JP2016127847A5 - - Google Patents
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- JP2016127847A5 JP2016127847A5 JP2016014732A JP2016014732A JP2016127847A5 JP 2016127847 A5 JP2016127847 A5 JP 2016127847A5 JP 2016014732 A JP2016014732 A JP 2016014732A JP 2016014732 A JP2016014732 A JP 2016014732A JP 2016127847 A5 JP2016127847 A5 JP 2016127847A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- pluripotent stem
- stem
- marker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000000130 stem cell Anatomy 0.000 claims 48
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 23
- 238000000034 method Methods 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 16
- 239000003550 marker Substances 0.000 claims 16
- 210000001900 endoderm Anatomy 0.000 claims 11
- 210000003494 hepatocyte Anatomy 0.000 claims 7
- 210000003445 biliary tract Anatomy 0.000 claims 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 6
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 5
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 5
- 210000000232 gallbladder Anatomy 0.000 claims 5
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 4
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 4
- 108091023040 Transcription factor Proteins 0.000 claims 4
- 102000040945 Transcription factor Human genes 0.000 claims 4
- 210000000013 bile duct Anatomy 0.000 claims 4
- 239000002458 cell surface marker Substances 0.000 claims 4
- 102000004877 Insulin Human genes 0.000 claims 3
- 108090001061 Insulin Proteins 0.000 claims 3
- -1 N-CAM Proteins 0.000 claims 3
- 239000007640 basal medium Substances 0.000 claims 3
- 210000004907 gland Anatomy 0.000 claims 3
- 229940125396 insulin Drugs 0.000 claims 3
- 108010005465 AC133 Antigen Proteins 0.000 claims 2
- 102000005908 AC133 Antigen Human genes 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- 102100029284 Hepatocyte nuclear factor 3-beta Human genes 0.000 claims 2
- 102100029087 Hepatocyte nuclear factor 6 Human genes 0.000 claims 2
- 101001002170 Homo sapiens Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial Proteins 0.000 claims 2
- 101001062347 Homo sapiens Hepatocyte nuclear factor 3-beta Proteins 0.000 claims 2
- 101000988619 Homo sapiens Hepatocyte nuclear factor 6 Proteins 0.000 claims 2
- 101000603702 Homo sapiens Neurogenin-3 Proteins 0.000 claims 2
- 101001069749 Homo sapiens Prospero homeobox protein 1 Proteins 0.000 claims 2
- 101000843556 Homo sapiens Transcription factor HES-1 Proteins 0.000 claims 2
- 101000711846 Homo sapiens Transcription factor SOX-9 Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 108010069196 Neural Cell Adhesion Molecules Proteins 0.000 claims 2
- 102100023616 Neural cell adhesion molecule L1-like protein Human genes 0.000 claims 2
- 102100038553 Neurogenin-3 Human genes 0.000 claims 2
- 102100033880 Prospero homeobox protein 1 Human genes 0.000 claims 2
- 102100020949 Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial Human genes 0.000 claims 2
- 102100034204 Transcription factor SOX-9 Human genes 0.000 claims 2
- 210000000941 bile Anatomy 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 210000001953 common bile duct Anatomy 0.000 claims 2
- 210000003459 common hepatic duct Anatomy 0.000 claims 2
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 238000000684 flow cytometry Methods 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 2
- 229940099552 hyaluronan Drugs 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 210000004153 islets of langerhan Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 239000012679 serum free medium Substances 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102100023635 Alpha-fetoprotein Human genes 0.000 claims 1
- 239000004382 Amylase Substances 0.000 claims 1
- 102000013142 Amylases Human genes 0.000 claims 1
- 108010065511 Amylases Proteins 0.000 claims 1
- 102000010637 Aquaporins Human genes 0.000 claims 1
- 108010063290 Aquaporins Proteins 0.000 claims 1
- 102000001187 Collagen Type III Human genes 0.000 claims 1
- 108010069502 Collagen Type III Proteins 0.000 claims 1
- 102000004266 Collagen Type IV Human genes 0.000 claims 1
- 108010042086 Collagen Type IV Proteins 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 108060006698 EGF receptor Proteins 0.000 claims 1
- 102000051325 Glucagon Human genes 0.000 claims 1
- 108060003199 Glucagon Proteins 0.000 claims 1
- 102000015779 HDL Lipoproteins Human genes 0.000 claims 1
- 108010010234 HDL Lipoproteins Proteins 0.000 claims 1
- 108010049606 Hepatocyte Nuclear Factors Proteins 0.000 claims 1
- 102000008088 Hepatocyte Nuclear Factors Human genes 0.000 claims 1
- 101000998011 Homo sapiens Keratin, type I cytoskeletal 19 Proteins 0.000 claims 1
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 1
- 101000652324 Homo sapiens Transcription factor SOX-17 Proteins 0.000 claims 1
- 101710123134 Ice-binding protein Proteins 0.000 claims 1
- 101710082837 Ice-structuring protein Proteins 0.000 claims 1
- 102100033420 Keratin, type I cytoskeletal 19 Human genes 0.000 claims 1
- 102000007547 Laminin Human genes 0.000 claims 1
- 108010085895 Laminin Proteins 0.000 claims 1
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 1
- 101710183548 Pyridoxal 5'-phosphate synthase subunit PdxS Proteins 0.000 claims 1
- 102100035459 Pyruvate dehydrogenase protein X component, mitochondrial Human genes 0.000 claims 1
- 239000012980 RPMI-1640 medium Substances 0.000 claims 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- 102000005157 Somatostatin Human genes 0.000 claims 1
- 108010056088 Somatostatin Proteins 0.000 claims 1
- 108010017842 Telomerase Proteins 0.000 claims 1
- 102100030243 Transcription factor SOX-17 Human genes 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- 101710107540 Type-2 ice-structuring protein Proteins 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 235000019418 amylase Nutrition 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 235000021588 free fatty acids Nutrition 0.000 claims 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 1
- 229960004666 glucagon Drugs 0.000 claims 1
- 239000000859 incretin Substances 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 230000009996 pancreatic endocrine effect Effects 0.000 claims 1
- 238000004091 panning Methods 0.000 claims 1
- 238000007747 plating Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000011669 selenium Substances 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 1
- 229960000553 somatostatin Drugs 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25684609P | 2009-10-30 | 2009-10-30 | |
| US61/256,846 | 2009-10-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012537054A Division JP5936547B2 (ja) | 2009-10-30 | 2010-10-28 | 肝外胆樹からの多能性幹細胞およびそれらを単離する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016127847A JP2016127847A (ja) | 2016-07-14 |
| JP2016127847A5 true JP2016127847A5 (enExample) | 2016-12-01 |
| JP6356165B2 JP6356165B2 (ja) | 2018-07-11 |
Family
ID=43922533
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012537054A Active JP5936547B2 (ja) | 2009-10-30 | 2010-10-28 | 肝外胆樹からの多能性幹細胞およびそれらを単離する方法 |
| JP2016014732A Active JP6356165B2 (ja) | 2009-10-30 | 2016-01-28 | 肝外胆樹からの多能性幹細胞およびそれらを単離する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012537054A Active JP5936547B2 (ja) | 2009-10-30 | 2010-10-28 | 肝外胆樹からの多能性幹細胞およびそれらを単離する方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20110135610A1 (enExample) |
| EP (2) | EP3725874A1 (enExample) |
| JP (2) | JP5936547B2 (enExample) |
| KR (4) | KR20120117758A (enExample) |
| CN (2) | CN105456292B (enExample) |
| AR (2) | AR078849A1 (enExample) |
| AU (1) | AU2016210783B2 (enExample) |
| BR (1) | BR112012009848B1 (enExample) |
| CA (2) | CA3169831C (enExample) |
| CL (1) | CL2012001117A1 (enExample) |
| CR (1) | CR20120254A (enExample) |
| ES (1) | ES2819028T3 (enExample) |
| IL (2) | IL219454A (enExample) |
| MX (1) | MX2012005087A (enExample) |
| NZ (3) | NZ709124A (enExample) |
| PH (1) | PH12012500845A1 (enExample) |
| RU (2) | RU2580246C2 (enExample) |
| SG (2) | SG10201407102QA (enExample) |
| TW (3) | TWI686478B (enExample) |
| WO (1) | WO2011053690A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3169831C (en) * | 2009-10-30 | 2025-11-18 | Sapienza Universita Di Roma | Pluripodent Stem Cells from the Extrahepatic Biliary Tree and Methods for Their Isolation |
| AU2012272586B2 (en) * | 2011-06-23 | 2016-07-07 | The Children's Hospital Of Philadelphia | Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof |
| US9533013B2 (en) | 2013-03-13 | 2017-01-03 | University Of North Carolina At Chapel Hill | Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree |
| CN103266084B (zh) * | 2013-05-27 | 2015-03-04 | 刘卫辉 | 富集干细胞的三步分离法 |
| WO2015142288A1 (en) * | 2014-03-17 | 2015-09-24 | Agency For Science, Technology And Research | METHOD FOR PREDICTING TOXICITY OF A COMPOUND BASED ON NUCLEAR FACTOR-κB TRANSLOCATION |
| GB201507894D0 (en) * | 2015-05-08 | 2015-06-24 | Imagen Biotech Ltd | Personalised media |
| GB201510950D0 (en) | 2015-06-22 | 2015-08-05 | Cambridge Entpr Ltd | In vitro Production of Cholangiocytes |
| AU2016344599B2 (en) * | 2015-10-30 | 2020-12-17 | Biolamina Ab | Methods for producing hepatocytes |
| GB201521179D0 (en) | 2015-12-01 | 2016-01-13 | Univ Leuven Kath | Methods for differentiating cells into hepatic stellate cells |
| CN105807053B (zh) * | 2016-04-15 | 2019-04-02 | 苏州药明康德新药开发股份有限公司 | 一种肿瘤解离试剂在流式细胞检测中的应用 |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| WO2018187439A1 (en) * | 2017-04-06 | 2018-10-11 | The University Of North Carolina At Chapel Hill | Cryopreservation method |
| IL277552B2 (en) * | 2018-03-29 | 2024-08-01 | Univ North Carolina Chapel Hill | Stem/progenitor cells from Brunner's duodenal glands and methods for their isolation and use |
| CN112126618B (zh) * | 2019-06-24 | 2023-09-12 | 上海拜羡生物科技有限公司 | 一种人胆囊干细胞的获取和长期体外培养的方法 |
| CN113388569B (zh) * | 2020-08-28 | 2022-05-17 | 广东乾晖生物科技有限公司 | 肝脏类器官的制备方法 |
| AU2021453264A1 (en) * | 2021-06-30 | 2023-12-14 | Polbionica Sp. Z O.O. | A medium for storing isolated pancreatic islets and a method for storing isolated pancreatic islets |
| CN115975913B (zh) * | 2023-02-03 | 2024-06-04 | 北京中医药大学深圳医院(龙岗) | 一种利用多能干细胞诱导分化胆囊祖细胞的方法 |
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| GB9605808D0 (en) * | 1996-03-20 | 1996-05-22 | Isis Innovation | CFTR gene regulator |
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| HK1046930B (zh) * | 1999-01-19 | 2012-08-10 | 查珀尔希尔北卡罗来纳大学 | 人肝脏祖先 |
| US7456017B2 (en) * | 1999-10-01 | 2008-11-25 | University Of North Carolina At Chapel Hill | Processes for clonal growth of hepatic progenitor cells |
| ATE328067T1 (de) * | 2000-04-28 | 2006-06-15 | Childrens Medical Center | Isolierung von mesenchymalen stammzellen und deren verwendung |
| US6828145B2 (en) * | 2000-05-10 | 2004-12-07 | Cedars-Sinai Medical Center | Method for the isolation of stem cells by immuno-labeling with HLA/MHC gene product marker |
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| ES2569951T3 (es) * | 2002-03-15 | 2016-05-13 | University Of North Carolina At Chapel Hill | Células madre hepáticas primitivas y proximales |
| WO2004071464A2 (en) * | 2003-02-12 | 2004-08-26 | Johns Hopkins University School Of Medicine | Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells |
| DE10336152B4 (de) * | 2003-08-06 | 2007-02-15 | Nephrogen LLC, Salt Lake City | Aufreinigungsverfahren für humane mesenchymale Stammzellen |
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| KR20070007030A (ko) * | 2003-10-28 | 2007-01-12 | 카리타스 세인트 엘리자베스 메디칼 센터 오브 보스톤, 인코포레이티드 | 신규한 다능성 줄기세포 및 그의 용도 |
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| WO2008109659A2 (en) * | 2007-03-06 | 2008-09-12 | University Of North Carolina At Chapel Hill | Complexes of hyaluronans, other matrix components, hormones and growth factors for maintenance, expansion and/or differentiation of cells |
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| CN101952415B (zh) * | 2007-07-31 | 2017-06-27 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
| CA3169831C (en) * | 2009-10-30 | 2025-11-18 | Sapienza Universita Di Roma | Pluripodent Stem Cells from the Extrahepatic Biliary Tree and Methods for Their Isolation |
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2010
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