JP2015531789A5 - - Google Patents
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- JP2015531789A5 JP2015531789A5 JP2015532458A JP2015532458A JP2015531789A5 JP 2015531789 A5 JP2015531789 A5 JP 2015531789A5 JP 2015532458 A JP2015532458 A JP 2015532458A JP 2015532458 A JP2015532458 A JP 2015532458A JP 2015531789 A5 JP2015531789 A5 JP 2015531789A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolysine
- mutein
- unnatural amino
- conjugated
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705116P | 2012-09-24 | 2012-09-24 | |
| US61/705,116 | 2012-09-24 | ||
| US201361862495P | 2013-08-05 | 2013-08-05 | |
| US61/862,495 | 2013-08-05 | ||
| PCT/EP2013/069888 WO2014044873A1 (en) | 2012-09-24 | 2013-09-24 | Amino acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015531789A JP2015531789A (ja) | 2015-11-05 |
| JP2015531789A5 true JP2015531789A5 (https=) | 2018-03-29 |
| JP6321658B2 JP6321658B2 (ja) | 2018-05-09 |
Family
ID=49237211
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532458A Expired - Fee Related JP6321658B2 (ja) | 2012-09-24 | 2013-09-24 | アミノ酸誘導体 |
| JP2015532457A Active JP6532404B2 (ja) | 2012-09-24 | 2013-09-24 | 細胞株 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532457A Active JP6532404B2 (ja) | 2012-09-24 | 2013-09-24 | 細胞株 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9670521B2 (https=) |
| EP (2) | EP2897935B1 (https=) |
| JP (2) | JP6321658B2 (https=) |
| KR (1) | KR102155389B1 (https=) |
| CN (2) | CN105026574B (https=) |
| AU (1) | AU2013320184B2 (https=) |
| BR (1) | BR112015006368B1 (https=) |
| CA (1) | CA2885796C (https=) |
| SG (2) | SG10201702387YA (https=) |
| WO (2) | WO2014044873A1 (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3202903B1 (en) | 2010-12-22 | 2020-02-12 | President and Fellows of Harvard College | Continuous directed evolution |
| IN2014DN09922A (https=) | 2012-05-18 | 2015-08-14 | Medical Res Council | |
| PL2859017T3 (pl) | 2012-06-08 | 2019-07-31 | Sutro Biopharma, Inc. | Przeciwciała zawierające swoiste dla miejsca, niewystępujące naturalnie reszty aminokwasowe, sposoby ich wytwarzania i sposoby ich zastosowania |
| WO2014004639A1 (en) | 2012-06-26 | 2014-01-03 | Sutro Biopharma, Inc. | Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
| SG10201702387YA (en) | 2012-09-24 | 2017-04-27 | Medimmune Ltd | Cell lines |
| BR112015022641B1 (pt) | 2013-03-15 | 2023-02-28 | Medimmune Limited | Construção de dna e processo de preparação de uma proteína-alvo |
| ES2865473T3 (es) * | 2013-07-10 | 2021-10-15 | Sutro Biopharma Inc | Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso |
| CN105980350B (zh) | 2013-08-05 | 2018-11-27 | 米迪缪尼有限公司 | 氨基酸衍生物 |
| JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
| US10179911B2 (en) | 2014-01-20 | 2019-01-15 | President And Fellows Of Harvard College | Negative selection and stringency modulation in continuous evolution systems |
| GB2528227A (en) * | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| US10920208B2 (en) | 2014-10-22 | 2021-02-16 | President And Fellows Of Harvard College | Evolution of proteases |
| JP6882978B2 (ja) | 2014-10-29 | 2021-06-02 | バイスクルアールディー・リミテッド | Ｍｔ１−ｍｍｐに特異的な二環性ペプチドリガンド |
| CN106146663B (zh) * | 2015-04-10 | 2019-11-08 | 北京大学 | 非天然氨基酸标记的新型抗体-药物偶联物及其制备 |
| WO2016168631A1 (en) | 2015-04-17 | 2016-10-20 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
| WO2017015545A1 (en) | 2015-07-22 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
| US11524983B2 (en) | 2015-07-23 | 2022-12-13 | President And Fellows Of Harvard College | Evolution of Bt toxins |
| US10612011B2 (en) | 2015-07-30 | 2020-04-07 | President And Fellows Of Harvard College | Evolution of TALENs |
| US10906990B2 (en) * | 2015-08-19 | 2021-02-02 | Riken | Antibody with non-natural amino acid introduced therein |
| JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したＣａｓ９蛋白質 |
| CN106929482A (zh) * | 2015-12-31 | 2017-07-07 | 北京大学 | 定点突变的流感病毒、其活疫苗及其制备方法和应用 |
| CN112725282A (zh) * | 2016-01-27 | 2021-04-30 | 北京大学 | 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建 |
| SG11201806419RA (en) | 2016-01-27 | 2018-08-30 | Sutro Biopharma Inc | Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates |
| CN105524167A (zh) * | 2016-01-30 | 2016-04-27 | 深圳市贝沃德克生物技术研究院有限公司 | 抗乙肝e抗原的绿色荧光抗体的制备方法 |
| CN105647918A (zh) * | 2016-02-20 | 2016-06-08 | 深圳市圣必智科技开发有限公司 | 抗乙肝e抗原的红色荧光抗体的制备方法 |
| BR112018076306A2 (pt) | 2016-06-17 | 2019-03-26 | Magenta Therapeutics, Inc. | composições e métodos para a supressão de células cd117+ |
| WO2018045376A2 (en) * | 2016-09-02 | 2018-03-08 | Ikaria Inc. | Functionally modified polypeptides and radiobiosynthesis |
| US10905107B2 (en) | 2016-09-05 | 2021-02-02 | Korea Advanced Institute Of Science And Technology | Transgenic mouse capable of spatial and temporal control of expression and site-specific modification of target protein, production method and uses thereof |
| WO2018044143A1 (ko) * | 2016-09-05 | 2018-03-08 | 한국과학기술원 | 목적 단백질의 위치 특이적 변형이 시공간적으로 조절되는 마우스, 이의 제조방법 및 그 용도 |
| WO2018115203A1 (en) * | 2016-12-23 | 2018-06-28 | Bicyclerd Limited | Peptide derivatives having novel linkage structures |
| MX395639B (es) | 2017-01-20 | 2025-03-25 | Heidelberg Pharma Res Gmbh | Composiciones y métodos para el agotamiento de células cd137+. |
| JP7301757B2 (ja) | 2017-06-26 | 2023-07-03 | バイスクルアールディー・リミテッド | 検出可能部分を持つ二環式ペプチドリガンドおよびその使用 |
| US11447809B2 (en) | 2017-07-06 | 2022-09-20 | President And Fellows Of Harvard College | Evolution of tRNA synthetases |
| CN111183147B (zh) | 2017-08-04 | 2024-07-05 | 拜斯科技术开发有限公司 | Cd137特异性的双环肽配体 |
| AU2018321405A1 (en) | 2017-08-25 | 2020-03-05 | Ipsen Biopharm Ltd. | Evolution of BoNT peptidases |
| US11624130B2 (en) | 2017-09-18 | 2023-04-11 | President And Fellows Of Harvard College | Continuous evolution for stabilized proteins |
| WO2019131964A1 (ja) | 2017-12-27 | 2019-07-04 | 協和発酵キリン株式会社 | Ｉｌ－２改変体 |
| JP2021514953A (ja) | 2018-02-23 | 2021-06-17 | バイスクルテクス・リミテッド | 多量体二環式ペプチドリガンド |
| WO2019241649A1 (en) | 2018-06-14 | 2019-12-19 | President And Fellows Of Harvard College | Evolution of cytidine deaminases |
| IL279489B2 (en) | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| CN110835633B (zh) * | 2018-08-13 | 2021-10-01 | 北京大学 | 利用优化的基因密码子扩展系统制备ptc稳定细胞系及应用 |
| CN112673109A (zh) * | 2018-09-07 | 2021-04-16 | 免疫医疗有限责任公司 | 细胞选择方法 |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| EP3870604B1 (en) | 2018-10-26 | 2022-11-23 | F. Hoffmann-La Roche AG | Multispecific antibody screening method using recombinase mediated cassette exchange |
| CN109553643B (zh) * | 2018-11-29 | 2020-09-22 | 深圳先进技术研究院 | 单糖类似物及包含其的分子探针和该分子探针的应用 |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| US12551567B2 (en) | 2018-12-21 | 2026-02-17 | Bicyclerd Limited | Bicyclic peptide ligands specific for PD-L1 |
| JP2022514618A (ja) | 2018-12-21 | 2022-02-14 | バイスクルテクス・リミテッド | Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド |
| GB201900529D0 (en) | 2019-01-15 | 2019-03-06 | Bicycletx Ltd | Bicyclic peptide ligands specific for CD38 |
| CN111850020B (zh) * | 2019-04-25 | 2021-05-07 | 苏州鲲鹏生物技术有限公司 | 利用质粒系统在蛋白中引入非天然氨基酸 |
| CN111909256A (zh) * | 2019-05-10 | 2020-11-10 | 宁波鲲鹏生物科技有限公司 | 多肽衍生物及其制备方法 |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| WO2021080846A1 (en) * | 2019-10-23 | 2021-04-29 | The Scripps Research Institute | Novel conjugation chemistry for catalytic anttibody 38c2 |
| IL300248A (en) | 2020-08-03 | 2023-03-01 | Bicycletx Ltd | peptide-based linkers |
| US20240316209A1 (en) * | 2020-09-10 | 2024-09-26 | Brickbio, Inc. | Antibodies containing unnatural amino acids and methods of making and using the same |
| US20240360422A1 (en) * | 2021-04-21 | 2024-10-31 | Michael T. Leonard | Stable production systems for adeno-associated virus production |
| WO2022232377A2 (en) * | 2021-04-28 | 2022-11-03 | The Regents Of The University Of California | Bioreactive proteins containing unnatural amino acids |
| US20240317832A1 (en) * | 2021-07-29 | 2024-09-26 | Novocodex Biopharmaceuticals Co., Ltd. | Unnatural amino acid, and use thereof, recombinant protein containing same, and recombinant protein conjugate |
| EP4130254A1 (en) * | 2021-08-03 | 2023-02-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Eukaryotic cell lysates comprising exogenous enzymes and methods for preparing the same |
| CN113788890B (zh) * | 2021-09-01 | 2022-11-08 | 浙江新码生物医药有限公司 | 一种人白细胞介素2-聚乙二醇偶联物及其应用 |
| CN113698468B (zh) * | 2021-09-01 | 2022-10-11 | 浙江新码生物医药有限公司 | 人白细胞介素2-聚乙二醇偶联物及其应用 |
| WO2023164676A1 (en) * | 2022-02-27 | 2023-08-31 | The Regents Of The University Of California | Methods to generate novel acyl-trna species |
| AU2024262114A1 (en) * | 2023-04-28 | 2025-10-09 | United Kingdom Research And Innovation | ACYL-tRNA SYNTHETASES |
| KR20260039735A (ko) * | 2023-07-10 | 2026-03-20 | 수리오 테라퓨틱스 컴퍼니 리미티드 | 기능화된 아우리스타틴, 약제학적 조성물, 및 치료적 적용 |
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| US3711458A (en) | 1969-08-21 | 1973-01-16 | Research Corp | Substituted and unsubstituted vinyloxycarbonyl groups as amino protecting groups in the syntheses of peptides |
| US4512979A (en) | 1981-03-23 | 1985-04-23 | Merck & Co., Inc. | Dipeptides containing thialysine and related amino acids as antihypertensives |
| JPH0710451B2 (ja) | 1986-11-25 | 1995-02-08 | 三五重機株式会社 | 鋼板カツタ− |
| HU207287B (en) | 1989-01-17 | 1993-03-29 | Biosignal Kutato Fejlesztoe Kf | Polyene fatty acid derivatives of tyrozine-quinaze inhibiting activity and pharmaceutical composition containing them as active component |
| WO1991016449A1 (en) | 1990-04-16 | 1991-10-31 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
| US7083970B2 (en) | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| EP2042196B1 (en) | 2001-10-10 | 2016-07-13 | ratiopharm GmbH | Remodelling and glycoconjugation of Granulocyte Colony Stimulating Factor (G-CSF) |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| US20040146941A1 (en) * | 2002-11-04 | 2004-07-29 | Biliang Zhang | Chemical encoding technology for combinatorial synthesis |
| WO2004094593A2 (en) * | 2003-04-17 | 2004-11-04 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| DK1812031T3 (en) | 2004-11-01 | 2015-09-14 | Univ California | Compositions and methods for the modification of biomolecules |
| JP2007037445A (ja) | 2005-08-02 | 2007-02-15 | Institute Of Physical & Chemical Research | ｔＲＮＡ合成方法、核酸、アミノアシルｔＲＮＡ合成方法及び非天然型アミノ酸組み込み蛋白質の製造方法 |
| AU2007219793A1 (en) | 2006-02-22 | 2007-09-07 | Riken | Method for synthesis of suppressor tRNA, DNA construct, and production of protein having non-natural amino acid integrated therein by using the DNA construct |
| EP2444499A3 (en) | 2006-05-02 | 2012-05-09 | Allozyne, Inc. | Amino acid substituted molecules |
| JP2010506591A (ja) * | 2006-10-18 | 2010-03-04 | ザ スクリップス リサーチ インスティテュート | 哺乳動物細胞中の蛋白質への非天然アミノ酸の遺伝的組込み |
| JP5590649B2 (ja) | 2007-09-20 | 2014-09-17 | 独立行政法人理化学研究所 | 変異体ピロリジル−ｔＲＮＡ合成酵素及びこれを用いる非天然アミノ酸組み込みタンパク質の製造方法 |
| WO2010008110A1 (en) | 2008-07-18 | 2010-01-21 | Alantum Corporation | Filter device for filtering automobile exhaust gas |
| CN102348807B (zh) | 2009-01-12 | 2015-04-15 | 苏特罗生物制药公司 | 利用体外蛋白合成体系将非天然氨基酸引入蛋白的单装载体系 |
| WO2010083148A1 (en) | 2009-01-13 | 2010-07-22 | Sutro Biopharma, Inc. | Use of dna gyrase inhibitors for in vitro polypeptide synthesis reactions |
| WO2010114615A2 (en) | 2009-04-03 | 2010-10-07 | The Scripps Research Institute | A facile system for encoding unnatural amino acids in mammalian cells |
| GB2470770A (en) | 2009-06-04 | 2010-12-08 | Medical Res Council | Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs |
| WO2011044255A1 (en) | 2009-10-06 | 2011-04-14 | The Ohio State University | Pyrrolysine analogs |
| JP2013515081A (ja) * | 2009-12-21 | 2013-05-02 | アンブルックス，インコーポレイテッド | 修飾されているブタのソマトトロピンポリペプチドおよびそれらの使用 |
| NZ600361A (en) * | 2009-12-21 | 2014-06-27 | Ambrx Inc | Modified bovine somatotropin polypeptides and their uses |
| DK2563753T6 (en) | 2010-04-27 | 2016-04-04 | Synaffix Bv | Fused cyclooctynforbindelser and their use in metal-free click-reactions |
| JP6173911B2 (ja) | 2010-09-10 | 2017-08-09 | メディミューン リミテド | 抗体誘導体 |
| DE102010041261A1 (de) * | 2010-09-23 | 2012-03-29 | Robert Bosch Gmbh | Flip-Chip Anordnung mit einem Kühlelement und Verfahren zur Herstellung einer Flip-Chip Anordnung |
| WO2012038706A1 (en) | 2010-09-24 | 2012-03-29 | Medical Research Council | Methods for incorporating unnatural amino acids in eukaryotic cells |
| DK2670767T3 (en) * | 2011-02-03 | 2018-03-26 | European Molecular Biology Laboratory | Non-naturally occurring amino acids comprising a cyclooctynyl or transcyclooctynyl analog group and uses thereof |
| HRP20220455T1 (hr) | 2012-08-31 | 2022-05-27 | Sutro Biopharma, Inc. | Modificirane aminokiseline koje sadrže azid grupu |
| SG10201702387YA (en) | 2012-09-24 | 2017-04-27 | Medimmune Ltd | Cell lines |
| BR112015022641B1 (pt) | 2013-03-15 | 2023-02-28 | Medimmune Limited | Construção de dna e processo de preparação de uma proteína-alvo |
-
2013
- 2013-09-24 SG SG10201702387YA patent/SG10201702387YA/en unknown
- 2013-09-24 JP JP2015532458A patent/JP6321658B2/ja not_active Expired - Fee Related
- 2013-09-24 EP EP13766526.1A patent/EP2897935B1/en not_active Not-in-force
- 2013-09-24 SG SG11201502216UA patent/SG11201502216UA/en unknown
- 2013-09-24 US US14/430,412 patent/US9670521B2/en not_active Expired - Fee Related
- 2013-09-24 WO PCT/EP2013/069888 patent/WO2014044873A1/en not_active Ceased
- 2013-09-24 EP EP13766525.3A patent/EP2898085B1/en active Active
- 2013-09-24 JP JP2015532457A patent/JP6532404B2/ja active Active
- 2013-09-24 AU AU2013320184A patent/AU2013320184B2/en active Active
- 2013-09-24 KR KR1020157010354A patent/KR102155389B1/ko active Active
- 2013-09-24 WO PCT/EP2013/069887 patent/WO2014044872A1/en not_active Ceased
- 2013-09-24 BR BR112015006368-3A patent/BR112015006368B1/pt active IP Right Grant
- 2013-09-24 US US14/430,542 patent/US9732367B2/en active Active
- 2013-09-24 CA CA2885796A patent/CA2885796C/en active Active
- 2013-09-24 CN CN201380060916.XA patent/CN105026574B/zh active Active
- 2013-09-24 CN CN201380060971.9A patent/CN104812734B/zh not_active Expired - Fee Related
-
2017
- 2017-06-01 US US15/611,116 patent/US10253345B2/en active Active
- 2017-06-01 US US15/610,931 patent/US10214761B2/en not_active Expired - Fee Related
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