JP2014515407A5 - - Google Patents
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- JP2014515407A5 JP2014515407A5 JP2014513785A JP2014513785A JP2014515407A5 JP 2014515407 A5 JP2014515407 A5 JP 2014515407A5 JP 2014513785 A JP2014513785 A JP 2014513785A JP 2014513785 A JP2014513785 A JP 2014513785A JP 2014515407 A5 JP2014515407 A5 JP 2014515407A5
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- JP
- Japan
- Prior art keywords
- group
- bonds
- pharmaceutical formulation
- divalent
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(C(c1cc(*)c(*)cc11)=O)=CC1=O Chemical compound CC(C(c1cc(*)c(*)cc11)=O)=CC1=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161492940P | 2011-06-03 | 2011-06-03 | |
| US61/492,940 | 2011-06-03 | ||
| PCT/US2012/040711 WO2012167236A1 (en) | 2011-06-03 | 2012-06-04 | Oral formulations of mitochondrially-targeted antioxidants and their preparation and use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017196849A Division JP6461276B2 (ja) | 2011-06-03 | 2017-10-10 | ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014515407A JP2014515407A (ja) | 2014-06-30 |
| JP2014515407A5 true JP2014515407A5 (https=) | 2015-07-02 |
| JP6448366B2 JP6448366B2 (ja) | 2019-01-09 |
Family
ID=47259946
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513785A Active JP6448366B2 (ja) | 2011-06-03 | 2012-06-04 | ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用 |
| JP2017196849A Active JP6461276B2 (ja) | 2011-06-03 | 2017-10-10 | ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017196849A Active JP6461276B2 (ja) | 2011-06-03 | 2017-10-10 | ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9192676B2 (https=) |
| EP (1) | EP2714024B1 (https=) |
| JP (2) | JP6448366B2 (https=) |
| CN (1) | CN103764132B (https=) |
| AU (1) | AU2012261854B2 (https=) |
| BR (1) | BR112013030605A2 (https=) |
| CA (1) | CA2837437C (https=) |
| EA (1) | EA031399B1 (https=) |
| ES (1) | ES2704064T3 (https=) |
| WO (1) | WO2012167236A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012167236A1 (en) * | 2011-06-03 | 2012-12-06 | Mitotech Sa | Oral formulations of mitochondrially-targeted antioxidants and their preparation and use |
| EA031799B1 (ru) * | 2013-01-22 | 2019-02-28 | Ооо Митотех | Способ лечения воспалительного расстройства при помощи антиоксиданта, направленного на митохондрии |
| EP3030267A2 (en) * | 2013-04-11 | 2016-06-15 | Mitotech SA | Mitochondrially-targeted timoquinones and toluquinones |
| WO2015162494A2 (en) | 2014-02-25 | 2015-10-29 | Mitotech, S.A. | Cosmetic compositions of mitochonrially targeted antioxidants |
| WO2019139831A1 (en) * | 2018-01-10 | 2019-07-18 | Dana-Farber Cancer Institute, Inc. | Methods for identification, assessment, prevention, and treatment of metabolic disorders using succinate |
| CN115551476A (zh) * | 2019-12-10 | 2022-12-30 | 米陀科技有限公司 | 用于线粒体靶向抗氧化剂的不同组合物的聚合物基质 |
| WO2021198786A1 (en) * | 2020-04-03 | 2021-10-07 | Mitotech S.A. | Use of mitochondria-targeted antioxidants to treat severe inflammatory conditions |
| CN114344274A (zh) * | 2022-01-05 | 2022-04-15 | 盖茨汉普(武汉)植物应用研究有限公司 | 一种Mitoq抗氧化硬胶囊配方及制备工艺 |
| WO2025078880A1 (en) * | 2023-10-11 | 2025-04-17 | Mitotech S.A. | Mitochondria-targeted antioxidants for use in the treatment of cell balloooning-associated diseases, such as non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash) |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5538974A (en) | 1994-01-27 | 1996-07-23 | Senju Pharamceutical Co., Ltd. | Ophthalmic composition for lowering intraocular pressure |
| NZ505352A (en) | 1997-11-25 | 2002-12-20 | Univ Otago | Mitochondrially targeted antioxidants |
| US6331532B1 (en) | 1998-11-25 | 2001-12-18 | University Of Otago | Mitochondrially targeted antioxidants |
| US20080275005A1 (en) | 1998-11-25 | 2008-11-06 | Murphy Michael P | Mitochondrially targeted antioxidants |
| US20070270381A1 (en) | 2000-05-25 | 2007-11-22 | Antipodean Pharmaceuticals, Inc. | Mitochondrially targeted antioxidants |
| US20020044913A1 (en) | 2000-02-11 | 2002-04-18 | Hamilton Nathan D. | Cosmetics to support skin metabolism |
| ITRM20010755A1 (it) | 2001-12-20 | 2003-06-20 | Simonelli Giuseppe | Uso del chinone q10 per il trattamento delle malattie oculari. |
| US6984636B2 (en) | 2002-08-12 | 2006-01-10 | Medical Research Council | Mitochondrially targeted antioxidants |
| WO2005033092A1 (en) | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | Chroman derivatives |
| CN1997403A (zh) | 2004-07-13 | 2007-07-11 | 奥里迪斯生物医学研究及开发有限责任公司 | 靶向线粒体的抗氧化剂在治疗肝病和上皮癌中的用途 |
| WO2006025247A1 (ja) * | 2004-08-30 | 2006-03-09 | Kaneka Corporation | ミトコンドリア賦活剤 |
| RU2318500C2 (ru) | 2005-10-18 | 2008-03-10 | Общество С Ограниченной Ответственностью "Митотехнология" | Способ воздействия на организм путем адресной доставки биологически активных веществ в митохондрии, фармацевтическая композиция для его осуществления и соединение, применяемое для этой цели |
| EP2119436A4 (en) | 2006-10-20 | 2010-03-03 | Ltd Liability Company Mitotech | PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF EYE DISEASES |
| WO2008048135A1 (fr) | 2006-10-20 | 2008-04-24 | Limited Liability Company 'mitotechnology' | Composition destinée à la régénération, la stimulation de la croissance et l'adaptation de plantes à tous types de facteurs de stress |
| EP2145623A4 (en) * | 2007-01-29 | 2010-10-27 | Ltd Liability Company Mitotech | PHARMACEUTICAL AND COSMETIC COMPOSITIONS FOR ACCELERATING THE PROCESS OF WOUND HEALING AND OTHER SURFACE INJURIES |
| US9439916B2 (en) * | 2007-04-11 | 2016-09-13 | Mitotech Sa | Composition for decelerating the aging in the organism and for extending the life time thereof and the use of said composition |
| US8518915B2 (en) * | 2007-06-29 | 2013-08-27 | Mitotech Sa | Use of mitochondrially-addressed compounds for preventing and treating cardiovascular diseases |
| WO2009158348A1 (en) | 2008-06-25 | 2009-12-30 | Edison Pharmaceuticals, Inc. | 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases |
| JP2012525397A (ja) | 2009-04-28 | 2012-10-22 | エジソン ファーマシューティカルズ， インコーポレイテッド | 眼科疾患を治療するためのトコトリエノールキノンの製剤 |
| CN102548548B (zh) * | 2009-06-10 | 2017-09-01 | 米拓科技有限公司（卢森堡） | 用于医学和兽医学的眼科药物组合物 |
| MX2012005356A (es) * | 2009-11-13 | 2013-01-29 | Obschestvo S Ogranichennoi Otvetstvennostyu Mitotekh | Substancias farmaceuticas basadas en antioxidantes dirigidos a mitocondria. |
| WO2012167236A1 (en) * | 2011-06-03 | 2012-12-06 | Mitotech Sa | Oral formulations of mitochondrially-targeted antioxidants and their preparation and use |
-
2012
- 2012-06-04 WO PCT/US2012/040711 patent/WO2012167236A1/en not_active Ceased
- 2012-06-04 ES ES12792111T patent/ES2704064T3/es active Active
- 2012-06-04 US US14/123,311 patent/US9192676B2/en active Active
- 2012-06-04 EP EP12792111.2A patent/EP2714024B1/en active Active
- 2012-06-04 AU AU2012261854A patent/AU2012261854B2/en not_active Ceased
- 2012-06-04 CA CA2837437A patent/CA2837437C/en active Active
- 2012-06-04 CN CN201280027129.0A patent/CN103764132B/zh not_active Expired - Fee Related
- 2012-06-04 BR BR112013030605A patent/BR112013030605A2/pt not_active Application Discontinuation
- 2012-06-04 JP JP2014513785A patent/JP6448366B2/ja active Active
- 2012-06-04 EA EA201301321A patent/EA031399B1/ru not_active IP Right Cessation
-
2015
- 2015-10-20 US US14/887,406 patent/US9572890B2/en active Active
-
2017
- 2017-10-10 JP JP2017196849A patent/JP6461276B2/ja active Active
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