MX2009013635A - Composiciones que inhiben la influenza y metodos. - Google Patents

Composiciones que inhiben la influenza y metodos.

Info

Publication number
MX2009013635A
MX2009013635A MX2009013635A MX2009013635A MX2009013635A MX 2009013635 A MX2009013635 A MX 2009013635A MX 2009013635 A MX2009013635 A MX 2009013635A MX 2009013635 A MX2009013635 A MX 2009013635A MX 2009013635 A MX2009013635 A MX 2009013635A
Authority
MX
Mexico
Prior art keywords
protein
peptide
influenza
fir
wild
Prior art date
Application number
MX2009013635A
Other languages
English (en)
Inventor
Robert F Garry
Russell B Wilson
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tulane filed Critical Univ Tulane
Publication of MX2009013635A publication Critical patent/MX2009013635A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/11—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/00033—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención proporciona péptidos, análogos de péptido, derivados de péptido y composiciones farmacéuticas útiles para tratar o prevenir infecciones de influenza o prevenir la transmisión de persona a persona de una infección de influenza. Un péptido de la invención comprende una porción que inhibe la fusión del virus de influenza-célula de la región de iniciación de fusión (FIR) de una proteína de hemaglutinina 2 de influenza de tipo silvestre o una variante de la misma. En una modalidad preferida, un péptido de la invención consiste de 8 a 40 residuos de aminoácido consecutivos de una porción de una proteína de hemaglutinina 2 de influenza de tipo silvestre o una variante de la misma, la porción de la proteína que comprende la FIR de la proteína y hasta cinco residuos de aminoácido sobre los lados amino-terminal y carboxi-terminal de la FIR.
MX2009013635A 2007-06-25 2008-06-25 Composiciones que inhiben la influenza y metodos. MX2009013635A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93712007P 2007-06-25 2007-06-25
PCT/US2008/007918 WO2009002516A1 (en) 2007-06-25 2008-06-25 Influenza inhibiting compositions and methods

Publications (1)

Publication Number Publication Date
MX2009013635A true MX2009013635A (es) 2010-05-19

Family

ID=40185954

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2009013635A MX2009013635A (es) 2007-06-25 2008-06-25 Composiciones que inhiben la influenza y metodos.
MX2014004158A MX363240B (es) 2007-06-25 2008-06-25 Composiciones que inhiben la influenza y métodos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2014004158A MX363240B (es) 2007-06-25 2008-06-25 Composiciones que inhiben la influenza y métodos.

Country Status (18)

Country Link
US (2) US8604165B2 (es)
EP (1) EP2170365B1 (es)
JP (2) JP5450402B2 (es)
KR (4) KR20180021930A (es)
CN (2) CN101848719B (es)
BR (1) BRPI0813922A2 (es)
CA (1) CA2691358C (es)
DK (1) DK2170365T3 (es)
EA (1) EA017957B1 (es)
ES (1) ES2581381T3 (es)
HK (2) HK1142804A1 (es)
HU (1) HUE029921T2 (es)
IL (2) IL202450A (es)
MX (2) MX2009013635A (es)
PL (1) PL2170365T3 (es)
PT (1) PT2170365T (es)
WO (1) WO2009002516A1 (es)
ZA (1) ZA200909130B (es)

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KR101153630B1 (ko) * 2009-10-16 2012-06-18 웅진코웨이주식회사 타닌산을 포함하는 인플루엔자 바이러스 감염의 예방용 조성물, 상기 조성물을 포함하는 기상필터 및 상기 필터를 포함하는 공기청정기
US20110126501A1 (en) 2009-10-16 2011-06-02 Woongjin Coway Co., Ltd. Composition for prevention of influenza viral infection comprising tannic acid, air filter comprising the same and air cleaning device comprising the filter
EP3492101A3 (en) * 2012-05-10 2019-10-23 Massachusetts Institute Of Technology Agents for influenza neutralization
US9649375B2 (en) 2013-03-14 2017-05-16 The Administrators Of The Tulane Educational Fund Immunogenic peptide conjugate and method for inducing an anti-influenza therapeutic antibody response therewith
US20180128545A1 (en) * 2016-11-08 2018-05-10 Berry Metal Company Modular furnace cooling wall
EP3548056A4 (en) * 2016-12-02 2020-08-12 Emory University PEPTIDES AND USES FOR VIRUS INFECTION MANAGEMENT
KR20230038416A (ko) 2020-05-08 2023-03-20 아카데미아 시니카 키메릭 인플루엔자 백신
WO2021253172A1 (zh) * 2020-06-15 2021-12-23 上海市公共卫生临床中心 利用受体识别域诱导抗新冠病毒中和抗体的方法
TW202334429A (zh) 2021-10-01 2023-09-01 中央研究院 Sars-cov-2棘蛋白特異性抗體及其用途

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Also Published As

Publication number Publication date
US9353157B2 (en) 2016-05-31
EP2170365B1 (en) 2016-05-25
PT2170365T (pt) 2016-07-12
KR101719135B1 (ko) 2017-03-23
MX363240B (es) 2019-03-15
KR20180021930A (ko) 2018-03-05
AU2008269081A1 (en) 2008-12-31
HK1142804A1 (zh) 2010-12-17
US20100152109A1 (en) 2010-06-17
IL202450A (en) 2015-05-31
EP2170365A1 (en) 2010-04-07
JP2010531362A (ja) 2010-09-24
IL202450A0 (en) 2011-08-01
BRPI0813922A2 (pt) 2017-05-09
US8604165B2 (en) 2013-12-10
KR20160113331A (ko) 2016-09-28
KR20150117303A (ko) 2015-10-19
KR20100056442A (ko) 2010-05-27
IL238404A (en) 2017-03-30
ES2581381T3 (es) 2016-09-05
EA017957B1 (ru) 2013-04-30
JP2013241432A (ja) 2013-12-05
EA201070053A1 (ru) 2010-08-30
PL2170365T3 (pl) 2017-03-31
CN105237629A (zh) 2016-01-13
CA2691358A1 (en) 2008-12-31
EP2170365A4 (en) 2012-05-02
US20140194347A1 (en) 2014-07-10
CN101848719B (zh) 2015-09-23
CN105237629B (zh) 2019-06-18
JP5764621B2 (ja) 2015-08-19
HK1215037A1 (zh) 2016-08-12
HUE029921T2 (en) 2017-04-28
CN101848719A (zh) 2010-09-29
IL238404A0 (en) 2015-06-30
CA2691358C (en) 2017-08-22
KR101660363B1 (ko) 2016-09-28
ZA200909130B (en) 2010-09-29
DK2170365T3 (en) 2016-09-05
JP5450402B2 (ja) 2014-03-26
WO2009002516A1 (en) 2008-12-31

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