JP2014515740A - 抗凝固薬の解毒剤 - Google Patents
抗凝固薬の解毒剤 Download PDFInfo
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- JP2014515740A JP2014515740A JP2014501575A JP2014501575A JP2014515740A JP 2014515740 A JP2014515740 A JP 2014515740A JP 2014501575 A JP2014501575 A JP 2014501575A JP 2014501575 A JP2014501575 A JP 2014501575A JP 2014515740 A JP2014515740 A JP 2014515740A
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- dabigatran
- chain variable
- variable domain
- antibody molecule
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Classifications
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
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- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K—PEPTIDES
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
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- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US201161469207P | 2011-03-30 | 2011-03-30 | |
| US61/469,207 | 2011-03-30 | ||
| PCT/EP2012/055397 WO2012130834A1 (en) | 2011-03-30 | 2012-03-27 | Anticoagulant antidotes |
Publications (2)
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| JP2014515740A true JP2014515740A (ja) | 2014-07-03 |
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| JP2014501575A Ceased JP2014515740A (ja) | 2011-03-30 | 2012-03-27 | 抗凝固薬の解毒剤 |
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| MX (1) | MX2013011092A (enExample) |
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| PT2663579T (pt) | 2011-01-14 | 2017-07-28 | Univ California | Terapêutica de anticorpos contra a proteína r0r-1 e métodos para sua utilização |
| ES2569674T3 (es) | 2011-11-29 | 2016-05-12 | Perosphere, Inc. | Agentes de reversión de los anticoagulantes |
| EP3003390B1 (en) * | 2013-06-06 | 2021-07-07 | Pierre Fabre Médicament | Anti-c10orf54 antibodies and uses thereof |
| MX368625B (es) * | 2013-07-30 | 2019-10-08 | Janssen Sciences Ireland Uc | Derivados de tieno[3,2-d]pirimidinas para el tratamiento de infecciones virales. |
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| WO2011023653A1 (en) * | 2009-08-24 | 2011-03-03 | Boehringer Ingelheim International Gmbh | Emergency interventions of active charcoal with dabigatran etexilate overdosing |
| JP5575923B2 (ja) * | 2010-01-20 | 2014-08-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗凝固薬の解毒剤 |
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| EP2691156A1 (en) | 2014-02-05 |
| MX2013011092A (es) | 2013-12-06 |
| US8821871B2 (en) | 2014-09-02 |
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| EA201301090A1 (ru) | 2014-05-30 |
| SG193552A1 (en) | 2013-11-29 |
| TN2013000388A1 (en) | 2015-01-20 |
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| PH12013501924A1 (en) | 2017-10-25 |
| AP2013007046A0 (en) | 2013-08-31 |
| BR112013025031A2 (pt) | 2017-08-01 |
| TW201302796A (zh) | 2013-01-16 |
| UY33994A (es) | 2012-09-28 |
| KR20140009437A (ko) | 2014-01-22 |
| IL227653A0 (en) | 2013-09-30 |
| MA34978B1 (fr) | 2014-03-01 |
| AR085758A1 (es) | 2013-10-23 |
| PE20140964A1 (es) | 2014-08-17 |
| US20140377265A1 (en) | 2014-12-25 |
| WO2012130834A1 (en) | 2012-10-04 |
| CA2827787A1 (en) | 2012-10-04 |
| US20120276123A1 (en) | 2012-11-01 |
| CL2013002551A1 (es) | 2014-02-14 |
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