JP2015521593A5 - - Google Patents

Info

Publication number

JP2015521593A5

JP2015521593A5 JP2015516723A JP2015516723A JP2015521593A5 JP 2015521593 A5 JP2015521593 A5 JP 2015521593A5 JP 2015516723 A JP2015516723 A JP 2015516723A JP 2015516723 A JP2015516723 A JP 2015516723A JP 2015521593 A5 JP2015521593 A5 JP 2015521593A5

Authority

JP

Japan

Prior art keywords

seq

aqueous composition

cdr2

cdr3

nos

Prior art date

2013-06-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229920001213 Polysorbate 20 Polymers 0.000 claims 6
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 6
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 6
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 6
• 229940068977 polysorbate 20 Drugs 0.000 claims 6
• 239000003381 stabilizer Substances 0.000 claims 6
• 239000004094 surface-active agent Substances 0.000 claims 6
• 229930006000 Sucrose Natural products 0.000 claims 5
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 5
• 239000005720 sucrose Substances 0.000 claims 5
• HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 4
• 239000004475 Arginine Substances 0.000 claims 4
• ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 4
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 4
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 4
• 229960003121 arginine Drugs 0.000 claims 4
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
• 229960003589 arginine hydrochloride Drugs 0.000 claims 4
• 229940071643 prefilled syringe Drugs 0.000 claims 4
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 3
• CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 claims 3
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 3
• 125000002446 fucosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O)[C@@H](O1)C)* 0.000 claims 3
• 229920001993 poloxamer 188 Polymers 0.000 claims 3
• 229940044519 poloxamer 188 Drugs 0.000 claims 3
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 3
• 241000124008 Mammalia Species 0.000 claims 2
• 229940024606 amino acid Drugs 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 102000007536 B-Cell Activation Factor Receptor Human genes 0.000 claims 1
• 108010046304 B-Cell Activation Factor Receptor Proteins 0.000 claims 1
• 208000012526 B-cell neoplasm Diseases 0.000 claims 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
• 206010025323 Lymphomas Diseases 0.000 claims 1
• 229930195725 Mannitol Natural products 0.000 claims 1
• 201000011152 Pemphigus Diseases 0.000 claims 1
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
• 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
• 210000003719 b-lymphocyte Anatomy 0.000 claims 1
• 230000000779 depleting effect Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 239000000594 mannitol Substances 0.000 claims 1
• 235000010355 mannitol Nutrition 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 201000000050 myeloid neoplasm Diseases 0.000 claims 1
• 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1