CA2871160C - Agents for influenza neutralization - Google Patents

Agents for influenza neutralization Download PDF

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Publication number
CA2871160C
CA2871160C CA2871160A CA2871160A CA2871160C CA 2871160 C CA2871160 C CA 2871160C CA 2871160 A CA2871160 A CA 2871160A CA 2871160 A CA2871160 A CA 2871160A CA 2871160 C CA2871160 C CA 2871160C
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CA
Canada
Prior art keywords
seq
influenza
binding
antibody
nos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2871160A
Other languages
English (en)
French (fr)
Other versions
CA2871160A1 (en
Inventor
S. Raguram
Viswanathan Sasisekharan
Venkataramanan Soundararajan
Ram Sasisekharan
Vidya Subramanian
Kannan Tharakaraman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of CA2871160A1 publication Critical patent/CA2871160A1/en
Application granted granted Critical
Publication of CA2871160C publication Critical patent/CA2871160C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2871160A 2012-05-10 2013-03-14 Agents for influenza neutralization Active CA2871160C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261645453P 2012-05-10 2012-05-10
US61/645,453 2012-05-10
PCT/US2013/031704 WO2013169377A1 (en) 2012-05-10 2013-03-14 Agents for influenza neutralization

Publications (2)

Publication Number Publication Date
CA2871160A1 CA2871160A1 (en) 2013-11-14
CA2871160C true CA2871160C (en) 2023-03-14

Family

ID=49548780

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2871160A Active CA2871160C (en) 2012-05-10 2013-03-14 Agents for influenza neutralization

Country Status (14)

Country Link
US (4) US9683030B2 (enExample)
EP (2) EP3492101A3 (enExample)
JP (2) JP6431477B2 (enExample)
KR (1) KR102122618B1 (enExample)
CN (2) CN109265541A (enExample)
AU (2) AU2013260123A1 (enExample)
BR (1) BR112014027991A2 (enExample)
CA (1) CA2871160C (enExample)
CL (1) CL2014003052A1 (enExample)
HK (1) HK1207970A1 (enExample)
IL (1) IL235237A0 (enExample)
MX (1) MX378749B (enExample)
SG (2) SG11201406769RA (enExample)
WO (1) WO2013169377A1 (enExample)

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CA2975655C (en) 2015-02-05 2023-09-19 Janssen Vaccines & Prevention B.V. Binding molecules directed against influenza hemagglutinin and uses thereof
CA2985402A1 (en) * 2015-05-11 2016-11-17 Janssen Vaccines & Prevention B.V. Influenza virus neutralizing peptidomimetic compounds
EP3374390A1 (en) 2015-11-13 2018-09-19 Visterra, Inc. Compositions and methods for treating and preventing influenza
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KR101887876B1 (ko) 2016-08-18 2018-08-13 한국과학기술연구원 H5형 조류독감 바이러스에 특이적으로 결합하는 핵산 압타머 및 이를 이용하는 h5형 조류독감 바이러스의 검출방법
EP3946613A1 (en) 2019-03-25 2022-02-09 Visterra, Inc. Compositions and methods for treating and preventing influenza
JP2023506156A (ja) * 2019-12-11 2023-02-15 ビステラ, インコーポレイテッド インフルエンザを処置または予防するための組成物および方法

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Also Published As

Publication number Publication date
CN104507500A (zh) 2015-04-08
US20190062407A1 (en) 2019-02-28
SG11201406769RA (en) 2014-11-27
EP3492101A2 (en) 2019-06-05
JP2015517492A (ja) 2015-06-22
AU2013260123A1 (en) 2014-11-13
US20170306003A1 (en) 2017-10-26
MX2014013678A (es) 2015-02-04
IL235237A0 (en) 2014-12-31
US9683030B2 (en) 2017-06-20
CA2871160A1 (en) 2013-11-14
AU2018202468B2 (en) 2020-04-16
CL2014003052A1 (es) 2015-06-26
JP2018118991A (ja) 2018-08-02
KR102122618B1 (ko) 2020-06-29
JP6431477B2 (ja) 2018-12-05
BR112014027991A2 (pt) 2017-07-18
US10538578B2 (en) 2020-01-21
WO2013169377A1 (en) 2013-11-14
EP2846833A1 (en) 2015-03-18
US10947300B2 (en) 2021-03-16
MX378749B (es) 2025-03-10
HK1207970A1 (en) 2016-02-19
SG10201807059QA (en) 2018-09-27
AU2018202468A1 (en) 2018-04-26
KR20150008180A (ko) 2015-01-21
EP3492101A3 (en) 2019-10-23
CN109265541A (zh) 2019-01-25
US20200123234A1 (en) 2020-04-23
US9982037B2 (en) 2018-05-29
EP2846833A4 (en) 2016-01-06
US20130302348A1 (en) 2013-11-14

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