JP2015531789A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015531789A5 JP2015531789A5 JP2015532458A JP2015532458A JP2015531789A5 JP 2015531789 A5 JP2015531789 A5 JP 2015531789A5 JP 2015532458 A JP2015532458 A JP 2015532458A JP 2015532458 A JP2015532458 A JP 2015532458A JP 2015531789 A5 JP2015531789 A5 JP 2015531789A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolysine
- mutein
- unnatural amino
- conjugated
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705116P | 2012-09-24 | 2012-09-24 | |
| US61/705,116 | 2012-09-24 | ||
| US201361862495P | 2013-08-05 | 2013-08-05 | |
| US61/862,495 | 2013-08-05 | ||
| PCT/EP2013/069888 WO2014044873A1 (en) | 2012-09-24 | 2013-09-24 | Amino acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015531789A JP2015531789A (ja) | 2015-11-05 |
| JP2015531789A5 true JP2015531789A5 (https=) | 2018-03-29 |
| JP6321658B2 JP6321658B2 (ja) | 2018-05-09 |
Family
ID=49237211
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532457A Active JP6532404B2 (ja) | 2012-09-24 | 2013-09-24 | 細胞株 |
| JP2015532458A Expired - Fee Related JP6321658B2 (ja) | 2012-09-24 | 2013-09-24 | アミノ酸誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532457A Active JP6532404B2 (ja) | 2012-09-24 | 2013-09-24 | 細胞株 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9670521B2 (https=) |
| EP (2) | EP2898085B1 (https=) |
| JP (2) | JP6532404B2 (https=) |
| KR (1) | KR102155389B1 (https=) |
| CN (2) | CN105026574B (https=) |
| AU (1) | AU2013320184B2 (https=) |
| BR (1) | BR112015006368B1 (https=) |
| CA (1) | CA2885796C (https=) |
| SG (2) | SG10201702387YA (https=) |
| WO (2) | WO2014044872A1 (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2825370A1 (en) | 2010-12-22 | 2012-06-28 | President And Fellows Of Harvard College | Continuous directed evolution |
| CA2873793C (en) | 2012-05-18 | 2022-02-22 | Medical Research Council | Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase |
| EP2859017B1 (en) | 2012-06-08 | 2019-02-20 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| WO2014004639A1 (en) | 2012-06-26 | 2014-01-03 | Sutro Biopharma, Inc. | Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
| EP2898085B1 (en) | 2012-09-24 | 2019-01-23 | MedImmune Limited | Cell lines |
| AU2014229999B2 (en) | 2013-03-15 | 2019-09-12 | Medimmune Limited | Novel nucleic acid molecules |
| WO2015006555A2 (en) * | 2013-07-10 | 2015-01-15 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| EP3030545B1 (en) | 2013-08-05 | 2020-10-07 | MedImmune Limited | Amino acid derivatives |
| EP3079668A1 (en) | 2013-12-09 | 2016-10-19 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
| WO2015134121A2 (en) | 2014-01-20 | 2015-09-11 | President And Fellows Of Harvard College | Negative selection and stringency modulation in continuous evolution systems |
| GB2528227A (en) * | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| WO2016077052A2 (en) | 2014-10-22 | 2016-05-19 | President And Fellows Of Harvard College | Evolution of proteases |
| CN107148425B (zh) | 2014-10-29 | 2021-08-03 | 拜斯科阿迪有限公司 | 对mt1-mmp特异性的双环肽配体 |
| CN106146663B (zh) * | 2015-04-10 | 2019-11-08 | 北京大学 | 非天然氨基酸标记的新型抗体-药物偶联物及其制备 |
| WO2016168631A1 (en) | 2015-04-17 | 2016-10-20 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
| WO2017015545A1 (en) | 2015-07-22 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
| US11524983B2 (en) | 2015-07-23 | 2022-12-13 | President And Fellows Of Harvard College | Evolution of Bt toxins |
| WO2017019895A1 (en) | 2015-07-30 | 2017-02-02 | President And Fellows Of Harvard College | Evolution of talens |
| EP3360960A4 (en) | 2015-08-19 | 2019-03-20 | Riken | ANTIBODIES WITH INGREDIENTS OF NON-NATURAL AMINO ACID |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| CN106929482A (zh) * | 2015-12-31 | 2017-07-07 | 北京大学 | 定点突变的流感病毒、其活疫苗及其制备方法和应用 |
| WO2017132615A1 (en) | 2016-01-27 | 2017-08-03 | Sutro Biopharma, Inc. | Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates |
| CN107012121B (zh) * | 2016-01-27 | 2021-01-26 | 北京大学 | 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建 |
| CN105524167A (zh) * | 2016-01-30 | 2016-04-27 | 深圳市贝沃德克生物技术研究院有限公司 | 抗乙肝e抗原的绿色荧光抗体的制备方法 |
| CN105647918A (zh) * | 2016-02-20 | 2016-06-08 | 深圳市圣必智科技开发有限公司 | 抗乙肝e抗原的红色荧光抗体的制备方法 |
| IL263744B2 (en) | 2016-06-17 | 2023-11-01 | Magenta Therapeutics Inc | Compositions and methods for the depletion of cd117 plus cells |
| US11214820B2 (en) * | 2016-09-02 | 2022-01-04 | Ikaria Inc. | Functionally modified polypeptides and radiobiosynthesis |
| WO2018044143A1 (ko) * | 2016-09-05 | 2018-03-08 | 한국과학기술원 | 목적 단백질의 위치 특이적 변형이 시공간적으로 조절되는 마우스, 이의 제조방법 및 그 용도 |
| US10905107B2 (en) | 2016-09-05 | 2021-02-02 | Korea Advanced Institute Of Science And Technology | Transgenic mouse capable of spatial and temporal control of expression and site-specific modification of target protein, production method and uses thereof |
| WO2018115203A1 (en) * | 2016-12-23 | 2018-06-28 | Bicyclerd Limited | Peptide derivatives having novel linkage structures |
| EP3571230A4 (en) | 2017-01-20 | 2020-12-16 | Magenta Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR DELETION OF CD137 + CELLS |
| EP3645549A1 (en) | 2017-06-26 | 2020-05-06 | BicycleRD Limited | Bicyclic peptide ligands with detectable moieties and uses thereof |
| US11447809B2 (en) | 2017-07-06 | 2022-09-20 | President And Fellows Of Harvard College | Evolution of tRNA synthetases |
| JP7670481B2 (ja) | 2017-08-04 | 2025-04-30 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
| US12060553B2 (en) | 2017-08-25 | 2024-08-13 | President And Fellows Of Harvard College | Evolution of BoNT peptidases |
| WO2019056002A1 (en) | 2017-09-18 | 2019-03-21 | President And Fellows Of Harvard College | CONTINUOUS EVOLUTION FOR STABILIZED PROTEINS |
| US12280118B2 (en) | 2017-12-27 | 2025-04-22 | Kyowa Kirin Co., Ltd. | IL-2 variant |
| CN111902429A (zh) | 2018-02-23 | 2020-11-06 | 拜斯科技术开发有限公司 | 多聚体双环肽配体 |
| WO2019241649A1 (en) | 2018-06-14 | 2019-12-19 | President And Fellows Of Harvard College | Evolution of cytidine deaminases |
| IL279489B2 (en) | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| CN110835633B (zh) * | 2018-08-13 | 2021-10-01 | 北京大学 | 利用优化的基因密码子扩展系统制备ptc稳定细胞系及应用 |
| CN112673109A (zh) * | 2018-09-07 | 2021-04-16 | 免疫医疗有限责任公司 | 细胞选择方法 |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| WO2020084034A1 (en) | 2018-10-26 | 2020-04-30 | F. Hoffmann-La Roche Ag | Multispecific antibody screening method using recombinase mediated cassette exchange |
| CN109553643B (zh) * | 2018-11-29 | 2020-09-22 | 深圳先进技术研究院 | 单糖类似物及包含其的分子探针和该分子探针的应用 |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| WO2020128527A1 (en) | 2018-12-21 | 2020-06-25 | Bicyclerd Limited | Bicyclic peptide ligands specific for pd-l1 |
| US12492224B2 (en) | 2018-12-21 | 2025-12-09 | Bicycletx Limited | Bicyclic peptide ligands specific for PD-L1 |
| GB201900529D0 (en) | 2019-01-15 | 2019-03-06 | Bicycletx Ltd | Bicyclic peptide ligands specific for CD38 |
| CN111850020B (zh) * | 2019-04-25 | 2021-05-07 | 苏州鲲鹏生物技术有限公司 | 利用质粒系统在蛋白中引入非天然氨基酸 |
| CN111909256A (zh) * | 2019-05-10 | 2020-11-10 | 宁波鲲鹏生物科技有限公司 | 多肽衍生物及其制备方法 |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| KR20220087519A (ko) * | 2019-10-23 | 2022-06-24 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 촉매 항체 38c2를 위한 신규 접합 화학 |
| AU2021322934A1 (en) | 2020-08-03 | 2023-03-30 | Bicycletx Limited | Peptide-based linkers |
| WO2022056318A1 (en) * | 2020-09-10 | 2022-03-17 | Brickbio, Inc. | Antibodies containing unnatural amino acids and methods of making and using the same |
| CN117529558A (zh) * | 2021-04-21 | 2024-02-06 | 阿西莫夫公司 | 用于腺相关病毒产生的稳定产生系统 |
| WO2022232377A2 (en) * | 2021-04-28 | 2022-11-03 | The Regents Of The University Of California | Bioreactive proteins containing unnatural amino acids |
| KR20240024235A (ko) * | 2021-07-29 | 2024-02-23 | 노보코덱스 바이오파마슈티컬즈 컴퍼니 리미티드 | 비천연 아미노산, 및 이의 용도, 이를 함유하는 재조합 단백질, 및 재조합 단백질 컨주게이트 |
| EP4130254A1 (en) * | 2021-08-03 | 2023-02-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Eukaryotic cell lysates comprising exogenous enzymes and methods for preparing the same |
| CN113698468B (zh) * | 2021-09-01 | 2022-10-11 | 浙江新码生物医药有限公司 | 人白细胞介素2-聚乙二醇偶联物及其应用 |
| CN113788890B (zh) * | 2021-09-01 | 2022-11-08 | 浙江新码生物医药有限公司 | 一种人白细胞介素2-聚乙二醇偶联物及其应用 |
| WO2023164676A1 (en) * | 2022-02-27 | 2023-08-31 | The Regents Of The University Of California | Methods to generate novel acyl-trna species |
| EP4702156A1 (en) * | 2023-04-28 | 2026-03-04 | United Kingdom Research and Innovation | Trna-based methods and related compositions |
| KR20260039735A (ko) * | 2023-07-10 | 2026-03-20 | 수리오 테라퓨틱스 컴퍼니 리미티드 | 기능화된 아우리스타틴, 약제학적 조성물, 및 치료적 적용 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3711458A (en) | 1969-08-21 | 1973-01-16 | Research Corp | Substituted and unsubstituted vinyloxycarbonyl groups as amino protecting groups in the syntheses of peptides |
| US4512979A (en) | 1981-03-23 | 1985-04-23 | Merck & Co., Inc. | Dipeptides containing thialysine and related amino acids as antihypertensives |
| JPH0710451B2 (ja) | 1986-11-25 | 1995-02-08 | 三五重機株式会社 | 鋼板カツタ− |
| HU207287B (en) | 1989-01-17 | 1993-03-29 | Biosignal Kutato Fejlesztoe Kf | Polyene fatty acid derivatives of tyrozine-quinaze inhibiting activity and pharmaceutical composition containing them as active component |
| WO1991016449A1 (en) | 1990-04-16 | 1991-10-31 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
| WO2002085923A2 (en) | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| ES2411007T3 (es) | 2001-10-10 | 2013-07-04 | Novo Nordisk A/S | Remodelación y glicoconjugación de péptidos |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| US20040146941A1 (en) * | 2002-11-04 | 2004-07-29 | Biliang Zhang | Chemical encoding technology for combinatorial synthesis |
| JP5642916B2 (ja) * | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| US7807619B2 (en) | 2004-11-01 | 2010-10-05 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
| JP2007037445A (ja) * | 2005-08-02 | 2007-02-15 | Institute Of Physical & Chemical Research | ｔＲＮＡ合成方法、核酸、アミノアシルｔＲＮＡ合成方法及び非天然型アミノ酸組み込み蛋白質の製造方法 |
| EP1992698B1 (en) | 2006-02-22 | 2018-09-05 | Riken | METHOD FOR SYNTHESIS OF SUPPRESSOR tRNA, DNA CONSTRUCT, AND PRODUCTION OF PROTEIN HAVING NON-NATURAL AMINO ACID INTEGRATED THEREIN BY USING THE DNA CONSTRUCT |
| JP5313129B2 (ja) | 2006-05-02 | 2013-10-09 | アロザイン， インコーポレイテッド | 非天然アミノ酸置換ポリペプチド |
| WO2008073184A2 (en) * | 2006-10-18 | 2008-06-19 | The Scripps Research Institute | Genetic incorporation of unnatural amino acids into proteins in mammalian cells |
| JP5590649B2 (ja) | 2007-09-20 | 2014-09-17 | 独立行政法人理化学研究所 | 変異体ピロリジル−ｔＲＮＡ合成酵素及びこれを用いる非天然アミノ酸組み込みタンパク質の製造方法 |
| CN102159803B (zh) | 2008-07-18 | 2014-07-23 | 阿兰图姆公司 | 用于净化汽车尾气的过滤装置 |
| JP5798489B2 (ja) | 2009-01-12 | 2015-10-21 | ストロ バイオファーマ， インコーポレイテッド | インビトロタンパク質合成システムを用いて非天然アミノ酸をタンパク質に選択的に導入するためのモノチャージシステム |
| US20100203587A1 (en) | 2009-01-13 | 2010-08-12 | Sutro Biopharma, Inc. | Use of dna gyrase inhibitors for in vitro polypeptide synthesis reactions |
| WO2010114615A2 (en) | 2009-04-03 | 2010-10-07 | The Scripps Research Institute | A facile system for encoding unnatural amino acids in mammalian cells |
| GB2470770A (en) | 2009-06-04 | 2010-12-08 | Medical Res Council | Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs |
| WO2011044255A1 (en) | 2009-10-06 | 2011-04-14 | The Ohio State University | Pyrrolysine analogs |
| BR112012015597A2 (pt) * | 2009-12-21 | 2017-01-31 | Ambrx Inc | peptídeos de somatotropina suínos modificados e seus usos |
| MX349301B (es) * | 2009-12-21 | 2017-07-21 | Ambrx Inc | Polipéptidos de somatotropina bovina modificados y sus usos. |
| EP2563753B9 (en) | 2010-04-27 | 2016-07-06 | SynAffix B.V. | Fused cyclooctyne compounds and their use in metal-free click reactions |
| EP2640745B1 (en) | 2010-09-10 | 2018-11-07 | MedImmune Limited | Bivalent and bispecific anti-il6/anti-il23 antibodies |
| DE102010041261A1 (de) * | 2010-09-23 | 2012-03-29 | Robert Bosch Gmbh | Flip-Chip Anordnung mit einem Kühlelement und Verfahren zur Herstellung einer Flip-Chip Anordnung |
| EP2619305A1 (en) * | 2010-09-24 | 2013-07-31 | Medical Research Council | Methods for incorporating unnatural amino acids in eukaryotic cells |
| ES2661095T3 (es) * | 2011-02-03 | 2018-03-27 | European Molecular Biology Laboratory | Aminoácidos no naturales que comprenden un grupo análogo de ciclooctinilo o trans-ciclooctenilo y usos de los mismos |
| EP2890402B1 (en) | 2012-08-31 | 2019-04-17 | Sutro Biopharma, Inc. | Modified amino acids comprising an azido group |
| EP2898085B1 (en) | 2012-09-24 | 2019-01-23 | MedImmune Limited | Cell lines |
| AU2014229999B2 (en) | 2013-03-15 | 2019-09-12 | Medimmune Limited | Novel nucleic acid molecules |
-
2013
- 2013-09-24 EP EP13766525.3A patent/EP2898085B1/en active Active
- 2013-09-24 US US14/430,412 patent/US9670521B2/en not_active Expired - Fee Related
- 2013-09-24 EP EP13766526.1A patent/EP2897935B1/en not_active Not-in-force
- 2013-09-24 AU AU2013320184A patent/AU2013320184B2/en active Active
- 2013-09-24 CA CA2885796A patent/CA2885796C/en active Active
- 2013-09-24 JP JP2015532457A patent/JP6532404B2/ja active Active
- 2013-09-24 WO PCT/EP2013/069887 patent/WO2014044872A1/en not_active Ceased
- 2013-09-24 KR KR1020157010354A patent/KR102155389B1/ko active Active
- 2013-09-24 CN CN201380060916.XA patent/CN105026574B/zh active Active
- 2013-09-24 WO PCT/EP2013/069888 patent/WO2014044873A1/en not_active Ceased
- 2013-09-24 US US14/430,542 patent/US9732367B2/en active Active
- 2013-09-24 CN CN201380060971.9A patent/CN104812734B/zh not_active Expired - Fee Related
- 2013-09-24 SG SG10201702387YA patent/SG10201702387YA/en unknown
- 2013-09-24 SG SG11201502216UA patent/SG11201502216UA/en unknown
- 2013-09-24 JP JP2015532458A patent/JP6321658B2/ja not_active Expired - Fee Related
- 2013-09-24 BR BR112015006368-3A patent/BR112015006368B1/pt active IP Right Grant
-
2017
- 2017-06-01 US US15/611,116 patent/US10253345B2/en active Active
- 2017-06-01 US US15/610,931 patent/US10214761B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015531789A5 (https=) | ||
| JP2015532295A5 (https=) | ||
| JP2020097577A5 (https=) | ||
| JP2016153410A5 (https=) | ||
| EP4681777A3 (en) | Prodrugs of ketamine, compositions and uses thereof | |
| JP2009523724A5 (https=) | ||
| JP2019524883A5 (https=) | ||
| JP2016106149A5 (https=) | ||
| JP2010521485A5 (https=) | ||
| JP2012518029A5 (https=) | ||
| JP2020507589A5 (https=) | ||
| JP2017515901A5 (https=) | ||
| CY1115719T1 (el) | Νεοι φαρμακευτικοι συνδυασμοι για τη θεραπεια νοσων των αναπνευστικων οδων | |
| JP2016531871A5 (https=) | ||
| JP2013518107A5 (https=) | ||
| JP2013508279A5 (https=) | ||
| JP2017531619A5 (https=) | ||
| JP2011517683A5 (https=) | ||
| JP2020529994A5 (https=) | ||
| JP2016503052A5 (https=) | ||
| JP2003306481A5 (https=) | ||
| JP2019510027A5 (https=) | ||
| JP2017517565A5 (https=) | ||
| JP2014515407A5 (https=) | ||
| JP2018521056A5 (https=) |