CL2014003052A1 - Anticuerpos para la neutralización de la influenza - Google Patents

Anticuerpos para la neutralización de la influenza

Info

Publication number
CL2014003052A1
CL2014003052A1 CL2014003052A CL2014003052A CL2014003052A1 CL 2014003052 A1 CL2014003052 A1 CL 2014003052A1 CL 2014003052 A CL2014003052 A CL 2014003052A CL 2014003052 A CL2014003052 A CL 2014003052A CL 2014003052 A1 CL2014003052 A1 CL 2014003052A1
Authority
CL
Chile
Prior art keywords
influenza
neutralization
antibodies
Prior art date
Application number
CL2014003052A
Other languages
English (en)
Spanish (es)
Inventor
S Raguram
Viswanathan Sasisekharan
Venkataramanan Soundararajan
Ram Sasisekharan
Vidya Subramanian
Kannan Tharakaraman
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of CL2014003052A1 publication Critical patent/CL2014003052A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CL2014003052A 2012-05-10 2014-11-10 Anticuerpos para la neutralización de la influenza CL2014003052A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261645453P 2012-05-10 2012-05-10

Publications (1)

Publication Number Publication Date
CL2014003052A1 true CL2014003052A1 (es) 2015-06-26

Family

ID=49548780

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014003052A CL2014003052A1 (es) 2012-05-10 2014-11-10 Anticuerpos para la neutralización de la influenza

Country Status (14)

Country Link
US (4) US9683030B2 (enExample)
EP (2) EP2846833A4 (enExample)
JP (2) JP6431477B2 (enExample)
KR (1) KR102122618B1 (enExample)
CN (2) CN109265541A (enExample)
AU (2) AU2013260123A1 (enExample)
BR (1) BR112014027991A2 (enExample)
CA (1) CA2871160C (enExample)
CL (1) CL2014003052A1 (enExample)
HK (1) HK1207970A1 (enExample)
IL (1) IL235237A0 (enExample)
MX (1) MX378749B (enExample)
SG (2) SG10201807059QA (enExample)
WO (1) WO2013169377A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9683030B2 (en) 2012-05-10 2017-06-20 Massachusetts Institute Of Technology Agents for influenza neutralization
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
EA038407B1 (ru) 2015-02-05 2021-08-24 Янссен Вэксинс Энд Превеншн Б.В. Связывающие молекулы, направленные против гемагглютинина вируса гриппа, и пути их применения
BR112017024206A2 (pt) * 2015-05-11 2018-07-17 Janssen Vaccines & Prevention Bv compostos peptidomiméticos neutralizadores do vírus da gripe
WO2017083627A1 (en) 2015-11-13 2017-05-18 Visterra, Inc. Compositions and methods for treating and preventing influenza
CN109195629A (zh) 2016-02-24 2019-01-11 威特拉公司 流行性感冒抗体分子制剂
KR101887876B1 (ko) 2016-08-18 2018-08-13 한국과학기술연구원 H5형 조류독감 바이러스에 특이적으로 결합하는 핵산 압타머 및 이를 이용하는 h5형 조류독감 바이러스의 검출방법
CA3132521A1 (en) 2019-03-25 2020-10-01 Visterra, Inc. Compositions and methods for treating and preventing influenza
WO2021119467A1 (en) 2019-12-11 2021-06-17 Visterra, Inc. Compositions and methods for treating and preventing influenza

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL23522C (enExample) 1927-03-23
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4270537A (en) 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
US4957939A (en) 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4472509A (en) 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4938948A (en) 1985-10-07 1990-07-03 Cetus Corporation Method for imaging breast tumors using labeled monoclonal anti-human breast cancer antibodies
US4886499A (en) 1986-12-18 1989-12-12 Hoffmann-La Roche Inc. Portable injection appliance
GB8704027D0 (en) 1987-02-20 1987-03-25 Owen Mumford Ltd Syringe needle combination
US4940460A (en) 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US5750172A (en) 1987-06-23 1998-05-12 Pharming B.V. Transgenic non human mammal milk
US5339163A (en) 1988-03-16 1994-08-16 Canon Kabushiki Kaisha Automatic exposure control device using plural image plane detection areas
FR2638359A1 (fr) 1988-11-03 1990-05-04 Tino Dalto Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
SG46445A1 (en) 1990-01-26 1998-02-20 Immunomedics Inc Vaccines against cancer and infectious diseases
JPH049249A (ja) 1990-04-27 1992-01-14 Kusuda:Kk 塗型剤吹き付け機
US5190521A (en) 1990-08-22 1993-03-02 Tecnol Medical Products, Inc. Apparatus and method for raising a skin wheal and anesthetizing skin
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
JPH06247995A (ja) 1991-06-24 1994-09-06 Asahi Chem Ind Co Ltd 新規なシアリル（α２−６）ラクトテトラオシルセラミド
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
SE9102652D0 (sv) 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
US5328483A (en) 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
ATE193301T1 (de) 1993-03-09 2000-06-15 Genzyme Corp Verfahren zur isolierung von proteinen aus milch
US5500161A (en) 1993-09-21 1996-03-19 Massachusetts Institute Of Technology And Virus Research Institute Method for making hydrophobic polymeric microparticles
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
WO1995024176A1 (en) 1994-03-07 1995-09-14 Bioject, Inc. Ampule filling device
US5466220A (en) 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
JP3584990B2 (ja) * 1994-05-09 2004-11-04 タカラバイオ株式会社 抗ヒトインフルエンザウイルス抗体
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US5893397A (en) 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
GB9607549D0 (en) 1996-04-11 1996-06-12 Weston Medical Ltd Spring-powered dispensing device
DE19643314A1 (de) 1996-10-21 1998-04-23 Boehringer Mannheim Gmbh Monoklonale Antikörper gegen das Epitop YPYDVPDYA, Verfahren zu deren Herstellung und Verwendung
US5993412A (en) 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
IT1298087B1 (it) 1998-01-08 1999-12-20 Fiderm S R L Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
WO2000059932A1 (fr) 1999-03-31 2000-10-12 Otsuka Pharmaceutical Co., Ltd. Peptides se liant a l'hemagglutinine du virus de la grippe
JP2005502322A (ja) 2001-04-19 2005-01-27 ザ スクリップス リサーチ インスティテュート 非天然アミノ酸のインビボ組込み
CA2464690A1 (en) 2001-09-27 2003-04-10 Pieris Proteolab Ag Muteins of apolipoprotein d
WO2003029462A1 (en) 2001-09-27 2003-04-10 Pieris Proteolab Ag Muteins of human neutrophil gelatinase-associated lipocalin and related proteins
CN1639199A (zh) 2002-03-04 2005-07-13 独立行政法人科学技术振兴机构 新型支链状唾液糖分子与使用该糖分子的抗病毒剂
WO2003080672A1 (en) 2002-03-22 2003-10-02 Aprogen, Inc. Humanized antibody and process for preparing same
EP1573047B1 (en) 2002-08-20 2013-11-13 OpSaniTx LLC Lectin compositions and methods for modulating an immune response to an antigen
AU2005303817B8 (en) 2004-11-11 2010-09-30 Abbott Biologicals B.V. Defective influenza virus particles
US7892827B2 (en) 2004-11-26 2011-02-22 Pieris Ag Compound with affinity for the cytotoxic T lymphocyte-associated antigen (CTLA-4)
CN104803865A (zh) 2004-12-22 2015-07-29 Ambrx公司 含有非天然氨基酸和多肽的组合物、涉及非天然氨基酸和多肽的方法以及其用途
US7959929B2 (en) 2005-04-21 2011-06-14 University Of Florida Research Foundation, Inc. Materials and methods for respiratory disease control in canines
US7871626B2 (en) 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
US20090269342A1 (en) 2006-08-14 2009-10-29 Massachusetts Institute Of Technology Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
CN101553502A (zh) 2006-08-14 2009-10-07 麻省理工学院 血球凝集素多肽和其相关试剂和方法
US20090081193A1 (en) 2006-08-14 2009-03-26 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
WO2008021415A2 (en) 2006-08-14 2008-02-21 Massachusetts Institute Of Technology Glycan data mining system
BRPI0813922A2 (pt) * 2007-06-25 2017-05-09 Autoimmune Tech Llc composições de inibição de influenza e métodos.
FR2921928B1 (fr) 2007-10-08 2011-03-04 Sanofi Pasteur Anticorps monoclonaux specifiques de l'hemagglutinine du virus grippal
EP3524619A1 (en) * 2007-12-06 2019-08-14 Dana-Farber Cancer Institute, Inc. Antibodies against influenza virus and methods of use thereof
WO2009089121A2 (en) 2008-01-03 2009-07-16 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
ES2509959T5 (en) 2008-02-05 2024-12-19 Bicyclerd Ltd Methods and compositions
RU2553325C2 (ru) 2008-07-25 2015-06-10 Институт Фо Ресёч Ин Биомедицин Нейтрализующие антитела против вируса гриппа а и их использование
US8871207B2 (en) * 2008-07-25 2014-10-28 Humabs, LLC Neutralizing anti-influenza A virus antibodies and uses thereof
JP6210685B2 (ja) 2010-01-27 2017-10-11 マサチューセッツ インスティテュート オブ テクノロジー 標的化された広域スペクトルのインフルエンザ中和のための操作されたポリペプチド剤
JP2013531474A (ja) * 2010-04-30 2013-08-08 エスペランス ファーマシューティカルズ， インコーポレイテッド 溶解性ペプチド−Ｈｅｒ２／ｎｅｕ（ヒト上皮成長因子レセプター２）リガンド結合体およびその使用方法
SG10201709806VA (en) * 2010-10-04 2017-12-28 Massachusetts Inst Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
US9683030B2 (en) 2012-05-10 2017-06-20 Massachusetts Institute Of Technology Agents for influenza neutralization
JP6247995B2 (ja) 2014-04-22 2017-12-13 東京エレクトロン株式会社 接合方法、プログラム、コンピュータ記憶媒体、接合装置及び接合システム

Also Published As

Publication number Publication date
AU2018202468A1 (en) 2018-04-26
US20170306003A1 (en) 2017-10-26
SG11201406769RA (en) 2014-11-27
US20130302348A1 (en) 2013-11-14
AU2013260123A1 (en) 2014-11-13
CA2871160A1 (en) 2013-11-14
KR102122618B1 (ko) 2020-06-29
US9982037B2 (en) 2018-05-29
US10538578B2 (en) 2020-01-21
MX2014013678A (es) 2015-02-04
US20200123234A1 (en) 2020-04-23
EP3492101A3 (en) 2019-10-23
US9683030B2 (en) 2017-06-20
KR20150008180A (ko) 2015-01-21
CN104507500A (zh) 2015-04-08
IL235237A0 (en) 2014-12-31
CN109265541A (zh) 2019-01-25
JP6431477B2 (ja) 2018-12-05
CA2871160C (en) 2023-03-14
SG10201807059QA (en) 2018-09-27
EP2846833A1 (en) 2015-03-18
WO2013169377A1 (en) 2013-11-14
HK1207970A1 (en) 2016-02-19
US10947300B2 (en) 2021-03-16
US20190062407A1 (en) 2019-02-28
BR112014027991A2 (pt) 2017-07-18
EP3492101A2 (en) 2019-06-05
JP2015517492A (ja) 2015-06-22
JP2018118991A (ja) 2018-08-02
EP2846833A4 (en) 2016-01-06
MX378749B (es) 2025-03-10
AU2018202468B2 (en) 2020-04-16

Similar Documents

Publication Publication Date Title
CY2024011I1 (el) Αντισωματα anti-fcrn
PL2908912T3 (pl) Szeroko neutralizujące przeciwciała anty-hiv
HUE037048T2 (hu) Eljárások 4-cikloalkiloxibenzolszulfonamidok elõállítására
SI3715345T1 (sl) Priprava zaviralca lfa-1
DK2858671T3 (da) Antistofformulering
DK2890397T3 (da) Antiprolactinreceptor-antistofformulering
SMT202000512T1 (it) Anticorpi anti-tau umani
DK2934584T3 (da) Anti-gdf15-antistoffer
HRP20181646T1 (hr) Konjugati pirolobenzodiazepin - anti-psma protutijela
DK3117837T3 (da) Antistofformuleringer
PT2852391T (pt) Sistemas para tratamento de infeções pulmonares
CL2014003052A1 (es) Anticuerpos para la neutralización de la influenza
ES2603028T8 (es) Procedimiento para la preparación de (Z)-alfa-fluoro-beta-amino-acrilaldehídos sustituidos
CL2014003125A1 (es) Anticuerpos de anti-transglutaminasa 2
DK2828292T3 (da) Jcv-neutraliserende antistoffer
DK2935330T3 (da) Anti-notch3-antistoffer
DK2828284T3 (da) Jcv-neutraliserende antistoffer
BR112015000987A2 (pt) processo para a preparação de 5-fluoro-1h-pirazóis
ES1077013Y (es) Dispositivo para la fabricación de jabón
ES1078789Y (es) Angular para la fijacion de inodoros
ES1076945Y (es) Dispositivo para la vaporizacion de sustancias
ES1077477Y (es) Autolavado de mascotas
ES1076953Y (es) Dispositivo para la construccion de marquesinas para rotulos comerciales
CO6910041A1 (es) Procedimiento para la fabricacion de ataudes ecologicos
ES1076883Y (es) Dispositivo extraible para la sujecion de escaleras