JP2015519890A5 - - Google Patents
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- JP2015519890A5 JP2015519890A5 JP2015509079A JP2015509079A JP2015519890A5 JP 2015519890 A5 JP2015519890 A5 JP 2015519890A5 JP 2015509079 A JP2015509079 A JP 2015509079A JP 2015509079 A JP2015509079 A JP 2015509079A JP 2015519890 A5 JP2015519890 A5 JP 2015519890A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- natural killer
- culturing
- item
- serum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 63
- 210000000130 stem cell Anatomy 0.000 claims description 33
- 210000000822 natural killer cell Anatomy 0.000 claims description 32
- 238000012258 culturing Methods 0.000 claims description 29
- 239000012679 serum free medium Substances 0.000 claims description 29
- 210000002242 embryoid body Anatomy 0.000 claims description 20
- 210000004027 cell Anatomy 0.000 claims description 19
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 15
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 15
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 11
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims description 8
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims description 8
- 102000003812 Interleukin-15 Human genes 0.000 claims description 8
- 108090000172 Interleukin-15 Proteins 0.000 claims description 8
- 102000000588 Interleukin-2 Human genes 0.000 claims description 8
- 108010002350 Interleukin-2 Proteins 0.000 claims description 8
- 102000000646 Interleukin-3 Human genes 0.000 claims description 8
- 108010002386 Interleukin-3 Proteins 0.000 claims description 8
- 102000000704 Interleukin-7 Human genes 0.000 claims description 8
- 108010002586 Interleukin-7 Proteins 0.000 claims description 8
- 102000002698 KIR Receptors Human genes 0.000 claims description 8
- 108010043610 KIR Receptors Proteins 0.000 claims description 8
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 8
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 8
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 8
- 229940076264 interleukin-3 Drugs 0.000 claims description 8
- 229940100994 interleukin-7 Drugs 0.000 claims description 8
- 210000002536 stromal cell Anatomy 0.000 claims description 8
- 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims description 7
- 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims description 7
- 238000004220 aggregation Methods 0.000 claims description 7
- 230000002776 aggregation Effects 0.000 claims description 7
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 7
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims description 5
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims description 5
- 102100039564 Leukosialin Human genes 0.000 claims description 5
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims description 5
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 5
- 238000003501 co-culture Methods 0.000 claims description 5
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 5
- 239000002609 medium Substances 0.000 claims description 5
- 241000701022 Cytomegalovirus Species 0.000 claims description 4
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims description 4
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims description 4
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims description 4
- 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 claims description 4
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims description 4
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims description 4
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims description 4
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 4
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims description 4
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims description 4
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims description 4
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims description 4
- 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 claims description 4
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims description 4
- 102000036366 SCF complex Human genes 0.000 claims description 4
- 108091007047 SCF complex Proteins 0.000 claims description 4
- 241000700584 Simplexvirus Species 0.000 claims description 4
- 230000004931 aggregating effect Effects 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 4
- 239000002243 precursor Substances 0.000 claims description 4
- 241000700721 Hepatitis B virus Species 0.000 claims description 3
- 238000009169 immunotherapy Methods 0.000 claims description 3
- 230000001939 inductive effect Effects 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 230000000415 inactivating effect Effects 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 241000711549 Hepacivirus C Species 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 230000004523 agglutinating effect Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261637592P | 2012-04-24 | 2012-04-24 | |
| US61/637,592 | 2012-04-24 | ||
| PCT/US2013/037782 WO2013163171A1 (en) | 2012-04-24 | 2013-04-23 | Method for developing natural killer cells from stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017115944A Division JP6529541B2 (ja) | 2012-04-24 | 2017-06-13 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015519890A JP2015519890A (ja) | 2015-07-16 |
| JP2015519890A5 true JP2015519890A5 (https=) | 2016-06-23 |
| JP6339998B2 JP6339998B2 (ja) | 2018-06-06 |
Family
ID=48289670
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509079A Active JP6339998B2 (ja) | 2012-04-24 | 2013-04-23 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
| JP2017115944A Active JP6529541B2 (ja) | 2012-04-24 | 2017-06-13 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
| JP2019091121A Pending JP2019122415A (ja) | 2012-04-24 | 2019-05-14 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017115944A Active JP6529541B2 (ja) | 2012-04-24 | 2017-06-13 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
| JP2019091121A Pending JP2019122415A (ja) | 2012-04-24 | 2019-05-14 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9260696B2 (https=) |
| EP (2) | EP2841563B1 (https=) |
| JP (3) | JP6339998B2 (https=) |
| AU (3) | AU2013251785B2 (https=) |
| WO (1) | WO2013163171A1 (https=) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2841563B1 (en) * | 2012-04-24 | 2019-06-12 | Dan S. Kaufman | Method for developing natural killer cells from stem cells |
| AU2014248119B2 (en) * | 2013-04-03 | 2019-06-20 | Memorial Sloan-Kettering Cancer Center | Effective generation of tumor-targeted T-cells derived from pluripotent stem cells |
| AU2016211671B2 (en) | 2015-01-26 | 2022-05-26 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| US10836997B2 (en) * | 2015-03-09 | 2020-11-17 | Keio University | Method for differentiating pluripotent stem cells into desired cell type |
| WO2016187820A1 (zh) * | 2015-05-26 | 2016-12-01 | 中国科学院广州生物医药与健康研究院 | 一种人原代细胞培养基及其应用 |
| PL412787A1 (pl) * | 2015-06-22 | 2017-01-02 | Magdalena Król | Oparty na makrofagach celowany system dostarczania związków związanych z ferrytyną |
| AU2016299166B2 (en) * | 2015-07-24 | 2022-03-31 | Innate Pharma | Methods for detecting tissue infiltrating NK cells |
| KR102675213B1 (ko) * | 2015-09-08 | 2024-06-13 | 스미토모 파마 가부시키가이샤 | 망막 색소 표피 세포의 제조 방법 |
| JP6928604B2 (ja) | 2015-11-04 | 2021-09-01 | フェイト セラピューティクス，インコーポレイテッド | 万能性細胞のゲノム改変 |
| CA3003152A1 (en) | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| CN105296428A (zh) * | 2015-12-03 | 2016-02-03 | 广州医科大学附属第三医院 | 一种提高诱导多能干细胞的体外分化造血效率的方法 |
| ES2952064T3 (es) | 2015-12-16 | 2023-10-26 | Walter & Eliza Hall Inst Medical Res | Inhibición de la proteína SH2 inducida por citocinas en células NK |
| JP7039473B2 (ja) * | 2016-07-29 | 2022-03-22 | ダイキン工業株式会社 | 分化細胞の製造方法、及びその製造方法のために使用する培養バッグ |
| US20190194621A1 (en) * | 2016-09-08 | 2019-06-27 | Kyowa Hakko Bio Co., Ltd. | Medium for culturing stem cells, method for culturing stem cells, growth promoter for stem cells, and cell composition and method for producing same |
| WO2018147801A1 (en) * | 2017-02-07 | 2018-08-16 | Agency For Science, Technology And Research | Methods and kits for generating mimetic innate immune cells from pluripotent stem cells |
| WO2018160673A1 (en) | 2017-02-28 | 2018-09-07 | University Of Central Florida Research Foundation, Inc. | Pm21 particles to improve bone marrow homing of nk cells |
| EP3594322A4 (en) | 2017-03-08 | 2021-01-27 | Sumitomo Dainippon Pharma Co., Ltd. | METHOD FOR PRODUCING RETINAPIGMENT EPITHELIAL CELLS |
| CN110997904B (zh) * | 2017-03-21 | 2024-11-26 | 法国血液机构 | 改进造血移植物的方法 |
| KR102167548B1 (ko) * | 2017-09-21 | 2020-10-19 | 한국생명공학연구원 | 자연살해세포의 제조방법 및 그의 용도 |
| JP7433230B2 (ja) * | 2017-12-08 | 2024-02-19 | ジュノー セラピューティクス インコーポレイテッド | 細胞を培養するための無血清培地配合物およびその使用の方法 |
| EP3746095A4 (en) | 2018-02-01 | 2021-04-21 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| JP7273421B2 (ja) | 2018-02-21 | 2023-05-15 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用 |
| PT3755347T (pt) * | 2018-02-21 | 2025-07-25 | Univ Texas | Células de apresentação de antigénio universais e utilizações destas |
| CN113474450A (zh) | 2018-08-09 | 2021-10-01 | 朱诺治疗学股份有限公司 | 产生工程化细胞的方法以及所述工程化细胞的组合物 |
| CA3109804A1 (en) | 2018-08-16 | 2020-02-20 | The Regents Of The University Of California | Chemically and photochemically initiated cell membrane blebbing to induce cell vesicle production, modifications thereof, and uses thereof |
| PT3843757T (pt) | 2018-08-27 | 2024-07-08 | Affimed Gmbh | Células nk criopreservadas pré-carregadas com uma construção de anticorpo |
| US12497593B2 (en) | 2018-09-07 | 2025-12-16 | Wisconsin Alumni Research Foundation | Generation of hematopoietic progenitor cells from human pluripotent stem cells |
| US20220119767A1 (en) * | 2019-03-01 | 2022-04-21 | The Regents Of The University Of California | Natural killer cell induced cellular vesicles for cancer therapy |
| WO2020197318A1 (ko) * | 2019-03-28 | 2020-10-01 | 한국생명공학연구원 | Car 유전자가 도입된 nk 세포의 제조방법 및 그의 용도 |
| RU2731293C1 (ru) | 2019-04-12 | 2020-09-01 | Игорь Петрович Белецкий | Способ получения генно-модифицированных линий клеток натуральных киллеров с нокаутированным геном PD-1 и повышенной экспрессией белков семейства Фактора Некроза Опухолей для иммунотерапии онкологических заболеваний |
| WO2020220016A1 (en) * | 2019-04-26 | 2020-10-29 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Artificial antigen presenting cells comprising ligands for nkg2d for expanding immune cells for immunotherapy |
| CN114746543A (zh) | 2019-11-13 | 2022-07-12 | 延世大学校产学协力团 | 分离纯培养血管内皮细胞的方法、维持血管内皮细胞特性的培养基和包括其的培养方法 |
| CN111235105B (zh) * | 2020-03-06 | 2021-08-10 | 安徽中盛溯源生物科技有限公司 | 一种从人多能干细胞分化为自然杀伤细胞的方法及应用 |
| JP2023517220A (ja) * | 2020-03-11 | 2023-04-24 | リサーチ インスティテュート アット ネイションワイド チルドレンズ ホスピタル | 微生物感染症の治療のためのｎｋ細胞およびそれらの使用 |
| US11547726B2 (en) | 2020-03-26 | 2023-01-10 | Honed Life Sciences, Llc | Enhancement of production of NK cells from stem cells |
| WO2021256522A1 (ja) | 2020-06-17 | 2021-12-23 | 国立大学法人京都大学 | キメラ抗原受容体発現免疫担当細胞 |
| EP4189068A4 (en) * | 2020-07-27 | 2024-08-28 | Stemcell Technologies Canada Inc. | SYSTEMS AND METHODS FOR DIFFERENTIATION OF HEMATOPOETIC CELLS |
| US11591381B2 (en) | 2020-11-30 | 2023-02-28 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| CN112608895B (zh) * | 2020-12-18 | 2024-02-27 | 深圳市济因生物科技有限公司 | 一种人多能干细胞分化的自然杀伤细胞及其制备方法与应用 |
| WO2022144632A1 (en) * | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
| EP4326852A4 (en) * | 2021-04-22 | 2025-04-23 | Artec Biotech, Inc. | Method for producing hematopoietic cells from stem cells using vascular organoids |
| WO2022269393A1 (en) | 2021-06-23 | 2022-12-29 | Crispr Therapeutics Ag | Engineered cells with improved protection from natural killer cell killing |
| CN115261318B (zh) * | 2021-09-29 | 2024-05-28 | 苏州艾凯利元生物科技有限公司 | 产生自然杀伤细胞的方法 |
| US20250000974A1 (en) * | 2021-10-27 | 2025-01-02 | The Regents Of The University Of California | Combination of human natural killer cells and macrophages for cancer therapy |
| CN113957048A (zh) * | 2021-10-29 | 2022-01-21 | 深圳市默赛尔生物医学科技发展有限公司 | 一种利用脐带血单个核细胞生产自然杀伤细胞的方法 |
| EP4448729A1 (en) | 2021-12-17 | 2024-10-23 | Umoja Biopharma, Inc. | Cytotoxic innate lymphoid cell and uses thereof |
| US20250122474A1 (en) * | 2022-01-31 | 2025-04-17 | Healios K.K. | Production method for natural killer cells |
| CN114507641B (zh) * | 2022-04-20 | 2022-07-12 | 山东兴瑞生物科技有限公司 | 一种由人胚胎干细胞诱导分化为nk细胞的方法 |
| WO2023233342A2 (en) | 2022-06-01 | 2023-12-07 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| US20250354118A1 (en) * | 2022-06-09 | 2025-11-20 | Umoja Biopharma, Inc. | Compositions and methods for nk cell differentiation |
| CN115058387B (zh) * | 2022-06-11 | 2023-12-01 | 重庆医科大学 | 一种人胚胎干细胞与前列腺癌细胞共培养制备抗前列腺癌药物的方法 |
| CA3263301A1 (en) * | 2022-07-27 | 2024-02-01 | Umoja Biopharma, Inc. | Differentiation of stem cells in suspension culture |
| WO2024101863A1 (ko) * | 2022-11-07 | 2024-05-16 | 마루테라퓨틱스 주식회사 | 줄기세포 기원 및 발현 마커에 따른 nk 세포 분화 효율 증진 방법 |
| WO2024101862A1 (ko) * | 2022-11-07 | 2024-05-16 | 마루테라퓨틱스 주식회사 | Nk 세포의 분화 효율 및 기능성 증가를 위한 배양 방법 |
| WO2024101919A1 (ko) * | 2022-11-10 | 2024-05-16 | 의료법인 성광의료재단 | 전분화능 줄기세포에서 자연살해세포로의 분화 유도용 배지 조성물 및 이를 이용한 분화 방법 |
| TW202506996A (zh) * | 2023-04-27 | 2025-02-16 | 日商武田藥品工業股份有限公司 | 擴增ｃｄ５６＋／ｃｄ３－細胞之方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3065499D1 (en) | 1979-04-11 | 1983-12-15 | Mitsui Petrochemical Ind | Process for producing spherical carrier particles for olefin polymerisation catalyst, catalyst comprising such carrier particles, and use of such catalyst in olefin polymerisation |
| EP0187371B1 (en) | 1984-12-27 | 1991-06-19 | Asahi Kasei Kogyo Kabushiki Kaisha | Substituted isoquinolinesulfonyl compounds |
| US6355476B1 (en) | 1988-11-07 | 2002-03-12 | Advanced Research And Technologyinc | Nucleic acid encoding MIP-1α Lymphokine |
| JP3926842B2 (ja) | 1995-03-08 | 2007-06-06 | ザ・スクリプス・リサーチ・インステイチユート | 抗原提示系およびｔ−細胞の活性化方法 |
| ATE347588T1 (de) | 1996-05-23 | 2006-12-15 | Scripps Research Inst | Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten |
| CA2277278A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| US6790662B1 (en) | 1999-03-12 | 2004-09-14 | Ortho-Mcneil Pharmaceutical, Inc. | Method of isolating CD8+ cells, and related hybridoma cells antibodies and polypeptides |
| ES2295009T3 (es) | 1999-03-25 | 2008-04-16 | Mitsubishi Tanabe Pharma Corporation | Inhibidores de rho quinasa para la profilaxis y el tratamiento de neumonia intersticial y fibrosis pulmonar. |
| AU5250400A (en) | 1999-06-18 | 2001-01-09 | Mitsubishi Pharma Corporation | Osteogenesis promoters |
| US20040071671A1 (en) | 2001-02-20 | 2004-04-15 | Leturcq Didier J. | Cell therapy method for the treatment of tumors |
| MXPA04007196A (es) | 2002-01-23 | 2005-06-08 | Bayer Pharmaceuticals Corp | Inhibidores de rho-quinasa. |
| US6664266B2 (en) | 2002-03-14 | 2003-12-16 | Children's Medical Center Corporation | Axon regeneration with PKC inhibitiors |
| GB0206860D0 (en) | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
| AU2003234185C1 (en) | 2002-04-22 | 2009-11-19 | The Board Of Trustees Of The Leland Stanford Junior University | Peptide inhibitors of protein kinase C |
| CN101052712A (zh) | 2004-09-08 | 2007-10-10 | 威斯康星校友研究基金会 | 培养人胚胎干细胞 |
| ES2579762T3 (es) | 2006-03-01 | 2016-08-16 | Janssen Pharmaceutica N.V. | Tratamiento del cáncer combinando agente linfo - reductor con CLTs y citoquinas |
| CA2665568C (en) | 2006-10-04 | 2018-01-09 | Janssen Pharmaceutica, N.V. | Preparation of inactivated artificial antigen presenting cells and their use in cell therapies |
| US8513012B2 (en) | 2008-05-02 | 2013-08-20 | Cellular Dynamics International, Inc. | Method for production of mast cells from stem cells |
| KR101720961B1 (ko) | 2009-02-27 | 2017-03-29 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 다능성 세포의 분화 |
| CA3095576A1 (en) * | 2009-12-04 | 2011-06-09 | Astellas Institute For Regenerative Medicine | Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts |
| EP2841563B1 (en) * | 2012-04-24 | 2019-06-12 | Dan S. Kaufman | Method for developing natural killer cells from stem cells |
-
2013
- 2013-04-23 EP EP13720688.4A patent/EP2841563B1/en active Active
- 2013-04-23 WO PCT/US2013/037782 patent/WO2013163171A1/en not_active Ceased
- 2013-04-23 AU AU2013251785A patent/AU2013251785B2/en not_active Ceased
- 2013-04-23 EP EP19179319.9A patent/EP3567102A1/en not_active Withdrawn
- 2013-04-23 JP JP2015509079A patent/JP6339998B2/ja active Active
- 2013-04-23 US US13/868,785 patent/US9260696B2/en active Active
-
2017
- 2017-06-13 JP JP2017115944A patent/JP6529541B2/ja active Active
-
2018
- 2018-07-18 AU AU2018206749A patent/AU2018206749A1/en not_active Abandoned
-
2019
- 2019-05-14 JP JP2019091121A patent/JP2019122415A/ja active Pending
-
2020
- 2020-11-06 AU AU2020264375A patent/AU2020264375B2/en not_active Ceased
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