MX337666B - Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas. - Google Patents

Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas.

Info

Publication number
MX337666B
MX337666B MX2012004619A MX2012004619A MX337666B MX 337666 B MX337666 B MX 337666B MX 2012004619 A MX2012004619 A MX 2012004619A MX 2012004619 A MX2012004619 A MX 2012004619A MX 337666 B MX337666 B MX 337666B
Authority
MX
Mexico
Prior art keywords
fusion proteins
oncogenic fusion
total amount
proximity
present
Prior art date
Application number
MX2012004619A
Other languages
English (en)
Other versions
MX2012004619A (es
Inventor
Sharat Singh
Xinjun Liu
Original Assignee
Nestec Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nestec Sa filed Critical Nestec Sa
Publication of MX2012004619A publication Critical patent/MX2012004619A/es
Publication of MX337666B publication Critical patent/MX337666B/es

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57575—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La presente invención se refiere a matrices basadas en anticuerpos para detectar el estado de activación cantidad total y/o cantidad total de una o una pluralidad de proteínas de fusión oncogénicas en una muestra biológica como sangre con todas sus fracciones o tejido tumoral y métodos de uso de lo mismo. En ciertos casos, el estado de activación y/o la cantidad total de proteínas de fusión oncogénicas presentes en una muestra puede cuantificarse combinada con una o una pluralidad de moléculas de la transducción de señal. Las composiciones y métodos de la presente invención tienen las ventajas de especificidad asociada a ensayos de inmunoabsorción enzimática, sensibilidad asociada con amplificación de la señal y multiplexión de alto rendimiento asociada con micromatrices.
MX2012004619A 2009-10-20 2010-10-20 Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas. MX337666B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25339309P 2009-10-20 2009-10-20
US30508410P 2010-02-16 2010-02-16
US32748710P 2010-04-23 2010-04-23
US38303710P 2010-09-15 2010-09-15
PCT/US2010/053386 WO2011050069A1 (en) 2009-10-20 2010-10-20 Proximity-mediated assays for detecting oncogenic fusion proteins

Publications (2)

Publication Number Publication Date
MX2012004619A MX2012004619A (es) 2012-05-08
MX337666B true MX337666B (es) 2016-03-14

Family

ID=43242385

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012004619A MX337666B (es) 2009-10-20 2010-10-20 Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas.

Country Status (16)

Country Link
US (1) US20120277109A1 (es)
EP (1) EP2491385B1 (es)
JP (3) JP5819307B2 (es)
KR (1) KR20120110168A (es)
CN (1) CN102667478B (es)
AU (1) AU2010310746B2 (es)
BR (1) BR112012009296A2 (es)
CA (1) CA2777934A1 (es)
DK (1) DK2491385T3 (es)
ES (1) ES2637853T3 (es)
IL (1) IL219313A (es)
MX (1) MX337666B (es)
NZ (1) NZ599460A (es)
RU (1) RU2558797C2 (es)
WO (1) WO2011050069A1 (es)
ZA (1) ZA201202957B (es)

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EP2491385B1 (en) 2017-05-10
IL219313A (en) 2017-03-30
RU2012120722A (ru) 2013-11-27
EP2491385A1 (en) 2012-08-29
JP6301892B2 (ja) 2018-03-28
RU2558797C2 (ru) 2015-08-10
KR20120110168A (ko) 2012-10-09
WO2011050069A1 (en) 2011-04-28
NZ599460A (en) 2014-07-25
CN102667478A (zh) 2012-09-12
AU2010310746A1 (en) 2012-05-03
BR112012009296A2 (pt) 2021-02-02
CN102667478B (zh) 2018-06-01
JP5819307B2 (ja) 2015-11-24
MX2012004619A (es) 2012-05-08
AU2010310746B2 (en) 2015-07-23
DK2491385T3 (en) 2017-08-28
CA2777934A1 (en) 2011-04-28
JP2016028251A (ja) 2016-02-25
JP2018119975A (ja) 2018-08-02
JP2013508728A (ja) 2013-03-07
ZA201202957B (en) 2017-01-25
ES2637853T3 (es) 2017-10-17

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