JP2015525209A5 - - Google Patents
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- JP2015525209A5 JP2015525209A5 JP2015514192A JP2015514192A JP2015525209A5 JP 2015525209 A5 JP2015525209 A5 JP 2015525209A5 JP 2015514192 A JP2015514192 A JP 2015514192A JP 2015514192 A JP2015514192 A JP 2015514192A JP 2015525209 A5 JP2015525209 A5 JP 2015525209A5
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- lipid nanoparticles
- nanoparticles
- cationic
- spln
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000002632 lipids Chemical class 0.000 claims 35
- 239000002105 nanoparticle Substances 0.000 claims 25
- KWVJHCQQUFDPLU-YEUCEMRASA-N 2,3-bis[[(z)-octadec-9-enoyl]oxy]propyl-trimethylazanium Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC KWVJHCQQUFDPLU-YEUCEMRASA-N 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 5
- NHLUVTZJQOJKCC-UHFFFAOYSA-N n,n-dimethylhexadecan-1-amine Chemical compound CCCCCCCCCCCCCCCCN(C)C NHLUVTZJQOJKCC-UHFFFAOYSA-N 0.000 claims 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- NYDLOCKCVISJKK-WRBBJXAJSA-N [3-(dimethylamino)-2-[(z)-octadec-9-enoyl]oxypropyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(CN(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC NYDLOCKCVISJKK-WRBBJXAJSA-N 0.000 claims 3
- -1 cationic lipid Chemical class 0.000 claims 3
- LDGWQMRUWMSZIU-LQDDAWAPSA-M 2,3-bis[(z)-octadec-9-enoxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC\C=C/CCCCCCCC LDGWQMRUWMSZIU-LQDDAWAPSA-M 0.000 claims 2
- 108010067770 Endopeptidase K Proteins 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 108010026389 Gramicidin Proteins 0.000 claims 2
- 108091028049 Mir-221 microRNA Proteins 0.000 claims 2
- 150000001412 amines Chemical group 0.000 claims 2
- 235000019270 ammonium chloride Nutrition 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 108091061917 miR-221 stem-loop Proteins 0.000 claims 2
- 108091063489 miR-221-1 stem-loop Proteins 0.000 claims 2
- 108091055391 miR-221-2 stem-loop Proteins 0.000 claims 2
- 108091031076 miR-221-3 stem-loop Proteins 0.000 claims 2
- GLGLUQVVDHRLQK-WRBBJXAJSA-N n,n-dimethyl-2,3-bis[(z)-octadec-9-enoxy]propan-1-amine Chemical compound CCCCCCCC\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/CCCCCCCC GLGLUQVVDHRLQK-WRBBJXAJSA-N 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 claims 2
- ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 claims 2
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 claims 2
- 150000003512 tertiary amines Chemical class 0.000 claims 2
- ZWCXYZRRTRDGQE-LUPIJMBPSA-N valyl gramicidin a Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)CC(C)C)C(=O)NCCO)=CNC2=C1 ZWCXYZRRTRDGQE-LUPIJMBPSA-N 0.000 claims 2
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 claims 1
- CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 claims 1
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 1
- JFBCSFJKETUREV-LJAQVGFWSA-N 1,2-ditetradecanoyl-sn-glycerol Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](CO)OC(=O)CCCCCCCCCCCCC JFBCSFJKETUREV-LJAQVGFWSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 108010070875 Human Immunodeficiency Virus tat Gene Products Proteins 0.000 claims 1
- 102000003777 Interleukin-1 beta Human genes 0.000 claims 1
- 108090000193 Interleukin-1 beta Proteins 0.000 claims 1
- 108091033773 MiR-155 Proteins 0.000 claims 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- 239000005700 Putrescine Substances 0.000 claims 1
- 101900083372 Rabies virus Glycoprotein Proteins 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 101710192266 Tegument protein VP22 Proteins 0.000 claims 1
- HIHOWBSBBDRPDW-PTHRTHQKSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] n-[2-(dimethylamino)ethyl]carbamate Chemical compound C1C=C2C[C@@H](OC(=O)NCCN(C)C)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HIHOWBSBBDRPDW-PTHRTHQKSA-N 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 229920006317 cationic polymer Polymers 0.000 claims 1
- UMGXUWVIJIQANV-UHFFFAOYSA-M didecyl(dimethyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC UMGXUWVIJIQANV-UHFFFAOYSA-M 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- PSLWZOIUBRXAQW-UHFFFAOYSA-M dimethyl(dioctadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC PSLWZOIUBRXAQW-UHFFFAOYSA-M 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000000799 fusogenic effect Effects 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
- 229920000083 poly(allylamine) Polymers 0.000 claims 1
- 108010011110 polyarginine Proteins 0.000 claims 1
- 229940113116 polyethylene glycol 1000 Drugs 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000000941 radioactive substance Substances 0.000 claims 1
- 229940063673 spermidine Drugs 0.000 claims 1
- 229940063675 spermine Drugs 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261650729P | 2012-05-23 | 2012-05-23 | |
| US61/650,729 | 2012-05-23 | ||
| US201361784892P | 2013-03-14 | 2013-03-14 | |
| US61/784,892 | 2013-03-14 | ||
| PCT/US2013/042458 WO2013177419A2 (en) | 2012-05-23 | 2013-05-23 | Lipid nanoparticle compositions and methods of making and methods of using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015525209A JP2015525209A (ja) | 2015-09-03 |
| JP2015525209A5 true JP2015525209A5 (enExample) | 2016-03-17 |
Family
ID=48539454
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514193A Active JP6228191B2 (ja) | 2012-05-23 | 2013-05-23 | 脂質コートされたアルブミンナノ粒子組成物と、それを作製する方法、及びそれを使用する方法 |
| JP2015514192A Pending JP2015525209A (ja) | 2012-05-23 | 2013-05-23 | 脂質ナノ粒子組成物と、それを作製する方法、及びそれを使用する方法 |
| JP2015514189A Expired - Fee Related JP6220389B2 (ja) | 2012-05-23 | 2013-05-23 | アンチセンスオリゴヌクレオチドを送達するための脂質ナノ粒子組成物 |
| JP2017191221A Pending JP2018002727A (ja) | 2012-05-23 | 2017-09-29 | アンチセンスオリゴヌクレオチドを送達するための脂質ナノ粒子組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514193A Active JP6228191B2 (ja) | 2012-05-23 | 2013-05-23 | 脂質コートされたアルブミンナノ粒子組成物と、それを作製する方法、及びそれを使用する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514189A Expired - Fee Related JP6220389B2 (ja) | 2012-05-23 | 2013-05-23 | アンチセンスオリゴヌクレオチドを送達するための脂質ナノ粒子組成物 |
| JP2017191221A Pending JP2018002727A (ja) | 2012-05-23 | 2017-09-29 | アンチセンスオリゴヌクレオチドを送達するための脂質ナノ粒子組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9750819B2 (enExample) |
| EP (3) | EP2852381B1 (enExample) |
| JP (4) | JP6228191B2 (enExample) |
| KR (3) | KR20150020180A (enExample) |
| CN (3) | CN104428005B (enExample) |
| AU (4) | AU2013266232B2 (enExample) |
| BR (2) | BR112014027834A2 (enExample) |
| CA (3) | CA2874495A1 (enExample) |
| MX (3) | MX353567B (enExample) |
| WO (3) | WO2013177415A1 (enExample) |
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