AR122249A2 - Célula madre multipotencial del árbol biliar extrahepático de mamífero y composición que la comprende - Google Patents

Célula madre multipotencial del árbol biliar extrahepático de mamífero y composición que la comprende

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Publication number
AR122249A2
AR122249A2 ARP200100301A ARP200100301A AR122249A2 AR 122249 A2 AR122249 A2 AR 122249A2 AR P200100301 A ARP200100301 A AR P200100301A AR P200100301 A ARP200100301 A AR P200100301A AR 122249 A2 AR122249 A2 AR 122249A2
Authority
AR
Argentina
Prior art keywords
mammalian
biliary tree
composition
stem cell
multipotential stem
Prior art date
Application number
ARP200100301A
Other languages
English (en)
Inventor
Lola M Reid
Yunfang Wang
Vicenzo Cardinale
Eugenio Gaudio
Guido Carpino
Domenico Alvaro
Cai-Bin Cui
Original Assignee
Univ North Carolina Chapel Hill
Sapienza Univ Di Roma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43922533&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR122249(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ North Carolina Chapel Hill, Sapienza Univ Di Roma filed Critical Univ North Carolina Chapel Hill
Publication of AR122249A2 publication Critical patent/AR122249A2/es

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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Abstract

Reivindicación 1: Una composición caracterizada porque es para uso en un método para obtener o aislar células madre / progenitoras multipotenciales de mamífero capaces de diferenciarse en múltiples linajes endodérmicos, en donde las células se obtienen de tejido del árbol biliar de un mamífero, en donde dicho método comprende obtener tejido del árbol biliar, y sucesivamente, y en cualquier orden, o de manera sustancialmente simultánea obtener células que son positivas para: (i) al menos un marcador de superficie presente sobre las células madre / progenitoras seleccionado entre el grupo que consiste en EpCAM, N-CAM, CXCR4, CD44H, y CD133; (ii) al menos un marcador indicativo de un linaje de células hepáticas seleccionado entre HNF6, HES1, CK19, albúmina, y AFP; y (iii) al menos un marcador indicativo de un linaje de células pancreáticas seleccionado entre PDX1, PROX1, NGN3, e insulina.
ARP200100301A 2009-10-30 2020-02-04 Célula madre multipotencial del árbol biliar extrahepático de mamífero y composición que la comprende AR122249A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25684609P 2009-10-30 2009-10-30

Publications (1)

Publication Number Publication Date
AR122249A2 true AR122249A2 (es) 2022-08-31

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ID=43922533

Family Applications (2)

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ARP100104019A AR078849A1 (es) 2009-10-30 2010-10-29 Celulas madre multipotenciales del arbol biliar extrahepatico y metodos de aislamiento de las mismas
ARP200100301A AR122249A2 (es) 2009-10-30 2020-02-04 Célula madre multipotencial del árbol biliar extrahepático de mamífero y composición que la comprende

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ARP100104019A AR078849A1 (es) 2009-10-30 2010-10-29 Celulas madre multipotenciales del arbol biliar extrahepatico y metodos de aislamiento de las mismas

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Country Link
US (1) US20110135610A1 (es)
EP (2) EP3725874A1 (es)
JP (2) JP5936547B2 (es)
KR (4) KR102016870B1 (es)
CN (2) CN102918145B (es)
AR (2) AR078849A1 (es)
AU (1) AU2016210783B2 (es)
BR (1) BR112012009848B1 (es)
CA (2) CA2779144C (es)
CL (1) CL2012001117A1 (es)
CR (1) CR20120254A (es)
ES (1) ES2819028T3 (es)
IL (2) IL219454A (es)
MX (1) MX2012005087A (es)
NZ (3) NZ600068A (es)
RU (2) RU2756584C2 (es)
SG (2) SG10201407102QA (es)
TW (3) TWI686478B (es)
WO (1) WO2011053690A1 (es)

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RU2756584C2 (ru) * 2009-10-30 2021-10-01 Дзе Юниверсити Оф Норт Каролина Эт Чапел Хилл Мультипотентные стволовые клетки внепечёночных желчных путей и способы их выделения
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GB201521179D0 (en) 2015-12-01 2016-01-13 Univ Leuven Kath Methods for differentiating cells into hepatic stellate cells
CN105807053B (zh) * 2016-04-15 2019-04-02 苏州药明康德新药开发股份有限公司 一种肿瘤解离试剂在流式细胞检测中的应用
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
CN110913691A (zh) * 2017-04-06 2020-03-24 北卡罗来纳大学教堂山分校 低温保存方法
IL277552B2 (en) * 2018-03-29 2024-08-01 The Univ Of North Carolina At Chapel Hill Stem/progenitor cells from Brunner's duodenal glands and methods for their isolation and use
CN112126618B (zh) * 2019-06-24 2023-09-12 上海拜羡生物科技有限公司 一种人胆囊干细胞的获取和长期体外培养的方法
CN112111444B (zh) * 2020-08-28 2022-03-04 广东乾晖生物科技有限公司 脐带间充质干细胞重编程为肝脏细胞的方法及所制备的肝脏类器官
BR112023025612A2 (pt) * 2021-06-30 2024-02-27 Polbionica Sp Z O O Meio para armazenar ilhotas pancreáticas isoladas, e, método de armazenamento de ilhotas pancreáticas isoladas
CN115975913B (zh) * 2023-02-03 2024-06-04 北京中医药大学深圳医院(龙岗) 一种利用多能干细胞诱导分化胆囊祖细胞的方法

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