MX337666B - Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas. - Google Patents
Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas.Info
- Publication number
- MX337666B MX337666B MX2012004619A MX2012004619A MX337666B MX 337666 B MX337666 B MX 337666B MX 2012004619 A MX2012004619 A MX 2012004619A MX 2012004619 A MX2012004619 A MX 2012004619A MX 337666 B MX337666 B MX 337666B
- Authority
- MX
- Mexico
- Prior art keywords
- oncogenic fusion
- fusion proteins
- present
- proximity
- detecting
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
La presente invención se refiere a matrices basadas en anticuerpos para detectar el estado de activación cantidad total y/o cantidad total de una o una pluralidad de proteínas de fusión oncogénicas en una muestra biológica como sangre con todas sus fracciones o tejido tumoral y métodos de uso de lo mismo. En ciertos casos, el estado de activación y/o la cantidad total de proteínas de fusión oncogénicas presentes en una muestra puede cuantificarse combinada con una o una pluralidad de moléculas de la transducción de señal. Las composiciones y métodos de la presente invención tienen las ventajas de especificidad asociada a ensayos de inmunoabsorción enzimática, sensibilidad asociada con amplificación de la señal y multiplexión de alto rendimiento asociada con micromatrices.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25339309P | 2009-10-20 | 2009-10-20 | |
US30508410P | 2010-02-16 | 2010-02-16 | |
US32748710P | 2010-04-23 | 2010-04-23 | |
US38303710P | 2010-09-15 | 2010-09-15 | |
PCT/US2010/053386 WO2011050069A1 (en) | 2009-10-20 | 2010-10-20 | Proximity-mediated assays for detecting oncogenic fusion proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012004619A MX2012004619A (es) | 2012-05-08 |
MX337666B true MX337666B (es) | 2016-03-14 |
Family
ID=43242385
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012004619A MX337666B (es) | 2009-10-20 | 2010-10-20 | Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20120277109A1 (es) |
EP (1) | EP2491385B1 (es) |
JP (3) | JP5819307B2 (es) |
KR (1) | KR20120110168A (es) |
CN (1) | CN102667478B (es) |
AU (1) | AU2010310746B2 (es) |
BR (1) | BR112012009296A2 (es) |
CA (1) | CA2777934A1 (es) |
DK (1) | DK2491385T3 (es) |
ES (1) | ES2637853T3 (es) |
IL (1) | IL219313A (es) |
MX (1) | MX337666B (es) |
NZ (1) | NZ599460A (es) |
RU (1) | RU2558797C2 (es) |
WO (1) | WO2011050069A1 (es) |
ZA (1) | ZA201202957B (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120065092A1 (en) * | 2010-09-14 | 2012-03-15 | Wai Hobert | Fusion analyte cytometric bead assay, and systems and kits for performing the same |
KR20140002711A (ko) | 2010-12-23 | 2014-01-08 | 네스텍 소시에테아노님 | 항체-기반 어레이를 사용한 악성 암 치료를 위한 약물 선별법 |
DK2676137T3 (en) | 2011-02-17 | 2015-01-19 | Nestec Sa | TESTS TO DETECT AUTO ANTIBODIES FOR ANTI-TNF PHARMACEUTICALS |
EP2681552A2 (en) | 2011-03-02 | 2014-01-08 | Nestec S.A. | Prediction of drug sensitivity of lung tumors based on molecular and genetic signatures |
CN102676648A (zh) * | 2011-03-07 | 2012-09-19 | 重庆医科大学附属儿童医院 | 白血病诊疗的基因芯片 |
ES2639650T3 (es) | 2011-04-04 | 2017-10-27 | Pierian Holdings, Inc. | Métodos para predecir y mejorar la supervivencia de pacientes con cáncer gástrico |
RU2013154566A (ru) | 2011-05-10 | 2015-06-20 | Нестек С.А. | Способы анализа профиля активности болезни с целью проведения индивидуального лечения |
WO2012155019A1 (en) * | 2011-05-12 | 2012-11-15 | Genentech, Inc. | Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature pepides |
WO2013049398A2 (en) * | 2011-09-28 | 2013-04-04 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Protein-protein interaction as biomarkers |
US9335292B2 (en) | 2011-10-13 | 2016-05-10 | Auburn University | Electrochemical proximity assay |
WO2013086031A1 (en) | 2011-12-05 | 2013-06-13 | Nestec S.A. | Method of therapy selection for patients with cancer |
JP6517018B2 (ja) * | 2012-02-09 | 2019-05-22 | ヴァー2・ファーマシューティカルズ・アンパルトセルスカブVAR2 Pharmaceuticals ApS | コンドロイチン硫酸グリカンのターゲティング |
US10041950B2 (en) | 2012-03-27 | 2018-08-07 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
JP2014030572A (ja) * | 2012-08-03 | 2014-02-20 | Akira Sakai | 抗がん剤投与装置 |
US9422602B2 (en) | 2012-08-15 | 2016-08-23 | Bio-Rad Laboratories, Inc. | Methods and compositions for determining nucleic acid degradation |
SG11201502646RA (en) | 2012-10-05 | 2015-05-28 | Nestec Sa | Methods for predicting and monitoring mucosal healing |
CN103792364B (zh) * | 2012-10-31 | 2016-06-08 | 张宝弘 | 用于检测外周血中循环肿瘤细胞ror1蛋白的试剂及其应用 |
WO2014122600A1 (en) | 2013-02-05 | 2014-08-14 | Nestec S.A. | Methods of selecting combination therapy for colorectal cancer patients |
WO2014122599A1 (en) | 2013-02-05 | 2014-08-14 | Nestec S.A. | Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling |
EP2954068B8 (en) | 2013-02-05 | 2018-10-31 | Pierian Holdings, Inc. | Drug selection for non-small cell lung cancer therapy |
CN104007257B (zh) * | 2013-02-24 | 2017-02-08 | 北京莱尔生物医药科技有限公司 | 一种检测非体液性稀有有核细胞的方法和试剂盒 |
WO2014141306A2 (en) * | 2013-03-15 | 2014-09-18 | Rajiv Gandhi Centre For Biotechnology | Methods and materials for identifying therapeutic response in chronic myeloid leukemia |
KR20160009070A (ko) | 2013-05-21 | 2016-01-25 | 네스텍 소시에테아노님 | 대장암 환자의 생존율 예측 및 개선 방법 |
WO2015110989A1 (en) | 2014-01-23 | 2015-07-30 | Nestec S.A. | Biomarker panel for assessment of mucosal healing |
GB2524519B (en) * | 2014-03-25 | 2019-11-06 | Pelago Bioscience AB | Methods for identifying a biomarker indicative of a reduced drug response using a thermal shift assay |
WO2016000966A1 (en) * | 2014-06-30 | 2016-01-07 | Nestec S.A. | Collaborative enzyme enhanced reactive (ceer) immunoassay using flow cytometry |
EP3210016A1 (en) | 2014-10-20 | 2017-08-30 | Nestec S.A. | Methods for prediction of anti-tnf alpha drug levels and autoantibody formation |
US11149299B2 (en) * | 2015-06-25 | 2021-10-19 | Ramesh Vallabhaneni | Method and system for multiplex profiling of chromosomes in biological samples using target-specific DNA probes |
TWI734775B (zh) * | 2016-04-26 | 2021-08-01 | 美商美國泰福生技股份有限公司 | 細胞培養基 |
CN106645728A (zh) * | 2016-11-09 | 2017-05-10 | 百奥森(江苏)食品安全科技有限公司 | 一种食品中氟喹诺酮类药物的检测试剂盒 |
CN110191705A (zh) * | 2016-12-01 | 2019-08-30 | 亚尼塔公司 | 治疗癌症的方法 |
US10852274B2 (en) | 2017-03-09 | 2020-12-01 | Auburn University | Differential circuit for background correction in electrochemical measurements |
KR20180117529A (ko) * | 2017-04-19 | 2018-10-29 | 주식회사 프로티나 | 단백질-단백질 상호작용 분석에 의한 약물 반응성 예측 방법 |
EP3612843A1 (en) | 2017-05-31 | 2020-02-26 | Prometheus Biosciences, Inc. | Methods for assessing mucosal healing in crohn's disease patients |
US11505799B2 (en) | 2017-07-07 | 2022-11-22 | Innamed, Inc. | Aptamers for measuring lipoprotein levels |
US11560565B2 (en) | 2018-06-13 | 2023-01-24 | Auburn University | Electrochemical detection nanostructure, systems, and uses thereof |
CN109439759A (zh) * | 2018-12-18 | 2019-03-08 | 武汉迪安医学检验实验室有限公司 | 一种用于检测CBFβ-MYH11融合基因的试剂盒 |
WO2020140927A1 (en) * | 2019-01-02 | 2020-07-09 | Crownmab Biotech Inc. | Cancer treatment using multi-targeted kinase inhibitor in combination of protein kinase biomarkers |
WO2023286723A1 (ja) | 2021-07-13 | 2023-01-19 | キヤノン株式会社 | 検体の分析方法および検体分析装置 |
WO2023058624A1 (ja) * | 2021-10-08 | 2023-04-13 | コニカミノルタ株式会社 | 染色方法、評価方法および標本 |
Family Cites Families (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4197199A (en) | 1977-10-25 | 1980-04-08 | Manor Engineering Company Limited | Filter presses |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
US5532138A (en) | 1990-04-26 | 1996-07-02 | Behringwerke Ag | Method and kits for determining peroxidatively active catalysts |
US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
WO1992021032A1 (en) | 1991-05-24 | 1992-11-26 | The Regents Of The University Of California | Methods for the detection of bcr-abl and abnormal abl proteins in leukemia patients |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
DE69333807T2 (de) | 1992-02-06 | 2006-02-02 | Chiron Corp., Emeryville | Marker für krebs und biosynthetisches bindeprotein dafür |
JP3571337B2 (ja) | 1992-02-11 | 2004-09-29 | セル ジェネシス,インコーポレーテッド | 遺伝子標的現象による同型遺伝子接合 |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
US5332662A (en) | 1992-07-31 | 1994-07-26 | Syntex (U.S.A.) Inc. | Methods for determining peroxidatively active substances |
ATE149570T1 (de) | 1992-08-17 | 1997-03-15 | Genentech Inc | Bispezifische immunoadhesine |
US5618829A (en) | 1993-01-28 | 1997-04-08 | Mitsubishi Chemical Corporation | Tyrosine kinase inhibitors and benzoylacrylamide derivatives |
US5728868A (en) | 1993-07-15 | 1998-03-17 | Cancer Research Campaign Technology Limited | Prodrugs of protein tyrosine kinase inhibitors |
WO1995004136A1 (en) * | 1993-07-29 | 1995-02-09 | Cor Therapeutics, Inc. | Receptor function assays |
JP3498960B2 (ja) | 1993-09-03 | 2004-02-23 | デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 蛍光酸素チャンネリングイムノアッセイ |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
US6107457A (en) | 1995-02-16 | 2000-08-22 | Board Of Regents, The University Of Texas System | Bcr-Abl directed compositions and uses for inhibiting Philadelphia chromosome stimulated cell growth |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
US5639757A (en) | 1995-05-23 | 1997-06-17 | Pfizer Inc. | 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors |
PL190489B1 (pl) | 1996-04-12 | 2005-12-30 | Warner Lambert Co | Nieodwracalne inhibitory kinaz tyrozyny, kompozycja farmaceutyczna je zawierająca i ich zastosowanie |
US6057098A (en) | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
DK0983510T3 (da) * | 1997-05-20 | 2004-07-05 | Univ Erasmus | Genkendelse af tumorspecifikke genprodukter i cancer |
US6686165B2 (en) | 1997-05-20 | 2004-02-03 | Erasmus Universiteit Rotterdam | Recognition of tumor-specific gene products in cancer |
ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
US6100254A (en) | 1997-10-10 | 2000-08-08 | Board Of Regents, The University Of Texas System | Inhibitors of protein tyrosine kinases |
US6897073B2 (en) | 1998-07-14 | 2005-05-24 | Zyomyx, Inc. | Non-specific binding resistant protein arrays and methods for making the same |
US6780582B1 (en) | 1998-07-14 | 2004-08-24 | Zyomyx, Inc. | Arrays of protein-capture agents and methods of use thereof |
US6197599B1 (en) | 1998-07-30 | 2001-03-06 | Guorong Chin | Method to detect proteins |
US6740665B1 (en) | 1999-02-10 | 2004-05-25 | Ramachandran Murali | Tyrosine kinase inhibitors and methods of using the same |
US6245759B1 (en) | 1999-03-11 | 2001-06-12 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
WO2001000207A1 (en) | 1999-06-30 | 2001-01-04 | Merck & Co., Inc. | Src kinase inhibitor compounds |
EP1194152A4 (en) | 1999-06-30 | 2002-11-06 | Merck & Co Inc | SIN KINASE INHIBITOR COMPOUNDS |
WO2001000213A1 (en) | 1999-06-30 | 2001-01-04 | Merck & Co., Inc. | Src kinase inhibitor compounds |
US7179638B2 (en) | 1999-07-30 | 2007-02-20 | Large Scale Biology Corporation | Microarrays and their manufacture by slicing |
BR0013899A (pt) | 1999-09-10 | 2003-07-08 | Merck & Co Inc | Composto, composição farmacêutica, processos de tratamento ou prevenção de câncer, de uma doença em que a angiogênese esteja implicada, da vascularização retinal, da retinopatia diabética, da degeneração macular relacionada a idade, de doenças inflamatórias, de uma doença ou condições dependentes da tirosina quinase, de patologias associadas com ossos, e, processos para produzir uma composição farmacêutica, e de reduzir ou prevenir dano tecidual em seguida a um evento isquêmico cerebral |
BR0014843A (pt) | 1999-10-19 | 2002-06-11 | Merck & Co Inc | Composto, composição farmacêutica, métodos para tratar ou prevenir o câncer em um mamìfero, uma doença em que a angiogênese está implicada, a vascularização retinal, a retinipatia diabética, a degeneração macular relacionada com a idade, doença inflamatória, uma doença ou condição dependente de tirosina quinase e, patologias relacionadas com o osso, processo para fabricar uma composição farmacêutica, e, método para reduzir ou impedir o dano de tecido que segue um evento isquêmico |
US6794393B1 (en) | 1999-10-19 | 2004-09-21 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
AU778042B2 (en) | 1999-10-19 | 2004-11-11 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US6313138B1 (en) | 2000-02-25 | 2001-11-06 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US6420382B2 (en) | 2000-02-25 | 2002-07-16 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
AU2001277245A1 (en) | 2000-08-03 | 2002-02-18 | Massachusetts Institute Of Technology | Microarrays of functional biomolecules, and uses therefor |
US20020132274A1 (en) * | 2001-01-17 | 2002-09-19 | Nevalainen Marja T. | Diagnostic and monitorings methods for cancer |
US6777239B2 (en) | 2001-04-17 | 2004-08-17 | Xenoport, Inc. | Epitope-captured antibody display |
ATE316088T1 (de) | 2001-06-22 | 2006-02-15 | Merck & Co Inc | Tyrosin-kinase inhibitoren |
WO2003011836A1 (en) | 2001-08-01 | 2003-02-13 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US6927293B2 (en) | 2001-08-30 | 2005-08-09 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US20030190689A1 (en) * | 2002-04-05 | 2003-10-09 | Cell Signaling Technology,Inc. | Molecular profiling of disease and therapeutic response using phospho-specific antibodies |
US20030153013A1 (en) | 2002-11-07 | 2003-08-14 | Ruo-Pan Huang | Antibody-based protein array system |
US7354773B2 (en) * | 2003-05-14 | 2008-04-08 | Beckman Coulter, Inc. | Method and apparatus for preparing cell samples for intracellular antigen detection using flow cytometry |
EP1507147A1 (en) | 2003-08-12 | 2005-02-16 | Erasmus University Medical Center Rotterdam | Method for detecting low levels of a fusion protein |
US20050214301A1 (en) | 2004-03-24 | 2005-09-29 | Cell Signaling Technology, Inc. | Antibodies specific for BCR-ABL fusion protein and uses thereof |
US20060263837A1 (en) | 2004-06-17 | 2006-11-23 | Liu George D | Immunoassay system and method for detection of antigens |
US7771955B2 (en) | 2005-06-09 | 2010-08-10 | University Of Maryland | Affinity membrane for capture of a target biomolecule and formation thereof by site-directed immobilization of a capture biomolecule |
DE212006000071U1 (de) * | 2005-11-18 | 2008-07-24 | Board of Regents, The University of Texas System, Austin | Quantifizierung von Fusionsproteinen und ihrer Aktivität in Folge chromosomaler Translokation |
KR101485303B1 (ko) | 2006-09-21 | 2015-01-22 | 네스텍 소시에테아노님 | 희귀 순환세포 내의 다수의 신호전달인자를 검출하기 위한 항체 기반 분석법 |
BRPI0717416A2 (pt) | 2006-09-21 | 2013-11-12 | Prometheus Lab Inc | Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo |
US9250243B2 (en) | 2006-09-21 | 2016-02-02 | Nestec S.A. | Drug selection for lung cancer therapy using antibody-based arrays |
JP2008261764A (ja) * | 2007-04-13 | 2008-10-30 | Kyowa Hakko Kogyo Co Ltd | キナーゼ阻害物質の測定方法 |
GB0714573D0 (en) * | 2007-07-26 | 2007-09-05 | Imp Innovations Ltd | Marker gene |
EP2860247A1 (en) * | 2007-08-21 | 2015-04-15 | Nodality, Inc. | Methods for diagnosis, prognosis and methods of treatment |
JP5228416B2 (ja) * | 2007-09-12 | 2013-07-03 | 株式会社リコー | 定電流出力制御型スイッチングレギュレータ |
WO2009108637A1 (en) * | 2008-02-25 | 2009-09-03 | Prometheus Laboratories, Inc. | Drug selection for breast cancer therapy using antibody-based arrays |
EP2108956A1 (en) * | 2008-04-07 | 2009-10-14 | Erasmus University Medical Center Rotterdam | Improved methods and kits for detecting tumor-specific fusion proteins |
US8301258B2 (en) | 2008-08-14 | 2012-10-30 | The Chinese University Of Hong Kong | Methods and devices for preventing ankle sprain injuries |
-
2010
- 2010-10-20 WO PCT/US2010/053386 patent/WO2011050069A1/en active Application Filing
- 2010-10-20 RU RU2012120722/15A patent/RU2558797C2/ru not_active IP Right Cessation
- 2010-10-20 BR BR112012009296-0A patent/BR112012009296A2/pt not_active IP Right Cessation
- 2010-10-20 CN CN201080058150.8A patent/CN102667478B/zh not_active Expired - Fee Related
- 2010-10-20 AU AU2010310746A patent/AU2010310746B2/en not_active Ceased
- 2010-10-20 CA CA2777934A patent/CA2777934A1/en not_active Abandoned
- 2010-10-20 JP JP2012535336A patent/JP5819307B2/ja not_active Expired - Fee Related
- 2010-10-20 MX MX2012004619A patent/MX337666B/es active IP Right Grant
- 2010-10-20 ES ES10769132.1T patent/ES2637853T3/es active Active
- 2010-10-20 KR KR1020127012981A patent/KR20120110168A/ko not_active Application Discontinuation
- 2010-10-20 DK DK10769132.1T patent/DK2491385T3/en active
- 2010-10-20 NZ NZ599460A patent/NZ599460A/en not_active IP Right Cessation
- 2010-10-20 EP EP10769132.1A patent/EP2491385B1/en active Active
-
2012
- 2012-01-30 US US13/361,881 patent/US20120277109A1/en not_active Abandoned
- 2012-04-19 IL IL219313A patent/IL219313A/en not_active IP Right Cessation
- 2012-04-23 ZA ZA2012/02957A patent/ZA201202957B/en unknown
-
2015
- 2015-09-30 JP JP2015193770A patent/JP6301892B2/ja not_active Expired - Fee Related
-
2018
- 2018-03-01 JP JP2018036544A patent/JP2018119975A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112012009296A2 (pt) | 2021-02-02 |
ZA201202957B (en) | 2017-01-25 |
AU2010310746B2 (en) | 2015-07-23 |
CA2777934A1 (en) | 2011-04-28 |
RU2558797C2 (ru) | 2015-08-10 |
JP2016028251A (ja) | 2016-02-25 |
CN102667478A (zh) | 2012-09-12 |
JP2018119975A (ja) | 2018-08-02 |
EP2491385B1 (en) | 2017-05-10 |
RU2012120722A (ru) | 2013-11-27 |
JP2013508728A (ja) | 2013-03-07 |
AU2010310746A1 (en) | 2012-05-03 |
IL219313A (en) | 2017-03-30 |
IL219313A0 (en) | 2012-06-28 |
NZ599460A (en) | 2014-07-25 |
EP2491385A1 (en) | 2012-08-29 |
WO2011050069A1 (en) | 2011-04-28 |
US20120277109A1 (en) | 2012-11-01 |
KR20120110168A (ko) | 2012-10-09 |
CN102667478B (zh) | 2018-06-01 |
JP5819307B2 (ja) | 2015-11-24 |
ES2637853T3 (es) | 2017-10-17 |
JP6301892B2 (ja) | 2018-03-28 |
MX2012004619A (es) | 2012-05-08 |
DK2491385T3 (en) | 2017-08-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX337666B (es) | Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas. | |
WO2008021290A3 (en) | Organ-specific proteins and methods of their use | |
MX2010009766A (es) | Ensayo de proteasa. | |
WO2008070865A3 (en) | Materials and methods for efficient and accurate detection of analytes | |
ES2570731T3 (es) | Método de detección de cáncer | |
SG10201408392PA (en) | Methods of determining patient response by measurement of her-3 | |
NZ601022A (en) | Diagnosis and treatment of cancer using anti-ereg antibody | |
TW200720441A (en) | New labelling strategies for the sensitive detection of analytes | |
HK1115636A1 (en) | Use of cyfra 21-1 as a marker for colorectal cancer cyfra 21-1 | |
UA116618C2 (uk) | СКОНСТРУЙОВАНЕ НА ОСНОВІ ЦИСТЕЇНУ АНТИТІЛО ПРОТИ CD79b | |
ATE554389T1 (de) | Apex als marker für lungenkrebs | |
EP1930445A4 (en) | KIT AND METHOD FOR DETECTING UROTHELIAL CANCER | |
ATE471512T1 (de) | Verwendung des proteins s100a 12 als marker für kolorektalkarzinom | |
WO2010046443A3 (en) | Methods for detection and diagnosis of a bone or cartilage disorder | |
TR201907065T4 (tr) | Aptamer kullanarak hedef maddeyi tespit yöntemi. | |
CY1112553T1 (el) | Ανοσοπροσδιορισμοι υψηλης ευαισθησιας και κιτια για τον προσδιορισμο πεπτιδιων και πρωτεϊνων βιολογικου ενδιαφεροντος | |
WO2009019370A3 (fr) | Procede de dosage de l'apolipoproteine aii pour le diagnostic in vitro du cancer colorectal | |
WO2011036666A3 (en) | Systems and methods for measuring translation of target proteins in cells | |
PE20120592A1 (es) | Metodo con biomarcadores para el seguimiento de un tratamiento | |
HK1136873A1 (en) | Use of nnmt as a marker for lung cancer | |
WO2011008814A3 (en) | Multiplexed measurement of exogenous and endogenous dna | |
WO2009019369A3 (fr) | Procede de dosage de la plastine-i pour le diagnostic in vitro du cancer colorectal | |
DE60306865D1 (de) | Detektion von Vancomycin-resistenten Enterococcus-Subspezies | |
WO2010000467A8 (en) | Asc as a marker for lung cancer | |
MX341181B (es) | Metodo para someter a prueba a un sujeto que se cree esta predispuesto a tener cancer metastasico usando delta133p53beta. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or rights |
Owner name: NESTEC S.A. |
|
FG | Grant or registration |