CL2013002029A1 - Celula progenitora y no diferenciada neural humana expandible aislada; composicion que la comprende; metodo de cultivo in vitro; dicho cultivo in vitro; y su uso para tratar una condicion causada por perdida de mielina o de oligodendrocitos. - Google Patents
Celula progenitora y no diferenciada neural humana expandible aislada; composicion que la comprende; metodo de cultivo in vitro; dicho cultivo in vitro; y su uso para tratar una condicion causada por perdida de mielina o de oligodendrocitos.Info
- Publication number
- CL2013002029A1 CL2013002029A1 CL2013002029A CL2013002029A CL2013002029A1 CL 2013002029 A1 CL2013002029 A1 CL 2013002029A1 CL 2013002029 A CL2013002029 A CL 2013002029A CL 2013002029 A CL2013002029 A CL 2013002029A CL 2013002029 A1 CL2013002029 A1 CL 2013002029A1
- Authority
- CL
- Chile
- Prior art keywords
- vitro culture
- oligodendrocytes
- myelin
- treat
- loss
- Prior art date
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
- C12N2533/32—Polylysine, polyornithine
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- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Ophthalmology & Optometry (AREA)
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- Hospice & Palliative Care (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161431944P | 2011-01-12 | 2011-01-12 | |
US201161558527P | 2011-11-11 | 2011-11-11 |
Publications (1)
Publication Number | Publication Date |
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CL2013002029A1 true CL2013002029A1 (es) | 2014-05-09 |
Family
ID=45529155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2013002029A CL2013002029A1 (es) | 2011-01-12 | 2013-07-12 | Celula progenitora y no diferenciada neural humana expandible aislada; composicion que la comprende; metodo de cultivo in vitro; dicho cultivo in vitro; y su uso para tratar una condicion causada por perdida de mielina o de oligodendrocitos. |
Country Status (20)
Country | Link |
---|---|
US (1) | US8993320B2 (es) |
EP (1) | EP2663638B1 (es) |
JP (1) | JP5649745B2 (es) |
KR (1) | KR102099807B1 (es) |
CN (2) | CN103687941A (es) |
AR (1) | AR084835A1 (es) |
AU (2) | AU2012206411B2 (es) |
BR (1) | BR112013017685A2 (es) |
CA (1) | CA2821065C (es) |
CL (1) | CL2013002029A1 (es) |
DK (1) | DK2663638T3 (es) |
EA (1) | EA034058B1 (es) |
ES (1) | ES2732938T3 (es) |
IL (1) | IL227361B (es) |
MX (1) | MX364742B (es) |
MY (1) | MY173219A (es) |
PL (1) | PL2663638T3 (es) |
SG (1) | SG191729A1 (es) |
TW (1) | TWI586805B (es) |
WO (1) | WO2012095730A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1480521B1 (en) | 2002-02-15 | 2015-02-25 | Cornell Research Foundation, Inc. | Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells |
US9709553B2 (en) | 2008-05-08 | 2017-07-18 | University Of Rochester | Treating myelin diseases with optimized cell preparations |
JP6541577B2 (ja) * | 2013-02-06 | 2019-07-10 | ユニバーシティー オブ ロチェスター | ミエリン障害の治療のための誘導多能性細胞由来オリゴデンドロサイト前駆細胞 |
JP2016515403A (ja) * | 2013-04-17 | 2016-05-30 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ニューロン細胞培養のための培地組成物 |
US10202580B2 (en) | 2014-01-21 | 2019-02-12 | Japan Science And Technology Agency | Adult oligodendrocyte-type 2 astrocyte progenitor cell production method |
CN105154386B (zh) * | 2014-05-30 | 2018-04-24 | 中国人民解放军第二军医大学东方肝胆外科医院 | 人肝细胞长期维持和增殖传代培养的专用培养基和培养方法 |
KR101675123B1 (ko) * | 2014-06-27 | 2016-11-14 | 연세대학교 산학협력단 | Psa-ncam-양성 신경전구세포를 유효성분으로 포함하는 허혈성 질환 또는 신경염증 질환 치료용 조성물 |
KR101793722B1 (ko) | 2014-08-25 | 2017-11-03 | 한국생명공학연구원 | 성상세포의 생산방법 |
EP3265554B1 (en) | 2015-03-04 | 2021-11-17 | Mesoblast International Sàrl | Cell culture method for mesenchymal stem cells |
EP3279318A4 (en) * | 2015-03-30 | 2018-08-29 | Ajinomoto Co., Inc. | Human serum albumin-containing culture medium for growth of neural stem cells |
US10590387B2 (en) * | 2015-04-16 | 2020-03-17 | The Board Of Regents Of The University Of Texas System | CD133+ cells and method for expanding |
JP6844953B2 (ja) * | 2015-04-22 | 2021-03-17 | 公益財団法人東京都医学総合研究所 | アルツハイマー病研究を標的にしたグリア細胞システム |
US9724432B2 (en) | 2015-04-30 | 2017-08-08 | University Of Rochester | Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder |
ES2815537T3 (es) | 2015-06-26 | 2021-03-30 | S Biomedics | Composición para el tratamiento de enfermedades isquémicas o trastornos inflamatorios neurogénicos, que contienen el secretoma de células progenitoras neurales como ingrediente activo |
WO2017031092A1 (en) * | 2015-08-15 | 2017-02-23 | Asterias Biotherapeutics, Inc. | Stem cell-derived oligodendrocyte progenitor cells for the treatment of white matter stroke |
EP3430127A4 (en) * | 2016-03-18 | 2019-09-04 | Institute of Biophysics Chinese Academy of Sciences | CELL CULTURE MEDIA AND CULTURE MEDIUM SUPPLEMENT |
WO2017173064A1 (en) | 2016-03-30 | 2017-10-05 | Asterias Biotherapeutics, Inc. | Oligodendrocyte progenitor cell compositions |
CN106929474B (zh) * | 2017-03-31 | 2021-09-14 | 北京恒峰铭成生物科技有限公司 | 一种m2巨噬细胞诱导剂 |
EP3621434A4 (en) | 2017-05-10 | 2021-03-31 | University of Rochester | METHOD OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS |
KR101889228B1 (ko) * | 2017-09-29 | 2018-08-16 | 연세대학교 산학협력단 | Psa-ncam-양성 신경전구세포를 유효성분으로 포함하는 척수손상 치료용 조성물 |
CN107760649B (zh) * | 2017-11-02 | 2021-03-30 | 北京全式金生物技术有限公司 | 一种用于人神经系统细胞培养和人多能性干细胞向神经系统细胞分化的营养添加剂 |
CN108070558B (zh) * | 2017-11-24 | 2022-01-28 | 吉林省拓华生物科技有限公司 | 一种临床级神经干细胞的制备方法 |
KR101994640B1 (ko) | 2018-03-16 | 2019-07-02 | (주)메디노 | 신경줄기세포의 고효율 분리배양 방법 |
WO2019204309A1 (en) * | 2018-04-17 | 2019-10-24 | Case Western Reserve University | Induction of myelinating oligodendrocytes in human cortical spheroids |
CN108624560B (zh) * | 2018-06-01 | 2022-04-08 | 南京艾尔普再生医学科技有限公司 | 一种分化培养基及少突胶质前体细胞的制备方法 |
KR20210068050A (ko) * | 2018-09-19 | 2021-06-08 | 리니지 셀 테라퓨틱스, 인크. | 동적 현탁 배양에서 만능 줄기 세포를 분화시키는 방법 |
EP3914264A4 (en) | 2019-01-23 | 2022-11-23 | Asterias Biotherapeutics, Inc. | DORSAL DERIVATIVE OLIGODENDROCYTE PROGENITORS FROM HUMAN PLURIPOTENTIC STEM CELLS |
US20230123863A1 (en) * | 2020-06-30 | 2023-04-20 | National Yang-Ming University | A glia cell and neuron co-culture system and method |
CN114540301B (zh) * | 2020-11-20 | 2024-02-27 | 上海纽仁生物医药科技有限公司 | 少突胶质前体细胞亚群及其用途 |
US20230377685A1 (en) | 2022-04-15 | 2023-11-23 | Aspen Neuroscience, Inc. | Methods of classifying the differentiation state of cells and related compositions of differentiated cells |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0435911B1 (en) * | 1988-09-23 | 1996-03-13 | Cetus Oncology Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
DE19756864C5 (de) * | 1997-12-19 | 2014-07-10 | Oliver Brüstle | Neurale Vorläuferzellen, Verfahren zu ihrer Herstellung und ihre Verwendung zur Therapie von neuralen Defekten |
IL151170A0 (en) * | 2000-03-14 | 2003-04-10 | Es Cell Int Pte Ltd | Embryonic stem cells and neural progenitor cells derived therefrom |
EP1287116A2 (en) * | 2000-05-17 | 2003-03-05 | Geron Corporation | Neural progenitor cell populations |
IL157332A0 (en) * | 2001-02-14 | 2004-02-19 | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof | |
US9446073B2 (en) * | 2005-05-15 | 2016-09-20 | Biodontos, Llc | Non-lineage committed precursor cells from the dental papillary tissue of teeth |
US20080153167A1 (en) * | 2006-06-21 | 2008-06-26 | The Trustees Of Columbia University In The City Of New York | In vivo amplification of neural progenitor cells |
WO2008003042A2 (en) * | 2006-06-28 | 2008-01-03 | The University Of Medicine And Dentistry Of New Jersey | Amnion-derived stem cells and uses thereof |
US20110236971A2 (en) * | 2007-09-25 | 2011-09-29 | Maksym Vodyanyk | Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions |
CN102325878A (zh) * | 2008-12-23 | 2012-01-18 | 斯特姆塞尔思加利福尼亚有限公司 | 少突胶质前体细胞的靶向细胞群及制备与使用方法 |
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