JP2016130266A5 - - Google Patents

Info

Publication number

JP2016130266A5

JP2016130266A5 JP2016083344A JP2016083344A JP2016130266A5 JP 2016130266 A5 JP2016130266 A5 JP 2016130266A5 JP 2016083344 A JP2016083344 A JP 2016083344A JP 2016083344 A JP2016083344 A JP 2016083344A JP 2016130266 A5 JP2016130266 A5 JP 2016130266A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

compound

macular degeneration

composition according

cyclodextrin

Prior art date

2016-04-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 24
• 208000002780 macular degeneration Diseases 0.000 claims 15
• 150000001875 compounds Chemical class 0.000 claims 8
• 206010064930 age-related macular degeneration Diseases 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 6
• ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 4
• 229920000858 Cyclodextrin Polymers 0.000 claims 2
• 239000007864 aqueous solution Substances 0.000 claims 2
• 239000000872 buffer Substances 0.000 claims 2
• 239000000243 solution Substances 0.000 claims 2
• 206010003694 Atrophy Diseases 0.000 claims 1
• 229940126062 Compound A Drugs 0.000 claims 1
• NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
• 208000027073 Stargardt disease Diseases 0.000 claims 1
• 208000000208 Wet Macular Degeneration Diseases 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 239000003963 antioxidant agent Substances 0.000 claims 1
• 230000003078 antioxidant effect Effects 0.000 claims 1
• 230000037444 atrophy Effects 0.000 claims 1
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
• 229910052736 halogen Inorganic materials 0.000 claims 1
• 125000005843 halogen group Chemical group 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 239000008363 phosphate buffer Substances 0.000 claims 1
• 239000003755 preservative agent Substances 0.000 claims 1
• 230000002335 preservative effect Effects 0.000 claims 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
• LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 claims 1