MX356986B - Metodo para detectar aductos de nucleosomas. - Google Patents

Metodo para detectar aductos de nucleosomas.

Info

Publication number
MX356986B
MX356986B MX2014006866A MX2014006866A MX356986B MX 356986 B MX356986 B MX 356986B MX 2014006866 A MX2014006866 A MX 2014006866A MX 2014006866 A MX2014006866 A MX 2014006866A MX 356986 B MX356986 B MX 356986B
Authority
MX
Mexico
Prior art keywords
nucleosoma
aducts
detecting
adduct
protein
Prior art date
Application number
MX2014006866A
Other languages
English (en)
Other versions
MX2014006866A (es
Inventor
Jacob Vincent Micallef
Mark Edward Eccleston
Marielle Herzog
Original Assignee
Singapore Volition Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201121040A external-priority patent/GB201121040D0/en
Priority claimed from GBGB1121230.5A external-priority patent/GB201121230D0/en
Application filed by Singapore Volition Pte Ltd filed Critical Singapore Volition Pte Ltd
Publication of MX2014006866A publication Critical patent/MX2014006866A/es
Publication of MX356986B publication Critical patent/MX356986B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57595—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving intracellular compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7095—Inflammation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La invención se refiere al uso de aducto de nucleosoma-proteína como un biomarcador en una muestra de sangre para el diagnóstico de cáncer, en donde la proteína que forma un aducto con el nucleosoma comprende un factor de transcripción o una enzima modificada de cromatina.
MX2014006866A 2011-12-07 2012-12-07 Metodo para detectar aductos de nucleosomas. MX356986B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161568090P 2011-12-07 2011-12-07
GB201121040A GB201121040D0 (en) 2011-12-07 2011-12-07 Method for detecting nucleosome adducts
GBGB1121230.5A GB201121230D0 (en) 2011-12-12 2011-12-12 Methods of detecting nucleosome adducts
PCT/GB2012/053057 WO2013084002A2 (en) 2011-12-07 2012-12-07 Method for detecting nucleosome adducts

Publications (2)

Publication Number Publication Date
MX2014006866A MX2014006866A (es) 2014-11-10
MX356986B true MX356986B (es) 2018-06-22

Family

ID=48575008

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014006866A MX356986B (es) 2011-12-07 2012-12-07 Metodo para detectar aductos de nucleosomas.

Country Status (19)

Country Link
US (3) US9187780B2 (es)
EP (3) EP4092415A1 (es)
JP (1) JP6263474B2 (es)
KR (1) KR102039756B1 (es)
CN (1) CN104067125B (es)
AU (1) AU2012349855B2 (es)
BR (1) BR112014013082B1 (es)
CA (1) CA2855375C (es)
DK (1) DK2788767T3 (es)
ES (1) ES2649404T3 (es)
HR (1) HRP20171680T1 (es)
HU (1) HUE035855T2 (es)
MX (1) MX356986B (es)
PL (1) PL2788767T3 (es)
PT (1) PT2788767T (es)
RU (1) RU2634266C2 (es)
SG (2) SG11201402982TA (es)
WO (1) WO2013084002A2 (es)
ZA (1) ZA201403260B (es)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201115095D0 (en) * 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
AU2012349855B2 (en) 2011-12-07 2017-12-07 Belgian Volition Sprl Method for detecting nucleosome adducts
EP2820129A1 (en) 2012-03-02 2015-01-07 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
GB201303576D0 (en) * 2013-02-28 2013-04-10 Singapore Volition Pte Ltd Method for predicting therapy efficacy using nucleosome structure biomarkers
EP2971100A1 (en) 2013-03-13 2016-01-20 Sequenom, Inc. Primers for dna methylation analysis
EP3736344A1 (en) 2014-03-13 2020-11-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP6668255B2 (ja) * 2014-04-30 2020-03-25 エクスプレッション、パソロジー、インコーポレイテッドＥｘｐｒｅｓｓｉｏｎ Ｐａｔｈｏｌｏｇｙ， Ｉｎｃ． アンドロゲン受容体（ａｒ）タンパク質のｓｒｍ／ｍｒｍアッセイ
WO2016067029A1 (en) * 2014-10-29 2016-05-06 Singapore Volition Pte Limited Method for the enrichment of circulating tumor dna
GB201421933D0 (en) * 2014-12-10 2015-01-21 Singapore Volition Pte Ltd Method for a detection of hormone sensitive diease progression
GB201511512D0 (en) * 2015-07-01 2015-08-12 Singapore Volition Pte Ltd Use of cell-free nucleosomes as biomarkers
GB201511542D0 (en) * 2015-07-01 2015-08-12 Singapore Volition Pte Ltd Use of cell free nucleosomes as biomarkers
GB201518665D0 (en) * 2015-10-21 2015-12-02 Singapore Volition Pte Ltd Method for enrichment of cell free nucleosomes
GB201518674D0 (en) * 2015-10-21 2015-12-02 Singapore Volition Pte Ltd Method for detecting nuleosomes containing histone modifications and variants
GB201604806D0 (en) * 2016-03-22 2016-05-04 Singapore Volition Pte Ltd Method of identifying a cancer of unknown origin
GB201612815D0 (en) * 2016-07-25 2016-09-07 Belgian Volition Sa Novel combination test
ES2913665T3 (es) 2017-09-18 2022-06-03 Santersus Ag Método y dispositivo para la purificación de sangre a partir de ADN celular libre en circulación
GB201721569D0 (en) 2017-12-21 2018-02-07 Belgian Volition Sprl Method for the detection and treatment of colorectal adenomas
CN112119166B (zh) * 2018-03-13 2025-08-22 耶路撒冷希伯来大学伊萨姆研发有限公司 无细胞dna染色质免疫沉淀的诊断应用
GB201818965D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Method for the detection of colorectal cancer
GB201818963D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Methof for the detection of prostate cancer
GB201906201D0 (en) 2019-05-02 2019-06-19 Belgian Voltion Sprl Method for the detection of protate cancer
GB201906199D0 (en) 2019-05-02 2019-06-19 Belgian Volition Sprl Method for the detection of cancer
AU2020336928A1 (en) 2019-08-27 2022-03-24 Belgian Volition Srl Method of isolating circulating nucleosomes
GB201912251D0 (en) 2019-08-27 2019-10-09 Belgian Volition Sprl Method of isolating circulating nucleosomes
PL4070111T3 (pl) * 2019-12-02 2025-02-03 Belgian Volition Srl Zastosowanie wolnych pozakomórkowych nukleosomsów jako biomarkerów
IL296450A (en) 2020-03-20 2022-11-01 Belgian Volition Srl Triaging method using cell free nucleosome levels
CN111413497A (zh) * 2020-04-15 2020-07-14 上海市东方医院（同济大学附属东方医院） 组蛋白甲基转移酶ezh2在制备用于诊断脓毒症的生物标记物中的用途
JP2023544112A (ja) 2020-09-21 2023-10-20 ベルジアン ボリション エスアールエル 血液中の遊離ヌクレオソームのインラインモニタリングのための装置
TW202238131A (zh) 2020-11-25 2022-10-01 比利時商比利時意志有限公司 測量無細胞核蛋白染色質片段之方法
TW202238132A (zh) 2020-12-08 2022-10-01 比利時商比利時意志有限公司 多發性硬化症之診斷方法
TW202242145A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析
TW202242130A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 循環轉錄因子分析
TW202242146A (zh) 2021-01-13 2022-11-01 比利時商比利時意志有限公司 肺癌的檢測方法
GB202108185D0 (en) 2021-06-08 2021-07-21 Belgian Volition Sprl Standardisation of nucleosome assays using biologically derived calibrants
GB202108452D0 (en) 2021-06-14 2021-07-28 Belgian Volition Sprl Triaging method using cell free nucleosome levels
WO2023073179A1 (en) 2021-10-29 2023-05-04 Belgian Volition Srl Homogeneous immunoassay method
GB202117799D0 (en) 2021-12-09 2022-01-26 Belgian Volition Srl Method for the detection of blood cancer
US12053567B2 (en) 2021-12-27 2024-08-06 Santersus Ag Method and device for removal of circulating cell free DNA
US20250197944A1 (en) 2022-03-11 2025-06-19 Belgian Volition Srl Differential diagnosis method
GB202205212D0 (en) 2022-04-08 2022-05-25 Belgian Volition Sprl Method for transplant organ health assessment
US20260072040A1 (en) 2022-08-25 2026-03-12 Belgian Volition Srl Method for measuring cell free chromatin
EP4577835A1 (en) 2022-08-25 2025-07-02 Belgian Volition SRL Method for the detection of dementia
WO2024133222A1 (en) 2022-12-19 2024-06-27 Belgian Volition Srl Assessment of biological samples for nucleic acid analysis
WO2024133225A1 (en) 2022-12-19 2024-06-27 Belgian Volition Srl Calibration
GB202300607D0 (en) 2023-01-16 2023-03-01 Belgian Volition Srl Proteins and methods for isolating circulating nucleosomes
GB202303562D0 (en) 2023-03-10 2023-04-26 Belgian Volition Sprl Sample collection for liquid biopsy
EP4695610A1 (en) 2023-04-14 2026-02-18 Belgian Volition SRL Diagnosis method using cell free nucleosome levels
WO2024223947A1 (en) 2023-04-28 2024-10-31 Belgian Volition Srl Use of cell free nucleosomes as biomarkers of carcinomas
GB202307768D0 (en) 2023-05-24 2023-07-05 Belgian Volition Srl Use of cell free nucleosomes as biomarkers
GB202310137D0 (en) 2023-07-03 2023-08-16 Belgian Volition Srl Method for the detection of cancer
WO2025012440A1 (en) 2023-07-13 2025-01-16 Belgian Volition Srl Method for detection of the potential of a body fluid sample to produce extracellular traps
WO2025061853A1 (en) 2023-09-19 2025-03-27 Belgian Volition Srl Lateral flow test device
WO2025093747A1 (en) 2023-11-02 2025-05-08 Belgian Volition Srl Novel rapid high-throughput method of netosis induction and inhibition with physiologically relevant molecules
WO2025181348A1 (en) 2024-03-01 2025-09-04 Belgian Volition Srl Method for determining the origin of circulating dna
WO2025253002A1 (en) 2024-06-07 2025-12-11 Belgian Volition Srl Sample collection for liquid biopsy
WO2026052765A1 (en) 2024-09-05 2026-03-12 Belgian Volition Srl Method using nucleosome levels

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2652901A1 (fr) 1989-10-11 1991-04-12 Pasteur Institut Complexes biologiques a base de nucleosomes, et leurs applications, notamment dans le domaine du diagnostic in vitro du lupus erythemateux dissemine (led).
AU2934299A (en) * 1998-03-18 1999-10-11 Roche Diagnostics Gmbh Detection of apoptotic products
JP2001029077A (ja) * 1999-07-21 2001-02-06 Yoshihiro Koseki 新規ｍｉｔｅ様因子
NL1014106C2 (nl) 2000-01-18 2001-07-20 Univ Amsterdam Werkwijze voor het detecteren van een pathologische afwijking bij een cel, een antistof en een assay kit.
GB0319376D0 (en) * 2003-08-18 2003-09-17 Chroma Therapeutics Ltd Histone modification detection
WO2005040814A1 (en) * 2003-10-14 2005-05-06 Cancer Research Technology Limited Methods and means of cancer detection by histone modification
WO2007084253A2 (en) 2005-11-28 2007-07-26 Medimmune, Inc. High affinity antibodies against hmgb1 and methods of use thereof
RU2322264C1 (ru) * 2006-07-27 2008-04-20 Михаил Аркадьевич Шурдов Способ лечения заболеваний
JP5634259B2 (ja) * 2007-04-05 2014-12-03 シンバイオテック ゲゼルシャフト ツーア フォルシュング ウント エントヴィックルング アウフ デム ゲビート デア ビオテヒノロギー ミット ベシュレンクテル ハフツング Ｂｉｓ−ｍｅｔヒストン
CN102292102A (zh) 2008-11-21 2011-12-21 哥本哈根大学 免疫应答的引发
WO2010120942A2 (en) * 2009-04-14 2010-10-21 The Regents Of The University Of California Histone modification patterns for clinical diagnosis and prognosis of cancer
US20130183662A1 (en) 2010-04-22 2013-07-18 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Means and methods for identifying an increased risk of systemic lupus erythematosus (sle) patients for developing renal manifestations
FI20105715A0 (fi) 2010-06-18 2010-06-18 Helsingin Yliopisto Asetyloituun HMGB1:een sitoutuva polyklonaalinen vasta-aine
CN102147409B (zh) * 2010-12-31 2016-06-22 深圳市亚辉龙生物科技股份有限公司 一种测定抗核小体抗体IgG的方法及试剂装置
CN103402635A (zh) 2011-03-08 2013-11-20 三菱树脂株式会社 催化剂、氮氧化物净化用元件、和氮氧化物净化用系统
AU2012349855B2 (en) 2011-12-07 2017-12-07 Belgian Volition Sprl Method for detecting nucleosome adducts

Also Published As

Publication number Publication date
WO2013084002A2 (en) 2013-06-13
HK1249176A1 (en) 2018-10-26
CN104067125A (zh) 2014-09-24
EP2788767B1 (en) 2017-09-06
RU2014127493A (ru) 2016-01-27
PL2788767T3 (pl) 2018-03-30
EP3264090A2 (en) 2018-01-03
ES2649404T3 (es) 2018-01-11
CA2855375A1 (en) 2013-06-13
JP6263474B2 (ja) 2018-01-17
ZA201403260B (en) 2015-07-29
EP3264090B1 (en) 2022-05-18
CA2855375C (en) 2021-06-22
US9187780B2 (en) 2015-11-17
US11193939B2 (en) 2021-12-07
KR102039756B1 (ko) 2019-11-01
US20140322719A1 (en) 2014-10-30
MX2014006866A (es) 2014-11-10
US9709569B2 (en) 2017-07-18
WO2013084002A3 (en) 2013-08-29
SG11201402982TA (en) 2014-07-30
RU2634266C2 (ru) 2017-10-24
EP2788767A2 (en) 2014-10-15
BR112014013082A2 (pt) 2017-06-13
HRP20171680T1 (hr) 2018-04-06
HUE035855T2 (en) 2018-05-28
EP4092415A1 (en) 2022-11-23
SG10201604081YA (en) 2016-07-28
CN104067125B (zh) 2017-12-26
EP3264090A3 (en) 2018-03-28
AU2012349855A1 (en) 2014-05-22
PT2788767T (pt) 2017-12-06
AU2012349855B2 (en) 2017-12-07
BR112014013082B1 (pt) 2021-02-02
DK2788767T3 (da) 2017-11-27
JP2015500478A (ja) 2015-01-05
US20160097772A1 (en) 2016-04-07
US20170276684A1 (en) 2017-09-28
HK1202926A1 (en) 2015-10-09
KR20140109871A (ko) 2014-09-16

Similar Documents

Publication Publication Date Title
MX356986B (es) Metodo para detectar aductos de nucleosomas.
MX2013014153A (es) Biomarcadores paa terapia de inhibidor de hedgehog.
CL2012002741A1 (es) Metodo para determinar en una muestra de sangre la presencia de vitamina d libre; inmunoensayo para detrminar presencia de vitamina d libre en sangre; kit para efectuar inmunoensayo.
IL257330B (en) Compositions, methods and kits for diagnosis of lung cancer
EA201600085A1 (ru) Набор для обнаружения соевого события syht0h2
CL2013001883A1 (es) Metodo de inmunoensayo para vitamina d; inmunoensayo para detectar vitamina 25-oh d en sangre.
EA201590027A1 (ru) Способы детекции заболеваний или состояний
BR112014002616A2 (pt) método para detectar cãncer pancreático e reagente ou kit para detectar câncer pancreático
BR112014018995A2 (pt) Sistemas para executar ensaio automatizado
MX340453B (es) Biomarcadores para cancer de pulmon.
GB201305223D0 (en) Reflection detection type measurement apparatus for skin autofluorescence
IN2014DN04645A (es)
BR112012030587A2 (pt) métodos para diagnóstico de câncer pancreático, para identificar se um indivíduo precisa ou não de uma terapia contra câncer pancreático e para determinar se uma terapia contra câncer pancreático obtém sucesso, dispositivo para diagnóstico de câncer pancreático e uso de pelo menos um biomarcador
BR112014000443A2 (pt) métodos e ácidos nucléicos para determinação do prognóstico de um indivíduo com câncer
ITRM20120383A1 (it) Metodo e kit per la rivelazione di anticorpi.
WO2013107459A3 (en) Microrna for diagnosis of pancreatic cancer and/or prognosis of patients with pancreatic cancer by blood samples
BR112016008970A2 (pt) Método de ativação ex vivo e para avaliar ativação plasmática em um indivíduo, ensaio ex vivo para determinar atividade de calicreína plasmática em uma amostra
EA201591742A1 (ru) Способ улучшения диагностики заболеваний с использованием измеряемых аналитов
BR112013016241A2 (pt) composto, e, método para fabricar um composto
BR112013030886A2 (pt) método, reagente e kit para medir hemoglobina glicada.
BR112014008088A2 (pt) método para detectar anticorpos, uso de um método, e, kit
MX2019009539A (es) Aminoesteroides para tratamiento de una enfermedad asociada con proteina fosfatasa 1b ( ptp1b).
CL2011002973A1 (es) Metodo para detectar anticuerpos en una muestra que comprende contactar una muestra con un soporte que tiene fijado un peptoide; kit para detectar anticuerpos que son indicativos de una enfermedad neurodegenerativa.
ECSP11011376A (es) Dispositivo y procedimiento para la verificación y para el análisis cuantitativo de analitos, particularmente de micotoxinas
BR112013017499A2 (pt) combinação de sirosingopina e inibidores mitocondriais para o tratamento de câncer e imunossupressão

Legal Events

Date Code Title Description
FG Grant or registration