JP2014515407A5 - - Google Patents
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- JP2014515407A5 JP2014515407A5 JP2014513785A JP2014513785A JP2014515407A5 JP 2014515407 A5 JP2014515407 A5 JP 2014515407A5 JP 2014513785 A JP2014513785 A JP 2014513785A JP 2014513785 A JP2014513785 A JP 2014513785A JP 2014515407 A5 JP2014515407 A5 JP 2014515407A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- bonds
- pharmaceutical formulation
- divalent
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(C(c1cc(*)c(*)cc11)=O)=CC1=O Chemical compound CC(C(c1cc(*)c(*)cc11)=O)=CC1=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161492940P | 2011-06-03 | 2011-06-03 | |
| US61/492,940 | 2011-06-03 | ||
| PCT/US2012/040711 WO2012167236A1 (en) | 2011-06-03 | 2012-06-04 | Oral formulations of mitochondrially-targeted antioxidants and their preparation and use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017196849A Division JP6461276B2 (ja) | 2011-06-03 | 2017-10-10 | ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014515407A JP2014515407A (ja) | 2014-06-30 |
| JP2014515407A5 true JP2014515407A5 (https=) | 2015-07-02 |
| JP6448366B2 JP6448366B2 (ja) | 2019-01-09 |
Family
ID=47259946
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513785A Active JP6448366B2 (ja) | 2011-06-03 | 2012-06-04 | ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用 |
| JP2017196849A Active JP6461276B2 (ja) | 2011-06-03 | 2017-10-10 | ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017196849A Active JP6461276B2 (ja) | 2011-06-03 | 2017-10-10 | ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9192676B2 (https=) |
| EP (1) | EP2714024B1 (https=) |
| JP (2) | JP6448366B2 (https=) |
| CN (1) | CN103764132B (https=) |
| AU (1) | AU2012261854B2 (https=) |
| BR (1) | BR112013030605A2 (https=) |
| CA (1) | CA2837437C (https=) |
| EA (1) | EA031399B1 (https=) |
| ES (1) | ES2704064T3 (https=) |
| WO (1) | WO2012167236A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2714024B1 (en) * | 2011-06-03 | 2018-10-03 | Mitotech SA | Oral formulations of mitochondrially-targeted antioxidants and their preparation and use |
| JP6506177B2 (ja) * | 2013-01-22 | 2019-04-24 | ミトテック ソシエテ アノニム | ミトコンドリアにターゲティングされた抗酸化剤を含む医薬処方物 |
| WO2015063553A2 (en) * | 2013-04-11 | 2015-05-07 | Mitotech S.A. | Mitochondrially-targeted timoquinones and toluquinones |
| EA034726B1 (ru) * | 2014-02-25 | 2020-03-13 | Общество С Ограниченной Ответственностью "Митотех" | Косметическая композиция на основе митохондриально-адресованных антиоксидантов |
| WO2019139831A1 (en) * | 2018-01-10 | 2019-07-18 | Dana-Farber Cancer Institute, Inc. | Methods for identification, assessment, prevention, and treatment of metabolic disorders using succinate |
| CA3164227A1 (en) * | 2019-12-10 | 2021-06-17 | Mitotech S.A. | Polymer matrixes for different compositions of mitochondrially targeted antioxidants |
| CN116194100A (zh) * | 2020-04-03 | 2023-05-30 | 米拓科技有限公司 | 线粒体靶向抗氧化剂在治疗严重炎症中的用途 |
| CN114344274A (zh) * | 2022-01-05 | 2022-04-15 | 盖茨汉普(武汉)植物应用研究有限公司 | 一种Mitoq抗氧化硬胶囊配方及制备工艺 |
| WO2025078880A1 (en) * | 2023-10-11 | 2025-04-17 | Mitotech S.A. | Mitochondria-targeted antioxidants for use in the treatment of cell balloooning-associated diseases, such as non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash) |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5538974A (en) | 1994-01-27 | 1996-07-23 | Senju Pharamceutical Co., Ltd. | Ophthalmic composition for lowering intraocular pressure |
| US6331532B1 (en) | 1998-11-25 | 2001-12-18 | University Of Otago | Mitochondrially targeted antioxidants |
| ATE296305T1 (de) | 1997-11-25 | 2005-06-15 | Antipodean Biotechnology Ltd | Antioxidantien mit spezifischer wirkung auf mitochondrien |
| US20080275005A1 (en) | 1998-11-25 | 2008-11-06 | Murphy Michael P | Mitochondrially targeted antioxidants |
| US20070270381A1 (en) | 2000-05-25 | 2007-11-22 | Antipodean Pharmaceuticals, Inc. | Mitochondrially targeted antioxidants |
| US20020044913A1 (en) | 2000-02-11 | 2002-04-18 | Hamilton Nathan D. | Cosmetics to support skin metabolism |
| ITRM20010755A1 (it) | 2001-12-20 | 2003-06-20 | Simonelli Giuseppe | Uso del chinone q10 per il trattamento delle malattie oculari. |
| CA2397684A1 (en) | 2002-08-12 | 2004-02-12 | Michael P. Murphy | Mitochondrially targeted antioxidants |
| WO2005033093A1 (en) * | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | 7,8-bicycloalkyl-chroman derivatives |
| CN1997403A (zh) | 2004-07-13 | 2007-07-11 | 奥里迪斯生物医学研究及开发有限责任公司 | 靶向线粒体的抗氧化剂在治疗肝病和上皮癌中的用途 |
| WO2006025247A1 (ja) * | 2004-08-30 | 2006-03-09 | Kaneka Corporation | ミトコンドリア賦活剤 |
| RU2318500C2 (ru) | 2005-10-18 | 2008-03-10 | Общество С Ограниченной Ответственностью "Митотехнология" | Способ воздействия на организм путем адресной доставки биологически активных веществ в митохондрии, фармацевтическая композиция для его осуществления и соединение, применяемое для этой цели |
| EA200900582A1 (ru) | 2006-10-20 | 2009-08-28 | Общество С Ограниченной Ответственностью "Митотехнология" | Фармацевтические композиции для профилактики и лечения глазных патологий |
| EA200900583A1 (ru) | 2006-10-20 | 2009-08-28 | Общество С Ограниченной Ответственностью "Митотехнология" | Композиция для регенерации, стимуляции роста и адаптации растений к различным стрессовым факторам |
| EP2145623A4 (en) * | 2007-01-29 | 2010-10-27 | Ltd Liability Company Mitotech | PHARMACEUTICAL AND COSMETIC COMPOSITIONS FOR ACCELERATING THE PROCESS OF WOUND HEALING AND OTHER SURFACE INJURIES |
| WO2008127138A1 (fr) | 2007-04-11 | 2008-10-23 | Limited Liability Company 'mitotechnology' | Composition visant à ralentir le vieillissement et à allonger la durée de vie de l'organisme et utilisation de cette composition |
| WO2009005386A1 (en) | 2007-06-29 | 2009-01-08 | Limited Liability Company 'mitotechnology' | Use of mitochondrially-addressed compounds for preventing and treating cardiovascular diseases |
| JP5798481B2 (ja) | 2008-06-25 | 2015-10-21 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス疾患を治療するための２−ヘテロシクリルアミノアルキル−（ｐ−キノン）誘導体 |
| EA201101576A1 (ru) | 2009-04-28 | 2012-04-30 | Эдисон Фармасьютикалз, Инк. | Лекарственная форма токотриенол хинонов для лечения офтальмических (глазных) заболеваний |
| AU2009347921B8 (en) * | 2009-06-10 | 2014-07-24 | Mitotech Sa | Pharmaceutical composition for use in medical and veterinary ophthalmology |
| BR112012011197A2 (pt) * | 2009-11-13 | 2020-10-20 | Obschestvo S Ogranichennoi Otvetsvennostyu "Mitotekh" | subtâncias farmacêuticas com base em antioxidantes direcionados à mitocôndria |
| EP2714024B1 (en) * | 2011-06-03 | 2018-10-03 | Mitotech SA | Oral formulations of mitochondrially-targeted antioxidants and their preparation and use |
-
2012
- 2012-06-04 EP EP12792111.2A patent/EP2714024B1/en active Active
- 2012-06-04 AU AU2012261854A patent/AU2012261854B2/en not_active Ceased
- 2012-06-04 EA EA201301321A patent/EA031399B1/ru not_active IP Right Cessation
- 2012-06-04 ES ES12792111T patent/ES2704064T3/es active Active
- 2012-06-04 JP JP2014513785A patent/JP6448366B2/ja active Active
- 2012-06-04 WO PCT/US2012/040711 patent/WO2012167236A1/en not_active Ceased
- 2012-06-04 US US14/123,311 patent/US9192676B2/en active Active
- 2012-06-04 CN CN201280027129.0A patent/CN103764132B/zh not_active Expired - Fee Related
- 2012-06-04 BR BR112013030605A patent/BR112013030605A2/pt not_active Application Discontinuation
- 2012-06-04 CA CA2837437A patent/CA2837437C/en active Active
-
2015
- 2015-10-20 US US14/887,406 patent/US9572890B2/en active Active
-
2017
- 2017-10-10 JP JP2017196849A patent/JP6461276B2/ja active Active
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