JP2014515740A5 - - Google Patents
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- Publication number
- JP2014515740A5 JP2014515740A5 JP2014501575A JP2014501575A JP2014515740A5 JP 2014515740 A5 JP2014515740 A5 JP 2014515740A5 JP 2014501575 A JP2014501575 A JP 2014501575A JP 2014501575 A JP2014501575 A JP 2014501575A JP 2014515740 A5 JP2014515740 A5 JP 2014515740A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable domain
- antibody molecule
- dabigatran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161469207P | 2011-03-30 | 2011-03-30 | |
| US61/469,207 | 2011-03-30 | ||
| PCT/EP2012/055397 WO2012130834A1 (en) | 2011-03-30 | 2012-03-27 | Anticoagulant antidotes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014515740A JP2014515740A (ja) | 2014-07-03 |
| JP2014515740A5 true JP2014515740A5 (enExample) | 2015-05-14 |
Family
ID=45876804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014501575A Ceased JP2014515740A (ja) | 2011-03-30 | 2012-03-27 | 抗凝固薬の解毒剤 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8821871B2 (enExample) |
| EP (1) | EP2691156A1 (enExample) |
| JP (1) | JP2014515740A (enExample) |
| KR (1) | KR20140009437A (enExample) |
| CN (1) | CN103476459A (enExample) |
| AP (1) | AP2013007046A0 (enExample) |
| AR (1) | AR085758A1 (enExample) |
| BR (1) | BR112013025031A2 (enExample) |
| CA (1) | CA2827787A1 (enExample) |
| CL (1) | CL2013002551A1 (enExample) |
| CO (1) | CO6771448A2 (enExample) |
| EA (1) | EA201301090A1 (enExample) |
| EC (1) | ECSP13012997A (enExample) |
| IL (1) | IL227653A0 (enExample) |
| MA (1) | MA34978B1 (enExample) |
| MX (1) | MX2013011092A (enExample) |
| PE (1) | PE20140964A1 (enExample) |
| PH (1) | PH12013501924A1 (enExample) |
| SG (1) | SG193552A1 (enExample) |
| TN (1) | TN2013000388A1 (enExample) |
| TW (1) | TW201302796A (enExample) |
| UY (1) | UY33994A (enExample) |
| WO (1) | WO2012130834A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3252076B1 (en) | 2011-01-14 | 2019-09-04 | The Regents Of The University Of California | Diagnostic use of antibodies against ror-1 protein |
| CN104080772B (zh) | 2011-11-29 | 2016-10-05 | 佩罗斯菲尔股份有限公司 | 抗凝血逆转剂 |
| JP6824735B2 (ja) | 2013-06-06 | 2021-02-03 | ピエール、ファーブル、メディカマン | 抗Ｃ１０ｏｒｆ５４抗体およびその使用方法 |
| EP3027624B1 (en) * | 2013-07-30 | 2018-09-12 | Janssen Sciences Ireland UC | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections |
| KR101523503B1 (ko) * | 2013-09-17 | 2015-05-29 | 강원대학교산학협력단 | 아디포넥틴으로부터 유래한 펩타이드 및 이를 포함하는 조성물 |
| JP2016539926A (ja) | 2013-10-25 | 2016-12-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗凝血薬の解毒剤 |
| EP2980218A1 (en) * | 2014-07-30 | 2016-02-03 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamer thrombin complex for use as an antidote to direct acting thrombin inhibitors |
| US20210228742A1 (en) * | 2018-04-27 | 2021-07-29 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | In vivo gene therapy using intraosseous delivery of a lentiviralgene construct |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087380A (en) | 1949-11-24 | 2000-07-11 | Boehringer Ingelheim Pharma Kg | Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions |
| WO1988001649A1 (en) | 1986-09-02 | 1988-03-10 | Genex Corporation | Single polypeptide chain binding molecules |
| FI903489A0 (fi) | 1988-11-11 | 1990-07-10 | Medical Res Council | Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna. |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| JP3490437B2 (ja) | 1992-01-23 | 2004-01-26 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 単量体および二量体抗体フラグメント融合タンパク質 |
| DE4203965A1 (de) | 1992-02-11 | 1993-08-12 | Max Planck Gesellschaft | Antidot fuer hirudin und synthetische thrombininhibitoren |
| EP1498427B1 (en) | 1992-08-21 | 2009-12-16 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| DK0672142T3 (da) | 1992-12-04 | 2001-06-18 | Medical Res Council | Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse |
| ATE183513T1 (de) | 1993-06-03 | 1999-09-15 | Therapeutic Antibodies Inc | Herstellung von antikörperfragmenten |
| AT404357B (de) | 1995-06-13 | 1998-11-25 | Immuno Ag | Prothrombin-derivate |
| DE19605126A1 (de) | 1996-02-12 | 1997-08-14 | Basf Ag | Thrombinmuteine als Antidot für Thrombininhibitoren |
| US6200955B1 (en) | 1996-06-11 | 2001-03-13 | Commonwealth Biotechnologies, Inc. | Heparin binding peptides |
| GB9625640D0 (en) | 1996-12-10 | 1997-01-29 | Celltech Therapeutics Ltd | Biological products |
| PE121699A1 (es) | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
| JP2002505574A (ja) | 1997-04-30 | 2002-02-19 | エンゾン，インコーポレイテッド | ポリアルキレンオキシド修飾された単鎖ポリペプチド |
| US6440417B1 (en) | 1998-11-06 | 2002-08-27 | Conjuchem, Inc. | Antibodies to argatroban derivatives and their use in therapeutic and diagnostic treatments |
| US6624141B1 (en) | 1999-03-17 | 2003-09-23 | The Regents Of The University Of Michigan | Protamine fragment compositions and methods of use |
| JP2003530838A (ja) | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | アルブミン融合タンパク質 |
| CA2433877C (en) | 2001-01-17 | 2014-11-18 | Aptevo Research And Development Llc | Binding domain-immunoglobulin fusion proteins |
| US20040097547A1 (en) | 2001-04-16 | 2004-05-20 | Taveras Arthur G. | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| AU2002351896A1 (en) | 2001-12-11 | 2003-06-23 | Ablynx N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| EP1517921B1 (en) | 2002-06-28 | 2006-06-07 | Domantis Limited | Dual specific ligands with increased serum half-life |
| WO2004041862A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| SI1639011T1 (sl) | 2003-06-30 | 2009-04-30 | Domantis Ltd | Pegilirana protitelesa z enojno domeno (dAb) |
| BRPI0816837B1 (pt) | 2007-09-28 | 2022-10-18 | Portola Pharmaceuticals, Inc | Composições farmacêuticas, polipeptídeo isolado de duas cadeias e uso de uma composição farmacêutica |
| AR077909A1 (es) * | 2009-08-24 | 2011-09-28 | Boehringer Ingelheim Int | Intervenciones de urgencia de carbon vegetal activo con sobredosificacion con etexilato de dabigatran |
| AR079944A1 (es) | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | Anticuerpo neutralizante de la actividad de un anticoagulante |
-
2012
- 2012-03-27 WO PCT/EP2012/055397 patent/WO2012130834A1/en not_active Ceased
- 2012-03-27 AP AP2013007046A patent/AP2013007046A0/xx unknown
- 2012-03-27 CN CN2012800157134A patent/CN103476459A/zh active Pending
- 2012-03-27 MX MX2013011092A patent/MX2013011092A/es not_active Application Discontinuation
- 2012-03-27 PE PE2013002078A patent/PE20140964A1/es not_active Application Discontinuation
- 2012-03-27 CA CA2827787A patent/CA2827787A1/en not_active Abandoned
- 2012-03-27 EP EP12710300.0A patent/EP2691156A1/en not_active Withdrawn
- 2012-03-27 BR BR112013025031A patent/BR112013025031A2/pt not_active IP Right Cessation
- 2012-03-27 KR KR1020137025877A patent/KR20140009437A/ko not_active Withdrawn
- 2012-03-27 SG SG2013070719A patent/SG193552A1/en unknown
- 2012-03-27 EA EA201301090A patent/EA201301090A1/ru unknown
- 2012-03-27 PH PH1/2013/501924A patent/PH12013501924A1/en unknown
- 2012-03-27 JP JP2014501575A patent/JP2014515740A/ja not_active Ceased
- 2012-03-27 MA MA36273A patent/MA34978B1/fr unknown
- 2012-03-28 US US13/432,296 patent/US8821871B2/en active Active
- 2012-03-29 AR ARP120101085A patent/AR085758A1/es unknown
- 2012-03-29 TW TW101111195A patent/TW201302796A/zh unknown
- 2012-03-29 UY UY0001033994A patent/UY33994A/es unknown
-
2013
- 2013-07-25 IL IL227653A patent/IL227653A0/en unknown
- 2013-09-05 CL CL2013002551A patent/CL2013002551A1/es unknown
- 2013-09-20 CO CO13224736A patent/CO6771448A2/es unknown
- 2013-09-26 TN TNP2013000388A patent/TN2013000388A1/fr unknown
- 2013-10-25 EC ECSP13012997 patent/ECSP13012997A/es unknown
-
2014
- 2014-07-22 US US14/337,357 patent/US20140377265A1/en not_active Abandoned