CN104428005B - 用于反义寡核苷酸递送的脂质纳米颗粒组合物 - Google Patents

用于反义寡核苷酸递送的脂质纳米颗粒组合物 Download PDF

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CN104428005B
CN104428005B CN201380026005.5A CN201380026005A CN104428005B CN 104428005 B CN104428005 B CN 104428005B CN 201380026005 A CN201380026005 A CN 201380026005A CN 104428005 B CN104428005 B CN 104428005B
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cancer
lipid
targeting
nucleic acid
lipid nanoparticle
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CN104428005A (zh
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罗伯特·J·李
李永福
金德中
安昌浩
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Ohio State University
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Ohio State University
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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
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    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • C12N15/1135Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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CN201380026005.5A 2012-05-23 2013-05-23 用于反义寡核苷酸递送的脂质纳米颗粒组合物 Active CN104428005B (zh)

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Application Number Priority Date Filing Date Title
US201261650729P 2012-05-23 2012-05-23
US61/650,729 2012-05-23
US201361784892P 2013-03-14 2013-03-14
US61/784,892 2013-03-14
PCT/US2013/042454 WO2013177415A1 (en) 2012-05-23 2013-05-23 Lipid nanoparticle compositions for antisense oligonucleotides delivery

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CN104428005A CN104428005A (zh) 2015-03-18
CN104428005B true CN104428005B (zh) 2019-05-10

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CN201380026005.5A Active CN104428005B (zh) 2012-05-23 2013-05-23 用于反义寡核苷酸递送的脂质纳米颗粒组合物
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