AR122249A2 - Célula madre multipotencial del árbol biliar extrahepático de mamífero y composición que la comprende - Google Patents
Célula madre multipotencial del árbol biliar extrahepático de mamífero y composición que la comprendeInfo
- Publication number
- AR122249A2 AR122249A2 ARP200100301A ARP200100301A AR122249A2 AR 122249 A2 AR122249 A2 AR 122249A2 AR P200100301 A ARP200100301 A AR P200100301A AR P200100301 A ARP200100301 A AR P200100301A AR 122249 A2 AR122249 A2 AR 122249A2
- Authority
- AR
- Argentina
- Prior art keywords
- mammalian
- biliary tree
- composition
- stem cell
- multipotential stem
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 5
- 210000003445 biliary tract Anatomy 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 239000003550 marker Substances 0.000 abstract 3
- -1 N-CAM Proteins 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 102100023635 Alpha-fetoprotein Human genes 0.000 abstract 1
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 abstract 1
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 abstract 1
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 abstract 1
- 102100029087 Hepatocyte nuclear factor 6 Human genes 0.000 abstract 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 abstract 1
- 101001002170 Homo sapiens Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial Proteins 0.000 abstract 1
- 101000988619 Homo sapiens Hepatocyte nuclear factor 6 Proteins 0.000 abstract 1
- 101000998011 Homo sapiens Keratin, type I cytoskeletal 19 Proteins 0.000 abstract 1
- 101000603702 Homo sapiens Neurogenin-3 Proteins 0.000 abstract 1
- 101001069749 Homo sapiens Prospero homeobox protein 1 Proteins 0.000 abstract 1
- 101000843556 Homo sapiens Transcription factor HES-1 Proteins 0.000 abstract 1
- 101710123134 Ice-binding protein Proteins 0.000 abstract 1
- 101710082837 Ice-structuring protein Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 102100033420 Keratin, type I cytoskeletal 19 Human genes 0.000 abstract 1
- 102100038553 Neurogenin-3 Human genes 0.000 abstract 1
- 102100033880 Prospero homeobox protein 1 Human genes 0.000 abstract 1
- 101710183548 Pyridoxal 5'-phosphate synthase subunit PdxS Proteins 0.000 abstract 1
- 102100035459 Pyruvate dehydrogenase protein X component, mitochondrial Human genes 0.000 abstract 1
- 102100030798 Transcription factor HES-1 Human genes 0.000 abstract 1
- 101710107540 Type-2 ice-structuring protein Proteins 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 210000005229 liver cell Anatomy 0.000 abstract 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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Abstract
Reivindicación 1: Una composición caracterizada porque es para uso en un método para obtener o aislar células madre / progenitoras multipotenciales de mamífero capaces de diferenciarse en múltiples linajes endodérmicos, en donde las células se obtienen de tejido del árbol biliar de un mamífero, en donde dicho método comprende obtener tejido del árbol biliar, y sucesivamente, y en cualquier orden, o de manera sustancialmente simultánea obtener células que son positivas para: (i) al menos un marcador de superficie presente sobre las células madre / progenitoras seleccionado entre el grupo que consiste en EpCAM, N-CAM, CXCR4, CD44H, y CD133; (ii) al menos un marcador indicativo de un linaje de células hepáticas seleccionado entre HNF6, HES1, CK19, albúmina, y AFP; y (iii) al menos un marcador indicativo de un linaje de células pancreáticas seleccionado entre PDX1, PROX1, NGN3, e insulina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25684609P | 2009-10-30 | 2009-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR122249A2 true AR122249A2 (es) | 2022-08-31 |
Family
ID=43922533
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100104019A AR078849A1 (es) | 2009-10-30 | 2010-10-29 | Celulas madre multipotenciales del arbol biliar extrahepatico y metodos de aislamiento de las mismas |
ARP200100301A AR122249A2 (es) | 2009-10-30 | 2020-02-04 | Célula madre multipotencial del árbol biliar extrahepático de mamífero y composición que la comprende |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100104019A AR078849A1 (es) | 2009-10-30 | 2010-10-29 | Celulas madre multipotenciales del arbol biliar extrahepatico y metodos de aislamiento de las mismas |
Country Status (19)
Country | Link |
---|---|
US (1) | US20110135610A1 (es) |
EP (2) | EP3725874A1 (es) |
JP (2) | JP5936547B2 (es) |
KR (4) | KR102016870B1 (es) |
CN (2) | CN102918145B (es) |
AR (2) | AR078849A1 (es) |
AU (1) | AU2016210783B2 (es) |
BR (1) | BR112012009848B1 (es) |
CA (2) | CA2779144C (es) |
CL (1) | CL2012001117A1 (es) |
CR (1) | CR20120254A (es) |
ES (1) | ES2819028T3 (es) |
IL (2) | IL219454A (es) |
MX (1) | MX2012005087A (es) |
NZ (3) | NZ600068A (es) |
RU (2) | RU2756584C2 (es) |
SG (2) | SG10201407102QA (es) |
TW (3) | TWI686478B (es) |
WO (1) | WO2011053690A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2756584C2 (ru) * | 2009-10-30 | 2021-10-01 | Дзе Юниверсити Оф Норт Каролина Эт Чапел Хилл | Мультипотентные стволовые клетки внепечёночных желчных путей и способы их выделения |
WO2012178215A1 (en) * | 2011-06-23 | 2012-12-27 | The Children's Hospital Of Philadelphia | Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof |
US9533013B2 (en) * | 2013-03-13 | 2017-01-03 | University Of North Carolina At Chapel Hill | Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree |
CN103266084B (zh) * | 2013-05-27 | 2015-03-04 | 刘卫辉 | 富集干细胞的三步分离法 |
EP2842586A1 (en) | 2013-08-27 | 2015-03-04 | PharmaSens AG | Device with a lavet-type motor |
EP3120151A4 (en) * | 2014-03-17 | 2017-08-09 | Agency For Science, Technology And Research | METHOD FOR PREDICTING TOXICITY OF A COMPOUND BASED ON NUCLEAR FACTOR-kB TRANSLOCATION |
GB201507894D0 (en) * | 2015-05-08 | 2015-06-24 | Imagen Biotech Ltd | Personalised media |
GB201510950D0 (en) * | 2015-06-22 | 2015-08-05 | Cambridge Entpr Ltd | In vitro Production of Cholangiocytes |
CN108884438B (zh) * | 2015-10-30 | 2022-12-23 | 拜奥拉米那公司 | 肝细胞的生产方法 |
GB201521179D0 (en) | 2015-12-01 | 2016-01-13 | Univ Leuven Kath | Methods for differentiating cells into hepatic stellate cells |
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