EA201390801A1 - Способ культивирования для получения и поддержания чистой или обогащенной популяции нервных стволовых клеток и/или нервных клеток-предшественников млекопитающего, склонных к дифференцировке с образованием клеток олигодендроцитарной линии in vitro - Google Patents

Способ культивирования для получения и поддержания чистой или обогащенной популяции нервных стволовых клеток и/или нервных клеток-предшественников млекопитающего, склонных к дифференцировке с образованием клеток олигодендроцитарной линии in vitro

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EA201390801A1
EA201390801A1 EA201390801A EA201390801A EA201390801A1 EA 201390801 A1 EA201390801 A1 EA 201390801A1 EA 201390801 A EA201390801 A EA 201390801A EA 201390801 A EA201390801 A EA 201390801A EA 201390801 A1 EA201390801 A1 EA 201390801A1
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formation
cell
stem cell
ability
vitro
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EA201390801A
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EA034058B1 (ru
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Цунео Кидо
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Цунео Кидо
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Abstract

Выделенная способная к размножению человеческая нервная стволовая клетка или клетка-предшественник, представляющая собой клетку-предшественник или стволовую клетку, сохраняющая свою способность к дифференцировке с образованием нейронов, астроцитов и олигодендроцитов, сохраняющая свою способность к эффективной дифференцировке с образованием клеток олигодендроцитарной линии в течение нескольких пассажей и экспрессирующая, по меньшей мере, поверхностные клеточные антигены CD133 и CD140α. Также предложен способ in vitro-культивирования способной к размножению нервной клетки-предшественника или стволовой клетки, выделенной из центральной нервной системы млекопитающего, и сама культура, где указанная клетка сохраняет свою способность к дифференцировке с образованием нейронов, астроцитов и олигодендроцитов и свою способность к эффективной дифференцировке с образованием клеток олигодендроцитарной линии. Кроме того, предложен способ лечения состояния, вызванного утратой миелина или утратой олигодендроцитов, а также композиция, содержащая выделенную способную к размножению нервную стволовую клетку или клетку, культивированную способами по изобретению.
EA201390801A 2011-01-12 2012-01-12 Способ культивирования для получения и поддержания чистой или обогащенной популяции нервных стволовых клеток и/или нервных клеток-предшественников млекопитающего, склонных к дифференцировке с образованием клеток олигодендроцитарной линии in vitro EA034058B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161431944P 2011-01-12 2011-01-12
US201161558527P 2011-11-11 2011-11-11
PCT/IB2012/000030 WO2012095730A1 (en) 2011-01-12 2012-01-12 Culture method to obtain and maintain a pure or enriched population of mammalian neural stem cells and/or neural progenitor cells that are prone to differentiate into oligodendrocyte-lineage cells in vitro

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EA201390801A1 true EA201390801A1 (ru) 2014-06-30
EA034058B1 EA034058B1 (ru) 2019-12-23

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US (1) US8993320B2 (ru)
EP (1) EP2663638B1 (ru)
JP (1) JP5649745B2 (ru)
KR (1) KR102099807B1 (ru)
CN (2) CN109749996A (ru)
AR (1) AR084835A1 (ru)
AU (2) AU2012206411B2 (ru)
BR (1) BR112013017685A2 (ru)
CA (1) CA2821065C (ru)
CL (1) CL2013002029A1 (ru)
DK (1) DK2663638T3 (ru)
EA (1) EA034058B1 (ru)
ES (1) ES2732938T3 (ru)
IL (1) IL227361B (ru)
MX (1) MX364742B (ru)
MY (1) MY173219A (ru)
PL (1) PL2663638T3 (ru)
SG (1) SG191729A1 (ru)
TW (1) TWI586805B (ru)
WO (1) WO2012095730A1 (ru)

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EP2663638A1 (en) 2013-11-20
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IL227361B (en) 2018-03-29
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