CL2012001030A1 - Polipeptido inmunomodulador derivado de la il-2 que comprende varias mutaciones respecto a la secuencia de il-2 nativa que inhibe preferencialmente la actividad de il- 2 sobre celulas t reguladoras in vitro; proteína de fusión que lo comprende; y su uso para tratar cancer. - Google Patents
Polipeptido inmunomodulador derivado de la il-2 que comprende varias mutaciones respecto a la secuencia de il-2 nativa que inhibe preferencialmente la actividad de il- 2 sobre celulas t reguladoras in vitro; proteína de fusión que lo comprende; y su uso para tratar cancer.Info
- Publication number
- CL2012001030A1 CL2012001030A1 CL2012001030A CL2012001030A CL2012001030A1 CL 2012001030 A1 CL2012001030 A1 CL 2012001030A1 CL 2012001030 A CL2012001030 A CL 2012001030A CL 2012001030 A CL2012001030 A CL 2012001030A CL 2012001030 A1 CL2012001030 A1 CL 2012001030A1
- Authority
- CL
- Chile
- Prior art keywords
- regulatory
- native
- vitro
- cells
- activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20090203A CU23734A1 (es) | 2009-11-27 | 2009-11-27 | Polipéptidos inmunomoduladores derivados de la il-2 con actividad antagonista de esta citocina útiles en la terapia del cáncer y enfermedades infecciosas crónicas |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2012001030A1 true CL2012001030A1 (es) | 2012-07-20 |
Family
ID=43646474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2012001030A CL2012001030A1 (es) | 2009-11-27 | 2012-04-23 | Polipeptido inmunomodulador derivado de la il-2 que comprende varias mutaciones respecto a la secuencia de il-2 nativa que inhibe preferencialmente la actividad de il- 2 sobre celulas t reguladoras in vitro; proteína de fusión que lo comprende; y su uso para tratar cancer. |
Country Status (24)
Country | Link |
---|---|
US (1) | US8759486B2 (es) |
EP (1) | EP2505206B1 (es) |
JP (1) | JP5680661B2 (es) |
KR (1) | KR101484590B1 (es) |
CN (1) | CN102665754B (es) |
AR (1) | AR079197A1 (es) |
AU (1) | AU2010324254B2 (es) |
BR (1) | BR112012012025B8 (es) |
CA (1) | CA2781173C (es) |
CL (1) | CL2012001030A1 (es) |
CO (1) | CO6501124A2 (es) |
CU (1) | CU23734A1 (es) |
EA (1) | EA021867B1 (es) |
EC (1) | ECSP12011803A (es) |
ES (1) | ES2643465T3 (es) |
HK (1) | HK1169961A1 (es) |
MX (1) | MX2012006077A (es) |
MY (1) | MY162324A (es) |
NZ (1) | NZ599792A (es) |
PE (1) | PE20121636A1 (es) |
SG (1) | SG181089A1 (es) |
TN (1) | TN2012000182A1 (es) |
WO (1) | WO2011063770A2 (es) |
ZA (1) | ZA201203762B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2860170C (en) | 2010-12-22 | 2022-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
CA2925421C (en) | 2013-09-24 | 2023-08-29 | Medicenna Therapeutics, Inc. | Interleukin-2 fusion proteins and uses thereof |
CN106456730A (zh) | 2014-03-17 | 2017-02-22 | 德意志联邦共和国代表主席罗伯特·科赫研究所 | 用于诱导或延长细胞之细胞毒性免疫应答的方法的药物 |
JP6592505B2 (ja) * | 2014-04-24 | 2019-10-16 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | インターロイキン−2のスーパーアンタゴニスト、パーシャルアゴニスト及びアンタゴニスト |
WO2017096262A1 (en) | 2015-12-04 | 2017-06-08 | Jomoco, Corp. | Compositions and methods to mitigate or prevent an immune response to an immunogenic therapeutic molecule in non-human primates |
BR112019005944A2 (pt) | 2016-09-28 | 2019-06-11 | Musc Foudation For Res Development | anticorpos que se ligam à interleucina 2 e usos dos mesmos |
CU24483B1 (es) | 2016-11-15 | 2020-04-02 | Ct Inmunologia Molecular | Método para incrementar los niveles de secreción de la interleucina-2 |
BR112019018915A2 (pt) | 2017-03-15 | 2020-04-14 | Pandion Therapeutics Inc | imunotolerância direcionada |
MX2019013517A (es) | 2017-05-24 | 2020-08-17 | Pandion Operations Inc | Inmunotolerancia dirigida. |
JP7433051B2 (ja) | 2017-06-19 | 2024-02-19 | メディシナ セラピューティクス インコーポレイテッド | Il-2スーパーアゴニスト、アゴニスト、およびそれらの融合体の使用および方法 |
US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
BR112020019639A2 (pt) * | 2018-03-28 | 2021-01-05 | Ascendis Pharma Oncology Division A/S | Conjugados de il-2 |
TW202003551A (zh) | 2018-03-28 | 2020-01-16 | 美商必治妥美雅史谷比公司 | 介白素-2/介白素-2受體阿法融合蛋白及其使用方法 |
EP3802587A4 (en) * | 2018-06-07 | 2022-03-23 | Prottech Inc. | PHARMACEUTICAL COMPOSITION COMPRISING A FUSION PROTEIN AND USE THEREOF |
EP3806888B1 (en) | 2018-06-12 | 2024-01-31 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
TW202110885A (zh) | 2019-05-20 | 2021-03-16 | 美商潘迪恩治療公司 | 靶向MAdCAM之免疫耐受性 |
CN115362168A (zh) | 2020-01-14 | 2022-11-18 | 辛德凯因股份有限公司 | 偏向化il2突变蛋白方法和组合物 |
EP4107187A4 (en) | 2020-02-21 | 2024-07-03 | Pandion Operations Inc | TISSUE-TARGETED IMMUNOTOLERANCE WITH A CD39 EFFECTOR |
MX2023002648A (es) * | 2020-09-04 | 2023-04-05 | Shandong Simcere Biopharmaceutical Co Ltd | Mutante de il-2 y aplicacion de este. |
EP4232071A1 (en) | 2020-10-23 | 2023-08-30 | Asher Biotherapeutics, Inc. | Fusions with cd8 antigen binding molecules for modulating immune cell function |
CA3195260A1 (en) | 2020-10-29 | 2022-05-05 | Bristol-Myers Squibb Company | Fusion proteins for the treatment of disease |
KR20240026905A (ko) | 2021-04-30 | 2024-02-29 | 티젠 파마 에스에이 | 림프구의 단일 용기 확장 |
WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
WO2024097864A1 (en) | 2022-11-02 | 2024-05-10 | Tigen Pharma Sa | Expansion of lymphocytes |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4853332A (en) | 1982-10-19 | 1989-08-01 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins |
US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US5116943A (en) | 1985-01-18 | 1992-05-26 | Cetus Corporation | Oxidation-resistant muteins of Il-2 and other protein |
JP3024311B2 (ja) | 1991-10-03 | 2000-03-21 | 味の素株式会社 | Il−2受容体重鎖に結合するポリペプチド |
US5229109A (en) | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
US5635597A (en) | 1994-05-27 | 1997-06-03 | Affymax Technologies, N.V. | Peptides that bind IL-2 receptors |
US6955807B1 (en) | 1998-05-15 | 2005-10-18 | Bayer Pharmaceuticals Corporation | IL-2 selective agonists and antagonists |
US6168785B1 (en) | 1998-07-16 | 2001-01-02 | Institut Pasteur | Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents |
JP2002528389A (ja) | 1998-08-21 | 2002-09-03 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | Il−2及びその類似体から誘導される抗炎症性ペプチド |
PT1454138E (pt) | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
WO2005007121A2 (en) | 2003-07-18 | 2005-01-27 | Massachusetts Institute Of Technology | Mutant interleukin-2(il-2) polypeptides |
WO2008003473A2 (en) * | 2006-07-06 | 2008-01-10 | Merck Patent Gmbh | Compositions and methods for enhancing the efficacy of il-2 mediated immune responses |
US8906356B2 (en) * | 2007-11-05 | 2014-12-09 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
DE102008023820A1 (de) * | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
-
2009
- 2009-11-27 CU CU20090203A patent/CU23734A1/es active IP Right Grant
-
2010
- 2010-11-25 AR ARP100104366A patent/AR079197A1/es active IP Right Grant
- 2010-11-26 CA CA2781173A patent/CA2781173C/en active Active
- 2010-11-26 MX MX2012006077A patent/MX2012006077A/es active IP Right Grant
- 2010-11-26 ES ES10803437.2T patent/ES2643465T3/es active Active
- 2010-11-26 US US13/512,429 patent/US8759486B2/en active Active
- 2010-11-26 JP JP2012540281A patent/JP5680661B2/ja active Active
- 2010-11-26 PE PE2012000720A patent/PE20121636A1/es not_active Application Discontinuation
- 2010-11-26 BR BR112012012025A patent/BR112012012025B8/pt active IP Right Grant
- 2010-11-26 AU AU2010324254A patent/AU2010324254B2/en active Active
- 2010-11-26 EA EA201290395A patent/EA021867B1/ru not_active IP Right Cessation
- 2010-11-26 WO PCT/CU2010/000005 patent/WO2011063770A2/es active Application Filing
- 2010-11-26 NZ NZ599792A patent/NZ599792A/en unknown
- 2010-11-26 EP EP10803437.2A patent/EP2505206B1/en active Active
- 2010-11-26 MY MYPI2012002130A patent/MY162324A/en unknown
- 2010-11-26 KR KR1020127010828A patent/KR101484590B1/ko active IP Right Grant
- 2010-11-26 CN CN201080053369.9A patent/CN102665754B/zh active Active
- 2010-11-26 SG SG2012039053A patent/SG181089A1/en unknown
-
2012
- 2012-04-17 EC ECSP12011803 patent/ECSP12011803A/es unknown
- 2012-04-20 TN TNP2012000182A patent/TN2012000182A1/en unknown
- 2012-04-23 CL CL2012001030A patent/CL2012001030A1/es unknown
- 2012-05-23 ZA ZA2012/03762A patent/ZA201203762B/en unknown
- 2012-06-06 CO CO12095471A patent/CO6501124A2/es not_active Application Discontinuation
- 2012-10-30 HK HK12110868.4A patent/HK1169961A1/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2012001030A1 (es) | Polipeptido inmunomodulador derivado de la il-2 que comprende varias mutaciones respecto a la secuencia de il-2 nativa que inhibe preferencialmente la actividad de il- 2 sobre celulas t reguladoras in vitro; proteína de fusión que lo comprende; y su uso para tratar cancer. | |
CL2013001107A1 (es) | Polipeptido derivado de la il-2 con actividad agonista; proteina de fusion que lo comprende; composicion farmaceutica que lo comprende; y su uso para tratar cancer y enfermedades infecciosas cronicas. | |
HRP20181989T1 (hr) | Sredstva za i postupci određivanja biološke aktivnosti neurotoksičnih polipeptida u stanicama | |
IL261151A (en) | Water-soluble membrane proteins, methods for their preparation and use | |
BRPI1008740A2 (pt) | Proteínas pesticidas e métodos para seu uso. | |
CL2015000606A1 (es) | Polipeptidos que contienen fc con glicosilacion alterada y función efectora reducida. | |
BRPI1008061A2 (pt) | polipetídeos recombinantes estendidos e composições compreendendo os mesmos | |
CR20110640A (es) | Derivados de amiloide p sérico/de suero y su preparación y uso | |
BR112013010834A2 (pt) | polipeptídeos fator ix modificados e usos dos mesmos | |
BR112012013148A2 (pt) | formulação farmacêutica e uso | |
BRPI1009413A2 (pt) | emulsões e adesivos contendo proteína e produção e uso dos mesmos | |
DK3572091T3 (da) | Modificerede relaxinpolypeptider og anvendelser deraf | |
CL2013002361A1 (es) | Metodo para medir actividad de células natural killer (nk); kit para medir dicha actividad; proteína de fusión; composicion para activar células nk; polipéptido, oligonucleótido, vector y célula hospedera que comprenden la proteína; | |
BR112012004731A2 (pt) | peptídeos derivados de wnt10 e uso dos mesmos | |
CL2012000238A1 (es) | Polipéptido del factor ix; secuencia de adn que lo codifica; célula huésped eucariota; procedimiento de producción; conjugado; composición que lo comprende; y su uso para el tratamiento de la hemofilia b. | |
BR112013001423A2 (pt) | método, método in vitro, uso e kit útil para realizar o método | |
BR112012011464A2 (pt) | proteínas encapsuladas de óleo modificadas e seu uso | |
BRPI1008887A2 (pt) | peptídeos de foxm1 e vacinas contendo os mesmo | |
EP3604546A4 (en) | SYSTEM OF PROTEIN EXPRESSION IN A PLANT CELL AND ASSOCIATED USE | |
CL2014003525A1 (es) | Composicion farmaceutica que comprende fimasartan, hidroclorotiazida y un aglutinante; procedimiento de preparacion; su uso en el tratamiento de hipertension. | |
CL2013001128A1 (es) | Composicion que comprende penflufeno y oxido de cobre y/o tiabendazol; y su uso para proteger la madera frente a basidiomicetos. | |
EA201290541A1 (ru) | Модифицированные бычьи соматотропиновые полипептиды и их применение | |
BR112013011152A2 (pt) | proteína beta-glucocerebrosidase recombinante variante, composição e uso da proteína betaglucocerebrosidase recombinante variante | |
CL2011002994A1 (es) | Construccion de proteina que comprende polipeptido casb7439; composicion inmunogenica que comprende dicha construccion; uso de la composicion porque sirve para inducir respuesta inmunitaria al casb7439 en un animal. | |
CA142107S (en) | Log splitting wedge |