИОЛОГИЧЕСКОЙ ТЕРАПИИ TNFα |
| CN104718453B (zh) | 2012-10-03 | 2017-03-08 | Gyros专利公司 | 酸性条件下分析物测定用方法和试剂盒 |
| MX358730B (es) | 2012-10-05 | 2018-09-03 | Nestec Sa | Metodos para predecir y monitorear cicatrizacion de la mucosa. |
| BR112015012482A2 (pt) * | 2012-11-30 | 2017-07-11 | Nestec Sa | ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicos |
| WO2014122600A1 (en) | 2013-02-05 | 2014-08-14 | Nestec S.A. | Methods of selecting combination therapy for colorectal cancer patients |
| EP3639841B1 (en) | 2013-03-27 | 2023-09-06 | Cedars-Sinai Medical Center | Treating fibrosis by inhibiting tl1a |
| KR102295125B1 (ko) | 2013-05-17 | 2021-08-31 | 세다르스-신나이 메디칼 센터 | 크론병과 연관된 tnfsf15와 dcr3의 변이체 |
| EP3022295A4 (en) | 2013-07-19 | 2017-03-01 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| EP3654037A1 (en) | 2013-12-03 | 2020-05-20 | Prometheus Biosciences, Inc. | Methods for predicting post-operative recurrence of crohn's disease |
| WO2015110989A1 (en) | 2014-01-23 | 2015-07-30 | Nestec S.A. | Biomarker panel for assessment of mucosal healing |
| SG11201606291VA (en) | 2014-02-11 | 2016-08-30 | Genzyme Corp | Assays for detecting the presence or amount of an anti-drug antibody |
| US10267806B2 (en) | 2014-04-04 | 2019-04-23 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
| CN104034896A (zh) * | 2014-06-19 | 2014-09-10 | 华北制药集团新药研究开发有限责任公司 | 一种双抗体夹心elisa检测方法 |
| US10690676B2 (en) | 2014-07-29 | 2020-06-23 | Mayo Roundation for Medical Education and Research | Quantifying monoclonal antibody therapeutics by LC-MS/MS |
| WO2016063204A1 (en) * | 2014-10-20 | 2016-04-28 | Nestec S.A. | Methods for prediction of anti-tnf alpha drug levels and autoantibody formation |
| JP6739428B2 (ja) * | 2014-11-05 | 2020-08-12 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | エフェクター機能抑制型ヒトまたはヒト化薬物抗体に対する抗薬物抗体の決定方法 |
| ES2735085T3 (es) | 2014-12-05 | 2019-12-16 | Nestle Sa | Ensayos de cambio de movilidad homogéneos indirectos para la detección de agentes biológicos en muestras de pacientes |
| US11085931B2 (en) | 2015-01-09 | 2021-08-10 | W. Health L.P. | Universal assay for determining the quantity of TNFα inhibitory drugs and their corresponding anti-drug-antibodies |
| WO2016135707A1 (en) | 2015-02-27 | 2016-09-01 | Nestec S.A. | Diagnosis of major depressive disorder, mild cognitive impairment, and alzheimer's disease and other neurologic and psychiatric disorders |
| US11209439B2 (en) | 2015-09-24 | 2021-12-28 | Mayo Foundation For Medical Education And Research | Identification of immunoglobulin free light chains by mass spectrometry |
| ES2815224T3 (es) * | 2015-11-06 | 2021-03-29 | Promise Proteomics | Un método para cuantificar anticuerpos terapéuticos |
| JP7082945B2 (ja) | 2016-03-17 | 2022-06-09 | シーダーズ―シナイ メディカル センター | Ｒｎａｓｅｔ２により炎症性腸疾患を診断する方法 |
| EP3482199A1 (en) | 2016-07-08 | 2019-05-15 | Atonomics A/S | A universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples |
| CN118443922A (zh) * | 2016-09-06 | 2024-08-06 | 富士瑞必欧株式会社 | 肿瘤标记物的测定方法及测定试剂 |
| US10955420B2 (en) | 2016-09-07 | 2021-03-23 | Mayo Foundation For Medical Education And Research | Identification and monitoring of cleaved immunoglobulins by molecular mass |
| US11946937B2 (en) | 2017-09-13 | 2024-04-02 | Mayo Foundation For Medical Education And Research | Identification and monitoring of apoptosis inhibitor of macrophage |
| US12153052B2 (en) | 2017-09-13 | 2024-11-26 | Mayo Foundation For Medical Education And Research | Identification and monitoring of immunoglobulin J chains |
| PL3717916T3 (pl) * | 2017-11-29 | 2025-04-07 | F. Hoffmann-La Roche Ag | Test do oznaczania przeciwciał przeciwlekowych z tłumieniem oddziaływania z cząsteczką docelową |
| ES3038185T3 (en) * | 2018-08-03 | 2025-10-10 | Bristol Myers Squibb Co | Methods for detecting anti-drug antibodies |
| EP3924352A4 (en) | 2019-02-11 | 2022-11-16 | Phoenix Molecular Designs | CRYSTALLINE FORMS OF AN RSK INHIBITOR |
| JP2020115139A (ja) * | 2020-03-11 | 2020-07-30 | 国立大学法人千葉大学 | 血管炎の検査方法 |
| KR102562006B1 (ko) | 2020-11-09 | 2023-08-02 | 바디텍메드(주) | 항tnf-알파 약물 모니터링을 위한 신속 검출 키트 |
| CN112362649B (zh) * | 2020-11-09 | 2024-07-12 | 长春金赛药业有限责任公司 | 一种rhGH中和抗体的检测方法 |
| KR102568430B1 (ko) * | 2020-11-16 | 2023-08-24 | 바디텍메드(주) | 항 약물 항체의 신속 검출 방법 |
| CN114236139A (zh) * | 2021-12-30 | 2022-03-25 | 苏州和锐生物科技有限公司 | 一种TNF-α生物制剂的抗体检测试剂盒、制备方法 |
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| CN103399144B (zh) | 2008-02-25 | 2015-10-28 | 雀巢产品技术援助有限公司 | 用抗体阵列选择乳腺癌治疗药物 |
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| AU2010315547C1 (en) | 2009-10-26 | 2015-06-04 | Société des Produits Nestlé S.A. | Assays for the detection of anti-TNF drugs and autoantibodies |
-
2012
- 2012-02-16 ES ES12707193.4T patent/ES2530175T3/es active Active
- 2012-02-16 KR KR1020137024583A patent/KR20140008397A/ko not_active Ceased
- 2012-02-16 JP JP2013554602A patent/JP6063398B2/ja not_active Expired - Fee Related
- 2012-02-16 DK DK12707193.4T patent/DK2676137T3/en active
- 2012-02-16 BR BR112013020981A patent/BR112013020981A2/pt not_active Application Discontinuation
- 2012-02-16 SG SG2013061692A patent/SG192770A1/en unknown
- 2012-02-16 CA CA2827609A patent/CA2827609A1/en not_active Abandoned
- 2012-02-16 EP EP12707193.4A patent/EP2676137B1/en active Active
- 2012-02-16 CN CN201280018741.1A patent/CN103502815B/zh not_active Expired - Fee Related
- 2012-02-16 AU AU2012254150A patent/AU2012254150B2/en not_active Ceased
- 2012-02-16 MX MX2013009570A patent/MX343327B/es active IP Right Grant
- 2012-02-16 WO PCT/US2012/025437 patent/WO2012154253A1/en not_active Ceased
- 2012-02-16 RU RU2013142278/15A patent/RU2013142278A/ru not_active Application Discontinuation
-
2013
- 2013-08-07 US US13/961,841 patent/US20140045276A1/en not_active Abandoned
- 2013-09-03 IL IL227853A patent/IL227853A/en active IP Right Grant
- 2013-09-16 ZA ZA2013/06950A patent/ZA201306950B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL227853A0 (en) | 2013-09-30 |
| AU2012254150B2 (en) | 2015-08-13 |
| KR20140008397A (ko) | 2014-01-21 |
| AU2012254150A1 (en) | 2013-05-02 |
| EP2676137A1 (en) | 2013-12-25 |
| WO2012154253A1 (en) | 2012-11-15 |
| HK1191688A1 (en) | 2014-08-01 |
| DK2676137T3 (en) | 2015-01-19 |
| EP2676137B1 (en) | 2014-12-31 |
| ZA201306950B (en) | 2015-04-29 |
| SG192770A1 (en) | 2013-09-30 |
| NZ614170A (en) | 2015-04-24 |
| ES2530175T3 (es) | 2015-02-26 |
| JP2014508930A (ja) | 2014-04-10 |
| CA2827609A1 (en) | 2012-11-15 |
| CN103502815B (zh) | 2015-09-23 |
| MX2013009570A (es) | 2013-09-06 |
| IL227853A (en) | 2017-07-31 |
| BR112013020981A2 (pt) | 2016-10-11 |
| JP6063398B2 (ja) | 2017-01-18 |
| MX343327B (es) | 2016-11-01 |
| CN103502815A (zh) | 2014-01-08 |
| US20140045276A1 (en) | 2014-02-13 |
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