BRPI1012924B8 - polipeptídeo de amilóide p de soro humano glicosilado, preparação farmacêutica que compreende o dito polipeptídeo, métodos para preparar e uso terapêuticos dos mesmos - Google Patents

polipeptídeo de amilóide p de soro humano glicosilado, preparação farmacêutica que compreende o dito polipeptídeo, métodos para preparar e uso terapêuticos dos mesmos

Info

Publication number
BRPI1012924B8
BRPI1012924B8 BRPI1012924A BRPI1012924A BRPI1012924B8 BR PI1012924 B8 BRPI1012924 B8 BR PI1012924B8 BR PI1012924 A BRPI1012924 A BR PI1012924A BR PI1012924 A BRPI1012924 A BR PI1012924A BR PI1012924 B8 BRPI1012924 B8 BR PI1012924B8
Authority
BR
Brazil
Prior art keywords
polypeptide
methods
sap
serum amyloid
human serum
Prior art date
Application number
BRPI1012924A
Other languages
English (en)
Inventor
J Caimi Richard
Scott Willett W
Original Assignee
Promedior Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promedior Inc filed Critical Promedior Inc
Priority to BR122020010980-7A priority Critical patent/BR122020010980B1/pt
Publication of BRPI1012924A2 publication Critical patent/BRPI1012924A2/pt
Publication of BRPI1012924B1 publication Critical patent/BRPI1012924B1/pt
Publication of BRPI1012924B8 publication Critical patent/BRPI1012924B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

derivados de amilóide p de soro e sua preparação e uso um aspecto da presente invenção refere-se à descoberta surpreendente que a modificação de uma estrutura do glicano sobre um polipeptídeo de sap humano pode aumentar a atividade biológica do polipeptídeo de sap em relação a uma amostra correspondente do sap do tipo selvagem, isolado do soro humano. a divulgação proporciona tanto os polipeptídeos de sap humanos variantes quanto os métodos para preparar os mesmos. em particular, a presente invenção proporciona métodos e composições para a adição, a remoção, ou a modificação in vitro e in vivo dos resíduos de açúcares, para produzir polipeptídeos de sap, tais como um polipeptídeo de sap humano, tendo um padrão de glicosilação desejado.
BRPI1012924A 2009-06-04 2010-06-04 polipeptídeo de amilóide p de soro humano glicosilado, preparação farmacêutica que compreende o dito polipeptídeo, métodos para preparar e uso terapêuticos dos mesmos BRPI1012924B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122020010980-7A BR122020010980B1 (pt) 2009-06-04 2010-06-04 Preparação farmacêutica compreendendo os polipeptídeos de amilóide p de soro humano, métodos de preparação dos referidos polipeptídeos, e usos terapêuticos

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21793109P 2009-06-04 2009-06-04
US61/217.931 2009-06-04
PCT/US2010/037542 WO2010141918A1 (en) 2009-06-04 2010-06-04 Serum amyloid p derivatives and their preparation and use

Publications (3)

Publication Number Publication Date
BRPI1012924A2 BRPI1012924A2 (pt) 2016-04-05
BRPI1012924B1 BRPI1012924B1 (pt) 2020-12-22
BRPI1012924B8 true BRPI1012924B8 (pt) 2021-05-25

Family

ID=43298203

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122020010980-7A BR122020010980B1 (pt) 2009-06-04 2010-06-04 Preparação farmacêutica compreendendo os polipeptídeos de amilóide p de soro humano, métodos de preparação dos referidos polipeptídeos, e usos terapêuticos
BRPI1012924A BRPI1012924B8 (pt) 2009-06-04 2010-06-04 polipeptídeo de amilóide p de soro humano glicosilado, preparação farmacêutica que compreende o dito polipeptídeo, métodos para preparar e uso terapêuticos dos mesmos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR122020010980-7A BR122020010980B1 (pt) 2009-06-04 2010-06-04 Preparação farmacêutica compreendendo os polipeptídeos de amilóide p de soro humano, métodos de preparação dos referidos polipeptídeos, e usos terapêuticos

Country Status (28)

Country Link
US (5) US9296800B2 (pt)
EP (2) EP3042915B1 (pt)
JP (3) JP5801293B2 (pt)
CN (1) CN102574902B (pt)
AU (1) AU2010256426B2 (pt)
BR (2) BR122020010980B1 (pt)
CA (1) CA2764461C (pt)
CO (1) CO6480917A2 (pt)
CR (1) CR20110640A (pt)
CY (1) CY1120817T1 (pt)
DK (2) DK3042915T3 (pt)
EA (1) EA030332B1 (pt)
ES (2) ES2563748T3 (pt)
HK (1) HK1168603A1 (pt)
HR (2) HRP20160221T1 (pt)
HU (1) HUE026737T2 (pt)
IL (1) IL216744A (pt)
LT (1) LT3042915T (pt)
MX (1) MX2011012738A (pt)
MY (1) MY158761A (pt)
NZ (1) NZ596849A (pt)
PL (2) PL3042915T3 (pt)
PT (1) PT3042915T (pt)
SI (2) SI2438083T1 (pt)
TR (1) TR201815592T4 (pt)
UA (1) UA110323C2 (pt)
WO (1) WO2010141918A1 (pt)
ZA (1) ZA201108857B (pt)

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CO6480917A2 (es) 2012-07-16
PT3042915T (pt) 2018-10-18
JP2015120754A (ja) 2015-07-02
AU2010256426A1 (en) 2012-01-12
ES2692815T3 (es) 2018-12-05
HRP20160221T1 (hr) 2016-03-25
HK1168603A1 (zh) 2013-01-04
EP3042915A1 (en) 2016-07-13
SI2438083T1 (sl) 2016-04-29
CA2764461C (en) 2021-05-04
MX2011012738A (es) 2012-02-21
BRPI1012924A2 (pt) 2016-04-05
CR20110640A (es) 2012-01-30
EP2438083B1 (en) 2015-12-02
HRP20181803T1 (hr) 2018-12-28
WO2010141918A1 (en) 2010-12-09
US20210179679A1 (en) 2021-06-17
HUE026737T2 (en) 2016-07-28
CN102574902B (zh) 2016-01-20
JP2012529429A (ja) 2012-11-22
NZ596849A (en) 2013-08-30
CN102574902A (zh) 2012-07-11
US20230058309A1 (en) 2023-02-23
CY1120817T1 (el) 2019-12-11
DK2438083T3 (en) 2016-03-07
IL216744A0 (en) 2012-02-29
PL2438083T3 (pl) 2016-06-30
JP5801293B2 (ja) 2015-10-28
ES2563748T3 (es) 2016-03-16
BRPI1012924B1 (pt) 2020-12-22
US20100317596A1 (en) 2010-12-16
EA201171490A1 (ru) 2012-05-30
LT3042915T (lt) 2018-11-12
JP2017082008A (ja) 2017-05-18
PL3042915T3 (pl) 2019-01-31
US20180044387A1 (en) 2018-02-15
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