CR20110640A - Derivados de amiloide p sérico/de suero y su preparación y uso - Google Patents
Derivados de amiloide p sérico/de suero y su preparación y usoInfo
- Publication number
- CR20110640A CR20110640A CR20110640A CR20110640A CR20110640A CR 20110640 A CR20110640 A CR 20110640A CR 20110640 A CR20110640 A CR 20110640A CR 20110640 A CR20110640 A CR 20110640A CR 20110640 A CR20110640 A CR 20110640A
- Authority
- CR
- Costa Rica
- Prior art keywords
- sérico
- serero
- amiloid
- derivatives
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Un aspecto de la presente invención se refiere al sorprendente descubrimiento de que la modificación de una estructura de glicanos de un polipéptido SAP puede aumentar la actividad biológica en relación a una muestra de SAP de tipo salvaje aislado de suero humano. La divulgación proporciona tanto polipéptidos SAP humanos variantes y los métodos para hacer la misma.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21793109P | 2009-06-04 | 2009-06-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20110640A true CR20110640A (es) | 2012-01-30 |
Family
ID=43298203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20110640A CR20110640A (es) | 2009-06-04 | 2011-11-29 | Derivados de amiloide p sérico/de suero y su preparación y uso |
Country Status (28)
Country | Link |
---|---|
US (5) | US9296800B2 (es) |
EP (2) | EP3042915B1 (es) |
JP (3) | JP5801293B2 (es) |
CN (1) | CN102574902B (es) |
AU (1) | AU2010256426B2 (es) |
BR (2) | BR122020010980B1 (es) |
CA (1) | CA2764461C (es) |
CO (1) | CO6480917A2 (es) |
CR (1) | CR20110640A (es) |
CY (1) | CY1120817T1 (es) |
DK (2) | DK3042915T3 (es) |
EA (1) | EA030332B1 (es) |
ES (2) | ES2563748T3 (es) |
HK (1) | HK1168603A1 (es) |
HR (2) | HRP20160221T1 (es) |
HU (1) | HUE026737T2 (es) |
IL (1) | IL216744A (es) |
LT (1) | LT3042915T (es) |
MX (1) | MX2011012738A (es) |
MY (1) | MY158761A (es) |
NZ (1) | NZ596849A (es) |
PL (2) | PL3042915T3 (es) |
PT (1) | PT3042915T (es) |
SI (2) | SI2438083T1 (es) |
TR (1) | TR201815592T4 (es) |
UA (1) | UA110323C2 (es) |
WO (1) | WO2010141918A1 (es) |
ZA (1) | ZA201108857B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5220025B2 (ja) * | 2006-12-04 | 2013-06-26 | プロメディオール, インコーポレイテッド | 線維症疾患を処置するための併用療法 |
US20090092574A1 (en) | 2006-12-29 | 2009-04-09 | Scott Richard W | Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof |
US8497243B2 (en) * | 2007-07-06 | 2013-07-30 | Promedior, Inc. | Methods and compositions useful in the treatment of mucositis |
US9884899B2 (en) | 2007-07-06 | 2018-02-06 | Promedior, Inc. | Methods for treating fibrosis using CRP antagonists |
ES2612922T3 (es) | 2009-03-11 | 2017-05-19 | Promedior Inc. | Métodos de tratamiento y diagnóstico para trastornos de hipersensibilidad |
AU2010224172B2 (en) * | 2009-03-11 | 2016-01-21 | Promedior, Inc. | Treatment methods for autoimmune disorders |
UA110323C2 (en) * | 2009-06-04 | 2015-12-25 | Promedior Inc | Derivative of serum amyloid p and their receipt and application |
ES2552793T3 (es) * | 2009-06-17 | 2015-12-02 | Promedior Inc. | Variantes de SAP y su uso |
FR2969153B1 (fr) * | 2010-12-17 | 2014-10-17 | Lab Francais Du Fractionnement | Procede de purification de proteine amyloide p et utilisation de la proteine ainsi purifiee |
TWI520951B (zh) | 2011-05-16 | 2016-02-11 | 塞爾西優蒂克斯公司 | 用於治療粘膜炎的化合物 |
DK2793927T3 (da) * | 2011-12-21 | 2019-06-11 | Promedior Inc | Serum-amyloid-P-antistof-fusionsproteiner |
EP3054959B1 (en) | 2013-10-08 | 2020-01-08 | Promedior Inc. | Methods for treating fibrotic cancers |
FR3012453B1 (fr) * | 2013-10-31 | 2015-11-13 | Lab Francais Du Fractionnement | Proteine chimerique dans le traitement de l’amylose |
CN105372214B (zh) * | 2014-08-18 | 2019-06-28 | 中国科学院上海有机化学研究所 | 一种鉴定新红细胞生成刺激蛋白的n-连接寡糖结构的方法 |
MX2019002734A (es) * | 2016-09-13 | 2019-05-27 | Bayer Healthcare Llc | Glicoformas del factor viia. |
JP6852397B2 (ja) | 2016-12-28 | 2021-03-31 | 株式会社島津製作所 | 分析用試料の調製方法および分析方法 |
CN108114001B (zh) * | 2017-12-23 | 2023-05-30 | 中国科学院海洋研究所 | 一种诱导海产双壳贝类产卵的诱导剂及其应用方法 |
US11771694B2 (en) | 2020-06-05 | 2023-10-03 | Innovation Pharmaceuticals Inc. | Arylamide compounds for treatment and prevention of viral infections |
JP2023550287A (ja) * | 2020-11-02 | 2023-12-01 | アトララス・インコーポレイテッド | Sap fc融合タンパク質及び使用方法 |
Family Cites Families (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1562244A (en) | 1976-11-11 | 1980-03-05 | Lock P M | Wound dressing materials |
GB1594389A (en) | 1977-06-03 | 1981-07-30 | Max Planck Gesellschaft | Dressing material for wounds |
GB8516081D0 (en) | 1985-06-25 | 1985-07-31 | Ciba Geigy Ag | Assay & purification of amyloid components |
US6071517A (en) | 1986-07-07 | 2000-06-06 | Medarex, Inc. | Bispecific heteroantibodies with dual effector functions |
EP0476721B1 (en) | 1987-11-20 | 1995-03-01 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | A method for removing serum amyloid protein |
US7070994B2 (en) | 1988-03-21 | 2006-07-04 | Oxford Biomedica (Uk) Ltd. | Packaging cells |
US5047335A (en) | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
US5092876A (en) | 1989-08-30 | 1992-03-03 | The United States Of America As Represented By The Department Of Health And Human Services | Cell attachment peptides derived from amyloid P component |
WO1992021364A1 (en) | 1991-05-31 | 1992-12-10 | New England Deaconess Hospital Corporation | Cea-binding proteins and methods for their isolation and use |
US5591709A (en) | 1991-08-30 | 1997-01-07 | Life Medical Sciences, Inc. | Compositions and methods for treating wounds |
WO1993023569A1 (en) | 1992-05-11 | 1993-11-25 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting viral replication |
EP0654077A4 (en) | 1992-07-17 | 1996-03-13 | Ribozyme Pharm Inc | PROCESS AND REAGENT FOR THE TREATMENT OF DISEASES IN ANIMALS. |
US6054121A (en) | 1993-02-26 | 2000-04-25 | The Picower Institute For Medical Research | Modulation of immune responses in blood-borne mesenchymal cells |
US5804446A (en) | 1993-02-26 | 1998-09-08 | The Picower Institute For Medical Research | Blood-borne mesenchymal cells |
US5654186A (en) | 1993-02-26 | 1997-08-05 | The Picower Institute For Medical Research | Blood-borne mesenchymal cells |
AU7043694A (en) | 1993-05-27 | 1994-12-20 | Regents Of The University Of Michigan, The | Method of treatment and prevention of immune complex-induced lung injury |
US5698589A (en) | 1993-06-01 | 1997-12-16 | International Medical Innovations, Inc. | Water-based topical cream containing nitroglycerin and method of preparation and use thereof |
GB9317120D0 (en) | 1993-08-17 | 1993-09-29 | Royal Postgrad Med School | Human serum amyloid p component |
US5981470A (en) | 1994-06-07 | 1999-11-09 | The University Of Birmingham | Uterine fibroid treatment |
US5989811A (en) | 1994-09-29 | 1999-11-23 | Urocor, Inc. | Sextant core biopsy predictive mechanism for non-organ confined disease status |
US6030815A (en) | 1995-04-11 | 2000-02-29 | Neose Technologies, Inc. | Enzymatic synthesis of oligosaccharides |
US5922577A (en) | 1995-04-11 | 1999-07-13 | Cytel Corporation | Enzymatic synthesis of glycosidic linkages |
US5876980A (en) | 1995-04-11 | 1999-03-02 | Cytel Corporation | Enzymatic synthesis of oligosaccharides |
US5728554A (en) | 1995-04-11 | 1998-03-17 | Cytel Corporation | Enzymatic synthesis of glycosidic linkages |
JP3830165B2 (ja) * | 1995-09-13 | 2006-10-04 | 第一ファインケミカル株式会社 | D−パントラクトン加水分解酵素およびそれをコードする遺伝子 |
US5750345A (en) | 1995-10-31 | 1998-05-12 | Evanston Hospital Corporation | Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders |
ATE226829T1 (de) | 1996-01-25 | 2002-11-15 | Profylakse Aps | Pharmazeutische zusammensetzung, enthaltend serum-amyloid p-komponenten, zur prophylaxe und therapie von viralen infektionen sowie kit zur detektionvon komplexen zwischen solchen zusammensetzungen und viralen komponenten |
CA2293829C (en) | 1997-06-24 | 2011-06-14 | Genentech, Inc. | Methods and compositions for galactosylated glycoproteins |
US6395713B1 (en) | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
US20030035829A1 (en) | 1997-07-24 | 2003-02-20 | Townsend And Townsend And Crew | Liposomal compositions for the delivery of nucleic acid catalysts |
US6365570B1 (en) * | 1997-10-10 | 2002-04-02 | Universiteit Utrecht | Pharmaceutical and diagnostic use of Serum Amyloid P component |
EP1028751B1 (en) | 1997-10-31 | 2008-12-31 | Genentech, Inc. | Methods and compositions comprising glycoprotein glycoforms |
HUP0100929A3 (en) | 1998-02-17 | 2005-10-28 | Celldex Therapeutics Inc | Treating and diagnosing macrophage-mediated diseases using fc receptor ligands |
DE99907899T1 (de) | 1998-03-11 | 2005-01-13 | Kabushiki Kaisha Soken | Hautnormalisierungsmittel |
ES2340112T3 (es) | 1998-04-20 | 2010-05-28 | Glycart Biotechnology Ag | Ingenieria de glicosilacion de anticuerpos para la mejora de la citotoxicidad celular dependiente de anticuerpos. |
JPH11319542A (ja) | 1998-05-08 | 1999-11-24 | Tokuyama Corp | 超薄層の製造方法 |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
US6600019B2 (en) | 2000-01-06 | 2003-07-29 | Curagen Corporation | Polypeptides and nucleic acids encoding same |
EP1267795A1 (en) | 2000-03-30 | 2003-01-02 | Brennen Medical Inc. | Anti-microbial and immunostimulating composition |
US20040068095A1 (en) | 2001-03-14 | 2004-04-08 | Shimkets Richard A. | Novel human proteins, polynucleotides encoding them and methods of using the same |
US7713705B2 (en) | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
US6872541B2 (en) | 2001-07-25 | 2005-03-29 | Coulter International Corp. | Method and compositions for analysis of pentraxin receptors as indicators of disease |
US6537811B1 (en) | 2001-08-01 | 2003-03-25 | Isis Pharmaceuticals, Inc. | Antisense inhibition of SAP-1 expression |
US20030199442A1 (en) | 2001-10-09 | 2003-10-23 | Alsobrook John P. | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
JP2004049214A (ja) | 2001-11-29 | 2004-02-19 | Nippon Shokubai Co Ltd | 蛋白質またはペプチドの細胞内導入方法 |
US7022476B2 (en) | 2002-02-26 | 2006-04-04 | New York Society For Ruptured And Crippled Maintaining The Hospital For Special Surgery | Human FcγRIIB gene polymorphisms for assessing development of systemic lupus erythematosus and compositions for use thereof |
GB0211136D0 (en) | 2002-05-15 | 2002-06-26 | Univ London | Treatment and prevention of tissue damage |
KR20050008717A (ko) | 2002-05-17 | 2005-01-21 | 노파르티스 아게 | 레닌 억제제, 칼슘 채널 차단제 및 이뇨제를 포함하는약제학적 조성물 |
GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
ATE536188T1 (de) | 2002-08-14 | 2011-12-15 | Macrogenics Inc | Fcgammariib-spezifische antikörper und verfahren zur verwendung davon |
AU2003300266B2 (en) | 2002-12-23 | 2009-10-08 | William Marsh Rice University | Methods and compositions for suppressing fibrocyte differentiation |
US7763256B2 (en) | 2002-12-23 | 2010-07-27 | William Marsh Rice University | Compositions and methods for suppressing fibrocytes and for detecting fibrocyte differentiation |
US8012472B2 (en) | 2002-12-23 | 2011-09-06 | William Marsh Rice University | Compositions and methods for suppressing fibrocytes |
JP2006526140A (ja) | 2002-12-24 | 2006-11-16 | バイオサイト インコーポレイテッド | 鑑別診断のためのマーカーおよびその使用方法 |
US20070149450A1 (en) | 2003-02-27 | 2007-06-28 | Ranjit Bhardwaj | Method for reducing levels of c-reactive protein |
JP5367982B2 (ja) | 2004-04-16 | 2013-12-11 | マクロジェニクス,インコーポレーテッド | FcγRIIB特異的抗体とその利用法 |
CA2565874C (en) | 2004-05-10 | 2017-10-03 | Macrogenics, Inc. | Humanized fc.gamma.riib-specific antibodies and methods of use thereof |
US7378504B2 (en) | 2004-06-03 | 2008-05-27 | Medarex, Inc. | Human monoclonal antibodies to Fc gamma receptor I (CD64) |
WO2006002930A2 (en) | 2004-06-30 | 2006-01-12 | Friedrich-Alexander- Universitaet Erlangen- Nuernberg | FcϜRIIa POLYMORPHISM AND ITS USE IN DIAGNOSIS |
KR101247908B1 (ko) | 2004-09-02 | 2013-03-26 | 제넨테크, 인크. | 항-fc-감마 riib 수용체 항체 및 그의 용도 |
EP1814984A2 (en) | 2004-09-17 | 2007-08-08 | Biomarin Pharmaceutical Inc. | Variants and chemically-modified variants of phenylalanine ammonia-lyase |
EP1846454A2 (en) | 2004-09-30 | 2007-10-24 | Medarex, Inc. | Human monoclonal antibodies to fc gamma receptor ii (cd32) |
US7405302B2 (en) | 2005-10-11 | 2008-07-29 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (FLAP) inhibitors |
CA2625403A1 (en) | 2005-10-17 | 2007-04-26 | Institute For System Biology | Tissue-and serum-derived glycoproteins and methods of their use |
WO2007098106A2 (en) | 2006-02-17 | 2007-08-30 | Pepgen Coporation | Respiratory tract delivery of interferon-tau |
JP5220025B2 (ja) | 2006-12-04 | 2013-06-26 | プロメディオール, インコーポレイテッド | 線維症疾患を処置するための併用療法 |
US9884899B2 (en) | 2007-07-06 | 2018-02-06 | Promedior, Inc. | Methods for treating fibrosis using CRP antagonists |
ES2554167T3 (es) | 2007-07-06 | 2015-12-16 | Promedior Inc. | Métodos y composiciones útiles en el tratamiento de mucositis |
US8497243B2 (en) | 2007-07-06 | 2013-07-30 | Promedior, Inc. | Methods and compositions useful in the treatment of mucositis |
ES2612922T3 (es) | 2009-03-11 | 2017-05-19 | Promedior Inc. | Métodos de tratamiento y diagnóstico para trastornos de hipersensibilidad |
AU2010224172B2 (en) | 2009-03-11 | 2016-01-21 | Promedior, Inc. | Treatment methods for autoimmune disorders |
CA2757500A1 (en) | 2009-04-01 | 2010-10-07 | Promedior, Inc. | Pulmonary and nasal delivery of serum amyloid p |
UA110323C2 (en) * | 2009-06-04 | 2015-12-25 | Promedior Inc | Derivative of serum amyloid p and their receipt and application |
ES2552793T3 (es) | 2009-06-17 | 2015-12-02 | Promedior Inc. | Variantes de SAP y su uso |
-
2010
- 2010-04-06 UA UAA201115614A patent/UA110323C2/ru unknown
- 2010-06-04 MX MX2011012738A patent/MX2011012738A/es active IP Right Grant
- 2010-06-04 DK DK15197076.1T patent/DK3042915T3/en active
- 2010-06-04 PT PT15197076T patent/PT3042915T/pt unknown
- 2010-06-04 SI SI201031135T patent/SI2438083T1/sl unknown
- 2010-06-04 BR BR122020010980-7A patent/BR122020010980B1/pt active IP Right Grant
- 2010-06-04 EP EP15197076.1A patent/EP3042915B1/en active Active
- 2010-06-04 SI SI201031760T patent/SI3042915T1/sl unknown
- 2010-06-04 PL PL15197076T patent/PL3042915T3/pl unknown
- 2010-06-04 CN CN201080028923.8A patent/CN102574902B/zh active Active
- 2010-06-04 ES ES10784210.6T patent/ES2563748T3/es active Active
- 2010-06-04 EP EP10784210.6A patent/EP2438083B1/en active Active
- 2010-06-04 US US12/794,132 patent/US9296800B2/en active Active
- 2010-06-04 MY MYPI2011005861A patent/MY158761A/en unknown
- 2010-06-04 BR BRPI1012924A patent/BRPI1012924B8/pt active IP Right Grant
- 2010-06-04 WO PCT/US2010/037542 patent/WO2010141918A1/en active Application Filing
- 2010-06-04 TR TR2018/15592T patent/TR201815592T4/tr unknown
- 2010-06-04 JP JP2012514212A patent/JP5801293B2/ja active Active
- 2010-06-04 CA CA2764461A patent/CA2764461C/en active Active
- 2010-06-04 AU AU2010256426A patent/AU2010256426B2/en active Active
- 2010-06-04 EA EA201171490A patent/EA030332B1/ru unknown
- 2010-06-04 PL PL10784210T patent/PL2438083T3/pl unknown
- 2010-06-04 HU HUE10784210A patent/HUE026737T2/en unknown
- 2010-06-04 LT LTEP15197076.1T patent/LT3042915T/lt unknown
- 2010-06-04 DK DK10784210.6T patent/DK2438083T3/en active
- 2010-06-04 ES ES15197076.1T patent/ES2692815T3/es active Active
- 2010-06-04 NZ NZ596849A patent/NZ596849A/xx unknown
-
2011
- 2011-11-29 CR CR20110640A patent/CR20110640A/es unknown
- 2011-12-01 IL IL216744A patent/IL216744A/en active IP Right Grant
- 2011-12-01 ZA ZA2011/08857A patent/ZA201108857B/en unknown
- 2011-12-21 CO CO11176414A patent/CO6480917A2/es active IP Right Grant
-
2012
- 2012-08-02 HK HK12107623.6A patent/HK1168603A1/zh unknown
-
2015
- 2015-03-27 JP JP2015067656A patent/JP2015120754A/ja active Pending
-
2016
- 2016-03-01 HR HRP20160221T patent/HRP20160221T1/hr unknown
-
2017
- 2017-02-10 JP JP2017023183A patent/JP2017082008A/ja active Pending
- 2017-04-20 US US15/492,085 patent/US20180044387A1/en not_active Abandoned
-
2018
- 2018-10-19 CY CY181101079T patent/CY1120817T1/el unknown
- 2018-10-31 HR HRP20181803TT patent/HRP20181803T1/hr unknown
-
2019
- 2019-12-31 US US16/731,320 patent/US20200369735A1/en not_active Abandoned
-
2020
- 2020-07-28 US US16/941,515 patent/US20210179679A1/en not_active Abandoned
-
2022
- 2022-03-15 US US17/695,071 patent/US20230058309A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CR20110640A (es) | Derivados de amiloide p sérico/de suero y su preparación y uso | |
CO6390023A2 (es) | Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de las celulas t | |
CL2012001030A1 (es) | Polipeptido inmunomodulador derivado de la il-2 que comprende varias mutaciones respecto a la secuencia de il-2 nativa que inhibe preferencialmente la actividad de il- 2 sobre celulas t reguladoras in vitro; proteína de fusión que lo comprende; y su uso para tratar cancer. | |
BR112013018399A2 (pt) | anticorpos anti-il1rap e seus usos para tratamento humano | |
SMT201700006B (it) | Analoghi della triazina e uso di essi come agenti terapeutici e sonde diagnostiche | |
CL2011000086A1 (es) | Anticuerpo aislado o proteina funcional contra el polipeptido baffr que inhibe la proliferacion de celulas b; secuencia nucleotidicas de dicho anticuerpo; vector y celula huesped que comprende dicha secuencia; y su uso para tratar enfermedades autoinmunes o neoplasias de celulas b. | |
CR20110470A (es) | Proteínas de union a il-17 | |
ECSP13012786A (es) | Anticuerpos anti-pcsk9 y métodos de uso | |
CL2013001107A1 (es) | Polipeptido derivado de la il-2 con actividad agonista; proteina de fusion que lo comprende; composicion farmaceutica que lo comprende; y su uso para tratar cancer y enfermedades infecciosas cronicas. | |
ECSP13012440A (es) | Anticuerpos anti-fap y métodos de uso | |
CO6531481A2 (es) | Proteinas de enlace al antigeno il-23 humanas | |
GT201200189A (es) | Antagonistas de pcsk9 | |
ECSP12012307A (es) | Proteínas de unión a il-1 | |
CR20120026A (es) | Construcciones novedosas de proteína del virus de papiloma humano (hpv) y su uso en la prevención de la enfermedad por el hpv | |
BRPI1007175A2 (pt) | Polipeptídeos hidroxifenilpriruvato dioxigenase mutantes e métodos de uso | |
CL2013001138A1 (es) | Composicion que comprende anticuerpo biespecífico cd19xcd3 para tratar masa tumoral de tejido de ganglios linfáticos y/o linfoma extranodal causado por el linfoma b difuso de células grandes (lbdcg); kit farmacéutico; uso de la composición. | |
CU23978B1 (es) | Composiciones para anticuerpos que se dirigen a la proteína de complemento c5 | |
BRPI0910852A2 (pt) | composições contendo lipídios e métodos de uso das mesmas | |
BR112013010834A2 (pt) | polipeptídeos fator ix modificados e usos dos mesmos | |
BR112014012121A2 (pt) | proteínas ligantes | |
BR112014011217A2 (pt) | substrato de polipeptídeo isolado, substrato de polipeptídeo adamts13, substrato de polipeptídeo liofilizado, método para clivar o substrato de polipeptídeo adamts13, método para medir a atividade de adamts13 em uma amostra, método para medida quantitativa da atividade da protease adamts13, kit para teste in vitro da atividade adamts13 em um indivíduo e uso do substrato de polipeptídeo adamts13 | |
CL2009001484A1 (es) | Sal glicinato de metformina; composición farmacéutica que comprende la sal; y su uso para tratar la hiperglicemia. | |
BRPI1014544A8 (pt) | anticorpos anti-il-17f e metodos de uso dos mesmos | |
BR112013009503A2 (pt) | kit para detectar o vírus da leucemia bovina (blv) e uso do mesmo | |
ECSP13012536A (es) | Composiciones de anticuerpo y métodos de uso |