WO1992007056A1 - Method and composition for cleaning contact lenses - Google Patents

Method and composition for cleaning contact lenses Download PDF

Info

Publication number
WO1992007056A1
WO1992007056A1 PCT/US1991/007742 US9107742W WO9207056A1 WO 1992007056 A1 WO1992007056 A1 WO 1992007056A1 US 9107742 W US9107742 W US 9107742W WO 9207056 A1 WO9207056 A1 WO 9207056A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
composition
cyclodextrins
lenses
method
beta
Prior art date
Application number
PCT/US1991/007742
Other languages
French (fr)
Inventor
Nimai C. De
David J. Heiler
David A. Marsh
Suzanne F. Groemminger
Original Assignee
Bausch & Lomb Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L12/00Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005Other compounding ingredients characterised by their effect
    • C11D3/0078Compositions for cleaning contact lenses, spectacles, lenses
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/22Carbohydrates or derivatives thereof
    • C11D3/222Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid, cyclodextrin
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/839Contact lens treatment
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/839Contact lens treatment
    • Y10S514/84Chemical sterilizing

Abstract

Contact lenses are cleaned by contacting the lenses with a composition containing an effective amount of one or more cyclodextrins. The compositions can also be employed at elevated temperatures or may contain suitable antimicrobial agents in order to simultaneously clean and disinfect the lenses.

Description

METHOD AND COMPOSITION FOR CLEANING CONTACT LENSES

BACKGROUND OF THE INVENTION

Field of the Invention

This invention relates generally to a method and composition for cleaning contact lenses. In one as¬ pect, the present invention relates to a method and composition for cleaning contact lenses with cyclodex- trins while in another aspect it relates to a method for simultaneously cleaning and disinfecting contact lenses by contacting the lenses with compositions con¬ taining cyclodextrins either under elevated tempera- tures or in the presence of antimicrobial agents.

Description of Art

In the normal course of wearing contact lenses, tear film and debris consisting of proteinaceous, oily, sebaceous, and related organic matter have a tendency to deposit and build-up on lens surfaces. As part of the routine and proper care regimen, contact lenses must be cleaned to remove these tear film deposits and debris. If these deposits are not properly removed, both the wettability and optical clarity of the lenses are substantially reduced causing discomfort for the wearer.

Conventionally, the cleaning of contact lenses is accomplished with one or both of two general classes of cleaners. Surfactant cleaners, generally known as "daily cleaners" because of their recommended daily use, are effective for the removal of most carbohydrate and lipid derived matter. However, they are not as effective for the removal of proteinaceous matter such as lysozy e. Proteolytic enzymes derived from plant, animal, and microbial sources are generally used to remove the proteinaceous deposits. These "enzyme" cleaners are typically recommended for weekly use and are conventionally employed by dissolving enzyme- containing tablets in suitable solutions. Both cleaners are currently recommended for proper care of contact lenses, particularly those made from hydrophilic materials.

Cyclodextrins have been known for nearly a century being first isolated from the degradation products of starch. They are cyclic oligosaccharides produced by the enzymatic degradation of starch. The degradation enzymes used are typically produced by various microorganisms such as bacilli. Generally, cyclodextrins have been commercially employed in the pharmaceutical industry as inclusion or entrapment agents for the purpose of solubilizing relatively insoluble compounds, preventing the evaporation of volatile compounds, stabilizing volatile or heat labile compounds, enhancing the bioavailability of certain drugs and related purposes. Hence, conventional uses of cyclodextrins involve the inclusion of an active compound into the cyclodextrin molecular structure prior to use and employ the cyclodextrin as a means for delivering the active compound.

It has now been found that cyclodextrin composi- tions can be employed under ambient and elevated tem¬ peratures to remove many of the deposits, which adhere to contact lenses during normal wear including, pro¬ teinaceous matter, typically the most difficult de¬ posits to remove. These compositions contain cyclodextrins which do not contain active compounds incorporated into the cavity of the cyclodextrin. Moreover, it has been surprisingly found that the continued and regular use of cyclodextrin cleaning compositions result in an effective technique for preventing proteinaceous deposit build-up on contact lenses.

SUMMARY OF THE INVENTION

According to this invention, a method for cleaning contact lenses is provided comprising contacting the lenses with a composition containing from 0.0001% to about 10% by weight of one or more cyclodextrins for a time sufficient to clean the lenses. A contact lens cleaning composition is also provided comprising from 0.0001% to about 10% by weight of one or more cyclodextrins.

Also provided herein is a method for simultane¬ ously cleaning and disinfecting contact lenses comprising contacting the lenses with a composition containing from 0.0001% to about 10% by weight of one or more cyclodextrins at a temperature of at least about 60°C for a time sufficient to clean and disinfect the lenses.

Yet another method is provided herein for simultaneously cleaning and disinfecting contact lenses comprising contacting the lenses with a composition containing from 0.0001% to about 10% by weight of one or more cyclodextrins and a disinfecting amount of an antimicrobial agent for a time sufficient to clean and disinfect the lenses. DETAILED DESCRIPTION OF THE INVENTION

The present invention can be used with all contact lenses such as conventional hard, soft, rigid gas per- meable, and silicone lenses but is preferably employed with soft lenses such as those commonly referred to as hydrogel lenses prepared from monomers such as hydrox- yethylmethacrylate, vinylpyrrolidone, glycerol- methacrylate, ethacrylic acid or acid esters and the like. Hydrogel lenses typically absorb significant amounts of water such as from 4 to 80 percent by weight.

The compositions employed herein contain at least one or more cyclodextrins in a suitable carrier. Other active or inactive components can also be employed in the cleaning compositions.

As described above, the cyclodextrins used in the present invention are cyclic oligosaccharides produced by the enzymatic degradation of starch and have multi¬ ple glucose or glucopyranose units, usually 6 to 8 units. Depending on the particular preparation reac¬ tion conditions employed, cyclodextrins generally con- tain six, seven or eight of such units, connected by alpha-(1,4) bonds. The six, seven or eight unit cy¬ clodextrins are commonly known as alpha-, beta-, and gamma-cyclodextrins, respectively.

Cyclodextrins have the shape of truncated cones with primary and secondary hydroxyl groups located at opposite ends of the torus. The glucosyl-o-bridges point into the center of the molecule and the primary hydrogel groups project from one outer edge while the secondary hydroxyl groups project from the other edge. The result is a molecule with a relatively hydrophobic center and a hydrophilic outer surface. These shapes and hydrophilic/hydrophobic domains provide for inclu¬ sion or incorporation of guest molecules into the cen¬ ter of the molecule.

Cyclodextrins are well known and are commercially produced by the enzymatic degradation of starch. For example, beta-cyclodextrin is the major product of the reaction between the enzyme cyclodextrin transglycosy- lase and a starch solution pretreated with gamma-amy- lase.

As used herein, the term "cyclodextrins" includes all cyclodextrin derivatives, such as cyclodextrin carbonates, ethers, esters, and polyethers; polymers or copoly ers of polymerized cyclodextrins, such as poly¬ merized beta-cyclodextrins; and substituted cyclodex¬ trins such as those with functional groups bonded to one or more of the hydroxyl groups. Suitable function groups include, but are not limited to, methyl, ethyl, hydroxyethyl, and hydroxypropyl and acetyl groups.

The preferred cyclodextrins are the beta- cyclodextrins and most preferred are beta-cyclodextrin selected from beta-cyclodextrin, hydroxypropyl beta- cyclodextrin, methyl beta-cyclodextrin and hydroxyethyl beta-cyclodextrin when the cyclodextrin compositions are employed at elevated temperatures.

The present invention employs an effective amount of cyclodextrin to clean the lenses. An effective amount is that required to remove a substantial porti < of the proteinaceous deposits, which occur during nor¬ mal wear of contact lenses, in a reasonable time. The precise amount of cyclodextrin required to make an ef¬ fective cleaner will depend on several factors includ- ing the type of cyclodextrin, the amount of proteina¬ ceous matter deposited on the lenses, the desired soaking period, the specific type of materials comprising the lenses, and the like. Further, it should be appreciated by one skilled in the art, that the cyclodextrin concentrations useful herein will be adjusted depending upon the time allowed for removing the proteinaceous matter, the other components in the composition and the factors previously mentioned. However, cyclodextrins will generally be present in an amount from 0.0001% to about 10%.by weight with from about 0.01% to about 2.0% being preferred.

The compositions of the present invention may contain various additional components which do not ad¬ versely affect, to any significant extent, the activity of the cyclodextrins. Illustrative examples of compo¬ nents which may be found in the composition include one or more of a suitable antimicrobial agent, buffering agent, chelating and/or sequestering agent, a tonicity adjusting agent, and surfactant.

The cyclodextrin composition may contain a pre¬ serving or disinfecting amount of one or more antimi- crobial agents which are compatible with and do not adversely affect the activity of the cyclodextrins or other components. Suitable chemical antimicrobial agents, as the term is used herein, include quaternary ammonium salts and polymers used in ophthalmic applications such as poly[ (dimethyliminio)-2-butene-

1,4-diyl chloride], [4-tris(2-hydroxyethyl) ammonio]-2- butenyl- -[tris(2-hydroxyethyl) ammonio]dichloride (chemical registry number 75345-27-6) generally available as polyquaternium 1® from ONYX Corporation; benzalkonium halides; trialkylammonium halides; biguanides such as salts of alexidine, alexidine free base, salts of chlorhexidine, hexa ethylene biguanides and their polymers; and the like. The salts of alexidine and chlorhexidine can be either organic or inorganic and are typically gluconates, nitrates, acetates, phosphates, sulfates, halides and the like.

Suitable oxidative antimicrobial agents, as the term is used herein, include any peroxide sources which produce active oxygen in solution and any iodine liberating sources which produce preserving or disinfecting amounts of iodine compounds in solution. Examples of such agents include hydrogen peroxide and its alkali metal salts; alkali metal perborates and persulfates; alkali metal carbonate peroxide; diperisophthalic acid; peroxydiphosphate salts; sodium aluminium aminohydroperoxide; iodine and iodophors. Preferred oxidative antimicrobial agents are peroxides and iodophors.

The antimicrobial agents can also be employed af¬ ter the cleaning step using the cyclodextrin composi¬ tion. In this application, the cleaning step would be followed with a disinfecting step in a conventional regimen.

A preserving amount of an antimicrobial agent is an amount which will substantially inhibit the microorganism population from growing while a disinfecting amount is an amount which will reduce the microorganism population. Preferably, a preserving ar.ount of antimicrobial agent will substantially inhibit the microorganism population growth for at least thirty (30) days after exposure to environmental air. Preferably, a disinfecting amount of an anti- microbial agent is that which will reduce the microbial burden by about two log orders in four hours and, more preferably, by about one log order in one hour. Typically, such agents are present in concentrations ranging from about 0.00001% to about 0.5% (w/v) , and more preferably, from about 0.00003% to about 0.05% (w/v) .

The compositions of the present invention can be prepared in various physical forms such as liquids, solids, emulsions or colloidal suspensions. For exam- pie, the cyclodextrins and additional ingredients can be dissolved or suspended in a suitable solvent such as water, glycerol, propylene glycol and the like. Alternatively, the composition can be in the form of a powder or tablet wherein the latter will typically contain binders or other excipients commonly used in the tableting industry. Further, the cyclodextrins can be incorporated into liposomes, microsponges, microspheres and other drug delivery systems.

Rather than including a disinfecting amount of an antimicrobial agent into the present composition, the cleaning composition can also be formulated for use in a contact lens heat disinfecting apparatus. Such de¬ vices are well known and are commercially available through numerous companies. These devices typically raise the temperature of the composition inside their wells to between about 60°C and 100°C for about 20 to 60 minutes as required to disinfect the lenses.

During the normal practice of one embodiment of the present invention, soiled lenses are placed in the cleaning composition for a period of about 15 minutes to about 12 hours either with or without a prior rub¬ bing (as is currently recommended for daily cleaners) . After soaking the lenses for the appropriate time, the lenses are removed and disinfected using conventional techniques such as elevated temperatures or disinfect¬ ing solutions.

In another embodiment of the invention, the composition can contain an effective amount of an antimicrobial agent. The composition can then be employed to simultaneously clean and disinfect the lenses during the required soaking period. In the case of oxidative antimicrobial agents, the residual agent remaining on the lenses must be neutralized prior to placing the lenses in the eye. Such neutralizing agents and methods are well known in the art. In the case of chemical antimicrobial agents, a neutralization step is generally not required.

In a preferred embodiment of the invention, the cleaning composition is placed in a contact lenses heat disinfecting unit which is capable of raising the tem¬ perature of the composition to at least 60"C for at least about 10 minutes or as otherwise necessary to disinfect the lenses. The soiled contact lenses are then placed in the cleaning composition within the unit for a time sufficient to clean and disinfect the lenses. Typically, the cleaning and disinfecting pro- cess will take less than about 60 minutes depending on the specific unit employed and is typically about 15 to about 40 minutes. Conventional heat disinfecting units already known to disinfect contact lenses are suitable for use with the cyclodextrin composition to achieve cleaning and disinfection. Advantageously, the lenses can be removed from the solution and placed directly into the eye without tne need for a separate disinfecting or neutralizing step. Optionally, the lenses may be rinsed with a suitable isotonic aqueous solution prior to insertion into the eye. The following detailed examples are presented to illustrate the present invention. Both ambient and thermal (elevated temperatures) cleaning efficacy were performed using protein deposited Group IV contact lenses and cyclodextrin compositions. All percentages below are by weight.

Group IV (etafilcon 58% water) lenses were de¬ posited by soaking each lens for 18 hours at 37βC (approximate corneal temperature) . The soaking solu¬ tion consisted of four major tear proteins: lysozyme, albumin, lactoferrin, and mucin; and electrolytes, all in concentrations reportedly found in human tears. The final soaking solution contained 0.1% mucin, 0.17% lysozyme, 0.05% lactoferrin, 0.085% albumin, 0.7% sodium chloride, 0.005% calcium chloride, and 0.05% sodium phosphate dibasic. The remainder of the soaking solution comprised deionized and distilled water with the pH adjusted to 7.2 with l N hydrochloric acid. After soaking for 18 hours each lens was rubbed and rinsed lightly with isotonic saline to remove non-bound protein solution.

Each of the cyclodextrin compositions were pre- pared by mixing 1.0% of the selected cyclodextrin in an aqueous isotonic phosphate buffered saline containing 0.3% hydrated sodium phosphate dibasic, and 0.9% sodium chloride. The remainder of the solution was deionized, distilled water with the pH adjusted to 7.2 with 1 N hydrochloric acid.

Example 1

Ten protein deposited lenses were allowed to soak in 10 ml per lens of the cyclodextrin composition. After 4 hours, the lenses were removed from the test solution and soaked in the isotonic phosphate buffered saline for about 10 minutes to rente a excess solution. The lenses were analyzed to determine the total remaining protein bound to the lens after cleaning using a standard ninhydrin assay for the colorimetric determination of protein adapted for use with hydrophilic contact lenses.

The ninhydrin reagent was prepared according to the method described by Shibata and Matoba in Modified Colorimetric Ninhydrin Methods for Peptidase Assay,

Analytical Biochemistry 1981; 118:173-184. A citrate- acetate buffer was prepared with 0.5 moles acetic acid and 0.1 moles citric acid adjusted to pH 5.0 with 10 N sodium hydroxide. The ninhydrin reagent was prepared by dissolving 20 mg of stannous chloride and 200 mg of ninhydrin in 10 ml of methyl cellosolve (ethylene gly- col, monomethyl ether) , then adding 10 ml of the cit- rateacetate buffer.

The protein bound to the lenses was hydrolyzed to their amino acid components by heating the lenses in 1 ml of 2.5 N NaCl for 2 hours at 100°C. Aliquots of hydrolyzed solution samples (0.015 ml) were placed into disposable polystyrene culture tubes. The samples were diluted with 2.5 N sodium hydroxide prior to performing the analysis. To neutralize the sodium hydroxide, glacial acetic acid (0.050 ml) was added to each of the culture tubes and the tubes were vortexed. Ninhydrin reagent (0.40 ml) was added to each tube, followed by vortexing.

The polystyrene tubes were capped and heated in a water bath at 90βC for 20 minutes, during which time color development occurred. After 20 minutes, samples were transferred to an ice bath and diluted with 1.0 ml of 50% aqueous 2-propanol. The absorbance of each sample was recorded at 570 nm on a Spectophotometer. Standard protein calibration curves (absorbance vs protein concentration) were prepared in the 0.0 - 15.0 ug range with a known amount of a lysozyme standard subjected to the same analysis procedure. A protein standard was prepared using lysozyme (Grade I, from chicken egg white, 3X crystallized, dialyzed and lyophilized; Sigma Chemical Company) . A known amount of lysozyme was added to a culture tube and dissolved in 1.0 ml of 2.5 N sodium hydroxide. The culture tubes containing the lenses and the lysozyme standard were tightly capped and placed into a heating block preheated to 100"C. Samples were hydrolyzed for two hours, removed from the heating block and allowed to cool to room temperature.

Protein concentrations were determined by comparison of absorbance readings with the lysozyme standard curve and calculating the concentration of protein per lens based on appropriate dilution factors. The results are shown in Table 1.

Example 2

Protein deposited lenses were placed into a Bausch & Lomb White Lens Carrying Case containing 3 ml of the cyclodextrin composition. The lens cases were cycled through one disinfecting cycle in a Bausch & Lomb DUIV Thermal Disinfecting Unit. The typical heat profile of this unit raises the solution temperature to greater than 60°C for about 20 minutes, and greater than 70°C for about 10 minutes. This heat profile is commonly accepted as that necessary to disinfect contact lenses. After the cycle was complete, each lens was soaked in an isotonic phosphate buffered saline solution to re- move any residual cyclodextrin composition adhering to the lenses prior to total protein analysis by a similar procedure as described in Example 1.

Control protein levels were established for the lenses by using 10 lenses which have had protein de¬ posited on them using the procedure described above and which have not been previously cleaned. The percent cleaning was determined by subtracting the tested val¬ ues from the control values and dividing by the control values. This number is multiplied by 100 to convert to percent. The results are shown in Table 1.

As shown in Table 1, the cyclodextrin composition exhibited cleaning activity under both ambient and elevated temperatures.

Thus, it should be apparent to those skilled in the art that the present invention is not limited by the examples set forth above and that the use of spe- cific compositions can be determined from the specifi¬ cation without departing from the invention as herein disclosed and described. It should be understood that the scope of the present invention includes all modifications and variations that fall within the scope of the attached claims.

TABLE 1

Ambient and Thermal Cleaning of Contact Lenses

Example l (Ambient)

Figure imgf000016_0001

Example 2 (Thermal)

Figure imgf000016_0002

SUBSTITUTE SHEET

Claims

What is claimed:
1. A contact lens cleaning composition compris¬ ing an effective amount of one or more cyclodextrins.
2. The composition of Claim 1 wherein the cyclodextrins are selected from the group consisting of alpha-cyclodextrins, beta-cyclodextrins and gamma-cy- clodextrins.
3. The composition of Claim 2 wherein the beta- cyclodextrins are selected from the group consisting of beta-cyclodextrin, hydroxypropyl beta-cyclodextrin, methyl beta-cyclodextrin and hydroxyethyl beta-cy- clodextrins.
4. The composition of Claim 1 wherein the cyclodextrins are present in an amount from 0.0001% to about 10% by weight.
5. The composition of Claim 4 wherein the cyclodextrins are present in an amount from about 0.01% to about 2.0% by weight.
6. The composition of Claim 4 containing one or more additional components selected from the group consisting of an antimicrobial agent, a buffering agent, a chelating agent, a sequestering agent, a tonicity adjusting agent, and a surfactant.
7. The composition of Claim 1 wherein the composition is a powder.
8. A method for cleaning contact lenses comprising contacting the lenses with a composition containing an effective amount of one or more cyclodextrins for a time sufficient to clean the lenses.
9. The method of Claim 8 wherein the cyclodex¬ trins are selected from the group consisting of alpha- cyclodextrins, beta-cyclodextrins and gamma-cyclodex- trins.
10. The method of Claim 8 wherein the cyclodex¬ trins are present in an amount from 0.0001% to about 10% by weight.
11. The method of Claim 10 wherein the composi¬ tion contains one or more additional components se¬ lected from the group consisting of an antimicrobial agent, a buffering agent, a chelating agent, a seques- tering agent, a tonicity adjusting agent, and a surfactant.
12. The method of Claim 8 wherein the composition is in the form of a tablet.
13. A method for simultaneously cleaning and disinfecting contact lenses comprising contacting the lenses with an aqueous composition containing an effective amount of one or more cyclodextrins at a temperature of at least about 60°C for a time sufficient to clean and disinfect the lenses.
14. The method of Claim 13 wherein the cyclodex¬ trins are selected from the group consisting of beta- cyclodextrin, hydroxypropyl beta-cyclodextrin, methyl beta-cyclodextrin, and hydroxyethyl beta-cyclodextrin.
15. The method of Claim 14 wherein the tempera¬ ture is at least 60 " C for at least about 10 minutes.
16. The method of Claim 15 wherein the cyclodex¬ trins are present in an amount from about 0.01% to about 2.0% by weight.
17. The method of Claim 13 wherein the composi¬ tion is in the form of a tablet.
18. A composition for cleaning and disinfecting contact lenses, said composition having a pH of about 6.5 to about 8.5, and comprising from 0.0001% to about 10% by weight of one or more cyclodextrins and a disinfecting amount of a suitable antimicrobial agent.
19. The composition of Claim 18 wherein the antimicrobial agent is a chemical disinfecting agent.
20. The composition of Claim 18 wherein the antimicrobial agent is an oxidative disinfecting agent.
21. A method for simultaneously cleaning and disinfecting contact lenses comprising contacting the lenses with an aqueous composition containing 0.0001% to about 10.0% by weight of one or more cyclodextrins and a disinfecting amount of an antimicrobial agent for a time sufficient to clean and disinfect the lenses.
22. The method of Claim 21 wherein the cyclodex¬ trin is a beta-cyclodextrin in an amount from about 0.01% to about 2.0% by weight.
23. A method for preventing proteinaceous deposit build-up on contact lenses comprising contacting the lenses with the compositions of Claim 1 or Claim 18.
PCT/US1991/007742 1990-10-22 1991-10-15 Method and composition for cleaning contact lenses WO1992007056A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US60244790 true 1990-10-22 1990-10-22
US602,447 1990-10-22

Publications (1)

Publication Number Publication Date
WO1992007056A1 true true WO1992007056A1 (en) 1992-04-30

Family

ID=24411401

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/007742 WO1992007056A1 (en) 1990-10-22 1991-10-15 Method and composition for cleaning contact lenses

Country Status (6)

Country Link
US (1) US5364637A (en)
EP (1) EP0506949A1 (en)
JP (1) JP3167152B2 (en)
CN (1) CN1060868A (en)
CA (1) CA2072001C (en)
WO (1) WO1992007056A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0586332A1 (en) * 1992-08-05 1994-03-09 Ciba-Geigy Ag Contact lenses made from lipophilic cyclodextrines
WO1994010280A1 (en) * 1992-11-05 1994-05-11 Wacker-Chemie Gmbh Cleaning agents containing cyclodextrines
WO1997031660A1 (en) * 1996-02-29 1997-09-04 Vision Pharmaceuticals L.P. Contact lens treating compositions, methods of treatment, and novel lenses
EP0915151A1 (en) * 1997-11-10 1999-05-12 Tomey Corporation Method of cleaning and disinfecting contact lenses
WO2003011350A2 (en) * 2001-07-27 2003-02-13 Bausch & Lomb Incorporated Composition and method for inhibiting uptake of biguanide disinfectants by poly(ethylene)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5683709A (en) * 1994-05-05 1997-11-04 Ciba Vision Corporation Poly(benzalkonium salt) as an anti-microbial agent for aqueous drug compositions
US6682694B2 (en) * 1994-08-12 2004-01-27 The Procter & Gamble Company Uncomplexed cyclodextrin solutions for odor control on inanimate surfaces
JPH08224288A (en) * 1995-02-21 1996-09-03 Tomey Technol Corp Washing and disinfecting agent for contact lens and method for washing and disinfecting contact lens
US7034013B2 (en) * 2001-03-20 2006-04-25 Cydex, Inc. Formulations containing propofol and a sulfoalkyl ether cyclodextrin
US6528464B1 (en) 2001-08-17 2003-03-04 Bausch & Lomb Incorporated Composition and method for inhibiting uptake of biguanide antimicrobials by hydrogels
JP5194218B2 (en) * 2006-06-05 2013-05-08 株式会社メニコンネクト Conserved water-absorptive contact lens by storage method and the storage method of the water-absorptive contact lens
US8932646B2 (en) * 2010-06-18 2015-01-13 Bausch & Lomb Incorporated Peroxide contact lens care solution
US20170119811A1 (en) * 2014-06-15 2017-05-04 Yeda Research And Development Co. Ltd. Surface treatment of contact lens and treatment of ocular discomfort by water soluble polymers and lipids/liposomes

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3240709A (en) * 1962-05-16 1966-03-15 Burton Parsons Chemicals Inc Method of cleansing contact lenses
US4259202A (en) * 1979-02-27 1981-03-31 Toyo Contact Lens Co., Ltd. Cleaning and preservative solution for contact lenses
US4537746A (en) * 1983-12-29 1985-08-27 Bausch & Lomb Incorporated Methods for disinfecting and preserving contact lenses
EP0301847A1 (en) * 1987-07-29 1989-02-01 Microgenics Corporation Cleaning using cyclodextrin
EP0392608A2 (en) * 1989-04-12 1990-10-17 THE PROCTER &amp; GAMBLE COMPANY Solid consumer product compositions containing small particle cyclodextrin complexes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USB724600I5 (en) * 1968-04-26

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3240709A (en) * 1962-05-16 1966-03-15 Burton Parsons Chemicals Inc Method of cleansing contact lenses
US4259202A (en) * 1979-02-27 1981-03-31 Toyo Contact Lens Co., Ltd. Cleaning and preservative solution for contact lenses
US4537746A (en) * 1983-12-29 1985-08-27 Bausch & Lomb Incorporated Methods for disinfecting and preserving contact lenses
EP0301847A1 (en) * 1987-07-29 1989-02-01 Microgenics Corporation Cleaning using cyclodextrin
EP0392608A2 (en) * 1989-04-12 1990-10-17 THE PROCTER &amp; GAMBLE COMPANY Solid consumer product compositions containing small particle cyclodextrin complexes

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0586332A1 (en) * 1992-08-05 1994-03-09 Ciba-Geigy Ag Contact lenses made from lipophilic cyclodextrines
US5391592A (en) * 1992-08-05 1995-02-21 Ciba-Geigy Corporation Contact lenses comprising lipophilised cyclodextrins
WO1994010280A1 (en) * 1992-11-05 1994-05-11 Wacker-Chemie Gmbh Cleaning agents containing cyclodextrines
WO1997031660A1 (en) * 1996-02-29 1997-09-04 Vision Pharmaceuticals L.P. Contact lens treating compositions, methods of treatment, and novel lenses
EP0915151A1 (en) * 1997-11-10 1999-05-12 Tomey Corporation Method of cleaning and disinfecting contact lenses
WO2003011350A2 (en) * 2001-07-27 2003-02-13 Bausch & Lomb Incorporated Composition and method for inhibiting uptake of biguanide disinfectants by poly(ethylene)
WO2003011350A3 (en) * 2001-07-27 2003-09-25 Bausch & Lomb Composition and method for inhibiting uptake of biguanide disinfectants by poly(ethylene)

Also Published As

Publication number Publication date Type
JPH04264422A (en) 1992-09-21 application
CN1060868A (en) 1992-05-06 application
CA2072001C (en) 1998-11-03 grant
CA2072001A1 (en) 1992-04-23 application
JP3167152B2 (en) 2001-05-21 grant
EP0506949A1 (en) 1992-10-07 application
US5364637A (en) 1994-11-15 grant

Similar Documents

Publication Publication Date Title
US6274133B1 (en) Method for treating extended-wear contact lenses in the eyes
US3888782A (en) Soft contact lens preserving solution
US6037328A (en) Method and composition for rewetting and preventing deposits on contact lens
US4560491A (en) Soft contact lens wetting solution and in-eye comfort solution containing preservative and method
US4670178A (en) Method for the simultaneous cleaning and disinfecting of contact lenses
US6180093B1 (en) Method and composition for rewetting contact lenses and relieving eye dryness
USRE32672E (en) Method for simultaneously cleaning and disinfecting contact lenses using a mixture of peroxide and proteolytic enzyme
US5872086A (en) Composition for wetting contact lenses
US5718895A (en) Enzymes with low isoelectric points for use in contact lens cleaning
EP0456467A2 (en) Contact lens cleaning and disinfecting with combinations of polymeric quaternary ammonium compounds and enzymes
US6096138A (en) Method for inhibiting the deposition of protein on contact lens
US6153568A (en) Compositions comprising polyquaterniums in combination with polymeric biguanides for disinfecting contact lenses
US6143799A (en) Use of borate-polyol complexes in ophthalmic compositions
US6309658B1 (en) Treatment of contact lenses with aqueous solution comprising a carbonate salt for enhanced cleaning
US3882036A (en) Contact lens cleaning and storing composition including nonionic surfactant, benzalkonium chloride and Na{hd 3{b EDTA
US6369112B1 (en) Treatment of contact lenses with aqueous solution comprising a biguanide disinfectant stabilized by tyloxapol
US4690773A (en) Microbial enzymatic contact lens cleaner and methods of use
US5096607A (en) Method for cleaning and disinfecting contact lenses
US4820352A (en) Cleaning and conditioning solutions for contact lenses and methods of use
US4614549A (en) Method for enzymatic cleaning and disinfecting contact lenses
US5424078A (en) Aqueous ophthalmic formulations and methods for preserving same
US5765579A (en) Treatment of contact lenses with an aqueous solution including sulfobetaine compounds
US6162393A (en) Contact lens and ophthalmic solutions
US6805836B2 (en) Prevention of preservative uptake into biomaterials
US4609493A (en) Solution and method for removing inorganic and organic deposits from contact lenses

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU BR CA

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE

WWE Wipo information: entry into national phase

Ref document number: 1992900544

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2072001

Country of ref document: CA

ENP Entry into the national phase in:

Ref country code: CA

Ref document number: 2072001

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 1992900544

Country of ref document: EP

WWR Wipo information: refused in national office

Ref document number: 1992900544

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1992900544

Country of ref document: EP