JP2015517492A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015517492A5 JP2015517492A5 JP2015511463A JP2015511463A JP2015517492A5 JP 2015517492 A5 JP2015517492 A5 JP 2015517492A5 JP 2015511463 A JP2015511463 A JP 2015511463A JP 2015511463 A JP2015511463 A JP 2015511463A JP 2015517492 A5 JP2015517492 A5 JP 2015517492A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- heavy chain
- variable region
- chain variable
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 52
- 239000003795 chemical substances by application Substances 0.000 claims description 29
- 238000006467 substitution reaction Methods 0.000 claims description 23
- 101710154606 Hemagglutinin Proteins 0.000 claims description 20
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 20
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 20
- 101710176177 Protein A56 Proteins 0.000 claims description 20
- 239000000185 hemagglutinin Substances 0.000 claims description 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 229920001184 polypeptide Polymers 0.000 claims description 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 14
- 206010022000 influenza Diseases 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 9
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims description 8
- 230000027455 binding Effects 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 210000004408 hybridoma Anatomy 0.000 claims description 3
- 210000004962 mammalian cell Anatomy 0.000 claims description 3
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 230000003472 neutralizing effect Effects 0.000 claims description 2
- 229940125644 antibody drug Drugs 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 102220538052 FAD-AMP lyase (cyclizing)_Y31F_mutation Human genes 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 1
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 1
- 102220040412 rs587778307 Human genes 0.000 claims 1
- 239000011230 binding agent Substances 0.000 description 25
- 150000001413 amino acids Chemical group 0.000 description 8
- 239000012634 fragment Substances 0.000 description 4
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 description 3
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 description 3
- 101710204410 Scaffold protein Proteins 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 229920001432 poly(L-lactide) Polymers 0.000 description 2
- 229920000962 poly(amidoamine) Polymers 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- VHSHLMUCYSAUQU-UHFFFAOYSA-N 2-hydroxypropyl methacrylate Chemical compound CC(O)COC(=O)C(C)=C VHSHLMUCYSAUQU-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000008102 Ankyrins Human genes 0.000 description 1
- 108010049777 Ankyrins Proteins 0.000 description 1
- 102000016904 Armadillo Domain Proteins Human genes 0.000 description 1
- 108010014223 Armadillo Domain Proteins Proteins 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000289632 Dasypodidae Species 0.000 description 1
- 206010015958 Eye pain Diseases 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000019298 Lipocalin Human genes 0.000 description 1
- 108050006654 Lipocalin Proteins 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010038687 Respiratory distress Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 102000002933 Thioredoxin Human genes 0.000 description 1
- 229940050528 albumin Drugs 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- -1 anticalin Proteins 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 229940045110 chitosan Drugs 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- OKPYIWASQZGASP-UHFFFAOYSA-N n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)C(C)=C OKPYIWASQZGASP-UHFFFAOYSA-N 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 108060008226 thioredoxin Proteins 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261645453P | 2012-05-10 | 2012-05-10 | |
| US61/645,453 | 2012-05-10 | ||
| PCT/US2013/031704 WO2013169377A1 (en) | 2012-05-10 | 2013-03-14 | Agents for influenza neutralization |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018070701A Division JP2018118991A (ja) | 2012-05-10 | 2018-04-02 | インフルエンザの中和のための薬剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517492A JP2015517492A (ja) | 2015-06-22 |
| JP2015517492A5 true JP2015517492A5 (enExample) | 2016-05-12 |
| JP6431477B2 JP6431477B2 (ja) | 2018-12-05 |
Family
ID=49548780
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511463A Active JP6431477B2 (ja) | 2012-05-10 | 2013-03-14 | インフルエンザの中和のための薬剤 |
| JP2018070701A Pending JP2018118991A (ja) | 2012-05-10 | 2018-04-02 | インフルエンザの中和のための薬剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018070701A Pending JP2018118991A (ja) | 2012-05-10 | 2018-04-02 | インフルエンザの中和のための薬剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9683030B2 (enExample) |
| EP (2) | EP3492101A3 (enExample) |
| JP (2) | JP6431477B2 (enExample) |
| KR (1) | KR102122618B1 (enExample) |
| CN (2) | CN109265541A (enExample) |
| AU (2) | AU2013260123A1 (enExample) |
| BR (1) | BR112014027991A2 (enExample) |
| CA (1) | CA2871160C (enExample) |
| CL (1) | CL2014003052A1 (enExample) |
| HK (1) | HK1207970A1 (enExample) |
| IL (1) | IL235237A0 (enExample) |
| MX (1) | MX378749B (enExample) |
| SG (2) | SG11201406769RA (enExample) |
| WO (1) | WO2013169377A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109265541A (zh) | 2012-05-10 | 2019-01-25 | 麻省理工学院 | 流感中和药剂 |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| JP6772157B2 (ja) | 2015-02-05 | 2020-10-21 | ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． | インフルエンザヘマグルチニンに対する結合分子及びその使用 |
| KR20180002713A (ko) * | 2015-05-11 | 2018-01-08 | 얀센 백신스 앤드 프리벤션 비.브이. | 인플루엔자 바이러스 중화 펩티드 모방 화합물 |
| WO2017083627A1 (en) | 2015-11-13 | 2017-05-18 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| WO2017147248A1 (en) | 2016-02-24 | 2017-08-31 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| KR101887876B1 (ko) * | 2016-08-18 | 2018-08-13 | 한국과학기술연구원 | H5형 조류독감 바이러스에 특이적으로 결합하는 핵산 압타머 및 이를 이용하는 h5형 조류독감 바이러스의 검출방법 |
| CN113924147A (zh) | 2019-03-25 | 2022-01-11 | 威特拉公司 | 用于治疗和预防流感的组合物和方法 |
| EP4073107A1 (en) * | 2019-12-11 | 2022-10-19 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL23522C (enExample) | 1927-03-23 | |||
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4957939A (en) | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
| US4472509A (en) | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4938948A (en) | 1985-10-07 | 1990-07-03 | Cetus Corporation | Method for imaging breast tumors using labeled monoclonal anti-human breast cancer antibodies |
| US4886499A (en) | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US5750172A (en) | 1987-06-23 | 1998-05-12 | Pharming B.V. | Transgenic non human mammal milk |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| EP0438803B1 (en) | 1990-01-26 | 1997-03-12 | Immunomedics, Inc. | Vaccines against cancer and infectious diseases |
| JPH049249A (ja) | 1990-04-27 | 1992-01-14 | Kusuda:Kk | 塗型剤吹き付け機 |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| JPH06247995A (ja) | 1991-06-24 | 1994-09-06 | Asahi Chem Ind Co Ltd | 新規なシアリル（α２−６）ラクトテトラオシルセラミド |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| ATE193301T1 (de) | 1993-03-09 | 2000-06-15 | Genzyme Corp | Verfahren zur isolierung von proteinen aus milch |
| US5500161A (en) | 1993-09-21 | 1996-03-19 | Massachusetts Institute Of Technology And Virus Research Institute | Method for making hydrophobic polymeric microparticles |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| JP3584990B2 (ja) * | 1994-05-09 | 2004-11-04 | タカラバイオ株式会社 | 抗ヒトインフルエンザウイルス抗体 |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| DE19643314A1 (de) | 1996-10-21 | 1998-04-23 | Boehringer Mannheim Gmbh | Monoklonale Antikörper gegen das Epitop YPYDVPDYA, Verfahren zu deren Herstellung und Verwendung |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| WO2000059932A1 (fr) | 1999-03-31 | 2000-10-12 | Otsuka Pharmaceutical Co., Ltd. | Peptides se liant a l'hemagglutinine du virus de la grippe |
| EP1490483B1 (en) | 2001-04-19 | 2015-06-03 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| EP1430136A1 (en) | 2001-09-27 | 2004-06-23 | Pieris ProteoLab AG | Muteins of apolipoprotein d |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| JPWO2003074570A1 (ja) | 2002-03-04 | 2005-06-30 | 独立行政法人科学技術振興機構 | 新規分岐状シアロ糖分子とそれを用いた抗ウイルス剤 |
| US8420353B2 (en) | 2002-03-22 | 2013-04-16 | Aprogen, Inc. | Humanized antibody and process for preparing same |
| AP2005003234A0 (en) | 2002-08-20 | 2005-03-31 | Genitrix Llc | Lectin compositions and methods for modulating an immune response to an antigen. |
| EP2272950A3 (en) | 2004-11-11 | 2011-07-20 | Abbott Biologicals B.V. | Defective influenza virus particles |
| EP2899277A1 (en) | 2004-11-26 | 2015-07-29 | Pieris AG | Compound with affinity for the cytotoxic T lymphocyte-associated antigen (CTLA-4) |
| GB2438982A (en) | 2004-12-22 | 2007-12-12 | Ambrx Inc | Compostions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| US7959929B2 (en) | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| US7871626B2 (en) | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
| US20090269342A1 (en) | 2006-08-14 | 2009-10-29 | Massachusetts Institute Of Technology | Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto |
| JP2010501074A (ja) | 2006-08-14 | 2010-01-14 | マサチューセッツ・インスティテュート・オブ・テクノロジー | グリカンのデータマイニングシステム |
| CN101501696A (zh) | 2006-08-14 | 2009-08-05 | 麻省理工学院 | 聚糖数据挖掘系统 |
| US20090081193A1 (en) | 2006-08-14 | 2009-03-26 | Massachusetts Institute Of Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| MX2009013635A (es) * | 2007-06-25 | 2010-05-19 | Univ Tulane | Composiciones que inhiben la influenza y metodos. |
| FR2921928B1 (fr) * | 2007-10-08 | 2011-03-04 | Sanofi Pasteur | Anticorps monoclonaux specifiques de l'hemagglutinine du virus grippal |
| RU2010127156A (ru) * | 2007-12-06 | 2012-01-20 | Дана-Фарбер Кэнсер Инститьют, Инк. (Us) | Антитела против вируса гриппа и их применение |
| CA2711334A1 (en) | 2008-01-03 | 2009-07-16 | Massachusetts Institute Of Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| US8680022B2 (en) | 2008-02-05 | 2014-03-25 | Bicycle Therapeutics Limited | Methods and compositions |
| US8871207B2 (en) * | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| CN102216327A (zh) | 2008-07-25 | 2011-10-12 | 生物医学研究所 | 中和抗甲型流感病毒抗体及其用途 |
| EP2528615B1 (en) | 2010-01-27 | 2020-05-13 | Massachusetts Institute of Technology | Engineered polypeptide agents for targeted broad spectrum influenza neutralization |
| US9586996B2 (en) * | 2010-04-30 | 2017-03-07 | Esperance Pharmaceuticals, Inc. | Lytic-peptide-Her2/neu (human epidermal growth factor receptor 2) ligand conjugates and methods of use |
| AU2011312178B2 (en) | 2010-10-04 | 2016-05-12 | Massachusetts Institute Of Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| CN109265541A (zh) | 2012-05-10 | 2019-01-25 | 麻省理工学院 | 流感中和药剂 |
| JP6247995B2 (ja) | 2014-04-22 | 2017-12-13 | 東京エレクトロン株式会社 | 接合方法、プログラム、コンピュータ記憶媒体、接合装置及び接合システム |
-
2013
- 2013-03-14 CN CN201811019451.4A patent/CN109265541A/zh active Pending
- 2013-03-14 SG SG11201406769RA patent/SG11201406769RA/en unknown
- 2013-03-14 CA CA2871160A patent/CA2871160C/en active Active
- 2013-03-14 SG SG10201807059QA patent/SG10201807059QA/en unknown
- 2013-03-14 CN CN201380024604.3A patent/CN104507500A/zh active Pending
- 2013-03-14 US US13/829,675 patent/US9683030B2/en active Active
- 2013-03-14 MX MX2014013678A patent/MX378749B/es unknown
- 2013-03-14 WO PCT/US2013/031704 patent/WO2013169377A1/en not_active Ceased
- 2013-03-14 HK HK15108594.6A patent/HK1207970A1/xx unknown
- 2013-03-14 KR KR1020147034586A patent/KR102122618B1/ko active Active
- 2013-03-14 JP JP2015511463A patent/JP6431477B2/ja active Active
- 2013-03-14 EP EP18196965.0A patent/EP3492101A3/en not_active Withdrawn
- 2013-03-14 BR BR112014027991A patent/BR112014027991A2/pt not_active Application Discontinuation
- 2013-03-14 AU AU2013260123A patent/AU2013260123A1/en not_active Abandoned
- 2013-03-14 EP EP13787149.7A patent/EP2846833A4/en not_active Withdrawn
-
2014
- 2014-10-21 IL IL235237A patent/IL235237A0/en active IP Right Grant
- 2014-11-10 CL CL2014003052A patent/CL2014003052A1/es unknown
-
2017
- 2017-05-15 US US15/595,407 patent/US9982037B2/en active Active
-
2018
- 2018-04-02 JP JP2018070701A patent/JP2018118991A/ja active Pending
- 2018-04-06 AU AU2018202468A patent/AU2018202468B2/en active Active
- 2018-04-23 US US15/959,430 patent/US10538578B2/en active Active
-
2019
- 2019-11-06 US US16/675,826 patent/US10947300B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015517492A5 (enExample) | ||
| HRP20201975T1 (hr) | Neutralizirajuća protutijela anti-influenca a virusa i njihova uporaba | |
| JP6325451B2 (ja) | Ａ型インフルエンザに特異的な抗体 | |
| FI3484915T3 (fi) | Uusia zikavirusepitooppeihin spesifisesti sitoutuvia vasta-aineita ja niiden käyttöjä | |
| RU2012107286A (ru) | Высокоаффинные человеческие антитела к человеческому ангиопоэтину-2 | |
| JP2011528901A5 (enExample) | ||
| JP2017500018A5 (enExample) | ||
| US10654915B2 (en) | Antibodies useful in passive influenza immunization | |
| HRP20161740T1 (hr) | Ljudske molekule za vezanje koje su sposobne neutralizirati viruse influence a filogenetske skupine 1 i filogenetske skupine 2, te viruse influence b | |
| JP2016513664A5 (enExample) | ||
| JP2011509245A5 (enExample) | ||
| JP2018500014A5 (enExample) | ||
| RU2018112861A (ru) | Стабильные антитела, связывающиеся с несколькими антигенами | |
| HRP20161146T1 (hr) | Anti-c5 antitijela s poboljšanom farmakokinetikom | |
| JP2014511179A5 (enExample) | ||
| JP2015503909A5 (enExample) | ||
| JP2010521147A5 (enExample) | ||
| JP2012525128A5 (enExample) | ||
| HRP20150799T1 (hr) | Sastavi i postupci za protutijela protiv komplementnog proteina c5 | |
| JP2015525795A5 (enExample) | ||
| JP2012525829A5 (enExample) | ||
| JP2015509097A5 (enExample) | ||
| JP2010528607A (ja) | スタヒロコッカス・アウレウスｏｒｆ０６５７ｎを標的とする抗原結合性タンパク質 | |
| RU2016100892A (ru) | Антитела против tweakr и их применение | |
| JP2013519364A5 (enExample) |