CR20120254A - Células madre multipotenciales en el árbol de billary extrahepática y métodos de aislamiento del mismo - Google Patents

Células madre multipotenciales en el árbol de billary extrahepática y métodos de aislamiento del mismo

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Publication number
CR20120254A
CR20120254A CR20120254A CR20120254A CR20120254A CR 20120254 A CR20120254 A CR 20120254A CR 20120254 A CR20120254 A CR 20120254A CR 20120254 A CR20120254 A CR 20120254A CR 20120254 A CR20120254 A CR 20120254A
Authority
CR
Costa Rica
Prior art keywords
extrahepathic
billary
multipotential
tree
same
Prior art date
Application number
CR20120254A
Other languages
English (en)
Spanish (es)
Inventor
Lola M Reid
Yunfang Wang
Vicenzo Cardinale
Eugenio Gaudio
Guido Carpino
Domenico Alvaro
Cai-Bin Cui
Original Assignee
Univ North Carolina
Sapienza Uni Di Roma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43922533&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20120254(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ North Carolina, Sapienza Uni Di Roma filed Critical Univ North Carolina
Publication of CR20120254A publication Critical patent/CR20120254A/es

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/413—Gall bladder; Bile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N5/0602—Vertebrate cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
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    • C12N2537/00—Supports and/or coatings for cell culture characterised by physical or chemical treatment
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CR20120254A 2009-10-30 2012-05-17 Células madre multipotenciales en el árbol de billary extrahepática y métodos de aislamiento del mismo CR20120254A (es)

Applications Claiming Priority (1)

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US25684609P 2009-10-30 2009-10-30

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CR20120254A true CR20120254A (es) 2012-09-24

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Country Link
US (1) US20110135610A1 (enExample)
EP (2) EP3725874A1 (enExample)
JP (2) JP5936547B2 (enExample)
KR (4) KR20120117758A (enExample)
CN (2) CN102918145B (enExample)
AR (2) AR078849A1 (enExample)
AU (1) AU2016210783B2 (enExample)
BR (1) BR112012009848B1 (enExample)
CA (2) CA2779144C (enExample)
CL (1) CL2012001117A1 (enExample)
CR (1) CR20120254A (enExample)
ES (1) ES2819028T3 (enExample)
IL (2) IL219454A (enExample)
MX (1) MX2012005087A (enExample)
NZ (3) NZ709124A (enExample)
PH (1) PH12012500845A1 (enExample)
RU (2) RU2580246C2 (enExample)
SG (2) SG10201407102QA (enExample)
TW (3) TWI740180B (enExample)
WO (1) WO2011053690A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110135610A1 (en) * 2009-10-30 2011-06-09 The University Of North Carolina At Chapel Hill Multipotent stem cells from the extrahepatic biliary tree and methods of isolating same
WO2012178215A1 (en) * 2011-06-23 2012-12-27 The Children's Hospital Of Philadelphia Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof
US9533013B2 (en) 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
CN103266084B (zh) * 2013-05-27 2015-03-04 刘卫辉 富集干细胞的三步分离法
JP6491671B2 (ja) * 2014-03-17 2019-03-27 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ 核因子−κＢの移行に基づいて化合物の毒性を予測するための方法
GB201507894D0 (en) * 2015-05-08 2015-06-24 Imagen Biotech Ltd Personalised media
GB201510950D0 (en) * 2015-06-22 2015-08-05 Cambridge Entpr Ltd In vitro Production of Cholangiocytes
CN108884438B (zh) * 2015-10-30 2022-12-23 拜奥拉米那公司 肝细胞的生产方法
GB201521179D0 (en) 2015-12-01 2016-01-13 Univ Leuven Kath Methods for differentiating cells into hepatic stellate cells
CN105807053B (zh) * 2016-04-15 2019-04-02 苏州药明康德新药开发股份有限公司 一种肿瘤解离试剂在流式细胞检测中的应用
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
CN110913691A (zh) * 2017-04-06 2020-03-24 北卡罗来纳大学教堂山分校 低温保存方法
EP3781181A4 (en) * 2018-03-29 2021-12-29 The University of North Carolina at Chapel Hill Stem/progenitor cells from duodenal brunner's glands and methods of isolating and using them
CN112126618B (zh) * 2019-06-24 2023-09-12 上海拜羡生物科技有限公司 一种人胆囊干细胞的获取和长期体外培养的方法
CN112111444B (zh) * 2020-08-28 2022-03-04 广东乾晖生物科技有限公司 脐带间充质干细胞重编程为肝脏细胞的方法及所制备的肝脏类器官
JP2024525215A (ja) * 2021-06-30 2024-07-10 ポルビオニカ スポルカ ジー オグラニクゾナ オドパウイエドジアルノシア 単離膵島を保存するための培地及び単離膵島の保存方法
CN116478904A (zh) * 2022-01-17 2023-07-25 香港中文大学 肝样细胞和人工肝组织的制备方法以及应用
CN115975913B (zh) * 2023-02-03 2024-06-04 北京中医药大学深圳医院(龙岗) 一种利用多能干细胞诱导分化胆囊祖细胞的方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3646197A (en) * 1969-05-14 1972-02-29 Zaidan Hojin Biseibutsu Novel process for removing copper from copper-containing bleomycin
US6069005A (en) * 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
US5660207A (en) * 1994-12-29 1997-08-26 Tylan General, Inc. Flow controller, parts of flow controller, and related method
US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells
GB9605808D0 (en) * 1996-03-20 1996-05-22 Isis Innovation CFTR gene regulator
US5830850A (en) * 1996-08-28 1998-11-03 Mount Sinai School Of Medicine Of The City Of New York Methods for the treatment of bone resorption disorders, including osteoporosis
KR100873690B1 (ko) * 1999-01-19 2008-12-12 유니버시티 오브 노스캐롤라이나 앳 채플 힐 인간 간 전구세포
US7456017B2 (en) * 1999-10-01 2008-11-25 University Of North Carolina At Chapel Hill Processes for clonal growth of hepatic progenitor cells
DE60120151D1 (de) * 2000-04-28 2006-07-06 Childrens Medical Center Isolierung von mesenchymalen stammzellen und deren verwendung
US6828145B2 (en) * 2000-05-10 2004-12-07 Cedars-Sinai Medical Center Method for the isolation of stem cells by immuno-labeling with HLA/MHC gene product marker
JP3602038B2 (ja) * 2000-07-24 2004-12-15 株式会社日立グローバルストレージテクノロジーズ 磁気ヘッドおよび磁気記録再生装置
DE10064804C2 (de) * 2000-12-22 2003-03-20 Schott Glas Alkalifreie Aluminoborosilicatgläser und ihre Verwendung
WO2003023018A2 (en) 2001-09-12 2003-03-20 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung A method for isolating, culturing and differentiating intestinal stem cells for therapeutic use
US7150990B2 (en) * 2002-03-06 2006-12-19 Reprocell, Inc. Self-renewing pluripotent hepatic stem cells
DK1490480T3 (en) * 2002-03-15 2016-04-11 Univ North Carolina PRIMITIVE AND PROXIMAL Liver Stem Cells
WO2004071464A2 (en) * 2003-02-12 2004-08-26 Johns Hopkins University School Of Medicine Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells
DE10336152B4 (de) * 2003-08-06 2007-02-15 Nephrogen LLC, Salt Lake City Aufreinigungsverfahren für humane mesenchymale Stammzellen
EP1716167A4 (en) * 2003-10-09 2008-10-08 Univ Monash SURFACE MARKER
EP1685237A4 (en) * 2003-10-28 2007-12-26 Caritas St Elizabeths Boston NEW MULTIPOTENTE STEM CELLS AND USE THEREOF
US7081582B2 (en) * 2004-06-30 2006-07-25 Microsoft Corporation System and method for aligning and mixing songs of arbitrary genres
JP4824036B2 (ja) 2004-12-23 2011-11-24 ヴィアサイト，インコーポレイテッド 胚体内胚葉細胞の増殖
JP4773777B2 (ja) * 2005-08-30 2011-09-14 グローバル・オーエルイーディー・テクノロジー・リミテッド・ライアビリティ・カンパニー アクティブマトリクス型表示装置
EP1941032A2 (en) * 2005-10-14 2008-07-09 Regents Of The University Of Minnesota Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype
BRPI0618724A2 (pt) * 2005-11-16 2011-09-06 Univ North Carolina componentes da matriz extracelular para expansão ou diferenciação de progenitores hepáticos
WO2008063675A2 (en) * 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
BRPI0808696A2 (pt) * 2007-03-06 2015-06-23 Univ North Carolina Complexos de hiluronanas, outros componentes de matriz, hormônios e fatores de crescimento para manutenção, expansão e/ou diferenciação de células
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
TW200916581A (en) * 2007-06-15 2009-04-16 Univ North Carolina Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same
US9096832B2 (en) * 2007-07-31 2015-08-04 Lifescan, Inc. Differentiation of human embryonic stem cells
US20110135610A1 (en) * 2009-10-30 2011-06-09 The University Of North Carolina At Chapel Hill Multipotent stem cells from the extrahepatic biliary tree and methods of isolating same
US10135700B2 (en) 2014-03-10 2018-11-20 Softphone SRL Enterprise application integration on client computing devices
US10387547B2 (en) 2014-09-09 2019-08-20 Intentional Software Corporation Layout engine for creating a visual layout tree for a document

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