JP2016006118A5 - - Google Patents
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- JP2016006118A5 JP2016006118A5 JP2015183047A JP2015183047A JP2016006118A5 JP 2016006118 A5 JP2016006118 A5 JP 2016006118A5 JP 2015183047 A JP2015183047 A JP 2015183047A JP 2015183047 A JP2015183047 A JP 2015183047A JP 2016006118 A5 JP2016006118 A5 JP 2016006118A5
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- formula
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- 0 *C(NC(C(N(C1)C1(Cc(cc1)ccc1NS(O)(=O)=O)c1c[s]c(*)n1)=O)[Rn-])=O Chemical compound *C(NC(C(N(C1)C1(Cc(cc1)ccc1NS(O)(=O)=O)c1c[s]c(*)n1)=O)[Rn-])=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22326009P | 2009-07-06 | 2009-07-06 | |
| US61/223,260 | 2009-07-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014048238A Division JP2014139208A (ja) | 2009-07-06 | 2014-03-11 | がん細胞の転移を予防するための化合物、組成物および方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017080657A Division JP6505153B2 (ja) | 2009-07-06 | 2017-04-14 | がん細胞の転移を予防するための化合物、組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016006118A JP2016006118A (ja) | 2016-01-14 |
| JP2016006118A5 true JP2016006118A5 (en:Method) | 2016-06-02 |
Family
ID=43429466
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011554058A Active JP5536113B2 (ja) | 2009-07-06 | 2010-01-12 | がん細胞の転移を予防するための化合物、組成物および方法 |
| JP2014048238A Pending JP2014139208A (ja) | 2009-07-06 | 2014-03-11 | がん細胞の転移を予防するための化合物、組成物および方法 |
| JP2015183047A Pending JP2016006118A (ja) | 2009-07-06 | 2015-09-16 | がん細胞の転移を予防するための化合物、組成物および方法 |
| JP2017080657A Active JP6505153B2 (ja) | 2009-07-06 | 2017-04-14 | がん細胞の転移を予防するための化合物、組成物および方法 |
| JP2019058234A Withdrawn JP2019089866A (ja) | 2009-07-06 | 2019-03-26 | がん細胞の転移を予防するための化合物、組成物および方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011554058A Active JP5536113B2 (ja) | 2009-07-06 | 2010-01-12 | がん細胞の転移を予防するための化合物、組成物および方法 |
| JP2014048238A Pending JP2014139208A (ja) | 2009-07-06 | 2014-03-11 | がん細胞の転移を予防するための化合物、組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017080657A Active JP6505153B2 (ja) | 2009-07-06 | 2017-04-14 | がん細胞の転移を予防するための化合物、組成物および方法 |
| JP2019058234A Withdrawn JP2019089866A (ja) | 2009-07-06 | 2019-03-26 | がん細胞の転移を予防するための化合物、組成物および方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US8569348B2 (en:Method) |
| EP (2) | EP2451279B1 (en:Method) |
| JP (5) | JP5536113B2 (en:Method) |
| KR (1) | KR101426125B1 (en:Method) |
| CN (3) | CN105412094A (en:Method) |
| AU (1) | AU2010271105C1 (en:Method) |
| BR (1) | BRPI1006897A2 (en:Method) |
| CA (1) | CA2748765C (en:Method) |
| DK (1) | DK2451279T3 (en:Method) |
| ES (1) | ES2726946T3 (en:Method) |
| IL (2) | IL214048A (en:Method) |
| MX (1) | MX2011007420A (en:Method) |
| MY (1) | MY160399A (en:Method) |
| NZ (1) | NZ594537A (en:Method) |
| PL (1) | PL2451279T3 (en:Method) |
| PT (1) | PT2451279T (en:Method) |
| RU (1) | RU2519123C2 (en:Method) |
| SG (2) | SG10201505672TA (en:Method) |
| TR (1) | TR201907783T4 (en:Method) |
| WO (1) | WO2011005330A1 (en:Method) |
| ZA (1) | ZA201105678B (en:Method) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007237096C1 (en) | 2006-04-07 | 2012-12-13 | EyePoint, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
| US7795444B2 (en) | 2006-06-27 | 2010-09-14 | Warner Chilcott Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US8846685B2 (en) | 2006-06-27 | 2014-09-30 | Aerpio Therapeutics Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
| US7589212B2 (en) | 2006-06-27 | 2009-09-15 | Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US9096555B2 (en) | 2009-01-12 | 2015-08-04 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome |
| US8883832B2 (en) | 2009-07-06 | 2014-11-11 | Aerpio Therapeutics Inc. | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| TR201907783T4 (tr) * | 2009-07-06 | 2019-06-21 | Aerpio Therapeutics Inc | Benzosulfonamit türevleri, bileşimleri ve kanser hücrelerinin metastazının önlenmesinde kullanımları. |
| AU2010314982B2 (en) | 2009-11-06 | 2013-08-29 | Aerpio Therapeutics Inc. | Compositions and methods for treating colitis |
| EP2624916B1 (en) * | 2010-10-07 | 2018-01-17 | Aerpio Therapeutics, Inc. | Thiadiazole derivatives for use in the treatment of ocular edema |
| EP2766043A4 (en) | 2011-10-13 | 2015-06-10 | Aerpio Therapeutics Inc | METHOD FOR THE TREATMENT OF CAPILLARY LECKSYNDROME AND CANCER |
| JP2014532072A (ja) | 2011-10-13 | 2014-12-04 | エアピオ セラピューティックス， インコーポレイテッド | 眼疾患の治療 |
| ES2885523T3 (es) | 2011-11-23 | 2021-12-14 | Therapeuticsmd Inc | Formulaciones y terapias de reposición hormonal de combinación naturales |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| KR20150129019A (ko) | 2013-03-15 | 2015-11-18 | 에르피오 세러퓨틱스 인코포레이티드 | 안과 질환을 치료하기 위한 조성물, 제형 및 방법 |
| US20160185808A1 (en) * | 2013-07-25 | 2016-06-30 | Srinivas Ganta | Platinum derivatives for hydrophobic formulations |
| US9828422B2 (en) | 2013-07-29 | 2017-11-28 | Samsung Electronics Co., Ltd. | Anti-Ang2 antibody |
| KR102196450B1 (ko) | 2013-09-17 | 2020-12-30 | 삼성전자주식회사 | Tie2와 결합을 유도하는 항 Ang2 항체를 포함하는 항암제 |
| CN106232120B (zh) | 2014-02-19 | 2021-01-08 | 爱尔皮奥治疗有限公司 | 制备n-苄基-3-羟基-4-取代的-吡啶-2-(1h)-酮的方法 |
| CN106456614A (zh) | 2014-03-14 | 2017-02-22 | 爱尔皮奥治疗有限公司 | HPTP‑β抑制剂 |
| WO2015179782A1 (en) | 2014-05-22 | 2015-11-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US9539245B2 (en) | 2014-08-07 | 2017-01-10 | Aerpio Therapeutics, Inc. | Combination of immunotherapies with activators of Tie-2 |
| CN104551003B (zh) * | 2014-12-30 | 2016-08-24 | 燕山大学 | 一种以醋酸兰瑞肽为模板制备纳米铂螺旋杆的方法 |
| CN106138019A (zh) * | 2015-03-25 | 2016-11-23 | 中国科学院大连化学物理研究所 | Gpr35受体激动剂及其应用 |
| EP3824908A1 (en) | 2015-04-10 | 2021-05-26 | Capsugel Belgium NV | Abiraterone acetate lipid formulations |
| EP3101007A1 (en) * | 2015-06-05 | 2016-12-07 | Lead Pharma Cel Models IP B.V. | Ror gamma (rory) modulators |
| EP3101005A1 (en) * | 2015-06-05 | 2016-12-07 | Lead Pharma Cel Models IP B.V. | Ror gamma (rory) modulators |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| EP3977994B1 (en) | 2015-09-23 | 2024-04-24 | EyePoint Pharmaceuticals, Inc. | Activators of tie-2 for use in treating intraocular pressure |
| TW201711566A (zh) * | 2015-09-28 | 2017-04-01 | 拜耳作物科學公司 | 製備ｎ－（１，３，４－㗁二唑－２－基）芳基甲醯胺之方法 |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| CN105796830A (zh) * | 2016-04-19 | 2016-07-27 | 王刚 | 一种治疗鼻旁窦支气管综合征的中药 |
| MX2019000727A (es) | 2016-07-20 | 2019-05-02 | Aerpio Therapeutics Inc | Anticuerpos monoclonales humanizados que tienen como blanco ve-ptp (hptp-b). |
| KR102011366B1 (ko) * | 2016-11-17 | 2019-10-14 | 연세대학교 산학협력단 | 암 전이 억제제의 스크리닝 방법 |
| BR112020001327A2 (pt) | 2017-07-21 | 2020-08-11 | Antabio Sas | compostos químicos |
| WO2019165349A1 (en) * | 2018-02-26 | 2019-08-29 | Aerpio Therapeutics, Inc. | METHODS OF TREATING DIABETIC NEPHROPATHY USING HPTPß INHIBITORS |
| KR102087044B1 (ko) * | 2018-04-30 | 2020-03-10 | 인하대학교 산학협력단 | Mmp-10 또는 이를 코딩하는 유전자의 발현을 억제하는 제제를 포함하는 암 전이 억제용 조성물 |
| US10894824B2 (en) | 2018-09-24 | 2021-01-19 | Aerpio Pharmaceuticals, Inc. | Multispecific antibodies that target HPTP-β (VE-PTP) and VEGF |
| CN109453195B (zh) * | 2018-11-29 | 2021-04-20 | 湖南补天药业股份有限公司 | 一种用于抑制肿瘤细胞的药物组合物 |
| AU2020264969B2 (en) | 2019-04-29 | 2025-06-05 | EyePoint, Inc. | Tie-2 activators targeting the schlemm's canal |
| US11413242B2 (en) | 2019-06-24 | 2022-08-16 | EyePoint Pharmaceuticals, Inc. | Formulations of Tie-2 activators and methods of use thereof |
| KR102249561B1 (ko) | 2019-09-24 | 2021-05-10 | 충북대학교 산학협력단 | N-아릴-2-[(6-부틸-1,3-디메틸-2,4-디옥소-1,2,3,4-테트라하이드로피리도[2,3-d]피리미딘-5-일)설페닐]아세트아마이드를 유효성분으로 함유하는 종양의 예방 및 치료용 조성물 |
| AU2020376807A1 (en) | 2019-10-29 | 2022-05-19 | EyePoint, Inc. | Small molecule activators of Tie-2 |
| CN111184726A (zh) * | 2020-02-25 | 2020-05-22 | 沈阳药科大学 | β-内酰胺类化合物的应用 |
| WO2021257754A1 (en) * | 2020-06-16 | 2021-12-23 | Ripka, Amy | Small molecule ve-ptp inhibitors |
| CN114456143B (zh) * | 2022-02-23 | 2023-08-15 | 北京丰帆生物医药科技有限公司 | 一种uPA的抑制剂及其制备方法和应用 |
| CN119874870A (zh) * | 2024-12-13 | 2025-04-25 | 杭州师范大学 | UFMylation修饰的YAP作为靶标在制备血管衰老治疗药物和/或检测试剂中的应用 |
Family Cites Families (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4673641A (en) | 1982-12-16 | 1987-06-16 | Molecular Genetics Research And Development Limited Partnership | Co-aggregate purification of proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE69332197T2 (de) | 1992-03-13 | 2003-04-17 | Organon Teknika B.V., Boxtel | Epstein-Barr-Virus verwandte Peptide und Nukleinsäuresegmenten |
| US5770565A (en) | 1994-04-13 | 1998-06-23 | La Jolla Cancer Research Center | Peptides for reducing or inhibiting bone resorption |
| US5688781A (en) | 1994-08-19 | 1997-11-18 | Bristol-Myers Squibb Company | Method for treating vascular leak syndrome |
| ES2333425T5 (es) | 1995-06-15 | 2012-08-28 | Crucell Holland B.V. | Sistemas de empaquetado para adenovirus recombinante humano destinados a terapia génica |
| US20030040463A1 (en) | 1996-04-05 | 2003-02-27 | Wiegand Stanley J. | TIE-2 ligands, methods of making and uses thereof |
| WO1998018914A1 (en) | 1996-10-31 | 1998-05-07 | Duke University | Soluble tie2 receptor |
| JPH11225351A (ja) | 1998-02-04 | 1999-08-17 | Matsushita Electric Ind Co Ltd | ページャー機能を備える無線通信装置のメッセージ消去方法および装置 |
| US5980929A (en) | 1998-03-13 | 1999-11-09 | Johns Hopkins University, School Of Medicine | Use of a protein tyrosine kinase pathway inhibitor in the treatment of retinal ischmemia or ocular inflammation |
| US5919813C1 (en) | 1998-03-13 | 2002-01-29 | Univ Johns Hopkins Med | Use of a protein tyrosine kinase pathway inhibitor in the treatment of diabetic retinopathy |
| AR022303A1 (es) | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
| PL200919B1 (pl) * | 1999-02-12 | 2009-02-27 | Lexigen Pharm Corp | Zastosowanie kompozycji czynnika hamującego angiogenezę i czynnika przeciwnowotworowego, kompozycja terapeutyczna do leczenia nowotworów i zestaw do traktowania komórki nowotworowej |
| JP2002540165A (ja) | 1999-03-26 | 2002-11-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｔｉｅ２レセプターアクチベーターによる血管透過性の調節 |
| US6455035B1 (en) | 1999-03-26 | 2002-09-24 | Regeneron Pharmaceuticals, Inc. | Angiopoietins and methods of use thereof |
| EP1046715A1 (en) | 1999-04-23 | 2000-10-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Interaction of vascular-endothelial protein-tyrosine phosphatase with the angiopoietin receptor tie-2 |
| WO2000065088A2 (en) | 1999-04-26 | 2000-11-02 | Amersham Pharmacia Biotech Ab | Primers for identifying typing or classifying nucleic acids |
| BR0010017A (pt) | 1999-04-28 | 2002-06-11 | Univ Texas | Composições e processos para o tratamento de câncer por inibição seletiva de vegf |
| WO2000070030A1 (en) | 1999-05-19 | 2000-11-23 | Amgen Inc. | Crystal of a lymphocyte kinase-ligand complex and methods of use |
| EP1212296B9 (en) | 1999-08-27 | 2006-05-10 | Sugen, Inc. | Phosphate mimics and methods of treatment using phosphatase inhibitors |
| US6589758B1 (en) | 2000-05-19 | 2003-07-08 | Amgen Inc. | Crystal of a kinase-ligand complex and methods of use |
| RU2292221C2 (ru) | 2000-06-23 | 2007-01-27 | Шеринг Акциенгезельшафт | Комбинации и композиции, которые оказывают воздействие на функцию систем vegf/ рецептор vegf и ангиопоэтин/рецептор tie (ii), и их применение |
| BR0114257A (pt) | 2000-09-27 | 2003-07-01 | Procter & Gamble | Ligandos de receptores de melanocortina |
| AU2002335085A1 (en) | 2001-10-25 | 2003-05-06 | Regeneron Pharmaceuticals, Inc. | Angiopoietins and methods of use thereof |
| WO2003084565A2 (en) | 2002-04-08 | 2003-10-16 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Ve-ptp as regulator of ve-cadherin mediated processes or disorders |
| AU2003231098A1 (en) | 2002-04-25 | 2003-11-10 | University Of Connecticut Health Center | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality |
| US7226755B1 (en) | 2002-09-25 | 2007-06-05 | The Procter & Gamble Company | HPTPbeta as a target in treatment of angiogenesis mediated disorders |
| US7507568B2 (en) | 2002-09-25 | 2009-03-24 | The Proctor & Gamble Company | Three dimensional coordinates of HPTPbeta |
| US6946479B2 (en) | 2002-11-09 | 2005-09-20 | The Procter & Gamble Company | N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones |
| US6930117B2 (en) | 2002-11-09 | 2005-08-16 | The Procter & Gamble Company | N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones |
| US20050154011A1 (en) | 2003-02-20 | 2005-07-14 | The Procter & Gamble Company | Tetrahydroisoquinolnyl sulfamic acids |
| AR046510A1 (es) | 2003-07-25 | 2005-12-14 | Regeneron Pharma | Composicion de un antagonista de vegf y un agente anti-proliferativo |
| US20050158320A1 (en) * | 2003-11-12 | 2005-07-21 | Nichols M. J. | Combinations for the treatment of proliferative diseases |
| US8298532B2 (en) | 2004-01-16 | 2012-10-30 | Regeneron Pharmaceuticals, Inc. | Fusion polypeptides capable of activating receptors |
| DK3112352T3 (en) | 2004-03-15 | 2019-01-28 | Janssen Pharmaceutica Nv | OPIOID RECEPTOR MODULATORS |
| US7771742B2 (en) | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
| DK1771474T3 (da) | 2004-07-20 | 2010-05-31 | Genentech Inc | Inhibitorer af angiopoitin-like 4 protein, kombinationer og anvendelser deraf |
| CA2581769C (en) | 2004-09-28 | 2014-03-11 | Genexel-Sein, Inc. | Methods of using chimeric coiled-coil molecule |
| PL1838733T3 (pl) | 2004-12-21 | 2012-02-29 | Medimmune Ltd | Przeciwciała skierowane przeciwko angiopoetynie-2 i ich zastosowania |
| EP1899467A2 (en) * | 2005-04-26 | 2008-03-19 | Coley Pharmaceutical GmbH | Modified oligoribonucleotide analogs with enhances immunostimulatory activity |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| US7893040B2 (en) | 2005-07-22 | 2011-02-22 | Oculis Ehf | Cyclodextrin nanotechnology for ophthalmic drug delivery |
| WO2007033216A2 (en) | 2005-09-12 | 2007-03-22 | Beth Israel Deaconess Medical Center | Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state |
| US20090123474A1 (en) | 2005-12-15 | 2009-05-14 | Astrazeneca Ab | Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or fltl antagonist for treating cancer |
| US7588924B2 (en) | 2006-03-07 | 2009-09-15 | Procter & Gamble Company | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase |
| AU2007237096C1 (en) | 2006-04-07 | 2012-12-13 | EyePoint, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
| US7795444B2 (en) | 2006-06-27 | 2010-09-14 | Warner Chilcott Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US7589212B2 (en) * | 2006-06-27 | 2009-09-15 | Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US8846685B2 (en) | 2006-06-27 | 2014-09-30 | Aerpio Therapeutics Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
| US20130023542A1 (en) | 2006-06-27 | 2013-01-24 | Aerpio Therapeutics Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
| US8957022B2 (en) | 2006-10-27 | 2015-02-17 | Sunnybrook Health Sciences Centre | Multimeric tie 2 agonists and uses thereof in stimulating angiogenesis |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
| US9403789B2 (en) | 2008-02-21 | 2016-08-02 | Sequoia Pharmaceuticals, Inc. | Benzofuran-containing amino acid inhibitors of cytochrome P450 |
| US9096555B2 (en) | 2009-01-12 | 2015-08-04 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome |
| SG10201702247SA (en) * | 2009-01-12 | 2017-04-27 | Aerpio Therapeutics Inc | Methods for treating vascular leak syndrome |
| BRPI1008920A2 (pt) | 2009-03-03 | 2015-08-25 | Alcon Res Ltd | Composição farmacêutica para liberação de compostos inibidores de receptor de tirosina quinase (rtki) para o olho |
| US20100227905A1 (en) | 2009-03-03 | 2010-09-09 | Alcon Research, Ltd. | Pharmaceutical Composition for Delivery of Receptor Tyrosine Kinase Inhibiting (RTKi) Compounds to the Eye |
| US8883832B2 (en) | 2009-07-06 | 2014-11-11 | Aerpio Therapeutics Inc. | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| TR201907783T4 (tr) | 2009-07-06 | 2019-06-21 | Aerpio Therapeutics Inc | Benzosulfonamit türevleri, bileşimleri ve kanser hücrelerinin metastazının önlenmesinde kullanımları. |
| AU2010314982B2 (en) | 2009-11-06 | 2013-08-29 | Aerpio Therapeutics Inc. | Compositions and methods for treating colitis |
| ES2877629T3 (es) | 2010-07-12 | 2021-11-17 | Immunogenesis Inc | Administración de profármacos activados por hipoxia y agentes antiangiogénicos para el tratamiento del cáncer |
| EP2624916B1 (en) | 2010-10-07 | 2018-01-17 | Aerpio Therapeutics, Inc. | Thiadiazole derivatives for use in the treatment of ocular edema |
| CN103249422A (zh) | 2010-12-02 | 2013-08-14 | 丸善制药株式会社 | Tie2活化剂、血管内皮生长因子抑制剂、血管生成抑制剂、血管成熟剂、血管正常化剂及血管稳定剂、以及药物组合物 |
| EP2766043A4 (en) | 2011-10-13 | 2015-06-10 | Aerpio Therapeutics Inc | METHOD FOR THE TREATMENT OF CAPILLARY LECKSYNDROME AND CANCER |
| JP2014532072A (ja) | 2011-10-13 | 2014-12-04 | エアピオ セラピューティックス， インコーポレイテッド | 眼疾患の治療 |
| US20130190324A1 (en) | 2011-12-23 | 2013-07-25 | The Regents Of The University Of Colorado, A Body Corporate | Topical ocular drug delivery |
| EP2836232A4 (en) | 2012-04-13 | 2016-03-16 | Univ Johns Hopkins | TREATMENT OF ISCHEMIC RETINOPATHY |
| WO2014022455A1 (en) | 2012-07-31 | 2014-02-06 | The Board Of Regents Of The University Of Texas System | Methods and compositions for in vivo induction of pancreatic beta cell formation |
| KR102235868B1 (ko) | 2012-10-11 | 2021-04-07 | 아센디스 파마 옵탈몰로지 디비젼 에이/에스 | 안구 병태의 치료를 위한 vegf 중화 프로드럭 |
| SG11201503637SA (en) | 2012-11-08 | 2015-06-29 | Clearside Biomedical Inc | Methods and devices for the treatment of ocular diseases in human subjects |
| US20150290235A1 (en) | 2012-11-23 | 2015-10-15 | Ab Science | Use of small molecule inhibitors/activators in combination with (deoxy)nucleoside or (deoxy)nucleotide analogs for treatment of cancer and hematological malignancies or viral infections |
| KR20150129019A (ko) | 2013-03-15 | 2015-11-18 | 에르피오 세러퓨틱스 인코포레이티드 | 안과 질환을 치료하기 위한 조성물, 제형 및 방법 |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| US10314882B2 (en) | 2013-04-11 | 2019-06-11 | Sunnybrook Research Institute | Methods, uses and compositions of Tie2 agonists |
| WO2014203182A1 (en) | 2013-06-20 | 2014-12-24 | Novartis Ag | Use of a vegf antagonist in treating choroidal neovascularisation |
| WO2014203183A1 (en) | 2013-06-20 | 2014-12-24 | Novartis Ag | Use of a vegf antagonist in treating macular edema |
| US20160151410A1 (en) | 2013-07-02 | 2016-06-02 | The Trustees Of Columbia University In The City Of New York | Clearance of bioactive lipids from membrane structures by cyclodextrins |
| KR20160029794A (ko) | 2013-07-11 | 2016-03-15 | 노파르티스 아게 | 소아 환자의 맥락망막 신생혈관성 및 투과성 장애의 치료에 있어서 vegf 길항제의 용도 |
| BR112016000282A2 (pt) | 2013-07-11 | 2017-12-12 | Novartis Ag | uso de antagonista de vegf em tratamento de retinopatia da prematuridade |
| US9828422B2 (en) | 2013-07-29 | 2017-11-28 | Samsung Electronics Co., Ltd. | Anti-Ang2 antibody |
| US10617755B2 (en) | 2013-08-30 | 2020-04-14 | Genentech, Inc. | Combination therapy for the treatment of glioblastoma |
| US20160252526A1 (en) | 2013-10-01 | 2016-09-01 | Sphingotec Gmbh | A method for predicting the risk of getting a major adverse cardiac event |
| WO2015066426A2 (en) | 2013-11-01 | 2015-05-07 | Regeneron Pharmaceuticals, Inc. | Angiopoietin-based interventions for treating cerebral malaria |
| CN106232120B (zh) | 2014-02-19 | 2021-01-08 | 爱尔皮奥治疗有限公司 | 制备n-苄基-3-羟基-4-取代的-吡啶-2-(1h)-酮的方法 |
| CN106456614A (zh) | 2014-03-14 | 2017-02-22 | 爱尔皮奥治疗有限公司 | HPTP‑β抑制剂 |
| WO2015152416A1 (ja) | 2014-04-04 | 2015-10-08 | 国立大学法人東北大学 | 眼圧降下剤 |
| US9719135B2 (en) | 2014-07-03 | 2017-08-01 | Mannin Research Inc. | Conditional angiopoietin-1/angiopoietin-2 double knock-out mice with defective ocular drainage system |
| US9539245B2 (en) | 2014-08-07 | 2017-01-10 | Aerpio Therapeutics, Inc. | Combination of immunotherapies with activators of Tie-2 |
| US20160082129A1 (en) | 2014-09-24 | 2016-03-24 | Aerpio Therapeutics, Inc. | VE-PTP Extracellular Domain Antibodies Delivered by a Gene Therapy Vector |
| TWI738632B (zh) | 2014-11-07 | 2021-09-11 | 瑞士商諾華公司 | 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 |
| US20160144025A1 (en) | 2014-11-25 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and formulations for treating vascular eye diseases |
| EP3977994B1 (en) | 2015-09-23 | 2024-04-24 | EyePoint Pharmaceuticals, Inc. | Activators of tie-2 for use in treating intraocular pressure |
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